Article
Biochemistry & Molecular Biology
Mitsuharu Okutsu, Mami Yamada, Ken Tokizawa, Shuri Marui, Katsuhiko Suzuki, Vitor A. Lira, Kei Nagashima
Summary: Regular exercise helps protect arterial endothelial cells and reduce atherosclerotic plaque formation in mice, potentially through increasing autophagy levels in endothelial cells.
Article
Plant Sciences
Minqi Xiong, Zilong Zhang, Jingang Cui, Xiaoye Du, Yu Chen, Teng Zhang
Summary: This study evaluated the potential impact of DYNT treatment on atherosclerosis. The results showed that DYNT treatment reduced the size of atherosclerotic plaques, lowered lipid retention, and mitigated macrophagic burden. Additionally, DYNT treatment offered protection against dyslipidemia, fatty liver pathologies, dysbiosis, and impairment in the intestinal epithelial barrier associated with atherosclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Vanessa Bianconi, Giacomo Cafaro, Massimo Raffaele Mannarino, Carlo Perricone, Elena Cosentini, Onelia Bistoni, Rita Paltriccia, Rita Lombardini, Roberto Gerli, Matteo Pirro, Elena Bartoloni
Summary: This study found that patients with primary Sjogren's syndrome (pSS) have significantly higher plasma PCSK9 levels compared to healthy controls (HCs), despite having a lower prevalence of dyslipidaemia. However, the relationship between PCSK9 and cardiovascular (CV) risk in pSS patients requires further investigation.
Review
Biochemistry & Molecular Biology
Guzel Bikbova, Toshiyuki Oshitari, Mukharram Bikbov
Summary: There is a clear connection between diabetes and atherosclerotic cardiovascular disease, necessitating therapeutic approaches that target both diseases. Ongoing clinical trials are examining the roles of obesity, adipose tissue, gut microbiota, and pancreatic beta cell function in diabetes. Inflammation plays a crucial role in diabetes pathophysiology and associated metabolic disorders, leading to increased interest in targeting inflammation for diabetes prevention and control. Diabetic retinopathy, a neurodegenerative and vascular disease that develops after poorly controlled diabetes, is also increasingly linked to inflammation. Molecular pathways such as oxidative stress and advanced glycation end-products contribute to the inflammatory response in diabetes-related complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Bin Wen, Yuan-ye Dang, Su-hua Wu, Yi-min Huang, Kong-yang Ma, Yi-ming Xu, Xi-Long Zheng, Xiao-yan Dai
Summary: DHC ameliorates atherosclerosis in ApoE(-/-) mice by inhibiting inflammation, likely by targeting macrophage p65- and ERK1/2-mediated pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Plant Sciences
Xiaonan Zhang, Zeping Wang, Xiaoya Li, Jiye Chen, Zongliang Yu, Xin Li, Changxin Sun, Lanqing Hu, Min Wu, Longtao Liu
Summary: The study aimed to assess the efficacy of polydatin on inflammation, cell death, and autophagy in atherosclerosis. The results showed that polydatin can inhibit inflammation and promote autophagy, thereby exerting anti-atherosclerotic effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marco Orecchioni, Dennis Wolf, Vasantika Suryawanshi, Holger Winkels, Kouji Kobiyama, Jeffrey Makings, William B. Kiosses, Klaus Ley
Summary: Atherosclerosis is caused by the retention of lipoproteins and cholesterol in the subendothelial layer, leading to an inflammatory process and plaque formation. Macrophages are found to be the main producers of the anti-inflammatory cytokine IL-10 in atherosclerotic plaques. IL-10 secretion by macrophages is critical for limiting atherosclerosis progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yang Wu, Gem Johnson, Fujie Zhao, Yin Wu, Guojun Zhao, Andrew Brown, Shaojin You, Ming-Hui Zou, Ping Song
Summary: The study found that hApoE2 rats had the lowest body weight and white fat mass, with higher levels of serum total cholesterol, triglycerides, and low-density lipoprotein and very low-density lipoprotein. ApoE KO rats also showed elevated levels of total cholesterol and LDL-C&VLDL-C. More severe atherosclerotic lesions were only detected in the aortic roots of hApoE2 and ApoE KO rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sungmin Kim, Yu-Ran Lee, Eun-Ok Lee, Hao Jin, Yeon-Hee Choi, Hee-Kyoung Joo, Byeong-Hwa Jeon
Summary: This study found that dietary capsanthin has anti-inflammatory and anti-vascular inflammation effects on atherosclerotic mice, reducing plaque formation and inflammatory marker levels.
Article
Chemistry, Multidisciplinary
Zhu-Qi Huang, Wu Luo, Wei-Xin Li, Pan Chen, Zhe Wang, Rui-Jie Chen, Yi Wang, Wei-Jian Huang, Guang Liang
Summary: Costunolide (CTD) has anti-atherosclerotic effects by reducing inflammatory responses and oxLDL uptake, and its mechanism involves the inhibition of NF-kappa B signaling pathway through covalent binding to IKKβ.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Medicinal
Qingjuan Zuo, Guorui Zhang, Lili He, Sai Ma, Huijuan Ma, Jianlong Zhai, Zhongli Wang, Tingting Zhang, Yan Wang, Yifang Guo
Summary: The study found that canagliflozin can attenuate hepatic steatosis by improving lipid metabolism, enhancing autophagy, and reducing inflammatory response. In addition, canagliflozin can effectively improve the aortic endothelial function, thereby suppressing the development of atherosclerosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Elham Hasheminasabgorji, Jay C. Jha
Summary: Diabetes prevalence is increasing rapidly, leading to various complications and premature mortality. Atherosclerosis, a major macro-vascular complication of diabetes, can be mitigated by controlling dyslipidemia and reducing inflammation and oxidative stress with pharmacological agents.
Article
Chemistry, Medicinal
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Evangelia Gkougkoudi, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Georgia Valsami
Summary: Dabigatran etexilate and exercise training have complementary effects on the development and stability of atherosclerotic lesions in diabetic mice, mediated by anti-inflammatory modulation.
Review
Biochemistry & Molecular Biology
Helen Williams, Corinne D. Mack, Stephen C. H. Li, John P. Fletcher, Heather J. Medbury
Summary: Monocytes play a crucial role in cardiovascular disease by infiltrating vessel walls to form atherosclerotic plaques. Different subsets of monocytes, including intermediate and nonclassical, have been associated with CVD and changes in inflammatory markers. Dyslipidemia can impact monocyte proportion and function, with lipid lowering medication showing some effect in reversing these changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Amir Abbas Momtazi-Borojeni, Mahmoud Reza Jaafari, Mohammad Afshar, Maciej Banach, Amirhossein Sahebkar
Summary: The study aimed to develop a nanoliposomal anti-PCSK9 vaccine for cholesterol lowering in hypercholesterolemic mice. The vaccine formulations induced high IgG response against PCSK9 peptide, inhibited PCSK9-LDLR interaction, and increased liver LDLR protein. Vaccines significantly reduced total cholesterol and LDL-C levels in hypercholesterolemic mice, with a long-lasting protective impact. Anti-inflammatory Th2 cells and IL-4 cytokine were increased in vaccinated mice.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Surgery
Punam P. Parikh, Diego Castilla, Roberta M. Lassance-Soares, Hongwei Shao, Manuela Regueiro, Yan Li, Roberto Vazquez-Padron, Keith A. Webster, Zhao-Jun Liu, Omaida C. Velazquez
ANNALS OF VASCULAR SURGERY
(2018)
Article
Cardiac & Cardiovascular Systems
Jian Shen, Ning Zhang, Yi-Nuo Lin, PingPing Xiang, Xian-bao Liu, Peng-fei Shan, Xin-yang Hu, Wei Zhu, Yao-liang Tang, Keith A. Webster, Renzhi Cai, Andrew V. Schally, Jian'an Wang, Hong Yu
CIRCULATION RESEARCH
(2018)
Article
Cell Biology
Bin Zhang, Gaoxing Zhang, Tianlu Wei, Zhen Yang, Wenfeng Tan, Ziqing Mo, Jinxue Liu, Dong Li, Yidong Wei, Lukun Zhang, Keith A. Webster, Jianqin Wei
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Cardiac & Cardiovascular Systems
Keyvan Yousefi, Camila I. Irion, Lauro M. Takeuchi, Wen Ding, Guerline Lambert, Trevor Eisenberg, Sarah Sukkar, Henk L. Granzier, Mei Methawasin, Dong Lee, Virginia S. Hahn, David A. Kass, Konstantinos E. Hatzistergos, Joshua M. Hare, Keith A. Webster, Lina A. Shehadeh
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Lei Song, Zachary M. Zigmond, Laisel Martinez, Roberta M. Lassance-Soares, Alejandro E. Macias, Omaida C. Velazquez, Zhao-Jun Liu, Alghidak Salama, Keith A. Webster, Roberto Vazquez-Padron
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Article
Physiology
Camila Iansen Irion, Julian C. Dunkley, Krista John-Williams, Jose Manuel Condor Capcha, Serene A. Shehadeh, Andre Pinto, Matthias Loebe, Keith A. Webster, Nicolas A. Brozzi, Lina A. Shehadeh
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Physiology
Ali Kamiar, Keyvan Yousefi, Julian C. Dunkley, Keith A. Webster, Lina A. Shehadeh
Summary: Chronic kidney disease affects approximately 14% of the global population and can lead to acute kidney injury with a high mortality rate and lack of effective treatment. beta(2)-Adrenergic receptors (beta(2)ARs) are expressed in multiple parts of the kidney and play a crucial role in regulating important cellular functions. Research is ongoing to explore the potential nephroprotective effects of activating beta(2)ARs in kidney-related diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Julian C. Dunkley, Camila I. Irion, Keyvan Yousefi, Serene A. Shehadeh, Guerline Lambert, Krista John-Williams, Keith A. Webster, Jeffrey J. Goldberger, Lina A. Shehadeh
Summary: In a mouse model of heart failure with preserved ejection fraction (HFpEF), exercise and carvedilol synergistically improved systolic function without affecting diastole. Carvedilol alone or in combination with exercise also improved kidney function. The observed improvements in cardiorenal functions were mediated at least in part by effects on serum osteopontin and related inflammatory cytokine cascades, presenting new potential therapeutic targets and approaches for HFpEF.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chang Dai, Keith A. Webster, Amit Bhatt, Hong Tian, Guanfang Su, Wei Li
Summary: Retinopathy of prematurity (ROP) is an ocular vascular disease that affects premature infants, characterized by pathological retinal neovascularization, dilated and tortuous retinal blood vessels, and retinal or vitreous hemorrhages. Current treatments include laser or cryotherapy, but there is ongoing research looking into selectively inhibiting pathological angiogenesis while promoting physiological angiogenesis in the treatment of ROP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Liyang Ji, Hong Tian, Keith A. Webster, Wei Li
Summary: Diabetic retinopathy is the leading cause of vision loss in working adults in developed countries, now recognized as a neurovascular disorder. Disturbance of the neurovascular unit can lead to vision-threatening clinical manifestations. While VEGF inhibitors are widely used to treat DR, their limited efficacy suggests the involvement of other signaling molecules in the pathogenesis of the disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chang Dai, Prabuddha Waduge, Liyang Ji, Chengchi Huang, Ye He, Hong Tian, Elizabeth Zuniga-Sanchez, Amit Bhatt, Iok-Hou Pang, Guanfang Su, Keith A. Webster, Wei Li
Summary: Secretogranin III (Scg3) is a disease-specific angiogenic factor that strictly regulates pathological angiogenesis without affecting physiological angiogenesis. The use of anti-Scg3 humanized antibody Fab (hFab) can effectively inhibit pathological angiogenesis without adverse effects, making it a potential safe and effective disease-targeted anti-angiogenic therapy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jinxue Liu, Eileen Wei, Jianqin Wei, Wei Zhou, Keith A. Webster, Bin Zhang, Dong Li, Gaoxing Zhang, Yidong Wei, Yusheng Long, Xiuyu Qi, Qianhuan Zhang, Dingli Xu
Summary: The interactions between miR-126, HIF-1α, and HMGB1 play a crucial role in regulating inflammation and angiogenesis in different physiological and pathological conditions. miR-126 plays a dominant role in regulating HMGB1 and its downstream proinflammatory effectors in endothelial cells under hypoxia with concurrent acidosis, while HIF-1α expression is suppressed independently of miR-126 in these conditions. The findings suggest that the inflammatory responses of endothelial cells to hypoxia with acidosis are dynamically regulated by the interactions between hypoxia signaling, miR-126, and HIF-1α on the master regulator HMGB1.
Article
Biochemistry & Molecular Biology
Liyang Ji, Prabuddha Waduge, Lili Hao, Avinash Kaur, Wencui Wan, Yan Wu, Hong Tian, Jinsong Zhang, Keith A. Webster, Wei Li
Summary: Choroidal neovascularization (CNV), a leading cause of blindness in the elderly, is commonly treated with vascular endothelial growth factor (VEGF) inhibitors, but these therapies have limited efficacy and potential side effects. This study explores the potential of secretogranin III (Scg3) as a disease-selective angiogenic factor for the treatment of CNV. The researchers found that Scg3 binds specifically to CNV vessels and its neutralization inhibits CNV. The combination of an anti-Scg3 antibody and a VEGF inhibitor showed synergistic effects in alleviating CNV. These findings suggest that Scg3 could be a next-generation targeted therapy for CNV.
Article
Biochemistry & Molecular Biology
Ye He, Hong Tian, Chang Dai, Rong Wen, Xiaorong Li, Keith A. Webster, Wei Li
Summary: The retinopathy of prematurity (ROP) is a major cause of childhood blindness, and there is an urgent need for a novel therapeutic treatment. Recent research has identified that anti-Scg3 hAb can alleviate pathological retinal neovascularization in mouse models, and it outperforms the current VEGF inhibitor aflibercept in terms of efficacy and safety.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Wei Li, Keith A. Webster, Michelle E. LeBlanc, Hong Tian
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)