p21-Activated Kinases Are Required for Transformation in a Cell-Based Model of Neurofibromatosis Type 2

A Functional Requirement for PAK1 Binding to the KH(2) Domain of the Fragile X Protein-Related FXR1

(2010) Evonne Say et al.   MOLECULAR CELL

Pak protein kinases and their role in cancer

(2009) Bettina Dummler et al.   CANCER AND METASTASIS REVIEWS

Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells

(2009) Beatrix Hage et al.   Cell Communication and Signaling

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

(2009) Christine Flaiz et al.   EXPERIMENTAL NEUROLOGY

Loss of the Tumor Suppressor Gene NF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling

(2009) M. A. Lopez-Lago et al.   MOLECULAR AND CELLULAR BIOLOGY

NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth

(2009) M. F. James et al.   MOLECULAR AND CELLULAR BIOLOGY

A tale of two Paks

(2008) Luis E. Arias-Romero et al.   BIOLOGY OF THE CELL

Dissecting and Targeting the Growth Factor-Dependent and Growth Factor-Independent Extracellular Signal-Regulated Kinase Pathway in Human Schwannoma

(2008) S. Ammoun et al.   CANCER RESEARCH

Validation of the p21-Activated Kinases as Targets for Inhibition in Neurofibromatosis Type 2

(2008) C. Yi et al.   CANCER RESEARCH

An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

(2008) Sean W. Deacon et al.   CHEMISTRY & BIOLOGY

PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac

(2008) E. Lozano et al.   JOURNAL OF CELL SCIENCE

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

(2008) Jasna Maksimoska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

P21-activated kinase is required for mitotic progression and regulates Plk1

(2008) B Maroto et al.   ONCOGENE