Modeling the TNFα-Induced Apoptosis Pathway in Hepatocytes

A formal model for analyzing drug combination effects and its application in TNF-α-induced NFκB pathway

(2010) Han Yan et al.   BMC Systems Biology

Systems biology of apoptosis signaling networks

(2010) Inna N Lavrik   CURRENT OPINION IN BIOTECHNOLOGY

Inhibition of NF-κB induces a switch from CD95L-dependent to CD95L-independent and JNK-mediated apoptosis in T cells

(2010) Michael K. Kießling et al.   FEBS LETTERS

Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner

(2010) Kathrin Schmich et al.   HEPATOLOGY

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

(2010) Lufang Zhou et al.   PLoS Computational Biology

Annotation and merging of SBML models with semanticSBML

(2009) F. Krause et al.   BIOINFORMATICS

Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways

(2009) Salvatore Papa et al.   BIOLOGICAL CHEMISTRY

Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach

(2009) Johannes Witt et al.   BMC Systems Biology

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation

(2009) H Düssmann et al.   CELL DEATH AND DIFFERENTIATION

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

(2009) Thomas Kaufmann et al.   IMMUNITY

Biological studies on Brazilian plants used in wound healing

(2009) C. Schmidt et al.   JOURNAL OF ETHNOPHARMACOLOGY

Understanding apoptosis by systems biology approaches

(2009) Inna N. Lavrik et al.   Molecular BioSystems

p38MAPK: stress responses from molecular mechanisms to therapeutics

(2009) Lydia R. Coulthard et al.   TRENDS IN MOLECULAR MEDICINE

ON/OFF and Beyond - A Boolean Model of Apoptosis

(2009) Rebekka Schlatter et al.   PLoS Computational Biology

Itch self-polyubiquitylation occurs through lysine-63 linkages

(2008) Flavia Scialpi et al.   BIOCHEMICAL PHARMACOLOGY

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes

(2008) Dorothée Walter et al.   HEPATOLOGY

Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells

(2008) John G. Albeck et al.   MOLECULAR CELL

Understanding NF-κB signaling via mathematical modeling

(2008) Raymond Cheong et al.   Molecular Systems Biology

Construction and analysis of a modular model of caspase activation in apoptosis

(2008) Heather A Harrington et al.   Theoretical Biology and Medical Modelling

Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death

(2008) John G Albeck et al.   PLOS BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY