Article
Pharmacology & Pharmacy
Hanhan Wu, Beijing Zhu, Daijin Li, Jing Xu, Jie Chang, Xiaoye Du, Jingang Cui, Ning Zhang, Teng Zhang, Yu Chen
Summary: This study demonstrates for the first time that Cuscuta chinensis Lam. (CCL) has protective effects on photoreceptors, alleviating the damage caused by photooxidative stress to retinal structure and function, and maintaining immune homeostasis. These findings provide novel evidence supporting the clinical application of CCL in the prevention and treatment of photoreceptor degenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Ashley C. Kramer, Katherine Gurdziel, Ryan Thummel
Summary: The study revealed that adult zebrafish have the ability to completely regenerate their retinas through the re-entry of Muller glia into the cell cycle and differentiation into new photoreceptors after intense light exposure. Additionally, the research identified two peaks of MG gliosis, a distinct transcriptional shift between 5- and 10-days post lesion, and different patterns of transcriptional recovery of photoreceptor opsins at 28 days post lesion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Ophthalmology
Weijie Jiang, Siqi He, Logen Liu, Xia Meng, Jing Lu, Juan Li, Tuo Chen, Ying Xu, Qiguo Xiao, Ling Qi, Jia Zhang
Summary: This review summarizes the roles of miRNAs in retinal Muller glial cell function, emphasizing the potential application of miRNAs in retinal repair and regeneration.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Neurosciences
Cuiping Zhou, Xiaoli Zhang, Yuxi Chen, Zihao Lin, Shuqiang Zhang, Zhiqiang Zhang, Lining Cao, Huaijin Guan, Jianfeng Lu, Hui Xu
Summary: Inflammation plays a complex and context-dependent role in retinal regeneration in fish. Different types of immune cells and levels of inflammatory cytokines are present in different retinal regeneration models. Proper levels of inflammation promote the reprogramming and cell cycle re-entry of Muller glia, while excessive inflammation suppresses cell proliferation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Juan S. Pena, Maribel Vazquez
Summary: Progressive and irreversible vision loss in mature and aging adults creates a global burden, and the neuroprotective abilities of retinal glial cells (Muller glia) have not been fully explored and utilized for vision restoration.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Biochemistry & Molecular Biology
Peng Zhong, Gaofeng Zeng, ChangCheng Lei, Guoping Tian, Shao Ouyang, Fangyao Liu, Jianye Peng
Summary: The study demonstrates that CNTF overexpression can prevent cardiac hypertrophy and fibrosis induced by chronic Ang II stimulation, potentially through upregulation of the Nrf2 antioxidant pathway and reduction of ROS levels. Moreover, CNTF overexpression also leads to a decrease in inflammatory cytokines release in response to chronic Ang II stimulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Ophthalmology
Henar Albertos-Arranz, Natalia Martinez-Gil, Xavier Sanchez-Saez, Agustina Noailles, Clara Monferrer Adsuara, Lidia Remoli Sargues, Juan J. Perez-Santonja, Pedro Lax, Ramon Calvo Andres, Nicolas Cuenca
Summary: This study aimed to determine whether COVID-19 affected retinal cells and establish correlations with clinical parameters. Immunostaining and confocal microscopy analysis revealed that Muller cells in COVID-19 patients showed stronger expression of ACE2 and CRALBP, and the retinas exhibited glial activation and neuronal alterations, mainly related to inflammation, hypoxic conditions, and age.
Article
Biochemistry & Molecular Biology
Adwaid Manu Krishna Chandran, Daniela Coltrini, Mirella Belleri, Sara Rezzola, Elena Gambicorti, Davide Romano, Francesco Morescalchi, Stefano Calza, Francesco Semeraro, Marco Presta
Summary: Idiopathic epiretinal membranes (ERMs) are fibrocellular membranes consisting of extracellular matrix proteins and epiretinal cells. Muller cells may play a key role in the pathogenesis of iERM, with different molecular profiles and clinical features observed in different patient clusters.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cell Biology
Maria Iribarne, David R. Hyde
Summary: This study investigated the role of microglia in zebrafish retinal regeneration after damage. The researchers found that acute and chronic damage led to different inflammation profiles and regeneration outcomes. Understanding the differences could provide valuable insights for improving therapeutic strategies for repairing injured mammalian tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Youichi Shinozaki, Kenji Kashiwagi, Schuichi Koizumi
Summary: Astrocytes, a type of glial cells in the nervous system, play crucial roles in regulating the physiological functions of the central nervous system. In diseases like glaucoma, astrocytes can undergo phenotypic changes and exhibit immune functions, which are associated with various pathological events such as tissue remodeling, neuronal death, and infiltration of immune cells. This review focuses on discussing the involvement of astrocyte-lineage cells' immune functions in the pathogenesis of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ana Karen Carapia, Erick J. Martinez-Colin, Deisy Segura-Villalobos, Rebeca Yael Victoria-Chavez, Ivonne Lezama, Eduardo Martinez-Martinez, Monica Lamas
Summary: Strict localization to the neural retina and survival in pathogenic conditions are unique properties of Muller glia. Muller cells can release extracellular vesicles (EVs) that can transmit signals and induce gene expression changes in neighboring cells. NMDA-treated Muller cells release EVs that can increase actin polymerization and upregulate multipotency genes.
Article
Ophthalmology
Kumar Abhiram Jha, Pratheepa Kumari Rasiah, Jordy Gentry, Nobel A. Del Mar, Ravi Kumar, Adebowale Adebiyi, Anton Reiner, Rajashekhar Gangaraju
Summary: This study demonstrates that intravitreal injection of adipose-derived stem cell concentrated conditioned medium (ASC-CCM) can significantly improve visual function and reduce retinal injury in a mouse model of ocular blast injury. In vitro experiments also show that ASC-CCM has antioxidant effects.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Cell Biology
Matthew R. Kent, Nergis Kara, James G. Patton
Summary: The study explores the mechanisms behind zebrafish retinal regeneration by inhibiting specific GABA(A) receptors and demonstrates the potential to induce mammalian retina regeneration. Inhibition of GABA(A)-rho receptors also triggers retina regeneration, with dual inhibition of both GABA receptor subtypes leading to enhanced regeneration. Gene expression analyses suggest that GABA(A)-rho receptor inhibition induces a canonical retinal regenerative response.
NEURAL REGENERATION RESEARCH
(2021)
Article
Ophthalmology
Jose Maria Cabrera-Maqueda, Raquel Boia, Fernando Lucas-Ruiz, Maria Jose Gonzalez-Riquelme, Antonio Francisco Ambrosio, Ana Raquel Santiago, Manuel Vidal-Sanz, Marta Agudo-Barriuso, Caridad Galindo-Romero
Summary: The main purpose of this study is to analyze the effects of unilateral optic nerve crush on the gene expression of pro- and anti-inflammatory mediators, and gliosis markers in injured and contralateral retinas. The results showed that both sham surgery and optic nerve crush changed the profile of inflammatory and gliosis markers in the injured and contralateral retinas, with more pronounced changes in optic nerve crush.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Madhu Sudhana Saddala, Xu Yang, Shibo Tang, Hu Huang
Summary: This study identified the core set of sensome and pro-inflammatory genes and their regulators in retinal microglial cells using transcriptome and data mining approaches. The transcriptional regulators identified may play crucial roles in regulating the sensome and inflammatory genes of RMCs and contribute to the pathogenesis of retinal neurodegenerative diseases.
Article
Ophthalmology
Alexandra Pietraszkiewicz, Freekje van Asten, Alan Kwong, Rinki Ratnapriya, Goncalo Abecasis, Anand Swaroop, Emily Y. Chew
Review
Neurosciences
Samantha Papal, Christopher E. Monti, Mackenzie E. Tennison, Anand Swaroop
JOURNAL OF NEUROSCIENCE RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Christie K. Campla, Hannah Mast, Lijin Dong, Jingqi Lei, Stephanie Halford, Sumathi Sekaran, Anand Swaroop
HUMAN MOLECULAR GENETICS
(2019)
Editorial Material
Medicine, Research & Experimental
Lina Zelinger, Anand Swaroop
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Dunja Lukovic, Ana Artero Castro, Koray Dogan Kaya, Daniella Munezero, Linn Gieser, Carlota Davo-Martinez, Marta Corton, Nicolas Cuenca, Anand Swaroop, Visvanathan Ramamurthy, Carmen Ayuso, Slaven Erceg
SCIENTIFIC REPORTS
(2020)
Article
Cell & Tissue Engineering
Kamil Kruczek, Anand Swaroop
Article
Ophthalmology
Elvira Agron, Julie Mares, Traci E. Clemons, Anand Swaroop, Emily Y. Chew, Tiarnan D. L. Keenan
Summary: This study found that higher dietary intake of multiple nutrients, including minerals, vitamins, and carotenoids, is associated with a decreased risk of progression to late age-related macular degeneration (AMD), with a stronger protective effect observed for geographic atrophy (GA). Certain nutrients were associated with an increased risk of AMD progression, suggesting a complex relationship between dietary intake and AMD risk. This data may support further research and randomized trials of supplementation in the future.
Article
Genetics & Heredity
Tobias Strunz, Christina Kiel, Felix Grassmann, Rinki Ratnapriya, Madeline Kwicklis, Marcus Karlstetter, Sascha Fauser, Nicole Arend, Anand Swaroop, Thomas Langmann, Armin Wolf, Bernhard H. F. Weber
Review
Medicine, General & Internal
Holly. Y. Chen, Ordan J. Lehmann, Anand Swaroop
Summary: Ocular morphogenesis in vertebrates is a highly organized process regulated by genetic programs, alterations of which can lead to hereditary or nonhereditary congenital disorders. Limited treatment options currently exist, but advancements in research, particularly in understanding the genetic complexities of early-onset ocular disorders, are ongoing.
Article
Neurosciences
Elena Kisseleff, Robin J. Vigouroux, Catherine Hottin, Sophie Lourdel, Leah Thomas, Parth Shah, Alain Chedotal, Muriel Perron, Anand Swaroop, Jerome E. Roger
Summary: The study reveals a unique role of GSK3 in controlling the production of ganglion cells in the inner nuclear layer, corresponding to dRGCs, a rare and poorly characterized retinal cell type. In Gsk3 mutant mice, an excess of dRGCs leads to more axons projecting into the non-image-forming visual circuit, and at least a subset of dRGCs are direction-selective RGCs.
Article
Biochemistry & Molecular Biology
Noor D. White, Zachary A. Batz, Edward L. Braun, Michael J. Braun, Karen L. Carleton, Rebecca T. Kimball, Anand Swaroop
Summary: The study used a probe set to capture 46 genes related to avian vision, achieving high success rates and saving sequencing resources, while avoiding the issue of chimeric assembly. By applying these data, positively selected genes in the evolution of night vision and high-speed vision were identified, providing a new perspective for evolutionary research.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Biochemistry & Molecular Biology
Claire Marchal, Nivedita Singh, Ximena Corso-Diaz, Anand Swaroop
Summary: This article presents mathematical concepts for estimating and predicting the resolution of Hi-C datasets, and introduces HiCRes, a docker pipeline, for analyzing multiple Hi-C libraries.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biology
Andrew J. Smith, Jayshree Advani, Daniel C. Brock, Jacob Nellissery, Jessica Gumerson, Lijin Dong, L. Aravind, Breandan Kennedy, Anand Swaroop
Summary: We identified a mitochondrial protein, GATD3A, with bacterial evolutionary affinities, that functions as a deglycase and restricts the formation of AGEs in mitochondria. GATD3A may play a role in maintaining the integrity of important biomolecules.
Article
Biochemistry & Molecular Biology
Xulong Liang, Sharda P. Yadav, Zachary A. Batz, Jacob Nellissery, Anand Swaroop
Summary: During retinal development, NRL protein specifies the fate of rod photoreceptor cells by controlling the expression of genes such as Rhodopsin. Our study reveals that protein kinase CK2 can phosphorylate Ser117 residue of NRL, thereby modulating its transcriptional regulatory activity. The regulation of NRL by CK2 highlights the intricate interdependence of transcriptional and signaling pathways in maintaining the homeostasis of rod photoreceptors.
HUMAN MOLECULAR GENETICS
(2022)
Article
Multidisciplinary Sciences
Claire Marchal, Nivedita Singh, Zachary Batz, Jayshree Advani, Catherine Jaeger, Ximena Corso-Diaz, Anand Swaroop
Summary: This study reveals the genomic regulation of the human retina using high-resolution chromatin contact maps, identifying candidate genes associated with retinal degeneration and susceptibility to eye diseases, and providing new insights into the genetic control of tissue-specific functions.
NATURE COMMUNICATIONS
(2022)