Article
Immunology
Carezza Botto-Mahan, Juana P. Correa, Raul Araya-Donoso, Francisca Farias, Esteban San Juan, Nicol Quiroga, Ricardo Campos-Soto, Claudio Reyes-Olivares, Daniel Gonzalez-Acuna
Summary: In this study, we assessed 4 lizard species in Chile for Trypanosoma cruzi and found that all species were infected. We also discovered that one species had the ability to transmit the protozoan, highlighting their role as reservoirs for T. cruzi.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Microbiology
Any Laura Flores-Villegas, Jesus Guillermo Jimenez-Cortes, James Gonzalez, Adriana Moreno-Rodriguez, Rebeca Perez-Cabeza de Vaca, Claudia Segal-Kischinevzky, Martha Bucio-Torres, Jose A. De Fuentes-Vicente, Elisabeth Nava-Lazaro, Paz Maria Salazar-Schettino, Margarita Cabrera Bravo
Summary: Trypanosoma cruzi, a parasite transmitted by triatomines, shows different virulence, tropism, and tssa gene expression in different isolates obtained from various triatomine species in Mexico.
Article
Infectious Diseases
Danilo Kluyber, Arnaud L. J. Desbiez, Nina Attias, Gabriel F. Massocato, Solange M. Gennari, Herbert S. Soares, Eduardo Bagagli, Sandra M. G. Bosco, Hans G. Garces, Jessica da S. Ferreira, Amanda N. B. Fontes, Philip N. Suffys, Luciana R. Meireles, Ana M. Jansen, Expedito J. A. Luna, Andre L. R. Roque
Summary: Zoonotic parasites including Toxoplasma gondii, Trypanosoma cruzi, and Paracoccidioides brasiliensis were detected in wild-caught armadillos from two different Brazilian ecosystems. The presence of these parasites in armadillos highlights their role in the epidemiology of zoonotic diseases.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Microbiology
Sergio Castaneda, Marina Munoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi and has a profound impact on the gastrointestinal tract. Alterations in the gut microbiome caused by the parasite may play a crucial role in host-parasite interactions and immune responses. Understanding this interaction could provide valuable insights into the pathophysiology of the disease and the development of new treatments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Parasitology
Nestor Anes, Gladys Crisante
Summary: Systematic microscopical observations on tissues from mice show that Trypanosoma cruzi does not exhibit tissue-specific tropism, highlighting its ability to invade various tissues within the mammal host without preference for any particular type.
Article
Immunology
Tamyres Bernadete Dantas Queiroga, Nathalie de Sena Pereira, Denis Dantas da Silva, Cleber de Mesquita Andrade, Raimundo Fernandes de Aaujo Junior, Carlos Ramon do Nascimento Brito, Lucia Maria da Cunha Galvao, Antonia Claudia Jacome da Camara, Manuela Sales Lima Nascimento, Paulo Marcos Matta Guedes
Summary: Resistance or susceptibility to T. cruzi infection is dependent on the host immunological profile, with high virulent strains inducing more severe myocarditis and mortality in infected mice by inhibiting the expression of certain innate immune receptors and increasing the levels of pro-inflammatory cytokines.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Paula Faral-Tello, Gonzalo Greif, Selva Romero, Andres Cabrera, Cristina Oviedo, Telma Gonzalez, Gabriela Libisch, Ana Paula Arevalo, Belen Varela, Jose Manuel Verdes, Martina Crispo, Yester Basmadjian, Carlos Robello
Summary: This study discovered Trypanosoma cruzi strains capable of vertical transmission, which have a higher transmission rate compared to strains of moderate or high virulence. The vertical transmission strains modulate placental gene expression, inducing anti-inflammatory responses and immune damage. This finding provides new insights into the mechanism of vertical transmission for this parasite.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Kezia Lizardo, Janeesh P. Ayyappan, Neelam Oswal, Louis M. Weiss, Philipp E. Scherer, Jyothi F. Nagajyothi
Summary: The study found that loss of adipocytes increases cardiac parasite load, pathology, and severity in a Chagas disease model, highlighting the importance of adipose tissue in the development of CCC.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Tamires Marielem Carvalho-Costa, Rafael Destro Rosa Tiveron, Maria Tays Mendes, Cecilia Gomes Barbosa, Jessica Coraiola Nevoa, Guilherme Augusto Roza, Marcos Vinicius Silva, Henrique Cesar Pereira Figueiredo, Virmondes Rodrigues, Siomar de Castro Soares, Carlo Jose Freire Oliveira
Summary: The study found that Rhodnius neglectus may be a potential vector of Trypanosoma cruzi, the causative agent of Chagas disease. The salivary glands and intestine play crucial roles during blood feeding. Infection with Trypanosoma cruzi significantly alters the physiology of these tissues, providing valuable insights for future research on parasite-vector interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Gerd Wallukat, Fernando Antonio Botoni, Manoel Otavio da Costa Rocha, Vitoria Louise, Johannes Mueller, Andre Talvani
Summary: The study found that dogs infected by Trypanosoma cruzi generate agonistic beta 1ARAb, beta 2ARAb, and M2RAb antibodies. Different strains of T. cruzi infection may impact the antibody activities. In cardiomyocytes culture, the antibodies recognized epitopes similar to those seen in human chronic Chagas cardiomyopathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biodiversity Conservation
Cecilia S. Andreazzi, Luis A. Martinez-Vaquero, Gisele R. Winck, Thiago S. Cardoso, Bernardo R. Teixeira, Samanta C. C. Xavier, Rosana Gentile, Ana Maria Jansen, Paulo S. D'Andrea
Summary: Land use changes and biodiversity loss disrupt ecosystem functioning and drive infectious disease outbreaks. Using a large database on small mammal infection by Trypanosoma cruzi in Brazil, we found that allometric traits and rodent abundance were key predictors of infection risk, along with variables related to landscape environmental quality. Changes in natural vegetation cover and biodiversity dimensions indirectly reduced infection by affecting host community composition. Integrating social inclusion and human welfare into biodiversity conservation and restoration efforts could help regulate T. cruzi prevalence and reduce transmission risk.
Article
Parasitology
Alicia Majeau, Erin Cloherty, A. Nikki Anderson, Susanne C. Straif-Bourgeois, Eric Dumonteil, Claudia Herrera
Summary: Raccoons in Louisiana serve as an important reservoir for Trypanosoma cruzi, the causative agent of Chagas disease. Assessing the genetic diversity of T. cruzi in raccoons is crucial to evaluate the risk to human health. The study revealed previously unreported DTU types and a significant association between DTU distribution and ecoregions in Louisiana, highlighting the need for ongoing surveillance and targeted interventions to mitigate human health risk.
Article
Immunology
Fabiola Gonzalez-Herrera, Natasha S. Clayton, Daniela Guzman-Rivera, Ileana Carrillo, Christian Castillo, Mabel Catalan, Renatto Anfossi, Helena Quintero-Pertuz, Maria Elena Quilaqueo, Claudio Olea-Azar, Mario Rivera-Meza, Ulrike Kemmerling, Anne J. Ridley, Raul Vivar, Juan Diego Maya
Summary: This study demonstrates that statins can inhibit ROCK activity, reduce inflammation, and promote anti-inflammatory cytokine expression, suggesting that statins may be a potential pharmacological strategy for preventing cardiac inflammation in CCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Parasitology
Marcela S. Rial, Chantal Reigada, Nilda Prado, Jacqueline Bua, Monica Esteva, Claudio A. Pereira, Laura E. Fichera
Summary: The study found that a drug containing isotretinoin as the main ingredient can effectively treat congestive heart failure and improve cardiac function.
Article
Immunology
Hellen Daghero, Romina Pagotto, Cristina Quiroga, Andrea Medeiros, Marcelo A. Comini, Mariela Bollati-Fogolin
Summary: Chagas disease is a life-threatening illness caused by the parasite Trypanosoma cruzi. This study established and characterized infection models using mouse intestinal organoids, and found that T. cruzi can invade and replicate in intestinal epithelial cells. This provides new opportunities for studying host-pathogen interactions and discovering effective anti-parasitic drugs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Materials Science, Composites
Isabella L. M. Costa, Paulo H. F. Pereira, Amanda Maria Claro, Nayara Cavichiolli do Amaral, Hernane da Silva Barud, Rosinei Batista Ribeiro, Daniella Regina Mulinari
Summary: This study evaluates the use of pine cone fibers as reinforcement in ABS composites filaments for 3D pen applications. The addition of bleached fibers significantly improves the thermal stability and distribution of the composites, making it a promising low-cost feedstock.
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
(2023)
Review
Oncology
David Hui, Bianca Sakamoto Ribeiro Paiva, Carlos Eduardo Paiva
Summary: The specialty of palliative care has evolved to provide symptom management, psychosocial support, and care planning for cancer patients. This review examines the delivery and impact of palliative care in outpatient, inpatient, and community-based settings. It discusses how these three branches of palliative care can work together to optimize patient outcomes under a unified model.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julia A. Gomes, Igor Araujo Vieira, Eduarda Sgarioni, Ana Claudia P. Tercas-Tretell, Juliana H. da Silva, Bethania Fr Ribeiro, Marcial F. Galera, Thalita M. de Oliveira, Maria Denise F. Carvalho de Andrade, Isabella F. Carvalho, Lavinia Schuler-Faccini, Fernanda S. L. Vianna
Summary: Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed during pregnancy. Studies show that ZIKV infection upregulates miR-124 expression, leading to a decrease in TFRC, a targeted gene of this miRNA. This study investigates whether genetic variants affecting the expression of these genes could increase the risk of CZS development.
Article
Anatomy & Morphology
W. J. Favaro, J. C. C. Alonso, B. R. de Souza, I. B. Reis, J. M. Goncalves, A. C. Deckmann, G. Oliveira, Q. C. Dias, N. Duran
Summary: BCG-based intravesical immunotherapy is the gold standard treatment for high-risk non-muscle invasive bladder cancer. However, some high-risk patients experience relapse and do not respond to BCG. Our research group developed OncoTherad (R) nano-immunotherapy, which showed positive outcomes and mechanisms of action in an animal model with NMIBC. OncoTherad (R) nano-immunotherapy was more effective than BCG treatment, reducing the malignancy rate by 70% through modulation of TLR4-mediated interferon and RANK/RANKL signaling pathways.
Article
Chemistry, Physical
Sonia H. Tatumi, Marcio Yee, Emilio A. A. Soares, Jefferson J. de Souza, Emanuele D. O. Grudzin, Casimiro S. Munita, Rogerio B. Ribeiro, Alvaro de Farias Soares, Noemi Aguiar Silva, Caroline P. Fernandes, Matheus T. Mathias, Rene R. Rocca, K. R. Nagabhushana, H. S. Lokesha, Marcelo S. Rocha, Luis A. C. Lopez, Diego W. P. Venancio, Solange dos S. Costa
Summary: The sediments collected from different locations in the Mariu Archipelago, Rio Negro, Brazil were analyzed. Quartz was found to be the predominant mineral in the sediments, along with a trace quantity of kaolinite. The sediments were also found to contain rare-earth elements, metals, and semi-metals. The characteristics and lifetimes of the quartz's thermoluminescence peaks were determined, and the samples were dated using the conventional SAR protocol.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Microbiology
Jefferson Luiz da Silva, Lia Vezenfard Barbosa, Camila Figueiredo Pinzan, Viviani Nardini, Irislene Simoes Brigo, Cassia Aparecida Sebastiao, Jefferson Elias-Oliveira, Vania Brazao, Jose Clovis do Prado Junior, Daniela Carlos, Cristina Ribeiro de Barros Cardoso
Summary: Dysbiosis and disturbances in gut homeostasis can lead to dysregulated responses in inflammatory bowel diseases. Melatonin has shown potential as a therapeutic option due to its interactions with immune responses and gut microbiota. In this study, MLT treatment increased inflammation in acute colitis and delayed recovery during remission.
Review
Plant Sciences
Camila Castanho Cardinelli, Josiane Elizabeth Almeida E. Silva, Rayssa Ribeiro, Valdir F. F. Veiga-Junior, Elisabete Pereira dos Santos, Zaida Maria Faria de Freitas
Summary: Vegetable oils are important resources in the Amazon, including oleoresins with interesting characteristics and potential pharmacological properties. Copaiba oils, which come from the trunks of Copaifera (Fabaceae) spp. trees, are composed of terpenes from the sesquiterpene and diterpene classes, with varying amounts depending on factors such as soil type. This review examines the toxicological studies of copaiba oils, both in vitro and in vivo, as well as the cytotoxic characteristics of the sesquiterpenes and diterpenes in these oils, using in silico, in vitro, and in vivo models.
Article
Management
Luis Augusto de Carvalho, Rosinei Batista Ribeiro, Rose Lima de Moraes Campos, Francisco Santos Sabbadini, Caio Fernando da Silva, Erik Leonel Luciano
Summary: In the period from January to December 2013, Micro and Small Enterprises contributed R$ 14.1 billion to the Federal Government's electronic purchases, accounting for 30% of the total. This represents a 60% increase compared to the same period in 2012.
REVISTA DE GESTAO E SECRETARIADO-GESEC
(2023)
Article
Nutrition & Dietetics
Livia Costa de Oliveira, Karla Santos da Costa Rosa, Thamiris Gaspar, Bianca Sakamoto Ribeiro Paiva, Carlos Eduardo Paiva, Wilza Arantes Ferreira Peres
Summary: This study aimed to evaluate the clinical usefulness of assessing nutritional status in palliative care patients with incurable cancer. The results showed that cancer cachexia was the only nutritional status parameter associated with function. Additionally, factors such as white skin color, higher educational level, and inadequate calorie intake were also found to be associated with the outcome.
Article
Computer Science, Artificial Intelligence
Luis Fernando Marin Sepulveda, Marcelo Gattass, Aristofanes Correa Silva, Roberto Quevedo, Diogo Michelon, Carlos Siedschlag, Roberto Ribeiro
Summary: Methods based on Machine Learning and Deep Learning are popular for interpreting large volumes of data across various areas and tasks. This work proposes a method to improve the generalization of a Deep Learning model for indicating natural gas in 2D seismic data by recommending training data and hyperparameter operations. The experiments show an increase in the correct indication of natural gas by 8% to 37% and a fluctuation in the increase of false positives by -2% to 13%, resulting in an improvement in the generalization of the Deep Learning model of up to 11% according to the F1 score metric or up to 10% according to the IoU metric.
PATTERN RECOGNITION
(2023)
Article
Health Care Sciences & Services
Talita Caroline de Oliveira Valentino, Carlos Eduardo Paiva, Marco Antonio de Oliveira, David Hui, Eduardo Bruera, Miguel Juliao, Bianca Sakamoto Ribeiro Paiva
Summary: This study aimed to evaluate the preferred place-of-death (PPoD) among patients with advanced cancer over time, and the concordance between preferred and actual place-of-death. The study found that home was the most common PPoD for patients, while palliative care units (PCUs) and hospitals were preferred for patients with severe symptoms. The overall agreement between last preference and actual place-of-death was low.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Energy & Fuels
Luis Fernando Marin Sepulveda, Marcelo Gattass, Aristofanes Correa Silva, Roberto Quevedo, Diogo Michelon, Carlos Siedschlag, Roberto Ribeiro
Summary: This article introduces a domain adaptation method based on comparing seismic features, which is used to detect natural gas in 2D seismic data. The proposed method does not require modifying the training data or DL model architecture, but focuses on analyzing the training data to recognize patterns for comparing and clustering similar seismic data. Compared to the DL model trained with all available seismic data, the proposed method achieves significant improvements in precision, recall, F1 score, and IoU.
GEOENERGY SCIENCE AND ENGINEERING
(2023)
Article
Medicine, General & Internal
Bianca Sakamoto Ribeiro Paiva, Bruna Minto Lourenco, Henrique Moraes Prata, Talita Caroline de Oliveira Valentino, Marco Antonio de Oliveira, Martins Fideles dos Santos Neto, Eduardo Bruera, Carlos Eduardo Paiva
Summary: This study aimed to evaluate the percentage of cancer patients who prefer cremation and identify the factors associated with this preference. The results showed that the majority of cancer patients in Brazil prefer burial. However, discussions about death, religious beliefs, and educational level seem to influence the preference for cremation.
SAO PAULO MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Tamara Taynah Medeiros da Silva, Fernanda de Castro Teixeira, Sara Cristina Matias de Araujo, Thais Brunna Mauricio Pinheiro, Isabel Karolyne Fernandes Costa, Kleyton Santos de Medeiros, Katia Regina Barros Ribeiro, Daniele Vieira Dantas, Rodrigo Assis Neves Dantas
Summary: Thirst is a bothersome symptom for patients in the immediate postoperative period. This study evaluated the effectiveness of menthol popsicles in relieving postoperative thirst in patients undergoing radical prostatectomy. The results showed that both menthol popsicles and popsicles without menthol were effective in relieving postoperative thirst, with no significant difference between the two groups.
SAGE OPEN MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Mario Alberto da Silveira Dib, Pedro Prates, Bernardete Ribeiro
Summary: With the ongoing digitization of the manufacturing industry, machine learning techniques have great potential in predicting defects and improving production process reliability. However, small and medium-sized companies lack sufficient data for applying machine learning models. This paper proposes a framework based on Federated Learning and Digital Envelopes to address data privacy concerns and effectively handle data poisoning attacks.
EXPERT SYSTEMS WITH APPLICATIONS
(2024)