Human RSPO1/R-spondin1 Is Expressed during Early Ovary Development and Augments β-Catenin Signaling

R-spondin1 is required for normal epithelial morphogenesis during mammary gland development

(2009) Sead Chadi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation

(2009) N. Henriette Uhlenhaut et al.   CELL

WNT4 is expressed in human fetal and adult ovaries and its signaling contributes to ovarian cell survival

(2009) Minna Jääskeläinen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice

(2009) Payel Bhanja et al.   PLoS One

R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/ -catenin pathway

(2009) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Goat RSPO1 over-expression rescues sex-reversal in Rspo1-knockout XX mice but does not perturb testis differentiation in XY or sex-reversed XX mice

(2009) Laurine Buscara et al.   TRANSGENIC RESEARCH

R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation

(2008) Ayhan Kocer et al.   BMC DEVELOPMENTAL BIOLOGY

Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development

(2008) Craig A Smith et al.   BMC DEVELOPMENTAL BIOLOGY

R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression

(2008) Wenyan Lu et al.   FEBS LETTERS

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

(2008) Kazuma Tomizuka et al.   HUMAN MOLECULAR GENETICS

Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal

(2008) Danielle M. Maatouk et al.   HUMAN MOLECULAR GENETICS

Activation of  -catenin signaling by Rspo1 controls differentiation of the mammalian ovary

(2008) A.-A. Chassot et al.   HUMAN MOLECULAR GENETICS

R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

(2008) Kyung-Ah Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

(2008) Ryohei Sekido et al.   NATURE

Genetics of Ovarian Differentiation: Rspo1, a Major Player

(2008) A.A. Chassot et al.   Sexual Development

Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation

(2007) Sara Tomaselli et al.   HUMAN MUTATION