Article
Microbiology
Dong-Wook Hyun, Jae-Yun Lee, Min-Soo Kim, Na-Ri Shin, Tae Woong Whon, Kyung Hyun Kim, Pil Soo Kim, Euon Jung Tak, Mi-Ja Jung, June Young Lee, Hyun Sik Kim, Woorim Kang, Hojun Sung, Che Ok Jeon, Jin-Woo Bae
Summary: This study focused on two newly isolated alpha-hemolytic Streptococcus strains from an ileostomy effluent of a colorectal cancer patient, identifying them as a novel species named Streptococcus ilei. The research revealed the prevalence, virulence factors, and pathogenicity of S. ilei in humans, with one strain demonstrating higher pathogenicity based on in vivo and in vitro data. This information will help prevent misidentification of S. ilei strains and improve management of streptococcal infections.
JOURNAL OF MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lin Li, Zhongpeng Zhao, Xiaolan Yang, Zhongyi Su, Wendong Li, Shaolong Chen, Lu Wang, Ting Sun, Chen Du, Ziyi Li, Zeqian Yang, Min Li, Tiecheng Wang, Ying Wang, Yubo Fan, Hui Wang, Jing Zhang
Summary: A linear B-cell epitope screening strategy was developed to identify a hotspot region in the Spike protein and a monomeric peptide vaccine (Epitope25) was developed. The vaccine induced specific and dose-dependent IgG antibody responses in mice and showed neutralizing activity against SARS-CoV-2.
Article
Biochemistry & Molecular Biology
Anastasiia Kotliarova, Alexandra V. V. Podturkina, Alla V. V. Pavlova, Daria S. S. Gorina, Anastasiya V. V. Lastovka, Oleg V. V. Ardashov, Artem D. D. Rogachev, Arseniy E. E. Izyurov, Alla B. B. Arefieva, Alexander V. V. Kulikov, Tatyana G. G. Tolstikova, Konstantin P. P. Volcho, Nariman F. F. Salakhutdinov, Yulia Sidorova
Summary: This study evaluated the neuroprotective effects of a novel compound, PA96, on dopamine neurons in Parkinson's disease. The results showed that PA96 supported the survival of naive and MPP+-challenged dopamine neurons in vitro and in vivo. PA96 also alleviated motor deficits in PD models and exhibited appropriate properties for drug development.
Article
Chemistry, Applied
Aiste Sliziene, Milda Pleckaityte, Mindaugas Zaveckas, Karolina Juskaite, Vytautas Rudokas, Gintautas Zvirblis, Aurelija Zvirbliene
Summary: Beta-enolase is a newly identified allergen in common carp. It was cloned from common carp muscle tissue and expressed in E. coli. Recombinant beta-enolase was reactive with blood serum samples of fish-allergic patients. Monoclonal antibodies generated against beta-enolase showed cross-reactivity with beta-enolases of other organisms.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2022)
Article
Oncology
Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Elisa De Camilli, Chaojun Song, Luisa Ganfini, Aurelien Lacombe, Ilaria Naldi, Paolo Sarmientos, Caterina Cinti, Boquan Jin, Guido Grandi, Giuseppe Viale, Luigi Terracciano, Renata Grifantini
BRITISH JOURNAL OF CANCER
(2016)
Article
Immunology
Luigi Fiaschi, Benedetta Di Palo, Maria Scarselli, Clarissa Pozzi, Kelly Tomaszewski, Bruno Galletti, Vincenzo Nardi-Dei, Letizia Arcidiacono, Ravi P. N. Mishra, Elena Mori, Michele Pallaoro, Fabiana Falugi, Antonina Torre, Maria Rita Fontana, Marco Soriani, Juliane Bubeck Wardenburg, Guido Grandi, Rino Rappuoli, Ilaria Ferlenghi, Fabio Bagnoli
CLINICAL AND VACCINE IMMUNOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
Francesca Zerbini, Ilaria Zanella, Davide Fraccascia, Enrico Koenig, Carmela Irene, Luca F. Frattini, Michele Tomasi, Laura Fantappie, Luisa Ganfini, Elena Caproni, Matteo Parri, Alberto Grandi, Guido Grandi
MICROBIAL CELL FACTORIES
(2017)
Article
Biochemical Research Methods
Laura Fantappie, Carmela Irene, Micaela De Santis, Alessandro Armini, Assunta Gagliardi, Michele Tomasi, Matteo Parri, Valeria Cafardi, Serena Bonomi, Luisa Ganfini, Francesca Zerbini, Ilaria Zanella, Chiara Carnemolla, Luca Bini, Alberto Grandi, Guido Grandi
MOLECULAR & CELLULAR PROTEOMICS
(2017)
Article
Oncology
David Cano-Rodriguez, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Elisa De Camilli, Chaojun Song, Boquan Jin, Aurelien Lacombe, Andrea Pierleoni, Mauro Bombaci, Chiara Cordiglieri, Marcel H. J. Ruiters, Giuseppe Viale, Luigi Terracciano, Paolo Sarmientos, Sergio Abrignani, Guido Grandi, Piero Pileri, Marianne G. Rots, Renata Grifantini
Article
Oncology
Alberto Grandi, Michele Tomasi, Ilaria Zanella, Luisa Ganfini, Elena Caproni, Laura Fantappie, Carmelo Irene, Luca Frattini, Samine J. Isaac, Enrico Konig, Francesca Zerbini, Simona Tavarini, Chiara Sammicheli, Fabiola Giusti, Ilaria Ferlenghi, Matteo Parri, Guido Grandi
FRONTIERS IN ONCOLOGY
(2017)
Article
Infectious Diseases
Monica Fabbrini, Fabio Rigat, Giovanna Tuscano, Emiliano Chiarot, Gilbert Donders, Roland Devlieger, Sara Filippini, Elisabetta Frigimelica, Pietro Forte, Frederick Wittke, Scott A. Halperin, Karen Slobod, Guido Grandi, Immaculada Margarit
JOURNAL OF INFECTION
(2018)
Article
Multidisciplinary Sciences
Emiliano Chiarot, Angela Spagnuolo, Silvia Maccari, Eleonora Naimo, Alessandra Acquaviva, Raffaella Cecchi, Bruno Galletti, Monica Fabbrini, Elena Mori, Paolo Ruggiero, Guido Grandi, Maria Rita Fontana, Giuliano Bensi, Immaculada Margarit
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Maricarmen Rojas-Lopez, Manuele Martinelli, Valentina Brandi, Gregory Jubelin, Fabio Polticelli, Marco Soriani, Mariagrazia Pizza, Mickael Desvaux, Roberto Rosini
SCIENTIFIC REPORTS
(2019)
Article
Biotechnology & Applied Microbiology
Stefania Capone, Angelo Raggioli, Michela Gentile, Simone Battella, Armin Lahm, Andrea Sommella, Alessandra Maria Contino, Richard A. Urbanowicz, Romina Scala, Federica Barra, Adriano Leuzzi, Eleonora Lilli, Giuseppina Miselli, Alessia Noto, Maria Ferraiuolo, Francesco Talotta, Theocharis Tsoleridis, Concetta Castilletti, Giulia Matusali, Francesca Colavita, Daniele Lapa, Silvia Meschi, Maria Capobianchi, Marco Soriani, Antonella Folgori, Jonathan K. Ball, Stefano Colloca, Alessandra Vitelli
Summary: The study introduced a novel replication-defective gorilla adenovirus-vectored vaccine encoding the pre-fusion stabilized Spike protein of SARS-CoV-2, which showed high immunogenicity in mice and macaques. The research highlighted the superiority of the pre-fusion stabilized Spike antigen in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies. Selection of the vector backbone and preliminary data identified GRAd-COV2 as a potential COVID-19 vaccine candidate, supporting its translation into a phase I clinical trial.
Article
Cell Biology
Simone Lanini, Stefania Capone, Andrea Antinori, Stefano Milleri, Emanuele Nicastri, Roberto Camerini, Chiara Agrati, Concetta Castilletti, Federica Mori, Alessandra Sacchi, Giulia Matusali, Roberta Gagliardini, Virginia Ammendola, Eleonora Cimini, Fabiana Grazioli, Laura Scorzolini, Federico Napolitano, Maria M. Plazzi, Marco Soriani, Aldo De Luca, Simone Battella, Andrea Sommella, Alessandra M. Contino, Federica Barra, Michela Gentile, Angelo Raggioli, Yufang Shi, Enrico Girardi, Markus Maeurer, Maria R. Capobianchi, Francesco Vaia, Mauro Piacentini, Guido Kroemer, Alessandra Vitelli, Stefano Colloca, Antonella Folgori, Giuseppe Ippolito
Summary: Safe and effective COVID-19 vaccines are crucial for ending the pandemic. A vaccine called GRAd-COV2, based on a gorilla adenovirus and expressing the spike protein of SARS-CoV-2, has been evaluated for safety and immunogenicity in healthy younger and older adults.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Michele Tomasi, Elena Caproni, Mattia Benedet, Ilaria Zanella, Sebastiano Giorgetta, Mattia Dalsass, Enrico Koenig, Assunta Gagliardi, Laura Fantappie, Alvise Berti, Silvia Tamburini, Lorenzo Croia, Gabriele Di Lascio, Erika Bellini, Silvia Valensin, Giada Licata, Guido Sebastiani, Francesco Dotta, Federica Armanini, Fabio Cumbo, Francesco Asnicar, Aitor Blanco-Miguez, Eliana Ruggiero, Nicola Segata, Guido Grandi, Alberto Grandi
Summary: A growing body of evidence supports the important role of the gut microbiome in cancer immunity, and it has been found that microbiome proteins can induce specific T cells, which can inhibit tumor growth. Furthermore, personalized mucosal cancer vaccines can be developed using engineered microbes and Outer Membrane Vesicles.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Silvia Tamburini, Yueru Zhang, Assunta Gagliardi, Gabriele Di Lascio, Elena Caproni, Mattia Benedet, Michele Tomasi, Riccardo Corbellari, Ilaria Zanella, Lorenzo Croia, Guido Grandi, Martin Mueller, Alberto Grandi
Summary: This study demonstrates that L2 epitopes can be efficiently expressed on the surface of E. coli outer membrane vesicles (OMVs), and a polypeptide composed of L2 epitopes from multiple serotypes shows broad cross-protective activity against HPV. This provides a highly effective and inexpensive solution for producing universal anti-HPV vaccines.
Article
Immunology
Alberto Grandi, Michele Tomasi, Irfan Ullah, Cinzia Bertelli, Teresa Vanzo, Silvia Accordini, Assunta Gagliardi, Ilaria Zanella, Mattia Benedet, Riccardo Corbellari, Gabriele Di Lascio, Silvia Tamburini, Elena Caproni, Lorenzo Croia, Micol Rava, Valeria Fumagalli, Pietro Di Lucia, Davide Marotta, Eleonora Sala, Matteo Iannacone, Priti Kumar, Walther Mothes, Pradeep D. Uchil, Peter Cherepanov, Martino Bolognesi, Massimo Pizzato, Guido Grandi
Summary: The study demonstrates that engineered OMVs vaccines can induce effective immune responses, producing neutralizing antibodies and protecting animals from SARS-CoV-2 infection. Furthermore, the vaccine can also elicit immune responses against the Omicron BA.1 and BA.5 variants. OMV-based SARS-CoV-2 vaccines, with the convenience of engineering, production, and distribution, can be a crucial addition to the currently available vaccines.
Meeting Abstract
Biotechnology & Applied Microbiology
Alexander Gaidamaka, Barb Thorne, Francesco Talotta, Albert Gianchetti, Remi Gloeckler, Marco Soriani