Article
Multidisciplinary Sciences
Alberto Domingo Lopez-Munoz, Ivan Kosik, Jaroslav Holly, Jonathan W. Yewdell
Summary: SARS-CoV-2 nucleocapsid protein induces strong immune responses and manipulates innate immunity.
Article
Multidisciplinary Sciences
Nadine A. Peart A. Akindele, Laharika Dasharath Katamoni, Jacqueline Brockhurst, Shristi Ghimire, San Suwanmanee, Lisa Pieterse, Kelly A. A. Metcalf Pate, Elaine Bunyan, Roy Bannister, Tomas Cihlar, Danielle P. P. Porter, Diane E. E. Griffin
Summary: Measles is a systemic disease caused by the measles virus (MeV) with initial infection in the respiratory tract. Despite its potential for significant mortality, there is no licensed antiviral therapy available. In this study, we evaluated the effectiveness of post-exposure prophylaxis and treatment with the broad-spectrum antiviral remdesivir using a well-characterized rhesus macaque model of measles.
SCIENTIFIC REPORTS
(2023)
Article
Virology
Sunil R. Vaidya, Neelakshi S. Kumbhar, Gargi K. Andhare, Nilesh Pawar, Atul M. Walimbe, Meenal Kinikar, Sunitha M. Kasibhatla, Urmila Kulkarni-Kale
Summary: This study investigated the neutralizing antibody response to vaccine and wild-type measles viruses in suspected measles cases reported from 2012 to 2016. The results showed significant differences in neutralizing antibody titers against different genotypes of measles viruses, and specific mutations were found to be associated with reduced neutralization capacity.
Review
Cell Biology
Emma Wanner, Harikrishnan Thoppil, Karl Riabowol
Summary: Mammalian development is a complex process involving cell division, differentiation, death, and aging, with programmed cell death and cellular senescence playing crucial roles in shaping organs and tissues. These processes have dual roles, with potential benefits in early life but contributing to deleterious effects and pathologies later in life.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chao Wu, Nicole D. Wagner, Austin B. Moyle, Annie Feng, Nitin Sharma, Sarah H. Stubbs, Callie Donahue, Robert A. Davey, Michael L. Gross, Daisy W. Leung, Gaya K. Amarasinghe
Summary: This study reveals the components and mechanisms of viral inclusion body (IB) formation during Ebola virus (EBOV) infection using a combined biophysical and cellular approach. The phase separation of the eNP0VP35 complex is reversible and modulated by ionic strength, with the multivalency of eVP35 being critical for phase separation. Over-expression of an eVP35 peptide disrupts IB formation, leading to reduced frequency of IB formation and limited viral infection.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jingru Fang, Guillaume Castillon, Sebastien Phan, Sara McArdle, Chitra Hariharan, Aiyana Adams, Mark H. Ellisman, Ashok A. Deniz, Erica Ollmann Saphire
Summary: Ebola virus infection induces the formation of biomolecular condensates called viral factories, which coordinate viral transcription, replication, and assembly. The authors characterized the phase separation properties and internal structures of intracellular viral factories induced by Ebola virus, and correlated these properties to important steps of viral biogenesis.
NATURE COMMUNICATIONS
(2023)
Article
Virology
Ching-Hsuan Liu, Chen-Jei Tai, Yu-Ting Kuo, Shen-Shong Chang, Liang-Tzung Lin
Summary: Hepatocellular carcinoma (HCC) is a challenging cancer to treat and requires more effective therapeutic strategies. In this study, the combination of oncolytic measles virus (MV) and natural triterpenoid compound ursolic acid (UA) showed synergistic cytotoxic effects on HCC cells, including those with hepatitis B virus (HBV) or hepatitis C virus (HCV) replication. The combination induced enhanced apoptosis, increased oxidative stress, and dysregulation of the mitochondria-dependent pathway. These findings highlight the potential of the MV and UA combination as a treatment strategy for HCC.
Review
Biochemistry & Molecular Biology
Quanhui Yan, Xiaodi Liu, Yawei Sun, Weijun Zeng, Yuwan Li, Feifan Zhao, Keke Wu, Shuangqi Fan, Mingqiu Zhao, Jinding Chen, Lin Yi
Summary: This review summarizes recent advances in autophagy, apoptosis, and innate immunity induced by swine enteric coronavirus (SeCoV) infection, emphasizing their relationship with viral replication and signaling pathway alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xiaowen Li, Keke Wu, Sen Zeng, Feifan Zhao, Jindai Fan, Zhaoyao Li, Lin Yi, Hongxing Ding, Mingqiu Zhao, Shuangqi Fan, Jinding Chen
Summary: Mitochondria, crucial organelles in eukaryotic cells, play a role in metabolism, programmed cell death, and the host's innate immunity against viruses. Studies have shown that viral infections can alter mitochondrial dynamics, induce cell death, and impact cellular immune responses, highlighting the importance of mitochondria in the host-virus interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jia Li, Thekla Kemper, Ruth Broering, Jieliang Chen, Zhenghong Yuan, Xueyu Wang, Mengji Lu
Summary: The study found that IFN alpha-2a treatment can interfere with multiple intracellular signaling pathways, promote autophagy initiation, but may also slightly increase HBV replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shih-Che Weng, Yu-Xian Zhou, Shin-Hong Shiao
Summary: This study developed a novel antiviral approach using a virus-inducible gene expression system to block the replication and transmission of dengue virus and Zika virus. The system successfully inhibited viral replication and production of infectious virus particles both in vitro and in mosquitoes.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Microbiology
Nan Song, Lihong Chen, Xingmei Ren, Nicholas R. Waterfield, Jian Yang, Guowei Yang
Summary: Tc toxins are exotoxins composed of TcA, TcB, and TcC subunits. They recognize host cells through N-glycans and heparan sulfates. Different Tc toxins use distinct receptors to bind to target cells, determined by TcA homopentamer. The identification of TcA homologues and their categorization into subfamilies provides insights into host specificity and potential therapeutic applications.
Article
Microbiology
Patrick Bohn, Irke Wassmann, Lisa Wendt, Anne Leske, Thomas Hoenen, Birke A. Tews, Allison Groseth
Summary: This study demonstrates that a specific mutation can accurately assess the role of a protein in viral antagonism of interferon production. The mutation inhibits the protein's exonuclease activity while still efficiently blocking interferon production.
Article
Multidisciplinary Sciences
Emeline Bonsergent, Eleonora Grisard, Julian Buchrieser, Olivier Schwartz, Clotilde Thery, Gregory Lavieu
Summary: A quantitative method was developed to investigate the release of extracellular vesicle contents, indicating a requirement for endosomal acidification and potential involvement of membrane fusion.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Grazielle Nathia-Neves, Caleb S. Calix-Rivera, Marina Villanueva, Felicidad Ronda
Summary: The impact of microwave treatments on the structure, solubility, and techno-functional properties of proteins in tef flour was investigated. Shorter treatments at low moisture content improved emulsifying stability, while longer treatments at higher moisture content increased hydration properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Prakash B. Palde, Ashima Bhaskar, Laura E. Pedro Rosa, Franck Madoux, Peter Chase, Vinayak Gupta, Timothy Spicer, Louis Scampavia, Amit Singh, Kate S. Carroll
ACS CHEMICAL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Priyanka Tyagi, Allimuthu T. Dharmaraja, Ashima Bhaskar, Harinath Chakrapani, Amit Singh
FREE RADICAL BIOLOGY AND MEDICINE
(2015)
Article
Cell Biology
Akhil Varshney, Jyoti Bala, Baby Santosh, Ashima Bhaskar, Suresh Kumar, Pramod K. Yadava
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2017)
Article
Multidisciplinary Sciences
Ashutosh Mani, Akhil Varshney, Ashima Bhaskar, Jyoti Bala, Pramod K. Yadava, Dwijendra K. Gupta
NATIONAL ACADEMY SCIENCE LETTERS-INDIA
(2016)
Article
Biochemistry & Molecular Biology
Mehak Zahoor Khan, Ashima Bhaskar, Sandeep Upadhyay, Pooja Kumari, Raju S. Rajmani, Preeti Jain, Amit Singh, Dhiraj Kumar, Neel Sarovar Bhavesh, Vinay Kumar Nandicoori
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biology
Saurabh Mishra, Prashant Shukla, Ashima Bhaskar, Kushi Anand, Priyanka Baloni, Rajiv Kumar Jha, Abhilash Mohan, Raju S. Rajmani, Valakunja Nagaraja, Nagasuma Chandra, Amit Singh
Article
Biochemistry & Molecular Biology
Kriti Sikri, Priyanka Duggal, Chanchal Kumar, Sakshi Dhingra Batra, Atul Vashist, Ashima Bhaskar, Kritika Tripathi, Tavpritesh Sethi, Amit Singh, Jaya Sivaswami Tyagi
Review
Biochemistry & Molecular Biology
Ashima Bhaskar, Cyntia De Piano, Ekaterina Gelman, John D. McKinney, Neeraj Dhar
Article
Multidisciplinary Sciences
Sibusiso Senzani, Dong Li, Ashima Bhaskar, Christopher Ealand, James Chang, Binayak Rimal, Chengyin Liu, Sung Joon Kim, Neeraj Dhar, Bavesh Kana
SCIENTIFIC REPORTS
(2017)
Article
Plant Sciences
Ved Prakash Dwivedi, Debapriya Bhattacharya, Mona Singh, Ashima Bhaskar, Santosh Kumar, Samreen Fatima, Parveen Sobia, Luc Van Kaer, Gobardhan Das
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Santosh Kumar, Chetan Sharma, Sandeep Rai Kaushik, Ankur Kulshreshtha, Shivam Chaturvedi, Ranjan Kumar Nanda, Ashima Bhaskar, Debprasad Chattopadhyay, Gobardhan Das, Ved Prakash Dwivedi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biology
Ashima Bhaskar, Santosh Kumar, Mehak Zahoor Khan, Amit Singh, Ved Prakash Dwivedi, Vinay Kumar Nandicoori
Review
Biochemistry & Molecular Biology
Samreen Fatima, Anjna Kumari, Meetu Agarwal, Isha Pahuja, Vinod Yadav, Ved Prakash Dwivedi, Ashima Bhaskar
Summary: Epigenetics plays a crucial role in the survival of TB pathogen and manipulation of the host immune response, with a significant impact on the host genome. By altering the activation status of genes involved in host immune response, the pathogen promotes its survival and subverts antibacterial strategies of the host, which can be utilized to design efficient host-directed therapies.
Article
Microbiology
Isha Pahuja, Akanksha Verma, Antara Ghoshal, Suparba Mukhopadhyay, Anjna Kumari, Aishwarya Shaji, Shivam Chaturvedi, Ved Prakash Dwivedi, Ashima Bhaskar
Summary: This study investigates the functionality of the carbapenem antibiotic-Biapenem (BPM) in generating long-lasting immunity against TB. It found that BPM treatment can significantly boost the activation status of the innate immune system and activate adaptive immune cells, leading to the generation of long-lived memory cells. These results suggest the potential of BPM as an adjunct immunomodulator for treating TB.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biology
Shingar Sharma, R. S. Rajmani, Arun Kumar, Ashima Bhaskar, Amit Singh, Venkatasamy Manivel, Anil K. Tyagi, Kanury V. S. Rao
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2015)