Article
Endocrinology & Metabolism
Kohei Kido, Tatsuro Egawa, Shinya Watanabe, Kentaro Kawanaka, Jonas T. Treebak, Tatsuya Hayashi
Summary: This study demonstrated the synergistic enhancement of insulin-stimulated TBC1D4 phosphorylation and glucose uptake by fasting and prior muscle contraction, which is associated with augmented AMPK pathway activation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Medicine, Research & Experimental
Anna Thors o Larsen, Simone A. Melander, Nina Sonne, Emma Bredtoft, Mays Al-Rubai, Morten A. Karsdal, Kim Henriksen
Summary: Dual amylin and calcitonin receptor agonists (DACRAs) have shown significant effects on weight loss and improvement in glucose control and insulin action in rats. However, it is still unclear to what extent DACRAs affect insulin sensitivity beyond weight loss and their impact on tissue-specific glucose uptake.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Renee N. O. Silva, Ricardo P. Llanos, Rosangela A. S. Eichler, Thiago B. Oliveira, Fabio C. Gozzo, William T. Festuccia, Emer S. Ferro
Summary: Intracellular peptides derived from skeletal muscle and adipose tissues play a role in regulating blood glucose levels and promoting muscle contraction in mice. Specifically, Ric4 and its derivatives show potential therapeutic effects in reducing glycemia.
Review
Biochemistry & Molecular Biology
A. Tate Lasher, Hemant Srivastava, Liou Y. Sun
Summary: Recent studies have shown that glucagon not only regulates glycemia, but also plays a role in amino acid and lipid metabolism, systemic endocrine and paracrine function, and the response to cardiovascular injury. Inhibition of glucagon receptor signaling through the use of glucagon receptor antagonists and tissue-specific genetic knockout models has provided valuable insights into the role of glucagon.
Article
Nutrition & Dietetics
Amy Zheng, Haiyan Wang, Edward B. Arias, Gengfu Dong, Jiahui Zhao, Gregory D. Cartee
Summary: The effects of calorie restriction on female wildtype and Akt substrate of 160 kDa knockout rats were evaluated. The results showed that calorie restriction increased muscle glucose uptake and GLUT4 protein abundance, and AS160 expression was essential for these increases.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Daniel Irelan, Abigail Boyd, Edward Fiedler, Peter Lochmaier, Will McDonough, Ileana V. Aragon, Lyudmila Rachek, Lina Abou Saleh, Wito Richter
Summary: cAMP-phosphodiesterase 4 (PDE4) inhibitors, approved for treating inflammatory diseases, can temporarily increase blood glucose levels in mice due to their ability to inhibit glucose uptake into muscle tissues, independent of insulin secretion and sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Zheng Zhang, Zhi-Peng Shang, Yan Jiang, Zhao-Xia Qu, Ren-Yong Yang, Jing Zhang, Ye-Xi Lin, Feng Zhao
Summary: Protein tyrosine phosphatase 1B (PTP1B) is an important target for treating type 2 diabetes. However, current PTP1B inhibitors lack selectivity and bioavailability. A study on Knoxia valerianoides led to the discovery of a unique anthraquinone-coumarin hybrid with good specificity for PTP1B. Further investigation of this plant led to the isolation of nine new anthraquinone glycosides and two known ones. All compounds showed PTP1B inhibitory activities, with compounds 4 and 8 exhibiting high selectivity for PTP1B over TCPTP.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Biochemistry & Molecular Biology
Sander A. J. Verbrugge, Julia A. Alhusen, Shimon Kempin, Nicolas J. Pillon, Jan Rozman, Henning Wackerhage, Maximilian Kleinert
Summary: Exercise is a cornerstone treatment for type 2 diabetes mellitus by improving insulin sensitivity of glucose uptake in skeletal muscle. A systematic review identified 176 genes related to muscle glucose uptake, with over 50% of them being regulated by exercise. Endurance and resistance exercise show both common and unique changes in gene expression and phosphorylation related to glucose uptake.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xiong Jia, Weishuai Liu
Summary: Vaccarin, a flavonoid found in vaccaria seeds, can ameliorate obesity and insulin resistance induced by a high-fat diet. The mechanism involves reducing fat accumulation, improving insulin sensitivity, and activating the insulin signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Yun-Kyoung Lee, Wen Du, Yaohui Nie, Bryan Diaz, Nishat Sultana, Takumi Kitamoto, Rudolph L. Leibel, Domenico Accili, Sandro Belvedere
Summary: Inhibition of FOXO1 to convert intestinal epithelial cells into insulin-producing cells is a feasible alternative treatment for diabetes.
MOLECULAR METABOLISM
(2022)
Article
Multidisciplinary Sciences
Haiyan Wang, Amy Zheng, Edward B. Arias, Gregory D. Cartee
Summary: AICAR treatment can increase γ3-AMPK activity and reduce membrane cholesterol content, leading to enhanced glucose uptake in aged skeletal muscles. This study provides insights into potential mechanisms for improving glucose metabolism in older individuals.
Article
Oncology
Zhe Tang, Patrick G. Pilie, Chuandong Geng, Ganiraju C. Manyam, Guang Yang, Sanghee Park, Daoqi Wang, Shan Peng, Cheng Wu, Guang Peng, Timothy A. Yap, Paul G. Corn, Bradley M. Broom, Timothy C. Thompson
Summary: ATR inhibitors in prostate cancer can activate immune pathways and induce cell autophagy, and when combined with anti-PD-L1 therapy, can result in a synergistic effect, providing therapeutic responses for CRPC patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Kirstin A. MacGregor, Iain J. Gallagher, Colin N. Moran
Summary: This study investigated the variation in insulin sensitivity across the menstrual cycle and found that it is influenced by body mass index (BMI), physical activity, and cardiorespiratory fitness (CRF). Rhythmicity in insulin sensitivity and associated metabolites were modified by these factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Yuan Luo, Wenhao Zhou, Ruixin Li, Samwel M. Limbu, Fang Qiao, Liqiao Chen, Meiling Zhang, Zhen-Yu Du
Summary: This study investigated the regulatory function of the PDK-PDHE1a axis in glucose metabolism in fish. The results showed that inhibiting PDK can enhance PDHE1a activity and improve glucose catabolism in fish.
Article
Endocrinology & Metabolism
Micaela Morettini, Laura Burattini, Christian Gobl, Giovanni Pacini, Bo Ahren, Andrea Tura
Summary: The study developed a mathematical model to describe glucagon kinetics during an oral glucose tolerance test, which is simple enough for clinical application. The model was validated and found to be reliable for estimating individual glucagon-related parameters.
FRONTIERS IN ENDOCRINOLOGY
(2021)