Article
Multidisciplinary Sciences
Angelo Forli, Michael M. Yartsev
Summary: This article examines hippocampal activity in groups of bats engaged in collective spatial behavior and finds that many hippocampal neurons are tuned to key features of group dynamics. Social responses are anatomically distributed and robustly represented at the population level.
Article
Cell Biology
Brad A. Radvansky, Jun Young Oh, Jason R. Climer, Daniel A. Dombeck
Summary: This study shows that the hippocampus in mice does not map space as a single coherent physical variable, but rather as a combination of sensory and abstract reference frames determined by the subject's behavioral goal. Different behavioral tasks lead to global remapping in the hippocampus, adapting to different spatial information modalities.
Review
Neurosciences
Nils Nyberg, Eleonore Duvelle, Caswell Barry, Hugo J. Spiers
Summary: This article discusses the neural cells related to goal localization in the mammalian brain, including different groups of neurons that play a role in different navigation stages, and their influence on navigation behavior.
Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Shao-Yu Tang, Yi-Chin Lee, Chien-Wei Tseng, Po-Hsun Huang, Ko-Lin Kuo, Der-Cherng Tarng
Summary: This study found that G-CSF can improve angiogenic function in patients with peripheral arterial disease (PAD) associated with chronic kidney disease (CKD) through a hypoxia/IL-10 signaling cascade.
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Oncology
Chong Wei, Yan Zhang, Wei Wang, Wei Zhang
Summary: Substituting PEG-rhG-CSF for short-acting rhG-CSF in the DA-EPOCH regimen significantly reduces the incidence of febrile neutropenia and related hospitalization, while simplifying management for both patients and healthcare providers.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Endocrinology & Metabolism
Guang-Yin Shen, Jeong-Hun Shin, Yi-Sun Song, Hyun-Woo Joo, In-Hwa Park, Jin-Hee Seong, Na-Kyoung Shin, A-Hyeon Lee, Young Jong Cho, Yonggu Lee, Young-Hyo Lim, Hyuck Kim, Kyung-Soo Kim
Summary: The study showed that G-CSF can reduce cardiomyocyte apoptosis in diabetic cardiomyopathy by increasing autophagy levels. The anti-apoptotic effect of G-CSF was found to be abrogated by autophagy inhibitors, indicating the significance of autophagy up-regulation in mediating the protective effects of G-CSF.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Article
Neurosciences
Lillian J. Brady, Kirsty R. Erickson, Kelsey E. Lucerne, Aya Osman, Drew D. Kiraly, Erin S. Calipari
Summary: Cocaine use disorder is associated with alterations in immune function and changes in peripheral cytokine expression, impacting responses to drug-related cues and highlighting the critical interaction between the brain and immune system. Upregulation of granulocyte colony-stimulating factor (G-CSF) by cocaine enhances the drug's effects on dopamine terminals through a release-based mechanism, indicating a potential role of immune factors in altering drug responses.
PSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yulia Michailov, Ali AbuMadighem, Eitan Lunenfeld, Joseph Kapelushnik, Mahmoud Huleihel
Summary: The study indicates that AML and CYT treatment have a significant negative impact on male fertility, but GCSF injection can improve this damage, restore spermatogenesis and fertility, showing potential value in preserving/restoring fertility in leukemia patients undergoing chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Ron Refaeli, Adi Doron, Aviya Benmelech-Chovav, Maya Groysman, Tirzah Kreisel, Yonatan Loewenstein, Inbal Goshen
Summary: The study utilized CLARITY technology to conduct large-scale detection of 3D astrocytic domains, revealing different distributions of neuronal content in CA1 and BLA astrocytic domains. SST neurons were found to be located in close proximity to neighboring astrocytes, relative to PV and VIP neurons.
Article
Oncology
Takeo Fujii, Hasan Rehman, Su Yun Chung, Janice Shen, James Newman, Vernon Wu, Adam Hines, Elham Azimi-Nekoo, Fatima Fayyaz, Meeyoung Lee, George Raptis, Mikala Egeblad, Xinhua Zhu
Summary: The study found that G-CSF use was not associated with an increased risk of brain metastasis in patients with de novo Stage IV breast cancer. However, pulmonary embolism/deep venous thrombosis may be related to brain metastasis. Further research is needed to determine if DVT/PE with or without elevated NETs levels in the blood can predict the development of brain metastasis in these patients.
Article
Neurosciences
Lars Karlsson, Maria Nazareth Gonzalez-Alvarado, Reza Motalleb, Yafeng Wang, Yong Wang, Mats Borjesson, Changlian Zhu, Hans-Georg Kuhn
Summary: Physical exercise can improve age-dependent cognitive decline by restoring neurogenesis, with myokines serving as a link between muscle and brain communication. However, chronic muscular overexpression of PGC-1 alpha does not translate into exercise-induced effects on hippocampal neurogenesis, despite differences in serum composition. This suggests that activation of PGC-1 alpha in skeletal muscle alone is not enough to mimic exercise-induced effects or prevent neurogenesis decline with aging.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Marion Walser, Johan Svensson, Lars Karlsson, Reza Motalleb, Maria Aberg, H. Georg Kuhn, Jorgen Isgaard, N. David Aberg
Summary: In recent years, evidence has been accumulating on hemoglobin synthesis in both animal and human brains. The neuroprotective activities of growth hormone and insulin-like growth factor-I against ischemia and neurodegenerative diseases appear to be influenced by systemic and local brain hemoglobin concentrations, with further exploration needed in specific experiments.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
N. D. Aberg, M. Adiels, M. Lindgren, J. Nyberg, H. Georg Kuhn, J. Robertson, M. Schaufelberger, N. Sattar, M. Aberg, A. Rosengren
Summary: The study revealed a significant shift in early-onset cardiovascular disease events among young individuals over time, showing a transition from acute myocardial infarction and cardiovascular disease mortality to heart failure and stroke incidence. These trends were found to be moderately impacted by changes in baseline Body Mass Index and cardiorespiratory fitness.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Neurosciences
Sravani Devarakonda, Dilip Kumar Malipatlolla, Piyush Patel, Rita Grander, H. Georg Kuhn, Gunnar Steineck, Fei Sjoberg, Ana Rascon, Margareta Nyman, Yohanna Eriksson, Jolie Danial, Ella Ittner, Rukaya Naama Walid, Olena Prykhodko, Spandana Masuram, Marie Kalm, Cecilia Bull
Summary: The study aimed to investigate the impact of radiation to the colorectum on hippocampal neurogenesis in mice, and whether a fiber-rich diet could modulate this impact. Results showed that pelvic radiotherapy may have a long-lasting effect on hippocampal neurogenesis, and dietary interventions, such as a fiber-rich diet, could potentially mitigate this impact. Analysis of serum cytokines revealed a negative correlation between MIP1-a levels and the number of immature neurons one week after irradiation.
Article
Neurosciences
Felix Jan Nitsch, Hannah Strenger, Stefan Knecht, Bettina Studer
Summary: The study found that patients with insula lesions were more likely to accept disadvantageous unequal offers than patients with brain injuries sparing the insula. Computational modeling confirmed that this difference was due to decreased aversion to disadvantageous inequity following insula damage, highlighting the causal role of the insula in social interactions.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Psychiatry
Jenny Nyberg, Malin Henriksson, Alexander Wall, Torbjorn Vestberg, Maria Westerlund, Marion Walser, Robert Eggertsen, Louise Danielsson, H. Georg Kuhn, N. David Aberg, Margda Waern, Maria Aberg
Summary: Anxiety severity in patients with anxiety disorders was found to be associated with executive functions, particularly working memory, independently of comorbid major depression, but not with lower fluid intelligence. Compared to a normed population, anxiety patients performed significantly worse on tests related to working memory, suggesting cognitive impairment in this population.
Article
Clinical Neurology
Malin Henriksson, Alexander Wall, Jenny Nyberg, Martin Adiels, Karin Lundin, Ylva Bergh, Robert Eggertsen, Louise Danielsson, H. Georg Kuhn, Maria Westerlund, N. David Aberg, Margda Waern, Maria Aberg
Summary: A 12-week exercise intervention with different intensities was found to effectively reduce anxiety symptoms in patients with anxiety disorders. Both exercise groups showed significant improvements compared to the control group, without differences in effect sizes, indicating a trend for intensity and symptom improvement.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Simon Skau, Kristoffer Sundberg, Hans-Georg Kuhn
Summary: This paper proposes a set of unifying definitions that are useful in all areas of fatigue research while remaining neutral to various theories about fatigue. By establishing 13 distinct definitions of fatigue and fatigue-related phenomena, it helps facilitate communication between different researchers, link phenomena from divergent research fields together, facilitate application and knowledge production.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kai Diederich, Kathrin Schmitt, Philipp Schwedhelm, Bettina Bert, Celine Heinl
Summary: This article highlights the importance of open science practices in translational biomedical research and provides practical methods that can be implemented throughout the research process. These methods contribute to improving the transparency and quality of research, as well as increasing the audience and scientific reach of published work.
Review
Veterinary Sciences
Paul Mieske, Ute Hobbiesiefken, Carola Fischer-Tenhagen, Celine Heinl, Katharina Hohlbaum, Pia Kahnau, Jennifer Meier, Jenny Wilzopolski, Daniel Butzke, Juliane Rudeck, Lars Lewejohann, Kai Diederich
Summary: Boredom refers to an emotional state where an individual has nothing to do, is not interested in the surrounding, and feels dreary and monotony. This state can have detrimental effects on the mental and physical health of laboratory animals. Providing enrichment in the environment has been recognized as a crucial solution to improve their welfare.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Maria Aberg, Josefina Robertson, Demir Djekic, Annika Rosengren, Maria Schaufelberger, Georg Kuhn, N. David Aberg, Linus Schioler, Martin Lindgren
Summary: A Swedish study found that body mass index at 18 years old can predict the risk of early acute coronary events, especially in the highest weight category at 40 years old.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Sport Sciences
Aron Onerup, Kirsten Mehlig, Agnes af Geijerstam, Elin Eblom-Bak, Hans Georg Kuhn, Lauren Lissner, Maria Aberg, Mats Borjesson
Summary: This study found that in healthy young men, there is an association between cardiorespiratory fitness and the incidence of specific site cancers. Higher cardiorespiratory fitness is associated with a lower risk of cancers in the head and neck, esophagus, stomach, pancreas, liver, colon, rectum, kidney, and lung. However, higher cardiorespiratory fitness is associated with a higher risk of prostate cancer and malignant skin cancer.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Behavioral Sciences
Benjamin Lang, Pia Kahnau, Katharina Hohlbaum, Paul Mieske, Niek P. Andresen, Marcus N. Boon, Christa Thoene-Reineke, Lars Lewejohann, Kai Diederich
Summary: The mechanisms underlying memory formation and retrieval are still being researched and discussed. Various models have been proposed, with most assuming a distinction between non-conscious and conscious memory processes. Despite incomplete understanding of these mechanisms, memory tests are widely conducted. This article discusses protocols for testing learning and memory in laboratory mice, including object recognition, spatial learning, procedural memory, and more. Researchers are increasingly concerned about study reproducibility and animal welfare, leading to the development of new approaches such as multi-step sequential lockboxes and group assays. Shifting focus to more natural settings may improve our understanding of memory formation and retrieval.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Psychology, Mathematical
Pia Kahnau, Anne Jaap, Kai Diederich, Lorenz Gygax, Juliane Rudeck, Lars Lewejohann
Summary: This study used consumer demand tests to measure the strength of female mice's preference for different liquids. The unique feature was that the test was carried out in a home-cage based setup, allowing the mice to perform the tasks undisturbed by group members and on a self-chosen schedule. The results showed that the mice worked harder for access to water than for sweetened liquids.
BEHAVIOR RESEARCH METHODS
(2023)
Article
Neurosciences
Simon Skau, Ola Helenius, Kristoffer Sundberg, Lina Bunketorp-Kall, Hans -Georg Kuhn
Summary: This study examines the relationships between mathematical cognition, general cognition, and neural foundation in 8 to 9-year-old children. The findings suggest that proactive control plays a more significant role in mathematical performance compared to other cognitive abilities, such as processing speed and attention. Functional near-infrared spectroscopy (fNIRS) imaging reveals differences in brain activity between proactive and reactive control, with increased activation in the left lateral prefrontal cortex during reactive beneficiary situations. Additionally, the dorsal medial prefrontal cortex shows increased activity in a text-based task involving additive reasoning compared to a task with spatial-geometric information.
TRENDS IN NEUROSCIENCE AND EDUCATION
(2022)