Article
Chemistry, Multidisciplinary
Laura Matino, Anna Mariano, Chiara Ausilio, Raghav Garg, Tzahi Cohen-Karni, Francesca Santoro
Summary: The correct wiring of a neural network requires neurons to integrate cues from their extracellular environment, and biologically inspired micro- and nanostructured substrates can regulate axonal outgrowth. Graphene, as a conductive neural interface, has the potential to enhance cell adhesion and neural sprouting. This study found that nanoscale protruding features influenced neuronal growth and branching, and the integrin-mediated contact adhesion points and plasma membrane curvature processes played a crucial role in neurons-to-graphene coupling.
Review
Neurosciences
Sonam Dolma, Abhijeet Joshi
Summary: The conduction of action potential along the axon relies heavily on the interaction between the axon and myelin-producing glial cells. Myelin, formed by Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system, serves as insulation and facilitates action potential. The nodes of Ranvier, intermittent gaps along the myelin sheath, play a crucial role in this process. Research has identified a comprehensive proteome at the nodes of Ranvier and highlighted the importance of axon-glia interactions in various neurological disorders. This review provides an update on the molecular composition of the nodes of Ranvier and discusses the consequences of disrupted axon-glia interactions in CNS and PNS disorders.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2023)
Review
Cell Biology
Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury is a devastating injury to the central nervous system, and current therapies have not been successful. MiRNA plays a crucial role in CNS development and pathological processes after neural injury, making it a promising candidate for SCI therapy.
Article
Neurosciences
Yu Chen, Wei Li
Summary: This study used two-photon microscopy to observe the structural dynamics of presynaptic axons at parallel fiber-Purkinje cell synapses in the cerebellar cortex of mice after motor training, and investigated the effect of REM sleep on synaptic plasticity. The results showed that motor training leads to increased formation of new axonal varicosities in cerebellar parallel fibers, and REM sleep promotes this formation. These findings reveal the effects of motor training and REM sleep on synaptic plasticity in the cerebellar cortex.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Chao Sun, Lin Qi, Yang Cheng, Yi Zhao, Chen Gu
Summary: Axonal varicosities occur immediately after head impact and are mainly induced by transverse compression rather than uniaxial stretch. The impact strength and direction determine the threshold and spatial pattern of axonal varicosity initiation.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Lenzie Ford, Arun Asok, Arielle D. Tripp, Cameron Parro, Michelle Fitzpatrick, Christopher A. de Solis, Po-Tao Y. Chen, Neeva Shafiian, Luana Fioriti, Rajesh K. Soni, Eric R. Kandel
Summary: Biomolecular condensates, specifically ribonucleoprotein granules (RNPs), are critical for local protein synthesis and have important roles in synaptic plasticity and long-term memory. Proteins within RNPs contain low-complexity motifs (LCM), allowing for diverse protein-protein interactions. This study highlights the significance of protein-protein interactions mediated by the LCM of cytoplasmic polyadenylation element binding protein 3 (CPEB3) in regulating synaptic plasticity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Physical
Sweety Verma, Suman Gahlyan, Payal Bhagat, Manju Rani, Mamta Bhagat, Seetu Rana, V. K. Rattan, Yongjin Lee, Sanjeev Maken
Summary: Excess properties provide valuable insight into the intermolecular interactions in mixtures. This study analyzed the excess molar volume, excess isentropic compressibility deviation in ultrasonic speed, and refractive index for mixtures of mesitylene and alkanol to understand their intermolecular interactions. The results showed that the rupture of H-bonding in self-associated alkanol dominated over the electron donor-acceptor interaction between alkanol and mesitylene. The electron donor-acceptor interaction weakened with increasing temperature. Additionally, the behavior of molecular association parameter, free intermolecular length, and available volume supported these observations.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Astronomy & Astrophysics
Chiung Hwang, Sara Pasquetti, Matteo Sacchi
Summary: We present an algorithm that dualizes linear quivers into their mirror dual in a piecemeal manner. The algorithm leverages two fundamental duality moves and the properties of the S-wall, all of which can be derived through iterative applications of Seiberg-like dualities.
Article
Biochemical Research Methods
Anne K. Engmann, John J. Hatch, Prakruti Nanda, Priya Veeraraghavan, Abdulkadir Ozkan, Alexandros Poulopoulos, Alexander J. Murphy, Jeffrey D. Macklis
Summary: During neuronal development, growth cones navigate complex environments to construct specific circuitry by responding to guidance cues. A recent integrated approach allows quantitative investigation of growth cone molecular machinery in the rodent central nervous system.
Article
Green & Sustainable Science & Technology
Zhenshan Yang, Haoran Wang, Linsheng Yang, Runde Fu
Summary: After facing climate change and other environmental problems, many countries have prioritized research on environmental protection. However, there is still a lack of relevant research in the field of regional green production and trade systems. This study examined the regions' abilities of constructing a green production and trade system on the local, inter-provincial, and international levels by measuring the green production and trade system efficiency of 30 Chinese provinces during 2012-2017. Factors such as economic level, industrial structure, government's administrative capacity, technological investment, energy structure, urbanization level, and external dependence level were found to affect the construction of these systems at different levels.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Neurosciences
Benjamin Drukarch, Micha M. M. Wilhelmus
Summary: Since the work of Edgar Adrian, the neuronal action potential has been considered as an electric signal, modeled using concepts and theories from electronic engineering. However, the current electrical conception of neuronal excitability appears to be incomplete as it does not account for non-electrical physical manifestations accompanying action potential propagation, leading to attempts to incorporate these manifestations into the modeling and explanation of the nerve signal. These attempts have faced opposition from mainstream neuroscience and remain underdeveloped, but have the potential to provide a more complete and integrated understanding of neuronal excitability and signal transport.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
J. C. Mateus, C. D. F. Lopes, M. Aroso, A. R. Costa, A. Geros, J. Meneses, P. Faria, E. Neto, M. Lamghari, M. M. Sousa, P. Aguiar
Summary: Recent technological advances have challenged long-standing assumptions about axon physiology, revealing that action potentials can originate from distal parts of the axon. These antidromic action potentials may affect neuronal function and have asymmetrical conduction velocities.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Md Ishak Khan, Fuad Hasan, Khandakar Abu Hasan Al Mahmud, Ashfaq Adnan
Summary: This study reveals that neurofilaments exhibit high stretchability and multiple stages of unfolding under high strain rate scenario, along with high tensile stiffness and correspondence to simplified viscoelastic models. This enhances existing axonal models focusing on axonal injury.
Article
Multidisciplinary Sciences
Yuzu Anazawa, Tomoki Kita, Rei Iguchi, Kumiko Hayashi, Shinsuke Niwa
Summary: Researchers have established Caenorhabditis elegans models for KIF1A-associated neuronal disorder (KAND) using CRISPR-Cas9 technology. They found that KIF1A mutations lead to reduced axonal transport and significantly impair the motility of heterodimeric motors composed of wild-type and mutant KIF1A.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Cristian Saquel, Romina J. Catalan, Rodrigo Lopez-Leal, Ramon A. Ramirez, David Necunir, Ursula Wyneken, Christophe Lamaze, Felipe A. Court
Summary: Functional recovery after peripheral nerve injuries relies on axonal regeneration, which is regulated by both autonomous and non-cell autonomous processes. This study demonstrates that neuronal activity enhances the release of repair Schwann cell-derived extracellular vesicles (EVs) and their transfer to neurons. This effect is mediated by the ATP-P2Y signaling pathway and leads to increased content of miRNA-21 in the EVs. These findings highlight the importance of neuron to glia communication in regulating axonal elongation through the transfer of EVs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Mira Chamoun, Marianne Groleau, Menakshi Bhat, Elvire Vaucher
JOURNAL OF PHYSIOLOGY-PARIS
(2016)
Article
Neurosciences
Mira Chamoun, Frederic Huppe-Gourgues, Isabelle Legault, Pedro Rosa-Neto, Daniela Dumbrava, Jocelyn Faubert, Elvire Vaucher
FRONTIERS IN HUMAN NEUROSCIENCE
(2017)
Article
Neurosciences
Mira Chamoun, Elena G. Sergeeva, Petra Henrich-Noack, Shaobo Jia, Lisa Grigartzik, Jing Ma, Qing You, Frederic Huppe-Gourgues, Bernhard A. Sabel, Elvire Vaucher
Article
Pharmacology & Pharmacy
Soumaya Hachana, Menakshi Bhat, Jacques Senecal, Frederic Huppe-Gourgues, Rejean Couture, Elvire Vaucher
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Article
Neurosciences
Marianne Groleau, Mira Chamoun, Elvire Vaucher
Article
Neurosciences
Frederic Huppe-Gourgues, Karim Jegouic, Elvire Vaucher
FRONTIERS IN NEURAL CIRCUITS
(2018)
Article
Neurosciences
Yasha Sheynin, Mira Chamoun, Alex S. Baldwin, Pedro Rosa-Neto, Robert F. Hess, Elvire Vaucher
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Pharmacology & Pharmacy
Rahmeh Othman, Elvire Vaucher, Rejean Couture
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Neurosciences
Elie Baho, Bidisha Chattopadhyaya, Marisol Lavertu-Jolin, Raffaele Mazziotti, Patricia N. Awad, Pegah Chehrazi, Marianne Groleau, Celine Jahannault-Talignani, Elvire Vaucher, Fabrice Ango, Tommaso Pizzorusso, Laura Baroncelli, Graziella Di Cristo
JOURNAL OF NEUROSCIENCE
(2019)
Article
Pharmacology & Pharmacy
Soumaya Hachana, Olivier Fontaine, Przemyslaw Sapieha, Mark Lesk, Rejean Couture, Elvire Vaucher
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Ophthalmology
Soumaya Hachana, Mylene Pouliot, Rejean Couture, Elvire Vaucher
CURRENT EYE RESEARCH
(2020)
Article
Neurosciences
Elvire Vaucher, Guillaume Laliberte, Marie-Charlotte Higgins, Manon Maheux, Pierre Jolicoeur, Mira Chamoun
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2019)
Article
Neurosciences
Yasha Sheynin, Pedro Rosa-Neto, Robert F. Hess, Elvire Vaucher
JOURNAL OF NEUROSCIENCE
(2020)
Article
Chemistry, Medicinal
Rahmeh Othman, Simon Berbari, Elvire Vaucher, Rejean Couture
Review
Cell Biology
Rahmeh Othman, Gael Cagnone, Jean-Sebastien Joyal, Elvire Vaucher, Rejean Couture
Summary: The kallikrein-kinin system (KKS) plays a role in retinal inflammation and neovascularization, particularly in diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD). Bradykinin type 1 (B1R) and type 2 (B2R) receptors have different roles in regulating physiological processes and promoting pathological inflammation, with their inhibition reducing inflammation and pathological neovascularization. Targeting the KKS, especially B1R, is a promising therapy for retinal diseases.