Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation

Advances in Development of Inhibitors of 17β-Hydroxysteroid Dehydrogenases

(2012) Donald Poirier   Anti-Cancer Agents in Medicinal Chemistry

17β-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in Addition to Estradiol Production

(2010) Juliette A. Aka et al.   MOLECULAR ENDOCRINOLOGY

Binary and ternary crystal structure analyses of a novel inhibitor with 17β-HSD type 1: a lead compound for breast cancer therapy

(2009) Mausumi Mazumdar et al.   BIOCHEMICAL JOURNAL

Biochemical Factors Governing the Steady-State Estrone/Estradiol Ratios Catalyzed by Human 17β-Hydroxysteroid Dehydrogenases Types 1 and 2 in HEK-293 Cells

(2009) Daniel P. Sherbet et al.   ENDOCRINOLOGY

New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity

(2009) Emmanuel Bey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17βHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells

(2009) Patricia Kruchten et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Recent advances in 17beta-hydroxysteroid dehydrogenases

(2009) Cornelia Prehn et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Dynamic Dysfunction in Dihydrofolate Reductase Results from Antifolate Drug Binding: Modulation of Dynamics within a Structural State

(2009) Randall V. Mauldin et al.   STRUCTURE

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative

(2008) Bengt Persson et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A 3D QSAR Model of 17β-HSD1 Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core Applying Molecular Dynamics Simulations and Ligand–Protein Docking

(2008) Sampo Karkola et al.   ChemMedChem

Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1

(2008) S. Gobec et al.   CURRENT MEDICINAL CHEMISTRY

Design and validation of specific inhibitors of 17 -hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis

(2008) J. M Day et al.   ENDOCRINE-RELATED CANCER

Substituted 6-Phenyl-2-naphthols. Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Design, Synthesis, Biological Evaluation, and Pharmacokinetics

(2008) Sandrine Marchais-Oberwinkler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

(2008) Emmanuel Bey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of (Hydroxyphenyl)naphthalene and -quinoline Derivatives: Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of Estrogen-Dependent Diseases

(2008) Martin Frotscher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis

(2008) Thomas R. Weikl et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS