Review
Medicine, General & Internal
Qingling Jiang, Junjie Chen, Fan Tian, Zhenmi Liu
Summary: The study aimed to evaluate the effects of silicone gel sheeting on hypertrophic scars, including 13 studies. Results showed that silicone gel sheeting compared to no treatment had some impact on the severity of scars and pain, but the certainty of the current evidence was low. There was also uncertainty in comparison with other treatment methods.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Surgery
Thijs C. H. Oosterhoff, Vivian K. Beekman, Jelle P. van dr List, Frank B. Niessen
Summary: This study evaluates the effects of different laser systems on specific objective characteristics of excessive scarring, with CO2 and Er:YAG fractional ablative lasers showing the best results for erythema, height, and pliability. However, there is heterogeneity in the results, and further randomized trials are needed to confirm these findings.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Review
Medicine, General & Internal
Rafael Leszczynski, Carolina A. P. da Silva, Ana Carolina Pereira Nunes Pinto, Uliana Kuczynski, Edina Mk da Silva
Summary: The effectiveness of laser therapy for treating hypertrophic and keloid scars is inconclusive based on current evidence. Further high-quality trials are needed to assess treatment outcomes and adverse effects.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Surgery
Xuan-Jun Liu, Wen-Hui Liu, Shao-Wen Fang, Xin-Long Zhou, Jia-Xiang Xu, Guang-Shuai Li
Summary: This study compared the effectiveness of laser and IPL therapies for pathological scars using a network meta-analysis. The results showed that the combination of IPL and CO2 laser may be the most effective intervention.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Surgery
Shune Xiao, Jianghong Qi, Jianyi Li, Bihua Wu, Hai Li, Zhiyuan Liu, Chenglan Yang, Zairong Wei, Dali Wang, Chengliang Deng
Summary: This study aimed to assess the therapeutic effects of SVF gel combined with fractional CO2 laser on hypertrophic scars. The results showed that the combination treatment resulted in less apparent and softer scars, thinner dermis, and more organized collagen fibers. This technique has great potential for clinical application to treat hypertrophic scars.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Review
Critical Care Medicine
Weihai Peng, Xi Zhang, Xiangli Kong, Kai Shi
Summary: The meta-analysis demonstrated that fractional CO2 laser therapy is effective in improving burn scars, as evidenced by significant improvements in scar scores, thickness, and symptoms. While some mild side effects were reported, they were generally well-tolerated.
Review
Critical Care Medicine
Nemanja Baletic, Robert J. Dabek, Johanna N. Riesel, Christopher Hughes, Martin R. Buta, Matthias Donelan, Branko Bojovic
Summary: Hypertrophic burn scars can be treated with monochromatic light therapies, but laser treatment may also lead to inflammatory and infectious complications. This study found that systemic inflammatory response syndrome (SIRS) with positive wound cultures of MSSA was the most common inflammatory complication, and the proportion of complications related to infection sources was low. Measures to prevent inflammatory and infectious complications include preoperative wound preparation and appropriate use of antibiotics.
Review
Dermatology
Erica G. Baugh, Olive Anagu, Kristen M. Kelly
Summary: This review evaluates the effectiveness of laser and combination laser plus adjunct topical therapy for hypopigmented burn and traumatic scars. The combination of nonablative fractional or ablative fractional laser treatment with topical prostaglandin analogue with or without topical retinoid showed superior repigmentation results.
DERMATOLOGIC SURGERY
(2022)
Article
Surgery
Jianguo Chen, Yingying Wan, Yan Lin, Haiyue Jiang
Summary: This study found that fractional carbon dioxide or erbium:YAG laser combined with platelet-rich plasma is more effective in treating postacne scars compared to laser alone, and can significantly increase patient satisfaction.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Multidisciplinary Sciences
Yangmyung Ma, Sabrina P. Barnes, Yung-Yi Chen, Naiem S. Moiemen, Janet M. Lord, Amanda V. Sardeli
Summary: This study aimed to explore the effect of laser therapy on burn scars in adults, focusing on factors such as timing of treatment initiation, type of laser used, treatment interval, and presence of complications. The meta-analysis of previous studies showed that laser therapy significantly improved various aspects of burn scars, including vascularity, pliability, pigmentation, and scar height. The results also indicated that the efficacy of laser therapy was influenced by the time lapse after injury and the type of laser used.
Article
Surgery
Bianca Y. Y. Kang, Sarah A. A. Ibrahim, Alexandra Weil, Kelly A. A. Reynolds, Tyler Johnson, Sarah Wilson, Ming H. H. Lee, John Y. S. Kim, McKenzie A. A. Dirr, Emily Poon, Murad Alam
Summary: This study evaluated the effectiveness and safety of combined PDL and NAFL treatment for surgical scars. The results showed that the combination treatment group had improved scar assessment scores compared to the control group, with significant improvements in thickness, stiffness, and erythema reported by both patients and physicians.
Article
Materials Science, Biomaterials
Zhixi Yu, Xinxian Meng, Shunuo Zhang, Xiaodian Wang, Yunsheng Chen, Peiru Min, Zheng Zhang, Yixin Zhang
Summary: IR-808-ES can enhance the effectiveness of PDT/PTT by increasing ROS generation and hyperthermia, inducing apoptosis in hypertrophic scar fibroblasts (HSFs) through the intrinsic mitochondrial pathway.
BIOMATERIALS SCIENCE
(2021)
Article
Oncology
M. Naomi Horiba, Sandra J. Casak, Pallavi S. Mishra-Kalyani, Pourab Roy, Julia A. Beaver, Richard Pazdur, Paul G. Kluetz, Steven J. Lemery, Lola A. Fashoyin-Aje
Summary: Nivolumab has been approved by the FDA as an adjuvant treatment for esophageal cancer after surgery. The approval was based on the results of the CheckMate 577 trial, which showed that nivolumab can prolong disease-free survival in patients.
CLINICAL CANCER RESEARCH
(2022)
Review
Medicine, General & Internal
Fan Tian, Qingling Jiang, Junjie Chen, Zhenmi Liu
Summary: Silicone gel sheeting (SGS) is a common treatment for keloid scars, but there is currently no up-to-date systematic review on its effectiveness. Two studies showed uncertain results regarding the severity of scars and pain when comparing SGS with no treatment, non-SGS, or intralesional injections of triamcinolone acetonide. Further studies are needed to reduce uncertainty and provide more evidence for decision-making in using SGS to treat keloid scars.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Surgery
Nathanial Miletta, Katherine Siwy, Chad Hivnor, Jason Clark, Joshua Shofner, David Zurakowski, R. Rox Anderson, Kachiu Lee, Matthias Donelan
Summary: This study demonstrates that fractional ablative CO2 laser treatment leads to significant and sustained improvement in elasticity, thickness, appearance, and symptoms of mature hypertrophic burn scars. Objective measurements and patient/physician-reported outcomes both show significant improvements, with the effects lasting for at least 6 months post-treatment.
Article
Surgery
Zhihua Qiao, Xiancheng Wang, Yiwen Deng, Qingfeng Li, Tao Zan, Yang Sun, Xiang Xiong, Xianxi Meng, Wenbo Li, Zhongjie Yi, Xiaofang Li, Borong Fang
Summary: This study suggests that combining tissue expansion with a perforator flap for large tissue reconstruction can be successful with limited complications.
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2023)
Article
Oncology
Qingxiong Yu, Rehanguli Aimaier, Man-Hon Chung, Xiwei Cui, Yuehua Li, Zhichao Wang, Qingfeng Li
Summary: Treatments for giant congenital melanocytic nevi (GCMN) are limited, and there is a need for targeted therapies. An immortalized GCMN cell line was established, which showed lower proliferation and higher melanin content. The cell line carries the NRAS(Q61K) mutation and is sensitive to PI3K/Akt and Bcl-2 inhibitors.
PIGMENT CELL & MELANOMA RESEARCH
(2022)
Article
Dermatology
Yun Xie, Sufan Wu, Shirong Li, Qingfeng Li, Hongyi Zhao
Summary: This study evaluated the long-term safety and biodegradability of two hyaluronic acid dermal fillers for correcting nasolabial folds. The results showed that both fillers achieved complete clinical biodegradation in a high proportion of recipients during the 104-week post-treatment period. Most recipients experienced complete clinical biodegradation within 52 weeks of the last treatment. Treatment-related adverse events were mostly mild local injection-site reactions.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Physiology
Jiahao He, Shengzhou Shan, Qingfeng Li, Bin Fang, Yun Xie
Summary: The epithelial-mesenchymal transition (EMT) is a critical regulator of embryonic development, tissue repair, and tumor malignancy. Mechanical signals have been found to play an important role in driving the EMT program in epithelial cells. This study demonstrates that the mechanically activated cation channel Piezo1 is a key determinant of mechanical force-induced EMT in keratinocytes and may have similar roles in other epithelial cells.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Oncology
Yihui Gu, Chengjiang Wei, Manhon Chung, Haibo Li, Zizhen Guo, Manmei Long, Yuehua Li, Wei Wang, Rehanguli Aimaier, Qingfeng Li, Zhichao Wang
Summary: In this study, MEKi-resistant cell models were generated and the mechanisms of MEKi resistance were investigated using high-throughput transcriptomic sequencing. The upregulation of LAMA4/ITGB1/FAK/SRC signaling was found to contribute to MEKi resistance in MPNST cells. Concurrent inhibition of MAPK signaling and FAK/SRC cascade could enhance the sensitivity of MPNST cells to MEKi.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yihui Gu, Wei Wang, Yuehua Li, Haibo Li, Zizhen Guo, Chengjiang Wei, Manmei Long, Manhon Chung, Rehanguli Aimaier, Qingfeng Li, Zhichao Wang
Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are rare and difficult to treat soft-tissue sarcomas. This study evaluated different MEK inhibitors for the treatment of MPNSTs, and found that p-ERK can serve as a biomarker for predicting prognosis and an effective therapeutic target. Trametinib was identified as the most potent MEK inhibitor for the treatment of MPNSTs.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiya Yin, Qingfeng Li, Patrick Michael McNutt, Yuanyuan Zhang
Summary: Epithelial tissue injuries can have significant impacts on patients' quality of life, healthcare spending, and global economy. Urine-derived stem cells show versatile potential for tissue regeneration in repairing epidermal and urothelial injuries.
Article
Dermatology
Boxuan Wei, Jieyu Gu, Bowen Gao, Yongyang Bao, Ran Duan, Qingfeng Li, Feng Xie
Summary: This study discovered an association between dMMR and LGCMN. Diagnostic IHC showed that dMMR was present in 37% of giant CMNs, 23% of large CMNs, and 7% of medium CMNs. Regression analyses revealed significant associations between MMR status and CMN size and the presence of satellites. Whole-exome sequencing detected rare deleterious germline mutations in DNA repair genes.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemical Research Methods
Shan Wu, Caixia Wang, Min Yao, Dong Han, Qingfeng Li
Summary: Noninvasive photothermal treatment can tighten the skin and subcutaneous tissue, but the mechanism is not well understood. This study found that thermal injury to adipocytes increases ALOX15 in macrophages, which stimulates the production of extracellular matrix (ECM) in fibroblasts. The ALOX15 metabolite 12(S)-HETE activates the p38 MAPK signaling pathway and mediates ECM production in fibroblasts.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Pathology
Yuehua Li, Chengjiang Wei, Wei Wang, Qingfeng Li, Zhi-Chao Wang
Summary: Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein encoded by the NTRK2 gene, plays a crucial role in neural development. Abnormal activation of TrkB caused by NTRK2 overexpression or fusion contributes to tumour initiation, progression, and therapeutic resistance in neurogenic tumours. Targeted therapies, including selective TrkB inhibitors and pan-TRK inhibitors, have been developed to target this mechanism in preclinical and clinical studies. This review provides an overview of the gene structure, biological function, abnormal TrkB activation mechanism, and current targeted therapies in neurogenic tumours.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Yangdan Liu, Dongsheng Wen, Chiakang Ho, Li Yu, Danning Zheng, Steven O'Reilly, Ya Gao, Qingfeng Li, Yifan Zhang
Summary: Fibrosis, caused by excessive deposition of extracellular matrix, is a common and serious condition leading to organ failure and death. Recent advances in epigenetics have provided new insights into the mechanism of fibrogenesis and potential therapeutic strategies for organ fibrosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Man-Hon Chung, Rehanguli Aimaier, Qingxiong Yu, Haibo Li, Yuehua Li, Chengjiang Wei, Yihui Gu, Wei Wang, Zizhen Guo, Manmei Long, Qingfeng Li, Zhichao Wang
Summary: RRM2 expression is significantly elevated in NF1-associated MPNST and high RRM2 expression correlates with poorer outcomes. Inhibition of RRM2 can suppress NF1-associated MPNST cell proliferation and promote apoptosis and S-phase arrest. Therefore, inhibiting RRM2 may be an effective strategy for treating NF1-associated MPNST.
Review
Biochemistry & Molecular Biology
Shengzhou Shan, Qingfeng Li, Tracy Criswell, Anthony Atala, Yuanyuan Zhang
Summary: Sphincter dysfunction is a common consequence of neuromuscular impairment in tubule organs, resulting from trauma, inflammation, and aging. Conventional pharmacological treatments have limited success, prompting the exploration of cell- or growth factor-based therapies. However, challenges such as poor cell retention and viability, and the short half-life of growth factors have hindered clinical translation. Natural biomaterials offer a promising solution for controlled growth factor delivery, which has shown improved outcomes in sphincter function recovery. This review provides insights into the potential therapeutic role of stem cells combined with controlled release of growth factors, highlighting their use in preclinical studies as a new strategy to treat incontinence or sphincter dysfunction.
CELL AND BIOSCIENCE
(2023)
Article
Immunology
Meixia Wang, Hongfei Mi, Na Li, Qingfeng Shi, Wei Sun, Tingjuan He, Jiabing Lin, Wenting Jin, Xiaodong Gao, Bijie Hu, Chenghao Su, Jue Pan
Summary: This study investigated the associations between overall comorbidity burden, inflammatory indicators in plasma, and Ct values in elderly COVID-19 patients. The results showed that patients with a high comorbidity burden had lower Ct values and higher inflammatory responses. Inflammation mediated the association between comorbidity burden and Ct values.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kang Wang, Dongsheng Wen, Xuewen Xu, Rui Zhao, Feipeng Jiang, Shengqin Yuan, Yifan Zhang, Ya Gao, Qingfeng Li
Summary: Skin fibrosis is characterized by excessive deposition of extracellular matrix (ECM), which plays a central role in providing structural support and creating a microenvironment for cellular activities. Recent studies have focused on the relationship between mechanical properties of ECM and the development of skin fibrosis, involving complex signaling pathways, activation of mechanosensitive proteins, and changes in immune regulation and metabolism. The stiffening of ECM during fibrosis disturbs mechanical and humoral homeostasis, forming a pro-fibrotic positive feedback loop. This review highlights the importance of ECM and its dynamic changes in skin fibrosis, particularly the role of mechanical cues in ECM remodeling. Various interventions targeting ECM are also discussed to provide new strategies for fibrotic diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)