Article
Nutrition & Dietetics
Vipin A. A. Vidyadharan, Chellakkan S. S. Blesson, Daren Tanchico, Ancizar Betancourt, Craig Smith, Chandra Yallampalli
Summary: This study investigated the effects of low protein programming on the structure and function of mitochondria in the hepatocytes of adult females. It was found that in utero exposure to a low protein diet led to increased mitochondrial fusion, upregulation of fusion-related genes, and downregulation of a fission gene. In addition, low protein programming impaired the mitochondrial function of hepatocytes. These findings suggest that hepatic mitochondrial dysfunction induced by in utero low protein diet may be a potential mechanism linking glucose intolerance and insulin resistance in adult offspring.
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Kyung-Ho Min, Wan Lee
Summary: This study reveals that excessive intake of saturated fatty acids (SFA) can lead to obesity and insulin resistance. The induction of miR-183-5p by SFA impairs insulin signaling, leading to the development of hepatic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Amy Romesberg, Bennett Van Houten
Summary: Mitochondria, the ATP-generating organelles in eukaryotic cells, are prone to oxidative damage on their DNA, which can lead to mtDNA mutations and deletions and result in various diseases. While previous studies have explored the mechanism of mitochondrial dysfunction, there are limitations in the methods used. This study introduces a novel chemoptogenetic approach to precisely investigate the downstream effects of ROS-induced damage on mitochondria and mtDNA.
Review
Physiology
Qianrang Lu, Xinyao Tian, Hao Wu, Jiacheng Huang, Mengxia Li, Zhibin Mei, Lin Zhou, Haiyang Xie, Shusen Zheng
Summary: NAFLD is often accompanied by systemic metabolic disorders, but the metabolic changes in hepatocytes are also crucial, impacting disease progression with close interactions between pathways. Some metabolic pathways can be potential therapeutic targets for NAFLD.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diya Sun, Zuoyou Ding, Lei Shen, Fan Yang, Jun Han, Guohao Wu
Summary: The study identified that miR-410-3p is highly expressed in subcutaneous adipose tissues and serum exosomes of CAC patients, significantly inhibiting adipogenesis and lipid accumulation. miR-410-3p targets the 3' noncoding region of IRS-1, downregulating IRS-1 and downstream adipose differentiation factors, ultimately inhibiting adipogenesis.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Hematology
Jinjian Sun, Haocheng Lu, Wenying Liang, Guizhen Zhao, Lu Ren, Die Hu, Ziyi Chang, Yuhao Liu, Minerva T. Garcia-Barrio, Jifeng Zhang, Y. Eugene Chen, Yanbo Fan
Summary: This study revealed the critical role of TFEB in endothelial metabolism, showing that TFEB can regulate glucose metabolism and enhance glucose uptake through the Akt signaling pathway. TFEB promotes glucose metabolism by upregulating IRS1 and IRS2 transcription and downregulating miRNAs (miR-335, miR-495, and miR-548o).
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yaqiong Li, Yi Lin, Xueya Han, Weihong Li, Wenmao Yan, Yuejiao Ma, Xin Lu, Xiaowu Huang, Rixing Bai, Haiyan Zhang
Summary: The study found that inhibiting GSK3 can enhance mitochondrial function in hepatocytes of obese patients, thereby improving hepatic steatosis and reducing lipid droplet size and triglyceride levels in hepatocytes.
Article
Multidisciplinary Sciences
Minxuan Xu, Jun Tan, Wei Dong, Benkui Zou, Xuepeng Teng, Liancai Zhu, Chenxu Ge, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Tingting Tang, Junjie Zhao, Longyan Wang, Jin Liu, Hao Wei, Yan Sun, Qiufeng Yang, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Mingxin Xiong, Jing Feng, Chufeng Zhang, Bochu Wang
Summary: This study reveals that Trim31 acts as an endogenous inhibitor of Rhbdf2 in mice, mitigating the development of NASH and potentially serving as a therapeutic target for treating NAFLD/NASH and associated metabolic disorders.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yue Xiong, Chiyuan Ma, Qin Li, Wenya Zhang, Huashan Zhao, Peigen Ren, Ke Zhang, Xiaohua Lei
Summary: In this study, the adverse effects of simulated microgravity on hepatocytes were investigated. It was found that microgravity impaired hepatocyte viability, caused cell cycle arrest and apoptosis, triggered lipid accumulation and impaired mitochondria function. Upregulation of genes related to lipid metabolism was also observed. Importantly, these defects could be suppressed by melatonin, suggesting its potential therapeutic intervention.
Article
Pharmacology & Pharmacy
Yu-Li Lo, Tse-Yuan Wang, Chun-Jung Chen, Yih-Hsin Chang, Anya Maan-Yuh Lin
Summary: This study presents a one-shot formulation of miR-125 and Afa, which modulates critical proteins and inhibits metabolic reprogramming and tumor progression in gastric cancer cells by targeting EGFR and mTOR pathways.
Article
Cell Biology
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian
Summary: It was found that deficiency of Ppm1k leads to reduced metabolism of branched-chain amino acids (BCAAs) and protects against obesity-induced glucose intolerance. Accumulation of branched-chain keto acids (BCKAs) inhibits glucose production in liver cells. It was observed that BCKAs suppress the activity of liver mitochondrial pyruvate carrier (MPC) and pyruvate-supported respiration. Selective suppression of pyruvate-supported gluconeogenesis was seen in Ppm1k-deficient mice and could be restored through pharmacological activation of BCKA catabolism by BT2. Furthermore, liver MPC was found to be most sensitive to circulating BCKA levels, making it a sensor of BCAA metabolism.
Review
Cell Biology
Jannik Prasuhn, Ryan L. Davis, Kishore R. Kumar
Summary: Parkinson's disease is complicated and mitochondrial dysfunction plays a key role in its pathophysiology. While there are still gaps in knowledge, targeting various aspects of mitochondrial function and using combined therapeutic approaches may offer the best chance for developing effective novel therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Qing Li, Changying Xing, Yanggang Yuan
Summary: Chronic kidney disease is a global public health issue, and patients often seek traditional Chinese medicine as an alternative treatment option. Mitochondrial dysfunction plays a crucial role in CKD, and herbal medicine can alleviate renal injury by restoring mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuhua Xu, Zixuan Tang, Hui Dai, Jue Hou, Fangqin Li, Zhuqi Tang, Dongmei Zhang
Summary: This study aimed to investigate the role and mechanism of miR-195 in pancreatic beta-cell dedifferentiation induced by hyperlipemia in type 2 diabetes mellitus. The results showed that miR-195 was upregulated during the dedifferentiation process and promoted it through inhibiting the IRS-1/2/Pi3k/Akt pathway activation and regulating Mfn2 expression.
Retraction
Biochemistry & Molecular Biology
Ying Zhou, Zhou-Fan Wang, Wei Li, Hui Hong, Juan Chen, Yi Tian, Zhao-Yun Liu
Summary: The article has been retracted due to allegations raised by a third party, as detailed investigation found that several image elements of the experimental data were published elsewhere in a different scientific context, rendering the conclusions invalid.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
