Article
Surgery
Yu He, Xinyu Zhang, Xuefeng Han, Facheng Li
Summary: This study evaluated the importance of adipose tissue structure and viability in fat grafting and found that protecting adipose tissue structure and viability is crucial for improving fat grafting outcomes.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Biotechnology & Applied Microbiology
Gretel S. Major, Jeremy W. Simcock, Tim B. F. Wood, Khoon S. Lim
Summary: Autologous fat grafting shows promise in repairing soft tissue deformities, but engineered solutions are needed to improve adipose tissue survival due to high resorption rates. Advances in material development and biofabrication have laid the foundation for functional adipose tissue constructs, but a balance is required between clinically feasible delivery and enhanced graft structural integrity. A new approach that combines clinical and research objectives can assist in developing mature adipose tissue constructs with controlled spatial arrangement and increased potential for neovascularization.
TRENDS IN BIOTECHNOLOGY
(2022)
Article
Surgery
Xin Bi, Bin Li, Jialiang Zou, Jing Zhao, Yunzi Chen, Xinhui Wang, Feng Lu, Ye Li, Ziqing Dong, Jianhua Gao
Summary: Low early macrophage infiltration hinders tissue regeneration after fat grafting, suggesting the importance of macrophages in early angiogenesis and adipogenesis. However, the source of these macrophages during this period is unclear.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
A. Jorien Tuin, Rutger H. Schepers, Frederik K. L. Spijkervet, Arjan Vissink, Johan Jansma
Summary: This study evaluated the overall and local volumetric effects of facial fat grafting and their correlation with patient satisfaction. The results showed that the highest volume gain was observed 6 weeks after grafting and gradually decreased thereafter. One year after grafting, there was still a substantial volume gain in the overall and zygomatic area, while this effect was lost in the lip area. The improvement in patient satisfaction was in line with the objective change in volume.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Xiangdong Zhang, Xiaoxuan Jin, Yibao Li, Mimi Xu, Yao Yao, Kaiyang Liu, Chijuan Ma, Yuchen Zhang, Jiangjiang Ru, Yunfan He, Jianhua Gao
Summary: This study aims to clarify the process of extracellular matrix (ECM) remodeling and its relationship with adipocyte survival and adipogenesis after fat grafting. The results demonstrate the various preservation modes of fat grafts after transplantation and underscore the importance of macrophage-mediated ECM remodeling in graft preservation.
Review
Surgery
Nicholas A. Vernice, Wooram F. Jung, Grant G. Black, Michele Demetres, David M. Otterburn
Summary: Although the optimal technique for fat grafting in breast reconstruction remains elusive, this systematic review suggests that active closed wash and filtration (ACWF) systems offer higher fat volumes in less time, with decreased rates of suboptimal outcomes and revisions. Further large-scale, randomized trials are needed to confirm these findings.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Surgery
Peter V. Vester-Glowinski, Mikkel Herly, Mathias Orholt, Bo S. Rasmussen, Felix C. Mueller, Jens J. Elberg, Carsten Thomsen, Krzysztof T. Drzewiecki
Summary: This trial investigated the use of ASCs in fat grafting for breast augmentation and found that ASC-enriched fat grafting did not show superior results compared to standard fat grafting in terms of fat retention after 1 year.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Surgery
Steven R. Cohen, Jordan Wesson, Sierra Willens, Taylor Nadeau, Chloe Hillman, Marek Dobke, Tunc Tiryaki
Summary: This study tracked the short- and long-term effects of facial fat grafting by ITR2 in the midfacial zone over 19 months. The results showed an initial volume loss followed by an increase in volume, with younger patients experiencing greater postoperative gain compared to older patients.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Surgery
Meiling Liu, Yujia Shang, Na Liu, Yonghuan Zhen, Youbai Chen, Yang An
Summary: Autologous fat grafting is a commonly used technique in plastic surgery, but the optimal processing technique and strategies for maximizing graft survival rate remain uncertain. Cell-assisted lipotransfer, particularly SVF-gel, shows promising potential for clinical application. Platelet-rich plasma (PRP) as a sustained-release material for endogenous growth factors also demonstrates feasibility.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Surgery
Keke Wang, Dali Mu, Xiaoyu Zhang, Yan Lin
Summary: Significant differences in postoperative volume retention rate were observed in patients with different lactation histories, with patients with a history of lactation showing a higher volume retention rate after breast augmentation with autologous fat. Further studies are needed to explore the influence of lactation on the response to autologous fat grafting.
AESTHETIC PLASTIC SURGERY
(2021)
Article
Surgery
Said C. Azoury, Sameer Shakir, Louis P. Bucky, Ivona Percec
Summary: The article discusses the principles and techniques for modern facial fat grafting to the face and neck, emphasizing the importance of understanding age-related changes and proper anatomical zones. Different techniques for fat processing and infiltration are compared, with a focus on the utility of fat grafting in facial rejuvenation procedures. The authors highlight the potential complications and success of fat grafting, and also mention emerging techniques such as lipotumescence.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Surgery
Gokay Baykara, Nezih Sungur, Kadri Ozer, Oguz Atan, Muzaffer Caydere, Pinar Nercis Kosar, Ugur Kocer
Summary: The study investigated the effects of autologous conditioned serum and platelet-rich plasma on fat graft outcomes. The results showed that autologous conditioned serum and platelet-rich plasma improved fat graft survival compared to saline, and autologous conditioned serum was associated with less inflammation, greater fat viability, and more integrity.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Surgery
Yujie Chen, Guangxue Li
Summary: This study evaluated the safety and effectiveness of autologous fat grafting for breast reconstruction after radiotherapy. Results showed that autologous fat grafting does not increase complications or tumor recurrence risk, with high patient satisfaction rates. Autologous fat grafting effectively corrects breast deformities caused by breast-conserving therapy and radiotherapy without increasing tumor recurrence.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Surgery
Ziang Zhang, Zijin Qin, Yu Li, Jie Long, Guo Chen, Botao Gao, Xuhua Zhou, Yuge Zhang, Baoqiang Song
Summary: An autologous fat grafting murine model for breast augmentation was developed to determine the optimal layer for fat retention. The results showed that retention rates were significantly higher in the subcutaneous and submuscular layers compared to the intramuscular layer at Week 16. The expression of integrins β1 and α6 was also higher in the intramuscular layer.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Surgery
Shengyang Jin, Zhibin Yang, Xuefeng Han, Facheng Li
Summary: This study investigated the impact of blood on the viability of fat grafts and adipose stem cells (ASCs). The results showed that blood decreased graft viability, inhibited proliferation, migration, and adipogenesis of ASCs, and increased reactive oxygen species production. The study suggests that washing to remove blood is crucial in fat processing.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Obstetrics & Gynecology
Tetsuya Hirata, Kaori Koga, Mari Kitade, Shinya Fukuda, Kazuaki Neriishi, Fuminori Taniguchi, Ritsuo Honda, Naoko Takazawa, Toshiaki Tanaka, Masatoshi Kurihara, Jun Nakajima, Shigeo Horie, Hidekatsu Nakai, Takayuki Enomoto, Masaki Mandai, Hisashi Narahara, Jo Kitawaki, Tasuku Harada, Hidetaka Katabuchi, Kotaro Yoshimura, Yutaka Osuga
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2020)
Article
Oncology
Hidenori Tsukui, Hisanaga Horie, Koji Koinuma, Hideyuki Ohzawa, Yasunaru Sakuma, Yoshinori Hosoya, Hironori Yamaguchi, Kotaro Yoshimura, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Article
Cell & Tissue Engineering
Koji Kanayama, Hitomi Takada, Natsumi Saito, Harunosuke Kato, Kahori Kinoshita, Takako Shirado, Takanobu Mashiko, Rintaro Asahi, Masanori Mori, Kensuke Tashiro, Ataru Sunaga, Akira Kurisaki, Katsutoshi Yoshizato, Kotaro Yoshimura
TISSUE ENGINEERING PART A
(2020)
Editorial Material
Surgery
Kotaro Yoshimura
AESTHETIC PLASTIC SURGERY
(2020)
Article
Biochemistry & Molecular Biology
Harunosuke Kato, Kahori Kinoshita, Natsumi Saito, Koji Kanayama, Masanori Mori, Natsumi Asahi, Ataru Sunaga, Katsutoshi Yoshizato, Satoshi Itami, Kotaro Yoshimura
Article
Cell Biology
Takanobu Mashiko, Koji Kanayama, Natsumi Saito, Takako Shirado, Rintaro Asahi, Masanori Mori, Kotaro Yoshimura
Summary: The study demonstrated that using microgravity conditions combined with microspheres can preserve the stemness of human adipose-derived stem cells (hASCs) and enhance their abilities for differentiation into multiple mesenchymal lineages. This novel culturing method may have significant implications for improving regenerative therapies using stem cells.
Letter
Surgery
Koji Kanayama, Jun Oba, Kengo Yoshii, Yoko Tomioka, Masakazu Kurita, Shimpei Miyamoto, Mutsumi Okazaki
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Dermatology
Koji Kanayama, Harunosuke Kato, Masanori Mori, Yuki Sakae, Mutsumi Okazaki
Summary: This study aimed to assess the surgical safety and postoperative clinical outcomes of using a robotic system for hair transplantation. The results showed that the robotic recipient site creation device had a high speed in creating sites and produced mostly satisfactory postoperative outcomes, indicating that it is safe, reliable, and easy to use.
DERMATOLOGIC SURGERY
(2021)
Review
Cell & Tissue Engineering
Bihang Zhang, Yunyan Wu, Masanori Mori, Kotaro Yoshimura
Summary: This systematic review investigated the therapeutic effects of adipose-derived stem cell (ASC) conditioned medium (CM) on wound healing in in vitro and in vivo studies, showing generally positive effects. ASC-CM can potentially offer a safe and cost-effective alternative to stem cell therapies. Modulation in the process of ASC culture and CM preparation may enhance its therapeutic potential for a variety of clinical conditions.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Letter
Dermatology
Koji Kanayama, Harunosuke Kato, Masanori Mori, Fumiyo Takahi, Shuichi Nakatsukasa, Mutsumi Okazaki
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Infectious Diseases
Takanobu Mashiko, Kunihisa Tsukada, Hitomi Takada, Szu-Hsien Wu, Koji Kanayama, Rintaro Asahi, Masanori Mori, Akira Kurisaki, Shinichi Oka, Kotaro Yoshimura
Summary: This study analyzed subcutaneous adipose tissue from patients with hemophilia, HIV infection, and lipodystrophy, and found that HIV infection led to inflammatory response, mitochondrial toxicity, chronic inflammation, progressive fibrosis, and adipocyte dysfunction in adipose tissue. The findings provide insights into the pathogenesis of HIV-associated lipodystrophy.
AIDS RESEARCH AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Yoko Tomioka, Masaki Sekino, Jian Gu, Masakazu Kurita, Shuji Yamashita, Shimpei Miyamoto, Takuya Iida, Koji Kanayama, Kotaro Yoshimura, Masahiro Nakagawa, Satoshi Akazawa, Yu Kagaya, Kentaro Tanaka, Yuki Sunaga, Keiko Ueda, Takuya Kawahara, Yukiko Tahara, Mutsumi Okazaki
Summary: Wearable sensors play a crucial role in healthcare, especially in monitoring tissue circulation after reconstructive surgery. By measuring pulse waves, skin color, and tissue temperature, this sensor provides real-time, continuous, multipoint, wireless, and reliable monitoring of patients. The results of a clinical trial involving 73 transplant surgery patients showed an overall agreement rate of 99.2% between the sensor findings and physician assessments.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Hakuba Takeishi, Shimpei Miyamoto, Yoko Tomioka, Koji Kanayama, Mutsumi Okazaki
Summary: Successful nasal alar reconstruction was achieved using free auricular helix flaps and the flow-through concept in two cases. Both cases had no vascular compromise or donor-site complications.