Polyfunctional T-Cell Responses Are Disrupted by the Ovarian Cancer Ascites Environment and Only Partially Restored by Clinically Relevant Cytokines

Granzymes in cancer and immunity

(2010) S P Cullen et al.   CELL DEATH AND DIFFERENTIATION

The Inducible Costimulator (ICOS) Is Critical for the Development of Human TH17 Cells

(2010) C. M. Paulos et al.   Science Translational Medicine

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

(2009) J. R. Almeida et al.   BLOOD

A phase 2, randomized study of SB-485232, rhIL-18, in patients with previously untreated metastatic melanoma

(2009) Ahmad A. Tarhini et al.   CANCER

A phase II trial of intraperitoneal interleukin-2 in patients with platinum-resistant or platinum-refractory ovarian cancer

(2009) Anda M. Vlad et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+T cells with tumor regression

(2009) Naoko Imai et al.   CANCER SCIENCE

Clinical and Biological Efficacy of Recombinant Human Interleukin-21 in Patients with Stage IV Malignant Melanoma without Prior Treatment: A Phase IIa Trial

(2009) I. D. Davis et al.   CLINICAL CANCER RESEARCH

Increased detection of proliferating, polyfunctional, HIV-1-specific T cells in DNA-modified vaccinia virus Ankara-vaccinated human volunteers by cultured IFN-γ ELISPOT assay

(2009) Nicola Winstone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Maintenance immunotherapy in recurrent ovarian cancer: Long term follow-up of a phase II study

(2009) Francesco Recchia et al.   GYNECOLOGIC ONCOLOGY

CD4 and CD8 T Cell Responses to the M. tuberculosis Ag85B-TB10.4 Promoted by Adjuvanted Subunit, Adenovector or Heterologous Prime Boost Vaccination

(2009) Tara Elvang et al.   PLoS One

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

(2009) C. Carpenito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control

(2008) A. L. Ferre et al.   BLOOD

A Dose-Escalation Study of Recombinant Human Interleukin-18 Using Two Different Schedules of Administration in Patients with Cancer

(2008) M. J. Robertson et al.   CLINICAL CANCER RESEARCH

Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells

(2008) Naoko Imai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Polyfunctional T cell responses are a hallmark of HIV-2 infection

(2008) Melody G. Duvall et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunotherapy opportunities in ovarian cancer

(2008) Christina S Chu et al.   Expert Review of Anticancer Therapy

The impact of T-cell immunity on ovarian cancer outcomes

(2008) Brad H. Nelson   IMMUNOLOGICAL REVIEWS

Phase I Study of Recombinant Interleukin-21 in Patients With Metastatic Melanoma and Renal Cell Carcinoma

(2008) John A. Thompson et al.   JOURNAL OF CLINICAL ONCOLOGY

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

(2008) Denis Gaucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multifunctional T-Cell Characteristics Induced by a Polyvalent DNA Prime/Protein Boost Human Immunodeficiency Virus Type 1 Vaccine Regimen Given to Healthy Adults Are Dependent on the Route and Dose of Administration

(2008) A. Bansal et al.   JOURNAL OF VIROLOGY

Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells

(2008) G. Badr et al.   JOURNAL OF VIROLOGY

Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy

(2008) M. Rehr et al.   JOURNAL OF VIROLOGY

Phase I/II Study of GM-CSF DNA as an Adjuvant for a Multipeptide Cancer Vaccine in Patients With Advanced Melanoma

(2008) Miguel-Angel Perales et al.   MOLECULAR THERAPY

An IFN-γ-IL-18 Signaling Loop Accelerates Memory CD8+ T Cell Proliferation

(2008) Yoshiko Iwai et al.   PLoS One

Distinct Effects of IL-18 on the Engraftment and Function of Human Effector CD8+ T Cells and Regulatory T Cells

(2008) Richard G. Carroll et al.   PLoS One

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

(2008) J. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunization with an HIV-1 immunogen induces CD4+ and CD8+ HIV-1-specific polyfunctional responses in patients with chronic HIV-1 infection receiving antiretroviral therapy

(2008) L. Valor et al.   VACCINE