Review
Pharmacology & Pharmacy
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu
Summary: Mechanosensing and mechanotransduction are crucial processes in mechanobiology, with purinergic P2 receptors playing a key role in cellular mechanotransduction. Understanding the specific mechanism of P2 receptor-mediated mechanotransduction is valuable, as interactions between P2 receptors and other mechanosensitive molecules affect physiological processes in cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Adel E. E. Khairullin, Sergey N. N. Grishin, Ayrat U. U. Ziganshin
Summary: The purine signaling system, represented by purine and pyrimidine nucleotides and nucleosides, plays a role through the adenosine, P2X and P2Y receptor families. While P2 receptors have a minor role in physiological conditions, they become more significant in certain pathophysiological conditions, functioning as dominant signaling molecules. The diversity and distribution of P2 receptors make them an attractive target for new mechanism drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Marta Boccazzi, Stefano Raffaele, Thomas Zanettin, Maria P. Abbracchio, Marta Fumagalli
Summary: Neurodevelopmental disorders (NDDs) encompass a range of congenital pathological conditions that affect cognitive, social behavior, and sensory/motor functioning. Recent research has linked genetic disorders involving purine metabolism to autism-like behaviors in humans. Dysregulated purine and pyrimidine levels have also been found in biofluids of individuals with other NDDs. Blocking specific purinergic pathways has been shown to reverse cognitive and behavioral defects in rodent models of NDDs. These findings suggest that targeting P2 receptor signaling could lead to the development of more specific treatments and early detection markers for NDDs.
Review
Hematology
Funda Tamer, Bibian M. E. Tullemans, Marijke J. E. Kuijpers, Theodora A. M. Claushuis, Johan W. M. Heemskerk
Summary: This article provides a systematic overview of the effects of common phytochemicals on platelet activation and signaling pathways, as well as their potential clinical relevance in thrombosis and hemostasis.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Biochemistry & Molecular Biology
Akhila Dandamudi, Huzoor Akbar, Jose Cancelas, Yi Zheng
Summary: Platelets play a crucial role in regulating hemostasis and thrombosis. Rho GTPases act as molecular switches that control cellular functions in platelets by mediating signal transduction. Inhibition of Rho GTPase family members RhoA, Rac1, and Cdc42 has been shown to affect platelet dynamics and lead to thrombus formation. The use of platelets as a non-transformed model has provided valuable insights into cell signaling principles. This review summarizes recent advances in Rho GTPase signaling in platelet regulation and highlights the potential development of antiplatelet therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Arundhati Tiwari, Deepa Gautam, Paresh P. Kulkarni, Mohammad Ekhlak, Vijay K. Sonkar, Vikas Agrawal, Debabrata Dash
Summary: Human platelets are capable of synthesizing Sonic Hedgehog (Shh) upon agonist stimulation, leading to activation of noncanonical signaling pathways and influencing platelet function. Inhibition of the Shh pathway significantly impairs arterial thrombosis in mice, suggesting its potential as a therapeutic target for thrombotic disorders.
Article
Multidisciplinary Sciences
Rui-Qi Xu, Ling Ma, Timson Chen, Wei-Xiong Zhang, Kuan Chang, Jing Wang
Summary: Biosurfactants, such as sophorolipid (SL), have shown promise as therapeutic agents for medical and cosmetic applications. This study found that SL has the potential to inhibit histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity. SL was found to remit histamine-induced scratching behaviors in mice and suppress calcium influx induced by histamine in HaCaT cells. These findings suggest that SL could be a useful treatment for histamine-dependent itch.
SCIENTIFIC REPORTS
(2023)
Article
Hematology
Walid Chayoua, Phillip L. R. Nicolson, Joost C. M. Meijers, Caroline Kardeby, Lourdes Garcia-Quintanilla, Katrien M. J. Devreese, Bas de Laat, Stephen P. Watson, Philip G. de Groot
Summary: This study investigated whether antiprothrombin antibodies induce platelet aggregation and identified the platelet receptors involved. It also found that reduced prothrombin levels resulted in less antiprothrombin antibody-mediated platelet aggregation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Neurosciences
Paula Mut-Arbona, Beata Sperlagh
Summary: The purinergic pathway is involved in both pro-inflammatory and anti-inflammatory responses, and the breakdown of ATP is essential in maintaining its balance. ATP is considered a clear indicator of cell damage and pathological conditions when released during tissue damage, inflammation, or hypoxia. This review focuses on the role of P2 receptor-mediated purinergic signaling in normal and pathological brain development, particularly in neurodevelopmental psychiatric disorders. The review emphasizes the timedependent dynamic changes in the purinome and its involvement in shaping the normal and aberrant patterns of central nervous system development and diseases over one's lifespan.
Article
Neurosciences
Youichi Shinozaki, Kozo Saito, Kenji Kashiwagi, Schuichi Koizumi
Summary: ATP, the energy source in cells, can be released to the extracellular space and serve as a signaling molecule. In the eye, ATP release in response to physiological stimuli regulates intraocular pressure, and dysregulated ATP signaling may contribute to elevated intraocular pressure and glaucoma pathogenesis.
Review
Cardiac & Cardiovascular Systems
Milka Koupenova, Alison C. Livada, Craig N. Morrell
Summary: Platelets not only play important roles in hemostasis and thrombosis, but also have significant immune cell functions. Platelets interact and activate immune cells in response to pathogen exposures, infection, and tissue injury. The immune potential of platelets depends on their molecular composition provided by their megakaryocyte precursor, making them first responders in coordinating pathogen immune responses.
CIRCULATION RESEARCH
(2022)
Article
Hematology
Zheng Xu, Ying Liang, M. Keegan Delaney, Yaping Zhang, Kyungho Kim, Jing Li, Yanyan Bai, Jaehyung Cho, Masuko Ushio-Fukai, Ni Cheng, Xiaoping Du
Summary: Research has shown that outside-in signaling activates mainly NOX2-mediated ROS generation, which triggers Syk-dependent secondary platelet activation, adhesion, and thrombosis with minimal effect on hemostasis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Manting Huang, Minzhen Deng, Wenqiang Nie, Dezhi Zou, Huanlin Wu, Danping Xu
Summary: Citrus flavanoids intake, especially naringenin, can reduce the risk of cardiovascular diseases by inhibiting platelet activation and aggregation, without causing prolonged bleeding time.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Moua Yang, Andaleb Kholmukhamedov
Summary: Deviation in lipid metabolism and other metabolic disorders significantly increase the risk for adverse thrombotic events, leading to a major cause of global mortality. Recent studies indicate that pre-activated platelets may contribute to the heightened thrombotic risk in dyslipidemia. Understanding the mechanisms driving pathological thrombosis in dyslipidemia and reevaluating the antithrombotic approach based on platelet signaling mechanisms may offer potential therapeutic avenues.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sun-Hee Woo, Tran Nguyet Trinh
Summary: ATP serves as a major energy source in mammalian cells but also acts as an extracellular chemical messenger through P2 purinergic receptors. Different types of cells release ATP, including neurons, endothelial cells, and muscle cells. Studies have shown the distribution and roles of P2 receptor subtypes in cardiac cells under physiological and pathological conditions, with specific genetic alterations and pharmacological approaches revealing distinct functions of P2 receptors in the heart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Hossein Dinmohammadi, Zahra Pirdel, Laleh Salarilak, Marc Hoylaerts, Reza Nejatbakhsh, Alireza Biglari, Marc Jacquemin, Tina Shahani
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2019)
Article
Multidisciplinary Sciences
Bartosz Ditkowski, Tiago R. Veloso, Martyna Bezulska-Ditkowska, Andreas Lubig, Stefan Jockenhoevel, Petra Mela, Ramadan Jashari, Marc Gewillig, Bart Meyns, Marc F. Hoylaerts, Ruth Heying
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Materials Science, Biomaterials
Fatemeh Kabirian, Bartosz Ditkowski, Ali Zamanian, Marc F. Hoylaerts, Masoud Mozafari, Ruth Heying
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Gastroenterology & Hepatology
Iris Detrez, Debby Thomas, Kristel Van Steen, Vera Ballet, Miet Peeters, Marc F. Hoylaerts, Gert Van Assche, Severine Vermeire, Marc Ferrante, Ann Gils
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Bartosz Ditkowski, Martyna Bezulska-Ditkowska, Ramadan Jashari, Pieter Baatsen, Philippe Moreillon, Filip Rega, Tiago R. Veloso, Marc F. Hoylaerts, Ruth Heying
Summary: The study found that bovine pericardium and BJV wall are more susceptible to Staphylococcus aureus adhesion during pulmonary valve replacement surgeries. Antiplatelet therapy can effectively reduce S aureus adherence to BJV, and dual antiplatelet therapy may be a realistic approach to prevent endocarditis and associated mortality.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Hematology
Marijke Peetermans, Severien Meyers, Laurens Liesenborghs, Karen Vanhoorelbeke, Simon F. De Meyer, Christophe Vandenbriele, Marleen Lox, Marc F. Hoylaerts, Kimberly Martinod, Marc Jacquemin, Thomas Vanassche, Peter Verhamme
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Biochemistry & Molecular Biology
Mayte Bolean, Benedetta Izzi, Soetkin van Kerckhoven, Massimo Bottini, Ana Paula Ramos, Jose Luis Millan, Marc F. Hoylaerts, Pietro Ciancaglini
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2020)
Article
Immunology
Alfonsina Tirozzi, Benedetta Izzi, Fabrizia Noro, Annalisa Marotta, Francesco Gianfagna, Marc F. Hoylaerts, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Alessandro Gialluisi
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Benedetta Izzi, Alfonsina Tirozzi, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Marc F. Hoylaerts, Licia Iacoviello, Alessandro Gialluisi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Abderrahim Nemmar, Marc F. Hoylaerts
Summary: Inhalation of particulate matter in polluted air can cause lung inflammation, platelet activation, and cardiovascular complications. Neutrophil enzymes release ADP and sensitize platelets, amplifying their contribution to the complications induced by ambient particle inhalation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Hematology
Marc F. Hoylaerts
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cell Biology
Benedetta Izzi, Alessandro Gialluisi, Francesco Gianfagna, Sabatino Orlandi, Amalia De Curtis, Sara Magnacca, Simona Costanzo, Augusto Di Castelnuovo, Maria Benedetta Donati, Giovanni de Gaetano, Marc F. Hoylaerts, Chiara Cerletti, Licia Iacoviello
Summary: Platelet distribution width (PDW) can serve as a simple and useful marker for platelet activation, specifically P-selectin dependent, with no sex differences, while mean platelet volume (MPV) shows no significant association. Further studies in larger cohorts are needed to fully understand the predictive value of PDW in thrombo-inflammatory conditions.
Article
Multidisciplinary Sciences
Wen-Yi Yang, Benedetta Izzi, Adam P. Bress, Lutgarde Thijs, Lorena Citterio, Fang-Fei Wei, Erika Salvi, Simona Delli Carpini, Paolo Manunta, Daniele Cusi, Marc F. Hoylaerts, Aernout Luttun, Peter Verhamme, Sheetal Hardikar, Tim S. Nawrot, Jan A. Staessen, Zhen-Yu Zhang
Summary: The genetic and epigenetic variability in the PEAR1 gene is associated with the risk of colorectal cancer. Methylation levels were also found to be related to colorectal cancer risk. These findings provide insights into the pathogenesis of colorectal cancer.
Meeting Abstract
Cardiac & Cardiovascular Systems
W. -Y. Yang, B. Izzi, Z. -Y. Zhang, L. Thijs, L. Citterio, F. -F. Wei, E. Salvi, S. Delli Carpini, P. Manuta, T. Kuznetsova, D. Cusi, M. F. Hoylaerts, A. Luttun, P. Verhamme, J. A. Staessen
EUROPEAN HEART JOURNAL
(2019)
Article
Hematology
Caroline Kardeby, Knut Falker, Elizabeth J. Haining, Maarten Criel, Madelene Lindkvist, Ruben Barroso, Peter Pahlsson, Liza U. Ljungberg, Mattias Tengdelius, G. Ed Rainger, Stephanie Watson, Johannes A. Eble, Marc F. Hoylaerts, Jonas Emsley, Peter Konradsson, Steve P. Watson, Yi Sun, Magnus Grenegard