Article
Biology
Cheon-Gyu Park, Wookyung Yu, Byung-Chang Suh
Summary: This study found that Ca-v beta subunits regulate the biophysical states of Ca-v 2.2 channels by modulating the interaction with different PIP2 binding sites.
Article
Biology
Dina Simkin, Kelly A. Marshall, Carlos G. Vanoye, Reshma R. Desai, Bernabe Bustos, Brandon N. Piyevsky, Juan A. Ortega, Marc Forrest, Gabriella L. Robertson, Peter Penzes, Linda C. Laux, Steven J. Lubbe, John J. Millichap, Alfred L. George, Evangelos Kiskinis
Summary: Mutations in the KCNQ2 gene result in neonatal epileptic encephalopathy with severe seizures and neurodevelopmental impairments. Patient-derived neurons show specific functional properties that can be replicated in control neurons by chronically inhibiting the M-current. Dyshomeostatic mechanisms exacerbate KCNQ2 loss-of-function in patient iPSC-derived neurons.
Article
Cardiac & Cardiovascular Systems
Nihal Ozturk, Serkan Uslu, Tanju Mercan, Orhan Erkan, Semir Ozdemir
Summary: The study demonstrated that rosuvastatin modulates the beta-adrenergic signaling cascade, particularly the AC-cAMP-PKA pathway, mimicking the effects of beta-adrenergic receptor blockers in adult ventricular myocytes.
CARDIOVASCULAR TOXICOLOGY
(2021)
Article
Neurosciences
Rahul Chaudhary, Stefanie Albrecht, Maia Datunashvili, Manuela Cerina, Annika Luettjohann, Ye Han, Venu Narayanan, Dane M. Chetkovich, Tobias Ruck, Tanja Kuhlmann, Hans-Christian Pape, Sven G. Meuth, Mehrnoush Zobeiri, Thomas Budde
Summary: There is no consensus on the exact prevalence of epileptic seizures or epilepsy in multiple sclerosis (MS). This study used a mouse model to investigate the relationship between epileptic activity, loss of myelin, and pro-inflammatory cytokines. The findings suggest that demyelination-related changes in thalamic inward current may contribute to the prevalence of seizures in MS.
Article
Biochemistry & Molecular Biology
Eric de Hoog, Gaynor E. Spencer
Summary: The metabolite of vitamin A, retinoic acid (RA), influences neuronal firing by inducing spike broadening and complex spiking, and modulates Ca2+ influx through CaV2 channels by enhancing inactivation of delayed rectifier voltage-gated K+ channels.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Fushun Wang, Wei Wang, Simeng Gu, Dan Qi, Nathan A. Smith, Weiguo Peng, Wei Dong, Jiajin Yuan, Binbin Zhao, Ying Mao, Peng Cao, Qing Richard Lu, Lee A. Shapiro, S. Stephen Yi, Erxi Wu, Jason H. Huang
Summary: The researchers discovered two distinct astrocytic Ca2+ signals in the mouse barrel cortex, which play different roles in modulating sensory transmission during sleep and arousal states.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Paula Maria Heister, Trevor Powell, Antony Galione
Summary: Insulin release from pancreatic beta-cells is associated with highly localized intracellular Ca2+ signals, which may be influenced by global Ca2+ signals and SERCA-based sequestration mechanisms. Previous work has demonstrated the importance of NAADP-induced Ca2+ release in stimulus-secretion coupling in beta-cells.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Dorina Zoephel, Chantal Hof, Annette Lis
Summary: Aging is an unstoppable process that affects every cell of the organism, especially the changes in Ca2+ signaling in immune cells which may profoundly impact the development of age-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sana Kouba, Frederic Hague, Ahmed Ahidouch, Halima Ouadid-Ahidouch
Summary: In the fight against cancer, the appearance of resistant cancer stem cells (CSCs) is a major obstacle for therapeutic strategies using cisplatin. Altered Ca2+ signaling, which is essential for various cellular processes, including proliferation and survival, has been linked to CSC functions and therapy resistance. Understanding the molecular mechanisms linking Ca2+ to cisplatin-induced resistance and CSC behaviors could lead to alternative therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Karen Bohmwald, Nicolas M. S. Galvez, Catalina A. Andrade, Valentina P. Mora, Jose T. Munoz, Pablo A. Gonzalez, Claudia A. Riedel, Alexis M. Kalergis
Summary: Most cellular functions require ion homeostasis and movement, with calcium playing a crucial role in regulating immune cell functions. Some viruses have evolved mechanisms to modulate intracellular calcium concentrations to increase infectivity and evade the immune system.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daniela Baracaldo-Santamaria, Sara Sofia Avendano-Lopez, Daniel Felipe Ariza-Salamanca, Mateo Rodriguez-Giraldo, Carlos A. Calderon-Ospina, Rodrigo E. Gonzalez-Reyes, Mauricio O. Nava-Mesa
Summary: Alzheimer's disease is a chronic neurodegenerative disease that causes progressive dementia in older adults. It is characterized by memory loss and cognitive impairment due to dysfunction in cholinergic pathways and neurotoxicity mediated by N-methyl-D-aspartate (NMDA). The presence of intracellular neurofibrillary tangles, extracellular amyloid-beta (A beta) plaques, and selective neurodegeneration are the pathological hallmarks of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Kwun Nok Mimi Man, Peter Bartels, Peter B. Henderson, Karam Kim, Mei Shi, Mingxu Zhang, Sheng-Yang Ho, Madeline Nieves-Cintron, Manuel F. Navedo, Mary C. Horne, Johannes W. Hell
Summary: The cellular mechanisms by which norepinephrine regulates behaviors in the brain remain unknown. This study identifies the L-type Ca2+ channel Ca(V)1.2 as a major target for alpha(1)-adrenergic receptors (ARs) in the hippocampus. Activation of alpha(1)AR signaling enhances LTCC activity through the PKC-Pyk2-Src pathway, suggesting that Ca(V)1.2 is a central conduit for norepinephrine signaling. Inhibition of Pyk2 and Src blocks hippocampal long-term potentiation (LTP), indicating that the enhancement of Ca(V)1.2 activity through alpha(1)AR-Pyk2-Src signaling regulates synaptic strength.
Review
Biochemistry & Molecular Biology
Evgenia Sitnikova, Elizaveta Rutskova, Kirill Smirnov
Summary: Spike-wave discharges are caused by thalamocortical network disorder in idiopathic generalized epilepsy. Currently available anti-epileptic drugs have significant side effects due to low selectivity to molecular targets. Activation of alpha2B adrenergic receptors (ARs) in the thalamus shows potential as a specific molecular target for absence epilepsy. HCN and calcium channels are proposed as relevant cellular targets of alpha2 ARs in spike-wave activity generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alexander Becker, Barbara Wardas, Houssein Salah, Maryam Amini, Claudia Fecher-Trost, Qiao Sen, Damian Martus, Andreas Beck, Stephan E. Philipp, Veit Flockerzi, Anouar Belkacemi
Summary: The study revealed that Cav beta 3 interacts with the IP3 receptor in isolated beta-cells independently of Cav channel functions, influencing Ca2+ signaling and regulating insulin expression and glucose-dependent release in a cell-autonomous manner.
Article
Virology
P. Sanjai Kumar, Anukrishna Radhakrishnan, Tathagata Mukherjee, Somlata Khamaru, Soma Chattopadhyay, Subhasis Chattopadhyay
Summary: This review highlights the importance of Ca2+ in diverse viruses and the role of Ca2+-conducting TRP channels in viral pathophysiology. TRP channels play a crucial role in various viral life-cycle events and may act as a target for antiviral therapeutics.
Article
Biochemical Research Methods
Niklas Huntemann, Anna Vogelsang, Linda Groeneweg, Alice Willison, Alexander M. Herrmann, Sven G. Meuth, Susann Eichler
Summary: This study investigates the influence of different components on the progression of experimental autoimmune encephalomyelitis (EAE) and provides a method for consistent EAE induction that reduces the number of mice used while maintaining consistent results.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Editorial Material
Clinical Neurology
Leoni Rolfes, Sven G. Meuth
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Amelie F. Menke, Fatme Seval Ismail, Klaus Dornmair, Manuela Cerina, Sven G. Meuth, Nico Melzer
Summary: This study investigated the direct pathogenic effect of GABA(A)R autoantibodies on hippocampal networks and found that they play a crucial role in seizure generation in GABA(A)R autoimmune encephalitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elham Poonaki, Ann-Christin Nickel, Mehdi Shafiee Ardestani, Lars Rademacher, Marilyn Kaul, Evgeny Apartsin, Sven G. Meuth, Ali Gorji, Christoph Janiak, Ulf Dietrich Kahlert
Summary: This study loaded the clinical-stage GLS1 inhibitor Telaglenastat (CB-839) onto PEGylated gold nanoparticles conjugated with the CD133 aptamer (Au-PEG-CD133-CB-839) and tested it on CD133-positive brain tumor models in vitro. The results showed that Au-PEG-CD133-CB-839 significantly reduced the viability of CD133-positive cancer cells, and the effect was stronger compared to individual components of the nanodrug. Interestingly, the treatment was effective in glioblastoma stem cells representing different transcriptomic subtypes. This platform serves as a foundation for further target specificity characterization and in vivo application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Kai Siebenbrodt, Vanessa Schuetz, Lara S. Costard, Valentin Neubert, Daniel Alvarez-Fischer, Kerstin Seidel, Bernd Schmeck, Sven G. Meuth, Felix Rosenow, Sebastian Bauer
Summary: This study quantified the release levels of hippocampal extracellular cytokines and chemokines in a rat model of mesial temporal lobe epilepsy with hippocampal sclerosis using microdialysis. The results showed that IL-1 beta release kinetics are consistent with its pro-epileptogenic properties, while IL-10 release kinetics suggest a counter-regulatory effect.
Review
Biochemistry & Molecular Biology
Marvin Korff, Ruben Steigerwald, Elena Bechthold, Dirk Schepmann, Julian A. Schreiber, Sven G. Meuth, Guiscard Seebohm, Bernhard Wuensch
Summary: GluN2B-NMDA receptors play a key role in neurological and neurodegenerative disorders. A new GluN2B-NMDA receptor modulator was developed with promising affinity and pharmacological activity, which could be suitable for human application.
BIOLOGICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Theresia Sarabhai, Lucia Mastrototaro, Sabine Kahl, Gidon J. Boenhof, Marc Jonuscheit, Pavel Bobrov, Hisayuki Katsuyama, Rainer Guthoff, Martin Wolkersdorfer, Christian Herder, Sven G. Meuth, Sven Dreyer, Michael Roden
Summary: This study aimed to examine the effects of hyperbaric oxygen therapy on whole-body glucose metabolism in individuals with type 2 diabetes. The results showed that hyperbaric oxygen therapy decreased fasting blood glucose, improved whole-body insulin sensitivity, and achieved this improvement through decreasing endoplasmic reticulum stress and increasing mitochondrial function.
Article
Cardiac & Cardiovascular Systems
A. G. Bejinariu, M. Schilling, P. Mueller, L. Clasen, S. Gerguri, S. Angendohr, S. Katsianos, J. Schmidt, C. Brinkmeyer, S. G. Meuth, M. Kelm, H. Makimoto
Summary: The total atrial conduction time (TACT) measured by echocardiography can predict the risk of atrial fibrillation (AF) and stroke; adding TACT to the revised Framingham stroke risk profile (rFSRP) significantly improves the prediction of stroke incidence.
Article
Immunology
Steffen Pfeuffer, Leoni Rolfes, Timo Wirth, Falk Steffen, Marc Pawlitzki, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Marcus Brand, Stefan Bittner, Tobias Ruck, Luisa Klotz, Heinz Wiendl, Sven G. Meuth
Summary: Immunoadsorption demonstrated better outcomes compared to double-dose methylprednisolone for treating steroid-refractory acute multiple sclerosis relapses, and modulation of B cell function may be a potential mechanism of action for immunoadsorption.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Harald Hefter, Dietmar Rosenthal, Alexander Jansen, Raphaela Brauns, Beyza Urer, Hans Bigalke, Hans-Peter Hartung, Sven G. Meuth, John-Ih Lee, Philipp Albrecht, Sara Samadzadeh
Summary: The study found that frequent injections of a complex protein-containing BoNT/A preparation are associated with a significantly higher risk of developing neutralizing antibodies (NABs) compared to injections with a complex protein-free BoNT/A preparation.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Isabel Lutfullin, Maria Eveslage, Stefan Bittner, Gisela Antony, Martina Flaskamp, Felix Luessi, Anke Salmen, Barbara Gisevius, Luisa Klotz, Catharina Korsukewitz, Achim Berthele, Sergiu Groppa, Florian Then Bergh, Brigitte Wildemann, Antonios Bayas, Hayrettin Tumani, Sven G. Meuth, Corinna Trebst, Uwe K. Zettl, Friedemann Paul, Christoph Heesen, Tania Kuempfel, Ralf Gold, Bernhard Hemmer, Frauke Zipp, Heinz Wiendl, Jan D. Luenemann
Summary: Obesity is associated with higher disease severity and poorer outcome in newly diagnosed patients with multiple sclerosis. The presence of obesity at disease onset is linked to higher disability at baseline and at follow-up periods of 2, 4, and 6 years. Obesity management could potentially improve the clinical outcome of multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Paul Disse, Isabel Aymanns, Nadine Ritter, Stefan Peischard, Lisanne Korn, Heinz Wiendl, Matthias Pawlowski, Stjepana Kovac, Sven G. Meuth, Thomas Budde, Nathalie Strutz-Seebohm, Bernhard Wunsch, Guiscard Seebohm
Summary: N-Methyl-D-aspartate receptors (NMDARs) are crucial for brain learning and information processing. Dysfunction of NMDARs can contribute to neurodegeneration and drug addiction. Developing selective NMDAR modulators is a promising approach for treating these diseases. We established a hiPSC-derived neural cell system to investigate the effects of NMDAR modulators and pharmaceuticals on human neurons.
BIOLOGICAL CHEMISTRY
(2023)
Article
Immunology
Amelie Semmler, Anna Katharina Mundorf, Anna Sabrina Kuechler, Karin Schulze-Bosse, Harald Heidecke, Kai Schulze-Forster, Matthias Schott, Markus Uhrberg, Sandra Weinhold, Karl J. Lackner, Marc Pawlitzki, Sven Guenther Meuth, Fritz Boege, Jana Ruhrlaender
Summary: SARS-CoV-2 mRNA vaccination may lead to chronic fatigue/dysautonomia known as post-acute COVID-19 vaccination syndrome (PACVS). Receptor autoantibodies and interleukin-6 (IL-6) were identified as somatic correlates of PACVS. Diagnostic blood markers, including increased Angiotensin II type 1 receptor antibodies, decreased alpha-2B adrenergic receptor antibodies, and elevated IL-6, can distinguish PACVS from normal post-vaccination state.
Meeting Abstract
Clinical Neurology
Sindhu Ramchandren, Jeff Guptill, Carlo Antozzi, Vera Bril, Josep Gamez, Sven Meuth, Richard Nowak, Dianna Quan, Maria Teresa Sevilla Mantecon, Leona Ling, Yaowei Zhu, Keith Karcher, Hong Sun
Meeting Abstract
Physiology
N. Rychlik, H. -C. Pape, S. G. Meuth, T. Budde
