Review
Oncology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Peixin Dong, Nikolaus Gassler, Mohammad Taheri, Aria Baniahmad, Nader Akbari Dilmaghani
Summary: This article summarizes the important role of Cyclin-dependent kinases (CDK) in cancer, emphasizing the significance of understanding CDK function and mechanisms for future cancer therapies targeting these kinases.
CANCER CELL INTERNATIONAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Ruilin Guan, Lina Xie, Lili Wang, Ying Zhou, Yu Chen, Liangnian Ji, Hui Chao
Summary: NecroIr1 and NecroIr2, iridium(iii) complexes, induce necroptosis in cisplatin-resistant lung cancer cells by selectively accumulating in mitochondria and causing oxidative stress. Additionally, they interfere with cell cycle progression, leading to G0/G1 phase arrest. The combined effect of necroptosis induction and cell cycle arrest makes them potential antitumor agents against drug-resistant cancer cells.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Neurosciences
Rui Chen, Ningxia Zhang, Yubin Zhou, Ji Jing
Summary: Proximity-dependent biotinylation techniques are widely used for analyzing protein-protein interactions in living cells. Researchers have developed a split TurboID variant called OptoID, which can be controlled using light for proximity-based biotinylation. These optical actuators and sensors have potential applications in precise proximity proteomics and rapid detection of biotinylation in living cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Oncology
Mitra Zabihi, Ramin Lotfi, Amir-Mohammad Yousefi, Davood Bashash
Summary: CDKs, cyclins, and CKIs play important roles in the cell cycle regulatory machinery, and dysregulation of their expression or function can contribute to tumorigenesis. While designing CDK inhibitors to target tumor cells shows promise, the non-canonical functions of CDKs pose challenges in their application. This review aims to explore the biology of CDKs and their contribution to tumorigenesis, and discuss the pros and cons of CDK inhibition in the treatment of human cancers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Ying Jin, Xin Li, Ying Jiang
Summary: Neurochemicals play a vital role in neural activity and can lead to various neurological disorders when abnormalities occur. Electrochemical systems are widely used in sensing neurochemicals in living brain environments, but there are still challenges that need to be addressed for their development and application.
Article
Chemistry, Analytical
Dan Xie, Yanrong Wen, Jingran Chen, Zhanchen Guo, Pengfei Li, Zhen Liu
Summary: In this study, a molecularly imprinted polymer (MIP)-based plasmonic immunosandwich assay (PISA) was developed for the specific recognition of 4PPTylation and detection of ALDH1L1 in single cells. The MIP-based PISA showed excellent binding properties and enabled the specific and sensitive detection of 4PPTylated ALDH1L1 in single living cells. The study also demonstrated possible crosstalk between different pathways in folate metabolism.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiaoxu Li, Bo Sun, Jianhua Zhu, Moting Qian, Yun Chen
Summary: Protein dimerization plays a significant role in cellular signaling and understanding its quantitative analysis is important for clinical cancer management.
ANALYTICAL CHEMISTRY
(2022)
Article
Microbiology
Chonglv Feng, Zhe Cheng, Zhijian Xu, Ye Tian, Huimin Tian, Fan Liu, Damin Luo, Yanhai Wang
Summary: This study describes the cell cycle regulation mechanism of germinative cells in the tapeworm Echinococcus multilocularis, which is influenced by the interaction between the parasite and the host. Host EGF regulates the G1/S phase of the cell cycle through the EGFR-ERK-EmCyclinD pathway.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aadil Javed, Mahdieh Yarmohammadi, Kemal Sami Korkmaz, Teresa Rubio-Tomas
Summary: Gastric cancer is characterized by uncontrolled growth and metastasis of gastric epithelial cells, which is predominantly in adenocarcinoma form. The regulation of gastric cell growth is influenced by key cell cycle regulators, including Cyclins and Cyclin-dependent kinases (CDKs). Dysregulation of these molecules can lead to disturbances in cell cycle dynamics and the development of gastric cancer. Numerous studies have examined the roles of Cyclins and CDKs in gastric cancer, and this review aims to compile evidence of upstream regulators that activate or inhibit Cyclins and CDKs. It serves as a comprehensive resource for future studies and hypothesis generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Sonal M. Manohar
Summary: This article reviews cyclin-dependent kinases as potential targets for colorectal cancer (CRC) and discusses therapeutic candidates to target CDKs.
FUTURE MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Marzena Staniszewska, Kajetan Kielbowski, Klaudia Rusinska, Estera Bakinowska, Ewa Gromowska, Andrzej Pawlik
Summary: In this review, the potential of cyclin-dependent kinases (CDK) as novel therapeutic targets in rheumatoid arthritis (RA) and psoriasis is evaluated. CDK inhibitors show promise due to their potential multidirectional effects on osteoclastogenesis, neutrophil apoptosis, and macrophage apoptosis, all of which play important roles in the development of joint destruction and inflammation in RA and psoriasis. However, further clinical trials are needed to assess the efficacy and safety of CDK-blocking therapy in these conditions.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Jodi L. Bubenik, Melissa Hale, Ona McConnell, Eric T. Wang, Maurice S. Swanson, Robert C. Spitale, J. Andrew Berglund
Summary: In vivo RNA structure analysis has evolved into a powerful tool through enrichment of low abundance targets for improved analysis of low abundance transcripts, allowing for studying autoregulated events in pre-mRNA in a cellular context.
Review
Oncology
Alessandra Merlini, Valeria Pavese, Giulia Manessi, Martina Rabino, Francesco Tolomeo, Sandra Aliberti, Lorenzo D'Ambrosio, Giovanni Grignani
Summary: Effective treatment of advanced/metastatic bone and soft tissue sarcomas remains a medical challenge. CDK inhibitors have shown potential therapeutic effects in various cancer types, including sarcomas. This review explores the molecular basis and therapeutic implications of CDK inhibitors in sarcoma treatment and discusses the possibility of combination therapies with conventional treatments, targeted therapy, and immunotherapy to integrate CDK inhibition in sarcoma treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Edward C. Dominguez, Carly Roleder, Brian Ball, Alexey V. Danilov
Summary: Targeting CDK9 in lymphoid malignancies shows promise in inducing apoptosis by inhibiting mRNA transcription. Early clinical trials have demonstrated the safety of CDK9 inhibitors, although further research is needed to confirm their efficacy.
LEUKEMIA & LYMPHOMA
(2023)
Article
Multidisciplinary Sciences
Valentina Gandin, Brian P. English, Melanie Freeman, Louis-Philippe Leroux, Stephan Preibisch, Deepika Walpita, Maritza Jaramillo, Robert H. Singer
Summary: This study combines live-cell spectroscopy and single-particle tracking to investigate the binding dynamics of mRNA translation initiation factors. By quantifying their diffusion characteristics, the assembly and disassembly sequence of initiation factors and the clustering of translation in neurons are revealed.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Olivia Howells, Natasha Rajendran, Sarah Mcintyre, Sara Amini-Asl, Pauline Henri, Yufei Liu, Owen Guy, Anthony E. G. Cass, May C. Morris, Sanjiv Sharma
Article
Dermatology
P. Henri, C. Prevel, M. Pellerano, J. Lacotte, P. E. Stoebner, M. C. Morris, L. Meunier
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Article
Biochemical Research Methods
Marion Peyressatre, Arthur Laure, Morgan Pellerano, Hassan Boukhaddaoui, Ines Soussi, May C. Morris
BIOTECHNOLOGY JOURNAL
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
May Morris, Frederic Bihel, Sebastien Diot, Clovis Peter, Celine Boucher, Jacques Bricard, Morgan Pellerano, Malik Hellal, Camille Prevel
Article
Chemistry, Multidisciplinary
Marion Peyressatre, Dominique Patomo Arama, Arthur Laure, Juan A. Gonzalez-Vera, Morgan Pellerano, Nicolas Masurier, Vincent Lisowski, May C. Morris
FRONTIERS IN CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Jessica Soamalala, Sebastien Diot, Morgan Pellerano, Christophe Blanquart, Mathieu Galibert, Magali Jullian, Karine Puget, May C. Morris
Summary: The study describes a fluorescent peptide biosensor derived from 6-phosphofructokinase that reports on CDK6 kinase activity through sensitive changes in fluorescence intensity. This biosensor enables quantification of differences in kinase activity in complex environments and highlights the differences in kinase activity between CDK6 and CDK4. The utility of these selective tools for monitoring two closely related kinases comparatively and simultaneously offers attractive perspectives for diagnostic and therapeutic purposes.
Article
Chemistry, Multidisciplinary
Carmen Mihaela Tilmaciu, Bhimareddy Dinesh, Morgan Pellerano, Sebastien Diot, Melanie Guidetti, Julien Vollaire, Alberto Bianco, Cecilia Menard-Moyon, Veronique Josserand, May C. Morris
Summary: The novel CDK1 activity reporter, utilizing the sensitivity of a fluorescent biosensor and the properties of carbon nanotubes, allows for sensitive and dose-dependent measurement of CDK1 activity, monitoring of intracellular kinases, and direct fluorescence imaging within tumor xenografts in mice.
Editorial Material
Biotechnology & Applied Microbiology
Julie Batut, Marina Kvaskoff, May C. Morris
Summary: This innovative program aims to provide support, encouragement, and guidance for women scientists in the early stages of their careers, particularly during their PhD.
NATURE BIOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
Francisco Fueyo-Gonzalez, Rosario Herranz, Simona Plesselova, Maria D. Giron, Rafael Salto, Jose Manuel Paredes, Angel Orte, May C. Morris, Juan A. Gonzalez-Vera
Summary: CDK5 kinase is activated through interactions with different partners, playing a key role in neuronal functions and contributing to neurodegenerative diseases and human cancers. The design of fluorescently labeled peptides allowed for the detection of CDK5 partners, demonstrating the potential of the biosensor to report on the relative abundance of p25.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Medicine, General & Internal
Atul Sharma, Rupesh Kumar Mishra, K. Yugender Goud, Mona A. Mohamed, Shekher Kummari, Swapnil Tiwari, Zhanhong Li, Roger Narayan, Lia A. Stanciu, Jean Louis Marty
Summary: Biosensors have become crucial in healthcare and clinical research for early diagnostics and countermeasures. Optical biosensors, with their advantages of speed, portability, specificity, and sensitivity, offer an effective method for rapid detection of pathogenic virus particles. Integration of intelligent nanomaterials in sensors enhances their sensitivity and advanced capabilities, providing valuable assistance to clinicians.
Review
Chemistry, Organic
May C. Morris
Summary: The development of sensitive and selective strategies for detecting disease biomarkers is a major challenge in diagnostics. Protein kinases play a significant role in cancer and can be potential therapeutic targets. However, quantifying kinase expression levels alone is insufficient to understand their activity, necessitating the use of technologies that report on kinase function. Fluorescent peptide biosensors can quantify kinase activity differences between healthy and cancer cells, and monitor therapeutic responses in vitro, in living cells and in vivo.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Biology
May C. Morris
Summary: Protein kinases play crucial roles in biological signalling pathways and their dysregulation has been implicated in diseases, particularly cancer. Fluorescent biosensors have been developed to monitor protein kinase activities, providing valuable functional information about enzymatic alterations associated with the disease.
Article
Cell Biology
Rebecca Harris, Ming Yang, Christina Schmidt, Chloe Royet, Sarbjit Singh, Amarnath Natarajan, May Morris, Christian Frezza, Heike Laman
Summary: Fbxo7 plays a crucial role in cancer and Parkinson's disease by promoting Cdk6 activation and regulating the ubiquitination and phosphorylation of PFKP. Cells lacking Fbxo7 show reduced Cdk6 activity, and hematopoietic and lymphocytic cells are highly dependent on Fbxo7. Decreased Fbxo7 expression in T cells leads to increased glycolysis, but lower cell viability and activation levels.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Celine Bouclier, Matthieu Simon, Guillaume Laconde, Morgan Pellerano, Sebastien Diot, Sylvie Lantuejoul, Benoit Busser, Laetitia Vanwonterghem, Julien Vollaire, Veronique Josserand, Baptiste Legrand, Jean-Luc Coll, Muriel Amblard, Amandine Hurbin, May C. Morris