TNFα Cooperates with IFN-γ to Repress Bcl-xL Expression to Sensitize Metastatic Colon Carcinoma Cells to TRAIL-mediated Apoptosis

Pilot Study of Sentinel-Node-Based Adoptive Immunotherapy in Advanced Colorectal Cancer

(2010) Mona Karlsson et al.   ANNALS OF SURGICAL ONCOLOGY

Histone deacetylase inhibitor-induced sensitization to TNFα/TRAIL-mediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression

(2010) Katalin Darvas et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin

(2010) Tanvi S. Jani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gossypol Induces Death Receptor-5 through Activation of the ROS-ERK-CHOP Pathway and Sensitizes Colon Cancer Cells to TRAIL

(2010) Bokyung Sung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD11c+ Dendritic Cells and B Cells Contribute to the Tumoricidal Activity of Anti-DR5 Antibody Therapy in Established Tumors

(2010) N. M. Haynes et al.   JOURNAL OF IMMUNOLOGY

Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells

(2010) Jing Xu et al.   PLoS One

c-FLIP Degradation Mediates Sensitization of Pancreatic Cancer Cells to TRAIL-Induced Apoptosis by the Histone Deacetylase Inhibitor LBH589

(2010) John Kauh et al.   PLoS One

Analysis of Death Receptor 5 and Caspase-8 Expression in Primary and Metastatic Head and Neck Squamous Cell Carcinoma and Their Prognostic Impact

(2010) Heath A. Elrod et al.   PLoS One

Tumor Associated Macrophages Protect Colon Cancer Cells from TRAIL-Induced Apoptosis through IL-1β- Dependent Stabilization of Snail in Tumor Cells

(2010) Pawan Kaler et al.   PLoS One

IFN-γ Upregulates Survivin and Ifi202 Expression to Induce Survival and Proliferation of Tumor-Specific T Cells

(2010) Mary Zimmerman et al.   PLoS One

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

IFN Regulatory Factor 8 Sensitizes Soft Tissue Sarcoma Cells to Death Receptor-Initiated Apoptosis via Repression of FLICE-like Protein Expression

(2009) D. Yang et al.   CANCER RESEARCH

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma

(2009) M. Vogler et al.   CANCER RESEARCH

A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme

(2009) A. Panner et al.   CANCER RESEARCH

Curcumin Potentiates the Antitumor Effects of Bacillus Calmette-Guerin against Bladder Cancer through the Downregulation of NF- B and Upregulation of TRAIL Receptors

(2009) A. M. Kamat et al.   CANCER RESEARCH

Coordination of Intratumoral Immune Reaction and Human Colorectal Cancer Recurrence

(2009) M. Camus et al.   CANCER RESEARCH

Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species

(2009) S. Yodkeeree et al.   CANCER RESEARCH

TNF-related apoptosis-inducing ligand (TRAIL): A new path to anti-cancer therapies

(2009) Peter A. Holoch et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Parathyroid hormone-related protein confers chemoresistance by blocking apoptosis signalingviadeath receptors and mitochondria

(2009) Sarah Gagiannis et al.   INTERNATIONAL JOURNAL OF CANCER

Improved Survival in Metastatic Colorectal Cancer Is Associated With Adoption of Hepatic Resection and Improved Chemotherapy

(2009) Scott Kopetz et al.   JOURNAL OF CLINICAL ONCOLOGY

Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice

(2009) S. Shankar et al.   MOLECULAR CANCER THERAPEUTICS

Histone deacetylase inhibitors cooperate with IFN-γ to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8

(2009) S Häcker et al.   ONCOGENE

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells

(2009) S White-Gilbertson et al.   ONCOGENE

Cyclophosphamide Chemotherapy Sensitizes Tumor Cells to TRAIL-Dependent CD8 T Cell-Mediated Immune Attack Resulting in Suppression of Tumor Growth

(2009) Robbert G. van der Most et al.   PLoS One

Death receptor-4 (DR4) expression is regulated by transcription factor NF-κB in response to etoposide treatment

(2008) Francisco José Mendoza et al.   APOPTOSIS

Mcl-1: A Gateway to TRAIL Sensitization

(2008) S.-H. Kim et al.   CANCER RESEARCH

Aspirin Sensitizes Cancer Cells to TRAIL-Induced Apoptosis by Reducing Survivin Levels

(2008) M. Lu et al.   CLINICAL CANCER RESEARCH

Sulforaphane Enhances the Therapeutic Potential of TRAIL in Prostate Cancer Orthotopic Model through Regulation of Apoptosis, Metastasis, and Angiogenesis

(2008) S. Shankar et al.   CLINICAL CANCER RESEARCH

Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-κB inhibition

(2008) Johannes U. Ammann et al.   INTERNATIONAL JOURNAL OF CANCER

IFN-γ Induces Apoptosis in HL-60 Cells Through Decreased Bcl-2 and Increased Bak Expression

(2008) Yan Zhou et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells

(2008) Y. Lin et al.   MOLECULAR CANCER THERAPEUTICS

A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma

(2008) O Ndozangue-Touriguine et al.   ONCOGENE