Article
Cardiac & Cardiovascular Systems
Judit Cubedo, Teresa Padro, Gemma Vilahur, Filippo Crea, Robert F. Storey, Jose Luis Lopez Sendon, Juan Carlos Kaski, Alessandro Sionis, Jordi Sans-Rosello, Estefania Fernandez-Peregrina, Alex Gallinat, Lina Badimon
Summary: This study found that circulating levels of glycosylated apolipoprotein J decrease significantly in the early phase of acute myocardial infarction, and lower levels are associated with increased rates of recurrent ischemic events and mortality in AMI patients after 6 months.
EUROPEAN HEART JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Izabela Berdowska, Malgorzata Matusiewicz, Malgorzata Krzystek-Korpacka
Summary: This review discusses the role of clusterin in Parkinson's disease, including its potential involvement in the pathological mechanism and its application in prognosis and diagnosis of Parkinson's disease.
Article
Cardiac & Cardiovascular Systems
Krzysztof Laudanski, Da Liu, Damodar Gullipalli, Wen-Chao Song, Tony Okeke, Wilson Y. Szeto
Summary: Protective complement factors decrease significantly 3 months after cardiac surgery, while C5a appears slightly elevated, indicating a long-lasting impact of cardiac surgery on the complement milieu into recovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Y. Li, Y-Q Song, Y. Zhang, T. Liu, Q. Qin
Summary: Apolipoprotein J has anti-inflammatory and anti-apoptotic effects, potentially playing a protective role in cardiovascular disease. This study revealed that it attenuates inflammation induced by cholesterol crystals through inhibition of the NOD-like receptor protein 3 inflammasome pathway in THP-1 macrophages.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Igor E. Mizikovsky, Victor P. Kuznetsov, Ekaterina P. Garina, Natalia S. Andryashina, Elena Romanovskaya
Summary: Rational use, technological improvement, and material flow management are key factors for enterprise growth. Effective management involves identifying and preventing material losses, and our study aims to provide information support for such decisions. Systematizing material flow and calculating costs at each stage reduces unproductive costs. Institutionalizing these calculations can significantly improve production efficiency.
IMITATION MARKET MODELING IN DIGITAL ECONOMY: GAME THEORETIC APPROACHES
(2022)
Article
Hematology
Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Davide Stefanoni, Francesca Cendali, Lorenzo Bertolone, Fabia Gamboni, Monika Dzieciatkowska, Pantelis Rousakis, Athina Vergaki, Vassilis Soulakis, Ourania E. Tsitsilonis, Konstantinos Stamoulis, Issidora S. Papassideri, Anastasios G. Kriebardis, Angelo D'Alessandro, Marianna H. Antonelou
Summary: Blood donor genetics and lifestyle have an impact on the quality of stored red blood cells (RBCs). This study examined the storability of RBCs from beta thalassemia donors and found that they exhibited better levels of storage hemolysis and resistance to osmotic, oxidative, and mechanical stress compared to controls. Metabolomics analysis revealed changes in purine and arginine pathways in beta thalassemia RBCs at baseline and during storage. The findings suggest that beta thalassemia mutations affect the metabolism and susceptibility to hemolysis of stored RBCs.
Article
Plant Sciences
Georgia I. Nasi, Foteini D. Aktypi, Panagiotis M. Spatharas, Nikolaos N. Louros, Paraskevi L. Tsiolaki, Vassiliki Magafa, Ioannis P. Trougakos, Vassiliki A. Iconomidou
Summary: This study investigates the amyloidogenic properties of a 34-residue-long peptide in Arabidopsis thaliana under different pH conditions, and explores its association with other A. thaliana proteins using bioinformatics tools.
Article
Biochemistry & Molecular Biology
Dimitris Papadopoulos, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Zoi Evangelakou, Panagiotis Malandrakis, Maria S. Manola, Despoina D. Gianniou, Efstathios Kastritis, Ioannis P. Trougakos, Meletios A. Dimopoulos, Vangelis Karalis, Evangelos Terpos
Summary: This study used machine learning techniques to analyze data from 302 subjects and found that younger subjects had higher levels of neutralizing antibodies. Age, obesity, and autoimmune diseases had negative effects on the development of NAbs against SARS-CoV-2 nine months after vaccination.
Article
Biochemistry & Molecular Biology
Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Zoi Evangelakou, Maria Gavriatopoulou, Maria S. Manola, Panagiotis Malandrakis, Despoina D. Gianniou, Efstathios Kastritis, Ioannis P. Trougakos, Meletios A. Dimopoulos
Summary: This study compared the neutralizing antibody levels after vaccination with BNT162b2 mRNA vaccine and ChAdOx1 (AZD1222) viral vector vaccine at different time points. The results showed that BNT162b2 induced stronger neutralizing antibody responses compared to AZD1222, and both vaccines showed a gradual decline in antibody titers over time. Additionally, the rate of antibody elimination was higher in those vaccinated with AZD1222 compared to BNT162b2. Age, gender, body mass index, or comorbidities did not significantly impact antibody levels over time.
Article
Hematology
Polyxeni Delaporta, Evangelos Terpos, Elena E. Solomou, Sentiljana Gumeni, Evangelia Nitsa, Filia Apostolakou, Dimitra Kyriakopoulou, Ioannis Ntanasis-Stathopoulos, Ioannis Papassotiriou, Ioannis P. Trougakos, Meletios A. Dimopoulos, Antonis Kattamis
Summary: Patients with transfusion-dependent thalassemia (TDT) can experience mild adverse events and generate protective antibodies comparable to the healthy population following vaccination with novel mRNA vaccines.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Chemistry, Medicinal
Charifat Said Hassane, Gaetan Herbette, Elnur Garayev, Fathi Mabrouki, Patricia Clerc, Nicole J. de Voogd, Stephane Greff, Ioannis P. Trougakos, Jamal Ouazzani, Mireille Fouillaud, Laurent Dufosse, Beatrice Baghdikian, Evelyne Ollivier, Anne Gauvin-Bialecki
Summary: This study focused on the biological screening of marine sponge extracts and selected Scopalina hapalia extract for chemical study. Four new compounds were discovered through detailed spectroscopic analysis, and molecular networking was employed to further understand the chemical composition of this species.
Article
Oncology
Andreas G. Tsantes, Ilectra Loukopoulou, Dimitrios V. Papadopoulos, Ioannis G. Trikoupis, Anastasios G. Roustemis, Stavros Goumenos, Rozeta Sokou, Konstantina A. Tsante, Anastasios G. Kriebardis, Panagiotis Koulouvaris, Dimitra Houhoula, Daniele Piovani, Panayiotis J. Papagelopoulos, Stefanos Bonovas, Argirios E. Tsantes
Summary: Malignancy-associated coagulopathy (MAC) in surgical patients with bone tumors is characterized by activations of the coagulation cascade, platelet activation, and hypofibrinolysis, resulting in a hypercoagulable state. Rotational thromboelastometry (ROTEM) analysis is more effective than conventional coagulation tests in detecting these qualitative changes in the hemostatic profile of patients with bone tumors.
Review
Biochemistry & Molecular Biology
Hara T. Georgatzakou, Sotirios P. Fortis, Effie G. Papageorgiou, Marianna H. Antonelou, Anastasios G. Kriebardis
Summary: Microvesicles, formed by outward budding of the plasma membrane, play a vital role in intercellular communication, material disposal, and membrane repair. Changes in their concentration or components are associated with various diseases.
Review
Biochemistry & Molecular Biology
Eleni-Myrto Trifylli, Anastasios G. Kriebardis, Evangelos Koustas, Nikolaos Papadopoulos, Melanie Deutsch, Georgios Aloizos, Sotirios P. Fortis, Effie G. Papageorgiou, Ariadne Tsagarakis, Spilios Manolakopoulos
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the general population and the leading cause of liver transplantation in the US. However, the lack of specific biomarkers and therapeutic strategies makes management of non-alcoholic steatohepatitis (NASH) difficult. Extracellular vesicles (EVs) and their cargo play a role in the progression and development of NASH, and the autophagy pathway is associated with the pathogenesis of NAFLD and NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Despoina D. Gianniou, Aimilia D. Sklirou, Maria-Alexandra Papadimitriou, Katerina-Marina Pilala, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas, Ioannis P. Trougakos
Summary: This study investigated the expression and role of HSPB2 and HSPB3 genes in bladder cancer patients and bladder cancer cells. The results showed increased expression levels of HSPB2 and HSPB3 genes and proteins in high-grade bladder cancer cells. In clinical samples, the expression levels of HSPB2 and HSPB3 genes were significantly downregulated in bladder tumors but showed an upregulation trend in muscle-invasive and high-grade tumors. These findings suggest that HSPB2 and HSPB3 have a pro-survival role in advanced bladder cancer and can be targeted as novel molecular markers for treatment optimization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Hematology
Marianna H. Antonelou
Article
Hematology
Santhi Devasundaram, Evangelos Terpos, Margherita Rosati, Ioannis Ntanasis-Stathopoulos, Jenifer Bear, Robert Burns, Stamatia Skourti, Panagiotis Malandrakis, Ioannis P. Trougakos, Meletios-Athanasios Dimopoulos, George N. Pavlakis, Barbara K. Felber
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Eleni-Myrto Trifylli, Anastasios G. Kriebardis, Evangelos Koustas, Nikolaos Papadopoulos, Sofia Vasileiadi, Sotirios P. Fortis, Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Panagiotis Sarantis, Effie G. Papageorgiou, Ariadne Tsagarakis, Georgios Aloizos, Spilios Manolakopoulos, Melanie Deutsch
Summary: This review provides an overview of the emerging role of extracellular vesicles in cholangiocarcinogenesis and their potential as diagnostic and therapeutic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Andreas G. Tsantes, Dimitrios V. Papadopoulos, Stavros Goumenos, Ioannis G. Trikoupis, Konstantina A. Tsante, Vanesa Bellou, Panagiotis Koulouvaris, Dimitra Houhoula, Anastasios Kriebardis, Daniele Piovani, Georgios K. Nikolopoulos, Andreas F. Mavrogenis, Panayiotis J. Papagelopoulos, Stefanos Bonovas, Argirios E. Tsantes
Summary: The study aimed to evaluate the diagnostic role of rotational thromboelastometry (ROTEM) in periprosthetic joint infections (PJIs). The results showed that several ROTEM parameters differed in patients with PJI, indicating a higher coagulation potential associated with the infection. Among these parameters, EXTEM maximum clot firmness (MCF) had the highest diagnostic accuracy for PJI.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Hematology
Vassilis L. Tzounakas, Monika Dzieciatkowska, Alkmini T. Anastasiadi, Dimitrios G. Karadimas, Athina Vergaki, Panagiotis Siourounis, Konstantinos Stamoulis, Issidora S. Papassideri, Anastasios G. Kriebardis, Angelo D'Alessandro, Marianna H. Antonelou
Summary: The storage conditions and G6PD deficiency have been found to affect the activity and distribution of red blood cell proteasomes. The changes in proteasome activity are only partially reversible in transfusion-mimicking conditions. These findings are of significant importance for further investigating their clinical impact on transfusion outcomes.