Article
Neurosciences
Brian Mathias, Andrea Waibel, Gesa Hartwigsen, Leona Sureth, Manuela Macedonia, Katja M. Mayer, Katharina von Kriegstein
Summary: The study found that sensorimotor-enriched training can change the representations of L2 words in the motor cortex, thereby facilitating the translation of L2 words. Different training methods have different effects on the translation speed of L2 words.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Pierpaolo Pani, Margherita Giamundo, Franco Giarrocco, Valentina Mione, Roberto Fontana, Emiliano Brunamonti, Maurizio Mattia, Stefano Ferraina
Summary: By recording and analyzing neuronal activity in monkeys performing a countermanding reaching task, researchers found a specific subspace in the premotor cortex where activities conveying temporal information were confined during active inhibition and position holding. Movement execution required activities to escape from this subspace and surpass a threshold associated with the maturation of the motor plan.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Lingyun Zhao, Xiaoqin Wang
Summary: This study investigates the frontal cortex of marmoset monkeys and finds that neural signals in the frontal cortex show distinct patterns for different call types, indicating a neural representation of vocalization features. These findings suggest an important role for the marmoset frontal cortex in supporting the production of diverse vocalizations.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Woranan Wongmassang, Taku Hasegawa, Satomi Chiken, Atsushi Nambu
Summary: The basal ganglia control voluntary movements through firing rate changes in the external and internal segments of the globus pallidus, with correlated activity playing a minor role in motor control in the healthy state.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Margherita Giamundo, Franco Giarrocco, Emiliano Brunamonti, Francesco Fabbrini, Pierpaolo Pani, Stefano Ferraina
Summary: Reward prospect influences motor decisions, with animals adopting different strategies based on reward information and PMd neuronal activity correlating with behavior.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Wei Song Ong, Seth Madlon-Kay, Michael L. Platt
Summary: Neurons in the mSTS region play a role in signaling strategic information related to social behavior, while neurons in the anterior cingulate gyrus carry less information about cooperative rewards. The findings suggest that the ability to compute models of other agents is deeply rooted in the social behavior of primates, with mSTS and the anterior cingulate gyrus supporting these computations.
NATURE NEUROSCIENCE
(2021)
Article
Cell Biology
Masashi Kondo, Masanori Matsuzaki
Summary: The study reveals that the activity of neocortical neurons in mice during classical conditioning is influenced by reward cues and outcome history, with the dorsomedial frontal cortex (dmFrC) playing a crucial role in licking movements.
Article
Neurosciences
Ilona Har-Paz, Elor Arieli, Anan Moran
Summary: The E4 allele of apolipoprotein E is the strongest genetic risk factor for late-onset Alzheimer's disease, potentially causing innate brain abnormalities before the onset of AD. Studies suggest that apoE4 may affect memory and learning abilities in young rats, leading to changes in neuronal activity.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Gunasingh Jeyaraj Masilamoni, Allison Weinkle, Stella M. Papa, Yoland Smith
Summary: This study found decreased serotonergic and catecholaminergic innervation in the frontal cortex at early stages of Parkinson's disease. The use of MPTP-treated monkeys as animal models revealed that these changes may contribute to early non-motor symptoms in PD.
Article
Multidisciplinary Sciences
Patrick Jendritza, Frederike J. Klein, Pascal Fries
Summary: The authors described a novel method to record and manipulate neural activity in awake, behaving marmosets. By performing multi-area neural recordings in marmosets and integrating optogenetics and behavior, they demonstrated the potential application of this method.
NATURE COMMUNICATIONS
(2023)
Review
Clinical Neurology
Danny Adrian Spampinato, Elias Paolo Casula, Giacomo Koch
Summary: The present review discusses the reciprocal connections between the cerebellum and primary motor cortex (M1) and explores how novel noninvasive brain stimulation (NIBS) methods can contribute to understanding these connections. The review focuses on recent animal studies on the integration of information from the cerebellum and thalamus into cortical motor neurons and the use of NIBS approaches in humans to assess cerebellar-M1 connectivity. It also discusses the potential of advanced NIBS methods to investigate and modulate cerebellar-cortical networks involved in movement behavior and plasticity and their application in translational research for restoring cortical activity and motor function in neurologic patients.
Article
Neurosciences
Hiroshi Maejima, Mika Kitahara, Yasuyuki Takamatsu, Hiroki Mani, Takahiro Inoue
Summary: This study aimed to investigate the impact of epigenetic treatment with an HDAC inhibitor and aerobic exercise on epigenetic markers and neurotrophic gene expressions in the motor cortex. Findings suggest that HDAC inhibition may offer a more enriched condition for neuroplasticity in the motor cortex, while exercise-induced neurotrophic gene expressions could vary depending on the exercise regimen.
Article
Medicine, General & Internal
Jia-Sheng Rao, Can Zhao, Rui-Han Wei, Ting Feng, Shu-Sheng Bao, Wen Zhao, Zhaolong Tian, Zuxiang Liu, Zhao-Yang Yang, Xiao-Guang Li
Summary: The study found that brain functional reorganization induced by regeneration therapy differs from spontaneous recovery after SCI. Neural regeneration in spinal cord injured monkeys elicits a unique spatiotemporal mode of brain functional reorganization, and does not simply reverse the process of brain plasticity induced by SCI. The relationship between local activity properties and information flow intensity differs between injured and treated animals, indicating different effects of spontaneous recovery and regenerative therapy on motor network reorganization after SCI.
ANNALS OF MEDICINE
(2022)
Article
Clinical Neurology
Jack Jiaqi Zhang, Zhongfei Bai, Kenneth N. K. Fong
Summary: This study investigated the effects of priming iTBS on poststroke hemiparetic upper limb recovery. The results showed that priming and nonpriming iTBS were both superior to sham stimulation in enhancing treatment gains from robot-assisted training. Priming iTBS may facilitate poststroke motor learning, especially for patients with a higher functioning upper limb.
Article
Psychology, Multidisciplinary
Marie Bernardo, Yannick Blandin, Gery Casiez, Cecile R. Scotto
Summary: This study aimed to investigate the impact of the reliability of on-line visual feedback on motor learning. The results showed that pointing was slower and long-term learning disrupted in the largely unreliable visual cursor condition. Furthermore, the performance difference between visuospatial transfer and motor transfer disappeared when the cursor was moderately or largely unreliable.
FRONTIERS IN PSYCHOLOGY
(2023)