Article
Agriculture, Dairy & Animal Science
Atle Mysterud, Isa Nergard Skjelbostad, Inger Maren Rivrud, Oystein Brekkum, Erling L. Meisingset
Summary: Chronic Wasting Disease, discovered in Norway in 2016, is a deadly infectious disease affecting cervids, which can be transmitted through environmental reservoirs. Anthropogenic food sources may cause spatial revisitation and aggregation in cervids, increasing the risk of infectious disease transmission.
Review
Biochemistry & Molecular Biology
Sayaka Ueno, Tamotsu Sudo, Akira Hirasawa
Summary: ATM serves as a crucial regulator of DNA damage and cellular stress responses, influencing various cellular processes such as DNA repair, apoptosis, and cell cycle regulation. Germline ATM pathogenic variants have been linked to an increased risk of cancers, particularly breast and pancreatic cancers. Inhibiting alternative DNA repair pathways may be a potential strategy for targeting ATM-deficient cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Di Wang, Zhenyu Tian, Peng Zhang, Lv Zhen, Qingju Meng, Benteng Sun, Xingli Xu, Tong Jia, Shengqiang Li
Summary: Recently, cuproptosis, a new form of cell death dependent on copper and mitochondrial respiration, has been discovered. It differs from other well-known cell death modes like apoptosis, necrosis, pyroptosis, and ferroptosis. Excessive copper induces cuproptosis by interfering with the tricarboxylic acid cycle and reducing iron-sulfur cluster protein levels. Disturbances to copper homeostasis lead to cuproptosis. Cuproptosis has been found to play a significant role in cardiovascular diseases such as myocardial ischemia/reperfusion injury, heart failure, atherosclerosis, and arrhythmias. Inhibiting cuproptosis through copper chelators and oxidative phosphorylation inhibitors may be a potential treatment for these diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Mujeeb Ur Rahman, Muhammad Bilal, Junaid Ali Shah, Ajeet Kaushik, Pierre-Louis Teissedre, Malgorzata Kujawska
Summary: Parkinson's disease and other neurodegenerative diseases have a significant impact on individuals and society. Recent research has identified neuroinflammation, oxidative stress, dysregulated protein degradation, and mitochondrial dysfunction as primary causes of Parkinson's disease. Gene-editing technologies hold promise for new treatment options.
Article
Marine & Freshwater Biology
Patrick R. Lind, Felicia S. Osburn, Andrew R. Dzialowski, Punidan D. Jeyasingh
Summary: The study found a positive correlation between cyanobacterial abundance and total iron in reservoirs, although variations in iron levels in freshwater ecosystems are not well understood. Results also suggest that considering elements beyond nitrogen and phosphorus could be useful in understanding harmful algal blooms.
Review
Biochemistry & Molecular Biology
Qing Wei Calvin Ho, Xiaofeng Zheng, Yusuf Ali
Summary: Ceramides, a class of sphingolipids, play a role in various skin disorders and metabolic diseases. Recent research has focused on identifying specific ceramide species and their effects on different diseases, and has found ceramides linked to metabolic dysfunction and cardiac decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Kazuma Murakami, Kenjiro Ono
Summary: The aggregation of amyloidogenic proteins is a pathological hallmark of various neurodegenerative diseases, but the molecular mechanisms behind these diseases are not yet fully understood. Different amyloid species can coexist in the same brain and even occur in individuals without disease. Advances in research related to biomolecular condensates and structural analysis have provided insights into the cross-seeding and cross-inhibition of amyloidosis. The potential clinical applications in central nervous system therapy are also highlighted.
Article
Biochemistry & Molecular Biology
Jordi Olloquequi, Patricia Castro-Santos, Roberto Diaz-Pena
Summary: Latin-American populations have been underrepresented in genomic studies of drug response and disease susceptibility. This study compared the frequency of gene variants involved in drug response among a Chilean population and others using the 1000 Genomes Project data. Several gene variants were found to have low prevalence in Chileans compared to other populations, and two markers showed significant differences between different Mapuche ancestry groups. These findings emphasize the importance of considering ancestry in pharmacogenetic studies and provide a pharmacogenetic landscape of an understudied Latin American population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Ting Qi, Yang Wu, Hailing Fang, Futao Zhang, Shouye Liu, Jian Zeng, Jian Yang
Summary: Most genetic variants identified from GWAS in humans are noncoding and play a role in gene regulation. Previous studies have shown links between GWAS signals and eQTLs, but the links to other genetic regulatory mechanisms, such as sQTLs, have not been extensively explored. This study introduces a new sQTL mapping method and identifies distinct cis-sQTLs that are not associated with eQTLs in brain transcriptomic data. By integrating sQTL data into GWAS for brain-related complex traits, the study identifies genes associated with these traits that cannot be discovered using eQTL data alone.
Article
Biochemistry & Molecular Biology
Amaya Lopez-Pascual, Paul Trayhurn, J. Alfredo Martinez, Pedro Gonzalez-Muniesa
Summary: Multiple studies have shown altered oxygen levels in tissue in metabolic disorders, suggesting a potential role for oxygen as a nutrient. Oxygen availability may be compromised in various metabolic conditions, including obesity, type 2 diabetes, and cardiovascular disease. Novel therapeutic strategies may involve oxygen-related adaptations such as intermittent hypoxia training and hyperoxia.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Malik Quasir Mahmood, Shakti D. Shukla, Chris Ward, Eugene Haydn Walters
Summary: COPD and lung cancer are leading causes of mortality globally, with the biological process of epithelial-to-mesenchymal transition (EMT) playing a crucial role in their development. COPD is identified as a strong independent risk factor for lung cancer, highlighting the importance of interdisciplinary research and attention for prevention and treatment.
Article
Medicine, General & Internal
Sofia Enhorning, Olle Melander, Gunnar Engstrom, Solve Elmstahl, Lars Lind, Peter M. Nilsson, Mats Pihlsgard, Simon Timpka
Summary: A study in Malmo, Sweden found that copeptin, a surrogate marker of vasopressin, exhibits a distinct seasonal variation with a peak in winter and a nadir in late summer. This seasonal variation may be related to an increased risk of cardiometabolic disease.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Panyun Wu, Tengteng Zhu, Yiyuan Huang, Zhenfei Fang, Fei Luo
Summary: Research in recent decades has revealed the presence and function of lactate in the body. Lactate, primarily produced through glycolysis, plays important roles in tissue and organ regulation, especially in the cardiovascular system. The heart, as both a net consumer and the organ with the highest lactate consumption, contributes to cardiovascular homeostasis through energy supply and signal regulation. Lactate also affects the occurrence, development, and prognosis of various cardiovascular diseases. This article aims to explore the regulation of the cardiovascular system by lactate under physiological and pathological conditions, provide a better understanding of the lactate-cardiovascular health relationship, and propose new ideas for preventing and treating cardiovascular diseases. Additionally, it summarizes the current progress in treatments targeting lactate metabolism, transport, and signaling in cardiovascular diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Ryoko Umebayashi, Haruhito Adam Uchida, Natsumi Matsuoka-Uchiyama, Hitoshi Sugiyama, Jun Wada
Summary: The study investigated the prevalence of CKD and its risk factors in five medical regions in Okayama Prefecture, Japan. The proportion of CKD patients at risk of developing ESRD ranged from 6-9% across regions, with variations in risk factors and underlying health problems. Tailored interventions are needed to prevent CKD progression based on the characteristics of each region.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Neurosciences
T. V. Salomons, G. D. Iannetti
Summary: This article discusses the controversy surrounding whether fetuses can feel pain in the Mississippi case that led to the overturning of Roe vs Wade. The authors argue that critical biological evidence used by the state was misinterpreted and that the state's argument conflated pain and nociception.
NATURE NEUROSCIENCE
(2022)