Article
Multidisciplinary Sciences
Domenico Tupone, Justin S. Cetas
Summary: Neurogenic fever after subarachnoid hemorrhage (SAH) is a major cause of morbidity in the neurointensive care unit (NICU) and is not responsive to standard anti-pyretic medications. Recent studies on rodent models have shown that NF following SAH is not dependent on PGE(2) and can be triggered by injection of whole blood or erythrocytes into the subarachnoid space. Activation of adenosine A1 receptors in the CNS may be a potential target for blocking brown adipose tissue thermogenesis contributing to NF after SAH. These distinct mechanisms of NF may lead to new therapies in the future.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Qian Xu, Zun Mao, Yi Yun
Summary: The study found that A(1)R agonists can reduce the impact of intestinal ischemia/reperfusion injury on Caco-2 cells, possibly through anti-apoptotic effects and activation of the PI3K/Akt/p53 signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Chemistry, Medicinal
Cristina Val, Carlos Rodriguez-Garcia, Ruben Prieto-Diaz, Abel Crespo, Jhonny Azuaje, Carlos Carbajales, Maria Majellaro, Alejandro Diaz-Holguin, Jose M. Brea, Maria Isabel Loza, Claudia Gioe-Gallo, Marialessandra Contino, Angela Stefanachi, Xerardo Garcia-Mera, Juan C. Estevez, Hugo Gutierrez-de-Teran, Eddy Sotelo
Summary: This study documents a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent A(1)AR ligands, confirming their selectivity and structure-activity relationships. The study highlights the influence of aromatic residues at positions R-4 and R-6 of the pyrimidine core, as well as the role of a methyl group at the exocyclic amino group on A(1)AR selectivity profile.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Brandon M. Fritz, Fuqin Yin, Brady K. Atwood
Summary: The medial and lateral dorsal striatum play different roles in driving goal-directed and habitual/compulsive behaviors, respectively. Adenosine A(1) receptors in the dorsal striatum regulate excitatory glutamate transmission, potentially influencing striatally-mediated behaviors. The study found that activation of presynaptic A1Rs led to synaptic depression in both DLS and DMS, suggesting a potential role of A1Rs in neuropsychiatric diseases.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Catia R. Lopes, Francisco Q. Goncalves, Simao Olaio, Angelo R. Tome, Rodrigo A. Cunha, Joao Pedro Lopes
Summary: Adenosine regulates synaptic transmission and plasticity through A(1) and A(2A) receptors. Supramaximal activation of A(1)R blocks hippocampal synaptic transmission, and A(2A)R activation decreases A(1)R-mediated inhibition during high-frequency-induced LTP.
Article
Endocrinology & Metabolism
Siham Abdelgani, Ahmed Khattab, John Adams, Mohamed Abu-Farha, Guisepe Daniele, Fahd Al-Mulla, Stefano Del Prato, Ralph A. DeFronzo, Muhammad Abdul-Ghani
Summary: The objective of this study was to investigate the mechanisms responsible for the increase in glucose and ketone production caused by empagliflozin in patients with type 2 diabetes mellitus. The results showed that empagliflozin ingestion led to an increase in endogenous glucose production, a decrease in plasma glucose and insulin concentrations, an increase in plasma glucagon, free fatty acid, and beta-hydroxybutyrate concentrations, and an increase in total-body norepinephrine turnover rate. In conclusion, empagliflozin increases plasma free fatty acid and ketone concentrations by decreasing insulin and increasing glucagon, and the increase in endogenous glucose production is likely explained by the increase in norepinephrine turnover.
Article
Biochemistry & Molecular Biology
Yoshitake Baba, Takanobu Takihara, Noritaka Okamura
Summary: Energy drinks with excessive caffeine intake have a negative effect on sleep, while green tea, which contains both caffeine and theanine, can improve sleep quality. This study found that theanine can reduce the negative effects of caffeine on sleep by suppressing caffeine-induced wake after sleep onset (WASO) time. However, there were no significant differences in sleep latency or the number of WASOs when comparing theanine, caffeine, or caffeine and theanine combined to a placebo.
Article
Physiology
Basu Chakrabarty, Marcus J. Drake, Anthony J. Kanai, Christopher H. Fry
Summary: Activation of adenosine A(1) receptors reduces the lower frequency component of nerve-mediated detrusor contractions and neuronal ATP release by inhibiting adenylyl cyclase activity and downstream cAMP generation. Adenosine has no effect on ACh release or the higher frequency component of contractions.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gabor Viczjan, Tamas Erdei, Ignac Ovari, Nora Lampe, Reka Szekeres, Mariann Bombicz, Barbara Takacs, Anna Szilagyi, Judit Zsuga, Zoltan Szilvassy, Bela Juhasz, Rudolf Gesztelyi
Summary: The study suggests that FSCPX may reduce cardiac interstitial adenosine accumulation in response to nucleoside transport blockade by inhibiting CD39 and CD73 enzymes. The paradoxical effect of FSCPX was successfully reproduced in rat models, indicating an additional action of FSCPX that may involve the inhibition of ectonucleotidase. Additionally, the study found that POM-1 can inhibit both CD39 and CD73 enzymes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Katarzyna Bednarska-Szczepaniak, Adam Mieczkowski, Aleksandra Kierozalska, Dijana Pavlovic Saftic, Konrad Glabala, Tomasz Przygodzki, Lidia Stanczyk, Kamil Karolczak, Cezary Watala, Harsha Rao, Zhan-Guo Gao, Kenneth A. Jacobson, Zbigniew J. Lesnikowski
Summary: A series of adenosine and 2'-deoxyadenosine pairs modified with a boron cluster or phenyl group showed a general tendency to preferentially bind to the A(3) adenosine receptor. Boron cluster-modified ligands exhibited higher A(3) receptor selectivity compared to phenyl analogs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Kiyoshi Takahara, Mamoru Kusaka, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki
Summary: This study retrospectively analyzed the risks and benefits of selective clamping in robot-assisted partial nephrectomy (RAPN). The results showed no significant differences in surgical time, warm ischemia time, or incidence rates of complications between the two groups. However, the estimated blood loss was significantly higher in the selective clamping group. Additionally, there were no significant intergroup differences in the postoperative preservation ratio of estimated glomerular filtration rate (eGFR) at 6 and 12 months of follow-up.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Amany E. El-Naggar, Mai M. Helmy, Sahar M. El-Gowilly, Mahmoud M. El-Mas
Summary: The cholinergic pathway and adenosinergic neurotransmission play important roles in regulating cardiovascular and inflammatory damage caused by sepsis. Nicotine and central A1 receptors contribute to counteracting this damage.
SCIENTIFIC REPORTS
(2023)
Article
Thermodynamics
Kai -hong Wang, Yu-qing Liu, Pei -hong Zhang, Yin-liang Guo
Summary: This study investigated the law of smoke propagation in long channel fires and the impact of wall thermal inertia on maximum smoke temperature and longitudinal attenuation. The results showed that wall thermal property significantly affects the maximum smoke temperature, and the effect of wall thermal inertia on longitudinal smoke temperature decay can be negligible when it is greater than or equal to 1.21 kW(2).s/(m(4).K-2). The study also found that the smoke temperature distribution is related to the heat release rate.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2023)
Article
Automation & Control Systems
Roman S. Khmyrov, Pavel A. Podrabinnik, Tatiana V. Tarasova, Mikhail A. Gridnev, Andrey D. Korotkov, Sergey N. Grigoriev, Alexandra Yu. Kurmysheva, Oleg B. Kovalev, Andrey V. Gusarov
Summary: Metals and alloys in amorphous state have excellent properties due to the absence of defects, but conventional technologies have size limitations for amorphous alloys. Additive manufacturing (AM) overcomes these limitations. Recent studies on Zr-based bulk metallic glass (BMG) alloys by selective laser melting (SLM) showed the possibility of achieving the amorphous state but revealed partial crystallization as a drawback. This study aims to analyze the conditions for partial crystallization and control it by optimizing the process parameters.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katharina Metzner, Tilman Gross, Annika Balzulat, Gesine Wack, Ruirui Lu, Achim Schmidtko
Summary: This study investigated the distribution of A(1)R in nociceptive tissues and evaluated the effects of targeting A(1)R with partial agonist capadenoson on neuropathic pain. Despite the expression of A(1)R in nociceptive neurons, the partial A(1)R agonist capadenoson did not reduce mechanical hypersensitivity in mouse models of neuropathic pain.
PURINERGIC SIGNALLING
(2021)
Article
Cardiac & Cardiovascular Systems
Lorenz Bott-Fluegel, Hans-Joerg Weig, Heiko Uehlein, Michael Nabauer, Karl-Ludwig Laugwitz, Melchior Seyfarth
EUROPEAN JOURNAL OF HEART FAILURE
(2008)
Article
Medicine, General & Internal
Stefanie Schulz-Schuepke, Sandra Heide, Senta Gewalt, Tareq Ibrahim, Maryam Linhardt, Katharina Haas, Katharina Hoppe, Corinna Boettiger, Philip Groha, Christian Bradaric, Roland Schmidt, Lorenz Bott-Fluegel, Ilka Ott, Julia Goedel, Robert A. Byrne, Simon Schneider, Christof Burgdorf, Tanja Morath, Sebastian Kufner, Michael Joner, Salvatore Cassese, Petra Hoppmann, Christian Hengstenberg, Juergen Pache, Massimiliano Fusaro, Steffen Massberg, Julinda Mehilli, Heribert Schunkert, Karl-Ludwig Laugwitz, Adnan Kastrati
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2014)
Article
Cardiac & Cardiovascular Systems
Hans-Joerg Weig, Lorenz Bott-Fluegel, Christian Staedele, Kerstin Winter, Roland Schmidt, Meinrad Gawaz, Karl-Ludwig Laugwitz, Melchior Seyfarth
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2008)
Article
Cardiac & Cardiovascular Systems
Melchior Seyfarth, Dirk Sibbing, Iris Bauer, Georg Froehlich, Lorenz Bott-Fluegel, Robert Byrne, Josef Dirschinger, Adnan Kastrati, Albert Schoemig
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2008)
Article
Medicine, General & Internal
Alessandra Moretti, Milena Bellin, Andrea Welling, Christian Billy Jung, Jason T. Lam, Lorenz Bott-Fluegel, Tatjana Dorn, Alexander Goedel, Christian Hoehnke, Franz Hofmann, Melchior Seyfarth, Daniel Sinnecker, Albert Schoemig, Karl-Ludwig Laugwitz
NEW ENGLAND JOURNAL OF MEDICINE
(2010)
Article
Multidisciplinary Sciences
Carolin Sonne, Lorenz Bott-Fluegel, Simon Hauck, Hasema Lesevic, Petra Barthel, Fabian Michalk, Katharina Hoppe, Joerg Hausleiter, Albert Schoemig, Christof Kolb
Article
Cardiac & Cardiovascular Systems
Carolin Sonne, Lorenz Bott-Flugel, Simon Hauck, Martin Hadamitzky, Hasema Lesevic, Gabriele Demetz, Daniel Braun, Petra Wolf, Joerg Hausleiter, Albert Schoemig, Christof Kolb
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2014)
Article
Genetics & Heredity
L Bott-Flügel, HJ Weig, M Knödler, C Städele, A Moretti, KL Laugwitz, M Seyfarth
JOURNAL OF MOLECULAR MEDICINE-JMM
(2005)
Article
Multidisciplinary Sciences
A Moretti, HJ Weig, T Ott, M Seyfarth, HP Holthoff, D Grewe, A Gillitzer, L Bott-Flügel, A Schömig, M Ungerer, KL Laugwitz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2002)
Article
Medicine, General & Internal
Dirk Sibbing, Karl-Ludwig Laugwitz, Lorenz Bott-Fluegel, Juergen Pache
CASE REPORTS IN MEDICINE
(2009)