Review
Biochemistry & Molecular Biology
Mario Bonomini, Luca Piscitani, Lorenzo Di Liberato, Vittorio Sirolli
Summary: The properties of the membrane in hemodialyzers play a crucial role in the success and quality of dialysis therapy. Biocompatibility is essential to minimize uremic complications and improve patient outcomes, making the development of more biocompatible membranes a priority.
Article
Engineering, Chemical
Jeanne Casetta, Danae Gonzalez Ortiz, Celine Pochat-Bohatier, Mikhael Bechelany, Philippe Miele
Summary: By depositing titanium dioxide (TiO2) on polysulfone hollow fiber (HF) membranes via atomic layer deposition (ALD), the hydrophilicity and fouling resistance of the PSF HF membranes were improved, leading to increased water permeability and reduced pore size.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Chintan Bhavsar, Rashmi Joshi, Trinette Fernandes, Sankaran Chandramouleeswaran, Tabassum Khan, Puthusserickal Abdulrahiman Hassan, Munira Momin, Raghumani S. Ningthoujam
Summary: This article proposes an alternative class of nanoparticles, hollow silver nanoparticles (HAgNPs), which use nontoxic and inexpensive precursors. The article investigates various parameters involved in the synthesis process to obtain uniform HAgNPs. It demonstrates the photothermally induced cytotoxicity of HAgNPs in cancer cells and proves their biocompatibility through in vivo and ex vivo models. Future studies are suggested to explore the in vivo antitumor activity of these nanoparticles and their role in tumor drug delivery.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jeanne Casetta, Celine Pochat-Bohatier, David Cornu, Mikhael Bechelany, Philippe Miele
Summary: By modifying the surface of polysulfone hollow fiber membranes using atomic layer deposition (ALD), coatings of titanium dioxide (TiO2), zinc oxide (ZnO), and alumina (Al2O3) can be applied to enhance the membrane's permeability and fouling resistance.
Article
Engineering, Biomedical
Malgorzata Sikora-Jasinska, Lea M. Morath, Maria P. Kwesiga, Margaret E. Plank, Alexia L. Nelson, Alexander A. Oliver, Martin L. Bocks, Roger J. Guillory, Jeremy Goldman
Summary: The study evaluated the mechanical performance and biodegradation properties of metallic molybdenum (Mo) as a potential material for biodegradable stents. The results showed favorable mechanical behavior and uniform degradation profile, suggesting Mo as an ideal source material for clinical applications. Mo implants in mouse arteries avoided cellular response and showed minimal neointimal hyperplasia, indicating good biocompatibility. However, potential pathological remodeling and impaired kidney function were observed, suggesting further investigation is needed.
BIOACTIVE MATERIALS
(2022)
Review
Materials Science, Multidisciplinary
Haifeng Ji, Yupei Li, Baihai Su, Weifeng Zhao, Jayachandran N. Kizhakkedathu, Changsheng Zhao
Summary: Hemodialysis is a common treatment for end-stage kidney disease, but the long-term contact of hemoincompatible hollow-fiber membranes (HFMs) can cause chronic inflammation, oxidative stress, and thrombosis, leading to increased cardiovascular diseases and mortality. This review analyzes the current progress in improving the hemocompatibility of HFMs and describes the design and clinical use of different HFMs. The adverse interactions between blood and HFMs, including protein adsorption, platelet adhesion and activation, and the activation of immune and coagulation systems, are discussed, along with strategies to improve the hemocompatibility of HFMs.
ADVANCED FIBER MATERIALS
(2023)
Article
Engineering, Environmental
Sumarni Mansur, Mohd Hafiz Dzarfan Othman, Muhammad Nidzhom Zainol Abidin, Ahmad Fauzi Ismail, Siti Hamimah Sheikh Abdul Kadir, Pei Sean Goh, Hasrinah Hasbullah, Be Cheer Ng, Mohd Sohaimi Abdullah, Ruslinda Mustafar
Summary: In this study, a highly biocompatible adsorptive membrane was developed by incorporating silica/alpha-mangostin hybrid nanoparticle into a polysulfone (PSf) based membrane. The modified membrane showed improved adsorption capacity for p-cresol and enhanced biocompatibility, making it a promising candidate for haemodialysis applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Huaze Wu, Takeshi Ueno, Kosuke Nozaki, Huichuan Xu, Yuki Nakano, Peng Chen, Noriyuki Wakabayashi
Summary: This study utilized anodization as a novel approach to immobilize lithium ions on a titanium surface and evaluated the changes in surface characteristics. The results showed that the surface charge characteristics were enhanced on the 3V-anodized surface, leading to increased adsorption of extracellular matrix proteins and improved attachment of osteoblast cells. This study suggests that anodization could be an effective method to promote osseointegration by modifying the surface charge characteristics and allowing for enhanced biological adhesion.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Wanni Guo, Mingjian Chen, Yuxin Yang, Guili Ge, Le Tang, Shuyi He, Zhaoyang Zeng, Xiaoling Li, Guiyuan Li, Wei Xiong, Steven Wu
Summary: In this study, the biocompatibility and biological effects of semiconducting polymer nanoparticles (Pdots) with different surface modifications were systematically investigated. The modification of sulfhydryl, carboxyl, and amino groups on Pdots had no significant effect on their physicochemical properties, except for the stability of amino-modified Pdots. Cellular studies showed that amino-modified Pdots reduced cellular uptake capacity and increased cytotoxicity. In vivo studies demonstrated that Pdots@SH and Pdots@COOH had better body circulation and metabolic clearance compared to Pdots@NH2. This research provides important data for the safety assessment and potential biomedical applications of Pdots with different surface modifications.
Article
Materials Science, Multidisciplinary
Changjiang Pan, Tingting Liu, Ziqin Zhang, Xiaolei Zhang, Xinglong Qiao, Youdong Hu, Qiuyang Zhang, Zhongmei Yang
Summary: The study involved preparing a regular nanotube array on titanium surface by anodization, followed by immobilizing a complex of chitosan and zinc ions (CS/Zn) to enhance biocompatibility. The CS/Zn coating not only promoted adhesion and proliferation of osteoblasts, but also up-regulated expression of ALP and OCN. Overall, this method can improve osteogenesis and osteointegration of titanium surface.
Article
Multidisciplinary Sciences
Adrien Rapeaux, Omaer Syed, Estelle Cuttaz, Christopher A. R. Chapman, Rylie A. Green, Timothy G. Constandinou
Summary: This article describes the preparation of rat sciatic nerves for ex vivo neurophysiology, providing an overview of the experiments possible with this method. The results obtained using this method are consistent and reliable, making it useful for testing new electrodes or interventions on the tissue.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Chemistry, Physical
Huanyu Liu, Yiying Wang, Wei Yin, Hao Yuan, Ting Guo, Tao Meng
Summary: In this study, bioinspired spindle-knotted microfibers with continuous hollow channels were fabricated using a microfluidic method. Compared to solid microfibers, these hollow microfibers showed improved water collection ability. This research has important implications for large-scale water collection and liquid transportation.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Review
Chemistry, Multidisciplinary
Chaoqun Wu, Jiuhan Zheng, Jianhua Hu
Summary: The study utilized living radical polymerization to prepare P(4VPx-r-SBMAy) copolymers, which were then added to construct modified PSF membrane surfaces exhibiting superior hydrophilicity and antifouling performance.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2021)
Article
Engineering, Biomedical
Matthew Simon Dargusch, Jeffrey Venezuela, Ali Dehghan-Manshadi, Sean Johnston, Nan Yang, Karine Mardon, Cora Lau, Rachel Allavena
Summary: The addition of 1% Ag enhances the mechanical properties and corrosion resistance of Fe-35Mn, while maintaining acceptable biocompatibility in vivo. The uniform dispersion of silver particles contributes to slight improvements in compressive properties through increased density and reduced porosity volume.The alloy exhibits properties suitable for orthopedic applications, with an initial increase in nonadverse tissue inflammatory responses at 4 weeks post-implantation that subside by 12 weeks.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Dan Yun, Dengyuan Liu, Jinlin Liu, Yanyi Feng, Hongyu Chen, Simiao Chen, Qingchun Xie
Summary: This study proposes a simplified surface modification strategy using cRGDyK peptide (RGD)-modified PLGA nanoparticles (NPs) loaded with paclitaxel. The results show that the modified NPs have excellent in vitro drug release properties and cellular uptake ability, leading to increased efficacy and reduced toxicity of the antitumor drug. In a mouse model experiment, the RGD-modified NPs exhibit a higher tumor weight suppression rate, demonstrating their promising potential in cancer therapy.
Article
Polymer Science
Akshay Modi, Jayesh Bellare
Article
Nanoscience & Nanotechnology
Deepak Gupta, Atul Kumar Singh, Ashwin Dravid, Jayesh Bellare
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Endocrinology & Metabolism
Subhashis Pal, Konica Porwal, Kunal Khanna, Manoj Kumar Gautam, Mohd Yaseen Malik, Mamunur Rashid, R. John Macleod, Muhammad Wahajuddin, Venkitanarayanan Parameswaran, Jayesh R. Bellare, Naibedya Chattopadhyay
Article
Engineering, Environmental
Akshay Modi, Jayesh Bellare
JOURNAL OF WATER PROCESS ENGINEERING
(2019)
Article
Biophysics
Surendra Kumar Verma, Akshay Modi, Jayesh Bellare
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Integrative & Complementary Medicine
Abhirup Basu, Mayur K. Temgire, Akkihebbal K. Suresh, Jayesh R. Bellare
Article
Plant Sciences
Snehasis Biswas, Rohit Dhumal, Nilakash Selkar, Sharad Bhagat, Mukesh Chawda, Kapil Thakur, Ramacharya Gudi, Geeta Vanage, Jayesh Bellare
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Shivaji Kashte, R. K. Sharma, Sachin Kadam
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Prissana Robkhob, Sougata Ghosh, Jayesh Bellare, Dhiraj Jamdade, I-Ming Tang, Sirikanjana Thongmee
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Engineering, Chemical
Preety Kumari, Akshay Modi, Jayesh Bellare
SEPARATION AND PURIFICATION TECHNOLOGY
(2020)
Article
Engineering, Environmental
Akshay Modi, Jayesh Bellare
JOURNAL OF WATER PROCESS ENGINEERING
(2020)
Review
Cell Biology
Ashim Gupta, Shivaji Kashte, Manu Gupta, Hugo C. Rodriguez, Shraddha Singh Gautam, Sachin Kadam
Review
Oncology
Sumit Saha, Sachin Kadam
Summary: The COVID-19 pandemic has led to global challenges in social, economic, and medical fields. The search for effective treatments and vaccines continues in the scientific community, with plasma therapy showing potential for critically ill patients. However, with uncertainties surrounding the efficacy of available treatments and vaccines against new strains of the virus, more research and data are needed for a clearer understanding of the disease and its therapies.
HEMATOLOGY TRANSFUSION AND CELL THERAPY
(2021)
Article
Engineering, Environmental
Akshay Modi, Jayesh Bellare
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2019)
Article
Pharmacology & Pharmacy
Dhiraj A. Jamdade, Dishantsingh Rajpali, Komal A. Joshi, Rohini Kitture, Anuja S. Kulkarni, Vaishali S. Shinde, Jayesh Bellare, Kaushik R. Babiya, Sougata Ghosh
ADVANCES IN PHARMACOLOGICAL SCIENCES
(2019)
