Article
Dentistry, Oral Surgery & Medicine
H. Alghutaimel, X. Yang, B. Drummond, H. Nazzal, M. Duggal, E. Raif
Summary: The study focused on investigating the vascularization capacity of a decellularized dental pulp matrix seeded with human dental pulp stem cells both in vitro and in vivo. Findings showed that recellularization with hDPSCs led to enhanced vascularization and expression of angiogenesis markers, with significant improvement in vascularization compared to unseeded groups. This suggests a promising strategy for dental pulp regeneration with the combination of DDP and hDPSCs.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Rehabilitation
Sonia Tome, Joana Matos, Jose Barreto, Joao Carvalho, Joana Leal, Catarina Aguiar Branco
Summary: This report describes two cases of congenital facial palsy with unilateral aplasia of the facial nerve, as shown by magnetic resonance imaging. A multidisciplinary approach is recommended for optimal care, and rehabilitative therapies may be valuable as complementary treatments.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Veterinary Sciences
Jessica Rossgardt, Laura Beate Heilen, Kathrin Buettner, Jutta Dern-Wieloch, Joerg Vogelsberg, Carsten Staszyk
Summary: The crown pulp of permanent brachydont teeth and hypsodont equine teeth exhibit different histomorphological features, indicating mature and less active status for the former and a highly productive status for the latter. As horses age, the size of the dental pulp decreases while the numbers of blood vessels, nerve fibers, and fibroblastic cells increase.
VETERINARY SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chaoning Zhan, Minchun Huang, Jiao Zeng, Ting Chen, Yanli Lu, Junyang Chen, Xinzhu Li, Linying Yin, Xiaojun Yang, Jin Hou
Summary: In this study, a rat model of sensory nerve irritation was established by ligating the inferior alveolar nerve (IAN), and face grooming behavior was analyzed as an indicator of pain sensation. Two months after dental sensory nerve irritation, more calcified particles were observed in the stimulated teeth. These calcified masses had a dentin-like structure with sparse, irregularly oriented tubules. Additionally, more CGRP-positive nerves were found in the stimulation group. Based on these findings, it can be concluded that the irritation of sensory nerves promotes the formation of dental pulp calcification, and the increased density of CGRP-immunolabeled fibers may contribute to this process.
JOURNAL OF ENDODONTICS
(2023)
Article
Cell & Tissue Engineering
Meer N. Ahmed, Delin Shi, Matthew T. Dailey, Kristi Rothermund, Michelle D. Drewry, Tia C. Calabrese, Xinyan T. Cui, Fatima N. Syed-Picard
Summary: This study demonstrates the use of DPC sheets as vehicles for NTF delivery that could augment the current methods for treating PNIs to accelerate regeneration and enhance the functional outcome.
TISSUE ENGINEERING PART A
(2021)
Article
Clinical Neurology
Xuezhen Shen, Feng Qu, Yilun Pei, Simeng Lei, Suhang Xia, Jing Liang, Shan Li, Xun Sun, Liang Liu
Summary: This study demonstrates that the combined application of functionalized self-assembling peptide gels and chitosan nerve conduits accelerates nerve healing and enhances morphological repair, providing a promising therapy for peripheral nerve regeneration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lihua Luo, Qunyan Zhu, Yejian Li, Fengting Hu, Jiangtao Yu, Xiangyan Liao, Zhenjie Xing, Yan He, Qingsong Ye
Summary: This study showed that in situ injection of PF127 hydrogel encapsulating dental pulp stem cells into the injured sites could promote the repair and regeneration of fallopian tube injury, providing an attractive strategy for future clinical treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Lihua Luo, Yan He, Ling Jin, Yanni Zhang, Fernando P. Guastaldi, Abdullkhaleg A. Albashari, Fengting Hu, Xiaoyan Wang, Lei Wang, Jian Xiao, Lingli Li, Jianming Wang, Akon Higuchi, Qingsong Ye
Summary: By optimizing the scaffold material synthesis protocol, a third-generation nerve regeneration conduit CSM-GFD was constructed and applied for repairing a 15-mm long defect of the sciatic nerve in a rat model. At histologic and physical levels, the conduit regenerated nerve tissue and achieved functional recovery, showing promising potential as a tissue engineering approach for treating large gap defects in peripheral nerve injuries.
BIOACTIVE MATERIALS
(2021)
Review
Clinical Neurology
Jing Fu, Xigong Li, Feilu Jin, Yanzhao Dong, Haiying Zhou, Ahmad Alhaskawi, Zewei Wang, Jingtian Lai, Chengjun Yao, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Bin Chen, Hui Lu
Summary: Peripheral nerve diseases are often caused by severe fractures, trauma, and surgeries, resulting in decreased quality of life and impaired physical and mental health. Dental pulp stem cells (DPSCs) with their strong differentiation potential and proliferation capacity, provide a novel cell source for nerve regeneration. DPSCs can express neurotrophic and immunomodulatory factors, promoting blood vessel formation and nerve regeneration. Therefore, DPSCs hold valuable therapeutic potential in the management of peripheral neuropathies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Yuka Imanishi, Masaki Hata, Ryohei Matsukawa, Atsushi Aoyagi, Maiko Omi, Makoto Mizutani, Keiko Naruse, Shogo Ozawa, Masaki Honda, Tatsuaki Matsubara, Jun Takebe
Summary: The study demonstrated the efficacy of DPSC-EVs in promoting bone formation when implanted with different scaffolds, with DPSC-EVs/COL specifically promoting bone formation in the center of the defects. Histological observation revealed that DPSC-EVs/COL promoted new bone formation, almost equivalent to transplantation of DPSCs/COL in the bone defect site.
INFLAMMATION AND REGENERATION
(2021)
Article
Medicine, Research & Experimental
Yiwen Liu, Liuchi Chen, Qimei Gong, Hongwei Jiang, Yihua Huang
Summary: This study found that FUNDC1 and hypoxia-inducible factor-1 alpha are upregulated in dental pulp tissues with pulpitis. It also showed that under hypoxic conditions, human dental pulp cells (HDPCs) exhibit enhanced autophagy, proliferation, migration, and odontoblastic differentiation. However, knockdown of FUNDC1 reversed these effects.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Wanqiu Xu, Xiaohang Xu, Lihong Yao, Bing Xue, Hualei Xi, Xiaofang Cao, Guiyan Piao, Song Lin, Xiumei Wang
Summary: The research aimed to investigate the effect of VEGFA-overexpressing rDPSCs combined with LCYE-PLGA NGC in repairing 10 mm facial nerve injury in rats. The results showed that VEGFA-modified rDPSCs combined with LC-YE-PLGA NGCs have certain advantages in the growth and functional recovery of facial nerves in rats.
Article
Medicine, General & Internal
Carlos Navarro Cuellar, Manuel Tousidonis Rial, Raul Antunez-Conde, Marc Agea Martinez, Ignacio Navarro Cuellar, Jose Ignacio Salmeron Escobar, Carlos Navarro Vila
Summary: This study evaluated oncologic patients with squamous cell carcinoma of the tongue and floor of the mouth who underwent wide resection and immediate reconstruction with FAMM flap and osseointegrated implants. The results showed that this approach led to favorable functional and aesthetic outcomes, even in patients undergoing radiation therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Shahriar Shahi, Fatemeh Dehghani, Elaheh Dalir Abdolahinia, Simin Sharifi, Elham Ahmadian, Mario Gajdacs, Krisztina Karpati, Solmaz Maleki Dizaj, Aziz Eftekhari, Taras Kavetskyy
Summary: This study assessed the morphological, physico-chemical, and biological properties of a new Gel-nHA scaffold for endodontic regeneration. The scaffold showed favorable effects on odontogenic activity and had potential for application in endodontic regeneration.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jose Alcides Almeida De Arruda, Heloisa de Sousa Gomes, Felipe Cavalcanti Sampaio, Kely Firmino Bruno, Carlos Estrela, Elismauro Francisco Mendonca, Diego Antonio Costa Arantes
Summary: The diagnosis of irreversible pulpitis (IP) relies on clinical data such as patient's chief complaint, visual inspection, response to stimuli, and radiographic examination. This study aimed to characterize nerve fibers (NF) in IP using immunohistochemistry and found that IP samples had lower density of intact NF and higher density of degenerated NF compared to healthy pulps (HP) samples. There was no association between inflammatory infiltrate intensity and NF density/integrity.
BRAZILIAN ORAL RESEARCH
(2023)
Article
Surgery
Yosuke Niimi, Hajime Matsumine, Yuichi Takeuchi, Osaki Hironobu, Satoshi Tsunoda, Mariko Miyata, Masayuki Yamato, Hiroyuki Sakurai
Article
Engineering, Biomedical
Jun Akimoto, Masamichi Nakayama, Soichi Takagi, Teruo Okano
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Review
Neurosciences
Yuichi Takeuchi, Antal Berenyi
NEUROSCIENCE RESEARCH
(2020)
Editorial Material
Cell & Tissue Engineering
Kyungsook Kim, David W. Grainger, Teruo Okano
REGENERATIVE THERAPY
(2019)
Article
Surgery
Ryo Sasaki, Toshihiro Okamoto, Yuichi Akagi, Tomohiro Ando
Summary: Tongue piercing can lead to complications such as bleeding, pain, and infection. This case report describes an 18-year-old woman who accidentally lost a needle in her mouth while attempting tongue piercing at home. After successful removal of the needle, the patient recovered with no complications two days post-surgery.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Article
Cell Biology
Yasuyuki Nagumo, Yoshifumi Ueta, Hisako Nakayama, Hironobu Osaki, Yuichi Takeuchi, Naofumi Uesaka, Masanobu Kano, Mariko Miyata
Article
Surgery
Ryo Sasaki, Toshihiro Okamoto, Noriko Miyamoto Sangu, Satoshi Kudo, Tomohiro Ando
Summary: A 74-year-old man presented with hemorrhage from the mandible after an injury caused by a metal square column. He underwent open reduction and internal fixation for a comminuted fracture of the right mandibular body, and restarted rivaroxaban 3 days after surgery.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Article
Physics, Applied
Hiroki Yasunaga, Toshihiro Takagi, Daisuke Shinko, Yusei Nakayama, Yuichi Takeuchi, Atsushi Nishikawa, Alexander Loesing, Masahiro Ohsawa, Hiroto Sekiguchi
Summary: A neural probe with MicroLEDs and neural electrodes was fabricated for optogenetic application, successfully recording local field potentials. The MicroLEDs showed consistent current-voltage characteristics and sufficient light output for manipulating neural activity. Simulation of light distribution in brain tissue and investigation of LED temperature increase led to valuable insights for improving efficiency.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2021)
Article
Clinical Neurology
Yuichi Takeuchi, Mark Harangozo, Lizeth Pedraza, Tamas Foldi, Gabor Kozak, Qun Li, Antal Berenyi
Summary: The study demonstrates that closed-loop electrical stimulation of the medial septum can effectively terminate intrahippocampal seizures and suppress secondary generalization, emphasizing the importance of internally driven stimulus timing. By precisely activating medial septum GABAergic neurons, successful intervention in pathological oscillations was achieved, providing a new avenue for future clinical translation in other neurological and psychiatric disorders.
Article
Biochemistry & Molecular Biology
Ryo Sasaki, Yorikatsu Watanabe, Masayuki Yamato, Toshihiro Okamoto
Summary: Studies have shown that nerve guides with mesenchymal stem cells can promote facial nerve regeneration, with evaluation methods including staining, immunohistological analysis, electron microscopic observation, and functional assessment. These stem cells can secrete neurotrophic factors to promote nerve regeneration.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Kathleen C. Robinson, Lajos Kemeny, Gillian L. Fell, Andrea L. Hermann, Jennifer Allouche, Weihua Ding, Ajay Yekkirala, Jennifer J. Hsiao, Mack Y. Su, Nicholas Theodosakis, Gabor Kozak, Yuichi Takeuchi, Shiqian Shen, Antal Berenyi, Jianren Mao, Clifford J. Woolf, David E. Fisher
Summary: Research has found that individuals with red hair have higher basal pain thresholds and increased sensitivity to opioid analgesics. The increased pain thresholds are attributed to a loss of MC1R function, which decreases melanocytic proopiomelanocortin transcription and systemic MSH levels. This leads to increased nociceptive thresholds by derepressing central opioid tone.
Review
Neurosciences
Yuichi Takeuchi, Anett J. Nagy, Livia Barcsai, Qun Li, Masahiro Ohsawa, Kenji Mizuseki, Antal Berenyi
Summary: The medial septum plays a crucial role in regulating oscillatory neuronal activities throughout the brain, and may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations. Precise timing of stimulation is essential to effectively terminate pathological oscillations and may provide an effective way of treating multiple disorders.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Editorial Material
Behavioral Sciences
Yuichi Takeuchi, Qun Li, Takeshi Kawano, Jun Nagai, Tatsuya Mima
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Qun Li, Yuichi Takeuchi, Jiale Wang, Levente Gellert, Livia Barcsai, Lizeth K. Pedraza, Anett J. Nagy, Gabor Kozak, Shinya Nakai, Shigeki Kato, Kazuto Kobayashi, Masahiro Ohsawa, Gyongyi Horvath, Gabriella Kekesi, Magor L. Lorincz, Orrin Devinsky, Gyorgy Buzsaki, Antal Berenyi
Summary: By studying the effects of manipulating the olfactory bulb and its cortex efferents, researchers found that reducing gamma oscillations in the limbic areas of the brain can induce depression-like behaviors in rodents. However, enhancing gamma oscillations can alleviate these behaviors. The findings suggest that restoring gamma oscillations may be a potential treatment for depressive symptoms.
Article
Multidisciplinary Sciences
Rodrigo Ordonez Sierra, Lizeth Katherine Pedraza, Livia Barcsai, Andrea Pejin, Qun Li, Gabor Kozak, Yuichi Takeuchi, Anett J. Nagy, Magor L. Lorincz, Orrin Devinsky, Gyoergy Buzsaki, Antal Berenyi
Summary: Dysregulated fear reactions can be caused by maladaptive processing of trauma-related memories. By manipulating hippocampal SWRs and cortical oscillations, fear extinction can be enhanced in male rats. The modified fear memories become resistant to recall and do not spontaneously reemerge. This effect is mediated by D2 receptor signaling-induced synaptic remodeling in the basolateral amygdala. These findings demonstrate the potential of neuromodulation in augmenting extinction learning and provide a new avenue for anxiety disorder treatments.
NATURE COMMUNICATIONS
(2023)