Article
Biochemistry & Molecular Biology
Loic J. Chareyron, Pamela Banta Lavenex, David G. Amaral, Pierre Lavenex
Summary: Recent studies have shown the presence of a large population of immature neurons in the paralaminar nucleus of the primate amygdala, which can differentiate into mature neurons during postnatal development or after selective lesion of the hippocampus. However, fundamental questions regarding the life and death of these neurons still remain unanswered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Yingxun Liu, Junrong Ren, Mengsi Kang, Chenyang Zhai, Qiangqiang Cheng, Jin Li, Yuzi Wu, Xiaofei Ruan, Jinlong Zhou, Juan Fan, Yingfang Tian
Summary: Research shows that PGRN treatment promotes acute functional recovery and stimulates neurogenesis in the subventricular zone after cerebral ischemia, which is beneficial for long-term recovery. The increase in neurogenesis may be associated with activation of the MAPK/ERK and PI3K/Akt pathways, suggesting a potential new strategy utilizing PGRN in ischemic stroke therapy.
Article
Multidisciplinary Sciences
Ana C. Delgado, Angel R. Maldonado-Soto, Violeta Silva-Vargas, Dogukan Mizrak, Thomas von Kanel, Kelly R. Tan, Alex Paul, Aviv Madar, Henar Cuervo, Jan Kitajewski, Chyuan-Sheng Lin, Fiona Doetsch
Summary: Adult neural stem cells in the ventricular-subventricular zone of mice can generate glial cells in addition to neurons, with certain domains remaining quiescent under normal conditions. Our study also uncovers an intraventricular oligodendrocyte progenitor derived from NSCs that is recruited upon injury.
Article
Cell Biology
Haoyang Li, Li Xu, Wei Jiang, Xiusheng Qiu, Huiming Xu, Fan Zhu, Yu Hu, Shuzhen Liang, Chengcheng Cai, Wei Qiu, Zhengqi Lu, Yaxiong Cui, Changyong Tang
Summary: This study reveals that cognitive impairment is associated with a decline in adult hippocampal neurogenesis (AHN). Pleiotrophin (PTN) expression decreases with aging, leading to impaired AHN and poor learning and memory. The study shows that PTN interacts with protein tyrosine phosphatase receptor type Z1 (PTPRZ1) to promote neural stem and progenitor cell (NSPC) proliferation and differentiation through AKT signaling. Overexpression of PTN or pharmacological activation of AKT signaling in aging mice restores AHN and improves memory deficits.
Article
Clinical Neurology
Pu-Tien Chiang, Hsin-Hsi Tsai, Ruoh-Fang Yen, Yi-Chieh Tsai, Chi-Han Wu, Ching-Hung Chiu, Li-Kai Tsai
Summary: In this study, we assessed the use of F-18-fluorothymidine (FLT) PET to detect cerebral cell proliferation and found that it is associated with stroke severity and outcomes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Review
Cell Biology
Milena Tucic, Vera Stamenkovic, Pavle Andjus
Summary: TnC plays a crucial role in regulating cell proliferation and migration during adult neurogenesis, with implications for regenerative therapies. Understanding ECM signaling in the CNS niche is essential for potential therapeutic applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katja Baur, Yomn Abdullah, Claudia Mandl, Gabriele Hoelzl-Wenig, Yan Shi, Udo Edelkraut, Priti Khatri, Anna M. Hagenston, Martin Irmler, Johannes Beckers, Francesca Ciccolini
Summary: According to the current consensus, murine neural stem cells generate differentiated progenitors either through rare asymmetric divisions or by relocating to the basal side of the ventricular-subventricular zone. However, this study finds that adult-born olfactory bulb interneurons largely derive from a different type of neural stem cells residing in the basal V-SVZ. These basal neural stem cells differ from apical neural stem cells in terms of Nestin expression, primary cilia extension, cell division frequency, and activation of Notch-related genes.
Article
Pediatrics
Daniel Alonso-Alconada, Pierre Gressens, Xavier Golay, Nicola J. Robertson
Summary: Hypoxia-ischemia can lead to a decrease in cell proliferation and neurogenesis in the neurogenic niche of the neonatal piglet, which may hinder the replacement of lost neurons and overall repair.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Jiyu Li, Chun Li, Pushpa Subedi, Xinli Tian, Xiaohong Lu, Sumitra Miriyala, Manikandan Panchatcharam, Hong Sun
Summary: Ischemic stroke is a major cause of death and disability globally, and neurogenesis plays a crucial role in post-stroke functional recovery. Alcohol consumption has a dose-dependent effect on the prognosis of ischemic stroke. The study found that light alcohol consumption can promote neurogenesis, reduce brain damage, and improve locomotor activity in mice.
Review
Clinical Neurology
Yue Li, Weixiang Guo
Summary: Adult neurogenesis is a crucial process that generates new and functional neurons from neural stem cells throughout life. Maintaining the proper function of the neurogenic niche requires niche cells to respond to external cues and adapt their roles to influence NSC behavior. Understanding the interactive regulation of NSCs and neurogenesis by the neurogenic niche is important for maintaining the integrative process and functional integrity of the adult brain.
Review
Neurosciences
Aikaterini Lampada, Verdon Taylor
Summary: Neurogenesis stops in most areas of the mammalian brain before or shortly after birth, but in certain brain regions, the production of new neurons continues into adulthood. Neural stem cells in these neurogenic zones are situated within niches that govern their activity and fate. Majority of adult brain stem cells are mitotically inactive and can remain dormant for extended periods. The molecular mechanisms regulating neural stem cell maintenance and differentiation are of great interest, with Notch signaling identified as a critical regulator in various tissues, including the nervous system. This review examines the roles of Notch signaling, as well as the functions of different Notch receptors and ligands, in the regulation of adult neurogenesis in mice.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Neurosciences
Mihai Ceanga, Mahmoud Dahab, Otto W. Witte, Silke Keiner
Summary: In the aftermath of a stroke, the brain undergoes various signaling cascades that reshape both the perilesional zone and more distant regions. Stroke leads to a significant increase in adult neurogenesis, offering hope for neurological recovery. However, there are significant regional differences in the effects of neurogenesis in the SVZ and SGZ post-stroke on functional recovery.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Daniel Esteve, Maria Micaela Molina-Navarro, Esther Giraldo, Noelia Martinez-Varea, Mari-Carmen Blanco-Gandia, Marta Rodriguez-Arias, Jose Manuel Garcia-Verdugo, Jose Vina, Ana Lloret
Summary: Neurogenesis and neuronal migration in the adult brain are impaired in Alzheimer's disease, leading to cell senescence and reduced odor discrimination ability. Studying the APP/PS1 Alzheimer's mouse model may provide insights for new Alzheimer's treatments based on senolytic compounds or pro-neurogenic factors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Toxicology
Bunichiro Ogawa, Yutaka Nakanishi, Masaki Wakamatsu, Yasunori Takahashi, Makoto Shibutani
Summary: Acrylamide (AA) is a neurotoxicant that inhibits synaptic function and neural cell differentiation in the hippocampus and olfactory bulb-subventricular zone (OB-SVZ) region. AA exposure decreased neuroblasts in the OB by suppressing neuronal migration and downregulating genes related to neuronal differentiation and migration. These findings indicate that AA has a similar detrimental effect on neurogenesis in the OB-SVZ as it does in the hippocampus.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Silvia Scaricamazza, Illari Salvatori, Susanna Amadio, Valentina Nesci, Alessio Torcinaro, Giacomo Giacovazzo, Aniello Primiano, Michela Gloriani, Niccolo Candelise, Luisa Pieroni, Jean-Philippe Loeffler, Frederique Rene, Cyril Quessada, Tesfaye W. Tefera, Hao Wang, Frederik J. Steyn, Shyuan T. Ngo, Gabriella Dobrowolny, Elisa Lepore, Andrea Urbani, Antonio Musaro, Cinzia Volonte, Elisabetta Ferraro, Roberto Coccurello, Cristiana Valle, Alberto Ferri
Summary: The therapeutic potential of the multi-target drug trimetazidine was evaluated in SOD1(G93A) mice. The results showed that trimetazidine delayed disease progression, improved motor function and metabolism, and increased overall survival of the mice.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Ana Bernal-Chico, Vanja Tepavcevic, Andrea Manterola, Carmen Utrilla, Carlos Matute, Susana Mato
Summary: This review summarizes the current understanding of the role and clinical relevance of endocannabinoid signaling in glial cells, as well as its therapeutic potential in neurodegenerative and chronic inflammatory disorders.
Article
Clinical Neurology
Ane Murueta-Goyena, Raffaela Cipriani, Mar Carmona-Abellan, Marian Acera, Naia Ayo, Rocio Del Pino, Beatriz Tijero, Tamara Fernandez-Valle, Inigo Gabilondo, Fatima Zallo, Carlos Matute, Rosario Sanchez-Pernaute, Vikram Khurana, Fabio Cavaliere, Estibaliz Capetillo-Zarate, Juan Carlos Gomez-Esteban
Summary: The levels of molecular biomarkers in the serum and cerebrospinal fluid of E46K-SNCA mutation carriers are highly correlated with clinical outcomes, suggesting that these biomarkers may be useful for tracking the conversion from asymptomatic to PD and predicting the progression to PD dementia.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Cell Biology
Yvette Akwa, Chiara Di Malta, Fatima Zallo, Elise Gondard, Adele Lunati, Lara Z. Diaz-de-Grenu, Angela Zampelli, Anne Boiret, Sara Santamaria, Maialen Martinez-Preciado, Katia Cortese, Jeffrey H. Kordower, Carlos Matute, Andres M. Lozano, Estibaliz Capetillo-Zarate, Thomas Vaccari, Carmine Settembre, Etienne E. Baulieu, Davide Tampellini
Summary: Synaptic stimulation promotes TFEB-mediated clearance of pathological MAPT/Tau, which provides neuroprotection. Deep brain stimulation activates TFEB and reduces MAPT/Tau levels in Parkinson disease patients, leading to neuroprotection.
Article
Mathematics, Applied
Roberta Bianchini, Roberto Natalini
Summary: In the context of hyperbolic systems of balance laws, the Shizuta-Kawashima coupling condition guarantees dissipativity of all variables, even in partially dissipative systems. This condition is crucial for the global existence of classical solutions. However, it is common to find physically based models that violate this condition. In this paper, we study two examples of partially dissipative hyperbolic systems that violate the Shizuta-Kawashima condition, and prove that as long as the source term is nonresonant in the non-dissipative directions, singularities formation is prevented and smooth solutions exist globally in time.
JOURNAL OF EVOLUTION EQUATIONS
(2022)
Article
Mathematics, Interdisciplinary Applications
Gabriella Bretti, Maurizio Ceseri, Roberto Natalini, Maria Carla Ciacchella, Maria Laura Santarelli, Giulia Tiracorrendo
Summary: This paper introduces a mathematical model to describe the intermediate chemical reactions in the carbonation process of concrete. Through simulation algorithms, researchers are able to accurately describe the effects of the interaction between concrete and CO2 on the porosity of the material, which is in substantial accordance with experimental results. Additionally, the dissolution of calcium carbonate under an acid environment is considered, and a trend inversion in the evolution of porosity is observed for long exposure times, significantly affecting the durability of the concrete.
GEM-INTERNATIONAL JOURNAL ON GEOMATHEMATICS
(2022)
Article
Neurosciences
Andres M. Baraibar, Lindsey Belisle, Giovanni Marsicano, Carlos Matute, Susana Mato, Alfonso Araque, Paulo Kofuji
Summary: Microcircuits in the neocortex are functionally organized along layers and columns, and astrocytes play a role in the functional organization and bidirectional interaction between neurons. Activation of astrocytes by endocannabinoids leads to an increase in Ca2+ levels, ATP/adenosine release, and temporary synaptic depression between layer 5 pyramidal neurons at relatively distant synapses. This form of heteroneuronal synaptic depression is specific to cortical columns and layers, depending on layer-specific neuron-to-astrocyte signaling.
Article
Cell Biology
Alejandro Montilla, Alazne Zabala, Marco Er-Lukowiak, Bjoern Rissiek, Tim Magnus, Noelia Rodriguez-Iglesias, Amanda Sierra, Carlos Matute, Maria Domercq
Summary: In multiple sclerosis and EAE, both resident microglia and infiltrating macrophages contribute to demyelination and remyelination, but their specific roles are unknown. By depleting microglia using CSF-1R inhibitor and distinguishing blood-derived macrophages from microglia, it was found that microglia and meningeal macrophages have a specific role in antigen presentation and T cell reactivation at initial stages of EAE.
CELL DEATH & DISEASE
(2023)
Article
Neurosciences
Vilma Alanko, Adhara Gaminde-Blasco, Tania Quintela-Lopez, Raul Loera-Valencia, Alina Solomon, Ingemar Bjorkhem, Angel Cedazo-Minguez, Silvia Maioli, Graziella Tabacaru, Maria Latorre-Leal, Carlos Matute, Miia Kivipelto, Elena Alberdi, Anna Sandebring-Matton
Summary: Oxidized cholesterol metabolite 27-hydroxycholesterol (27-OH) is a potential link between hypercholesterolemia and neurodegenerative diseases as it can cross the blood-brain barrier. This study found that high levels of 27-OH can impact oligodendrocyte function and contribute to the disconnection of neural networks in neurodegenerative diseases.
Article
Endocrinology & Metabolism
Laura Aguado, Ana Joya, Maider Garbizu, Sandra Plaza-Garcia, Leyre Iglesias, Maria Isabel Hernandez, Maria Ardaya, Naroa Mocha, Vanessa Gomez-Vallejo, Unai Cossio, Makoto Higuchi, Alfredo Rodriguez-Antiguedad, Mari Mar Freijo, Maria Domercq, Carlos Matute, Pedro Ramos-Cabrer, Jordi Llop, Abraham Martin
Summary: This study evaluated the effects of PHA 568487 on inflammation after cerebral ischemia using PET and MRI techniques. The activation of alpha 7 nAChRs resulted in a decrease of ischemic lesion, brain edema, and neurodegeneration. Treatment with PHA 568487 also improved the neurofunctional outcome and protected the integrity of the blood-brain barrier.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Mathematics, Applied
Roberto Natalini, Thierry Paul
Summary: In this paper, a general class of hybrid mathematical models is proposed to study the collective motions of cells under chemical stimuli. The models combine discrete entities represented by ODEs for cells and a continuous signal described by a diffusive equation for chemoattractant. The mean-field limit of this model is proved in the Wasserstein distance to a system comprised of a Vlasov-type equation coupled with the chemoattractant equation. The research is not based on empirical measures but instead focuses on the marginals of individual densities, and the limit system is shown to have explicit bounds with existence and uniqueness.
SIAM JOURNAL ON MATHEMATICAL ANALYSIS
(2023)
Article
Cell Biology
Alba Capelo-Diz, Sofia Lachiondo-Ortega, David Fernandez-Ramos, Jorge Canas-Martin, Naroa Goikoetxea-Usandizaga, Marina Serrano-Macia, Maria J. Gonzalez-Rellan, Laura Mosca, Joan Blazquez-Vicens, Alberto Tinahones-Ruano, Marcos F. Fondevila, Mason Buyan, Teresa C. Delgado, Virginia Gutierrez de Juan, Paula Ayuso-Garcia, Alejandro Sanchez-Rueda, Sergio Velasco-Aviles, Hector Fernandez-Susavila, Cristina Riobello-Suarez, Bartlomiej Dziechciarz, Cristina Montiel-Duarte, Fernando Lopitz-Otsoa, Maider Bizkarguenaga, Jon Bilbao-Garcia, Ganeko Bernardo-Seisdedos, Ana Senra, Mario Soriano-Navarro, Oscar Millet, Angel Diaz-Lagares, Ana B. Crujeiras, Aida Bao-Caamano, Diana Cabrera, Sebastiaan van Liempd, Miguel Tamayo-Caro, Luigi Borzacchiello, Beatriz Gomez-Santos, Xabier Buque, Diego Saenz de Urturi, Francisco Gonzalez-Romero, Jorge Simon, Ruben Rodriguez-Agudo, Asier Ruiz, Carlos Matute, Daniel Beiroa, Juan M. Falcon-Perez, Patricia Aspichueta, Juan Rodriguez-Cuesta, Marina Porcelli, Maria A. Pajares, Cristina Ameneiro, Miguel Fidalgo, Ana M. Aransay, Tomas Lama-Diaz, Miguel G. Blanco, Miguel Lopez, Ricardo Villa-Bellosta, Timo D. Mueller, Ruben Nogueiras, Ashwin Woodhoo, Maria Luz Martinez-Chantar, Marta Varela-Rey
Summary: This study reveals that hepatic S-adenosylmethionine (SAMe) acts as a metabolic sensor of nutrition and fine-tunes the fasting response by regulating various cellular processes in mice. It shows that SAMe modulates PEMT activity, ER-mitochondria contacts, lipid oxidation, ATP production in the liver, and FGF21-mediated lipolysis and thermogenesis in adipose tissues. Additionally, the study highlights the role of glucagon-induced SAMe synthesis in preventing excessive lipid oxidation and mitochondrial ATP synthesis, thereby protecting against ER stress and liver injury.
Review
Biochemistry & Molecular Biology
Eneritz Lopez-Muguruza, Carlos Matute
Summary: Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and neurodegeneration. Metabolic changes, including mitochondrial dysfunction and alterations in glucose and lipid metabolism, contribute significantly to the pathogenesis of MS. Understanding these mechanisms is crucial for developing targeted therapies to preserve myelin and promote neurological recovery in individuals with MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Mathematics, Applied
Elena Bonetti, Cecilia Cavaterra, Francesco Freddi, Maurizio Grasselli, Roberto Natalini
Summary: In this paper, a mathematical model is proposed and analyzed to describe the sulphation process of marble in a specific material. The model considers rugosity and damaging effects. However, there are technical difficulties that hinder the theoretical advancement. Physically reasonable modifications are introduced to establish the existence of a suitable solution. Numerical simulations are presented and discussed for further research.
NONLINEAR ANALYSIS-REAL WORLD APPLICATIONS
(2023)
