Review
Andrology
Chuan Huang, Xiren Ji, Wenjun Zhou, Zhenghui Huang, Xiangjie Peng, Liqing Fan, Ge Lin, Wenbing Zhu
Summary: The novel coronavirus outbreak in Wuhan at the end of December 2019 has threatened global health, potentially damaging male fertility; the harm may arise from viral replication and immunopathology.
Article
Cell Biology
Fei Han, Li Yin, Xiao Jiang, Xi Zhang, Ning Zhang, Jun-tang Yang, Wei-ming Ouyang, Xiang-lin Hao, Wen-bin Liu, Yong-sheng Huang, Hong-qiang Chen, Fei Gao, Zhong-tai Li, Qiao-nan Guo, Jia Cao, Jin-yi Liu
Summary: Sox30 is an age-related and essential regulator of meiosis in the postnatal testis, playing a critical role in germ-cell differentiation by directly regulating key regulators. Its re-expression in Sox30-null mice successfully restores germ-cell meiosis, differentiation and Leydig cell proliferation, improving fertility over time.
Article
Plant Sciences
Natthapol Lapyuneyong, Nareelak Tangsrisakda, Pannawat Choowong-In, Kowit Chaisiwamongkol, Nongnut Uabundit, Tarinee Sawatpanich, Supatcharee Arun, Alexander Tsang-Hsien Wu, Sitthichai Iamsaard
Summary: The study found that seed extract of Thai Mucuna pruriens (L.) DC. var. pruriens could improve cortisol level, protect reproductive tissues and sperm parameters, and protect against adverse reproductive parameters in chronic stress through improvements of functionally testicular markers and reductions of apoptotic proteins.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Genetics & Heredity
Shubo Jin, Yin Fu, Yuning Hu, Hongtuo Fu, Sufei Jiang, Yiwei Xiong, Hui Qiao, Wenyi Zhang, Yongsheng Gong, Yan Wu
Summary: The eyestalk of crustacean species plays a significant role in the regulation of male sexual development, with its ablation leading to increased vigor in testis development. Transcriptome profiling revealed differentially expressed genes and enriched metabolic pathways, indicating a more pronounced regulatory effect of double-side eyestalk ablation. The study also highlighted the positive regulatory effect of NFkB alpha on testis development in Macrobrachium nipponense.
FRONTIERS IN GENETICS
(2021)
Article
Toxicology
Yuan-Yuan Li, Yi-Ming Xiong, Xuan-Yue Chen, Jia-Yi Sheng, Lin Lv, Xing-Hong Li, Zhan-Fen Qin
Summary: This study found that exposure to TBBPA-BDBPE caused severe damage to the reproductive system in mice, including reduced sperm counts, increased sperm abnormality, and histological alterations of testes. Moreover, long-term exposure led to impaired fertility at late reproductive age.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Sakhawat Shah, Su-Su Zhang, Karam Khamis Elgizawy, Wen-Han Yan, Ning Tang, Gang Wu, Feng-Lian Yang
Summary: In this study, the effects of Diallyl trisulfide (DAT) on a detrimental pest were analyzed. It was found that DAT can alter the protein content and hormone levels of the reproductive tissues of the pest by disrupting key enzymes involved in hormonal pathways. Additionally, DAT affects sperm number and modulates endocrine secretion.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Clinical Neurology
Yasir Abdul, Weiguo Li, Rebecca Ward, Mohammed Abdelsaid, Sherif Hafez, Guangkuo Dong, Sarah Jamil, Victoria Wolf, Maribeth H. Johnson, Susan C. Fagan, Adviye Ergul
Summary: This study found that iron chelation therapy with deferoxamine can prevent vasoregression and improve functional outcomes in diabetic rats after stroke, but it does not have a significant effect in non-diabetic rats. Furthermore, iron chelation may inhibit ferroptosis and provide a novel therapeutic strategy for preventing post-stroke cognitive impairment in diabetes.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Environmental Sciences
Axelle Brulport, Daniel Vaiman, Marie-Christine Chagnon, Ludovic Le Corre
Editorial Material
Peripheral Vascular Disease
Daniel Vaiman
Article
Biochemistry & Molecular Biology
Caroline Eozenou, Audrey Lesage-Padilla, Vincent Mauffre, Gareth D. Healey, Sylvaine Camous, Philippe Bolifraud, Corinne Giraud-Delville, Daniel Vaiman, Takashi Shimizu, Akio Miyamoto, Iain Martin Sheldon, Fabienne Constant, Maelle Pannetier, Olivier Sandra
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Genetics & Heredity
Roland Abi Nahed, Deborah Reynaud, Nicolas Lemaitre, Solene Lartigue, Caroline Roelants, Daniel Vaiman, Mohamed Benharouga, Claude Cochet, Odile Filhol, Nadia Alfaidy
JOURNAL OF MOLECULAR MEDICINE-JMM
(2020)
Article
Biotechnology & Applied Microbiology
Axelle Brulport, Daniel Vaiman, Elias Bou-Maroun, Marie-Christine Chagnon, Ludovic Le Corre
Article
Genetics & Heredity
Camino S. M. Ruano, Clara Apicella, Sebastien Jacques, Geraldine Gascoin, Cassandra Gaspar, Francisco Miralles, Celine Mehats, Daniel Vaiman
Summary: The study reveals that alternative splicing is an important feature in placental diseases, affecting the expression of many genes, some of which are related to pregnancy and brain diseases. Additionally, alternative splicing variations in the placenta can be detected at the individual level, showing significant differences between different placentas.
Article
Immunology
Manuela Zinni, Jerome Mairesse, Julien Pansiot, Francesco Fazio, Luisa Iacovelli, Nico Antenucci, Rosamaria Orlando, Ferdinando Nicoletti, Daniel Vaiman, Olivier Baud
Summary: Perinatal inflammation plays a crucial role in brain vulnerability in neonates, with the metabotropic glutamate receptor 3 (mGlu3 receptor) being identified as a key regulator of neuroinflammation. Pharmacological activation of mGlu3 receptors may prevent inflammatory-induced perinatal brain injury.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Hideki Innan, Daniel Vaiman, Reiner A. Veitia
Summary: With the increasing lifespan and societal changes, women are now able to marry and have children later than in previous centuries. However, pathogenic genetic variants in the population can cause female subfertility or infertility before the average age of menopause, leading to counter-selection of these harmful alleles. It is speculated that as a logical consequence, menopause may occur later and women's reproductive lifespan may be extended. Factors such as medical interventions and lifestyle also play a role in female fertility.
Article
Environmental Sciences
Axelle Brulport, Ludovic Le Corre, Guillaume Maquart, Virginie Barbet, Aurelie Dastugue, Isabelle Severin, Daniel Vaiman, Marie-Christine Chagnon
Summary: This study found that perinatal exposure to BPS can lead to sex-dependent obesogen effects in multiple generations of mice. In the F1 generation, male mice showed overweight while female mice exhibited dyslipidemia. In the F2 generation, BPS exposure was associated with increased body weight, fat, and visceral adipose tissue in both males and females.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Johan Castille, Bruno Passet, Samira Makhzami, Marthe Vilotte, Katayoun Moazami-Goudarzi, Sandrine Truchet, Nathalie Daniel-Carlier, Anne-Laure Gaillard, Olivier Andreoletti, Daniel Vaiman, Christian Beauvallet, Anne Vaiman, Sandrine Floriot, Pierre Calvel, Sophie Mouillet-Richard, Amandine Duchesne, Vincent Beringue, Jean-Luc Vilotte
Summary: This study reveals the potential redundant or antagonistic roles of Shadoo and PrP proteins in developmental pathways, as well as the consequences of the concomitant knockout of these two genes, including intra-uterine growth retardation, increased perinatal lethality, and involvement in the lactation process.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Clara Apicella, Camino S. M. Ruano, Sebastien Jacques, Geraldine Gascoin, Celine Mehats, Daniel Vaiman, Francisco Miralles
Summary: Through analyzing the expression of non-coding genes in trophoblast fusion and placental diseases, key roles of miR-193b and UCA1 in cell function and gene expression have been identified. Knocking down UCA1 leads to the dysregulation of important trophoblast physiology genes, while in cells overexpressing STOX1B, the effects of UCA1 down-regulation are alleviated.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Victoria Cluzet, Marie M. Devillers, Florence Petit, Alice Pierre, Frank Giton, Eloise Airaud, David L'Hote, Alexandra Leary, Catherine Genestie, Isabelle Treilleux, Anne Mayeur, John A. Katzenellenbogen, Sung Hoon Kim, Joelle Cohen-Tannoudji, Stephanie Chauvin, Celine J. Guigon
Summary: This study demonstrates that estrogen (E2) can promote the progression of granulosa cell tumors (GCTs) by regulating ER alpha, and GCTs can be classified as hormone-related cancer. Moreover, the different forms of ER present in recurrent GCTs may underlie the variable efficiency of endocrine therapies.
JOURNAL OF PATHOLOGY
(2022)
Article
Neurosciences
Charlotte Avet, Emmanuel N. Paul, Ghislaine Garrel, Valerie Grange-Messent, David L'Hote, Chantal Denoyelle, Raphael Corre, Jean-Marie Dupret, Sophie Lanone, Jorge Boczkowski, Violaine Simon, Joelle Cohen-Tannoudji
Summary: The study found that exposure to carbon black nanoparticles does not disrupt estrous cyclicity in female mice, but increases FSH levels. Treating anterior pituitary or gonadotrope cells with CB NPs dose-dependently up-regulates FSH gene expression without affecting LH. The nanoparticles are internalized by cells and activate the cAMP/PKA pathway, leading to an imbalance in gonadotropins.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Charles Le Cicle, Vincent Pacini, Nicolas Rama, Servane Tauszig-Delamasure, Eloise Airaud, Florence Petit, Simon de Beco, Joelle Cohen-Tannoudji, David L'hote
Summary: Pituitary gonadotrope cells play a crucial role in the endocrine regulation of reproduction, but the molecular mechanisms underlying the organization of these cells during embryogenesis are poorly understood. This study identified NEUROD1 and NEUROD4 as regulators of genes involved in the focal adhesion pathway, and demonstrated that they affect cell adhesion and motility of gonadotrope cells. The study also revealed that NTRK3 is a major regulator of gonadotrope cell motility through its interaction with c-Src, and it is involved in the positioning of gonadotrope cells within the developing pituitary.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Magalie Vatin, Marie-Sophie Girault, Virginie Firlej, Carmen Marchiol, Come Ialy-Radio, Xavier Montagutelli, Daniel Vaiman, Sandrine Barbaux, Ahmed Ziyyat
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)