Article
Clinical Neurology
Tiffany Berrington, Matthias Schulz, Hans Delye, Greg James
Summary: This study provides a snapshot of current standards of care for craniosynostosis across high-volume centers of the European Reference Networks. The results can be used to analyze and guide the development of management guidelines for patients with both single-suture and multisutural craniosynostosis.
WORLD NEUROSURGERY
(2022)
Article
Surgery
Irene M. J. Mathijssen, Eppo B. Wolvius, Jochem K. H. Spoor, Marie-Lise C. van Veelen, Sarah L. Versnel
Summary: This study aims to identify certain types of craniosynostosis and surgical procedures that are more likely to require a secondary intracranial procedure. Patients with multisutural or syndromic craniosynostosis are at higher risk of needing repeat surgery due to insufficient outcome of skull shape or raised intracranial pressure. Specific surgical techniques such as biparietal outfracturing and endoscopic stripcraniectomy with helmet therapy have shown poorer outcomes for some types of craniosynostosis.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Medicine, Research & Experimental
Grace T. Wu, Jason R. Audlin, Jeewanjot S. Grewal, Sherard A. Tatum
Summary: This study evaluated the reliability of caliper measurements compared to CT measurements of the head, finding no significant difference between the two methods. This study concludes that caliper measurements are a simple and reliable way to assess cranial vault proportionality with growth after reconstruction.
Article
Pediatrics
Hugh O'Sullivan, Shirley Bracken, Jodie Doyle, Eilish Twomey, Dylan J. Murray, Louise Kyne
Summary: This study found that X-rays were not very useful in diagnosing abnormal skull shapes, especially craniosynostosis. Therefore, primary care clinicians should refer concerns to specialist teams.
Review
Dentistry, Oral Surgery & Medicine
Tyler J. Holley, Nathan J. Ranalli, Barry Steinberg
Summary: An understanding of the history of surgical management of craniosynostosis is crucial for comprehending current management approaches. The management of craniosynostosis has evolved from primitive techniques in the past to advanced surgical treatments in the present. Patient management in craniosynostosis continues to evolve.
ORAL AND MAXILLOFACIAL SURGERY CLINICS OF NORTH AMERICA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Firdaus Hariri, Nurul Aiman Farhana, Norli Anida Abdullah, Norliza Ibrahim, Norlisah Mohd Ramli, Azlindarita Aisyah Mohd Abdullah, Choo May May, Nurliza Khaliddin
Summary: The study revealed a narrowing of the optic canal in syndromic craniosynostosis patients compared to normal patients, with a halt in optic canal development with age. These findings suggest that optic canal anatomical characteristics may be associated with visual impairment among pediatric syndromic craniosynostosis patients.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
D. Kulker, A. Louisy, A. Listrat, N. Travers, A. Pare, B. Laure
Summary: Reverse frontal cranioplasty (RFC) is an effective surgical technique for correcting frontal malformations associated with craniosynostosis. The study findings show a high level of patient satisfaction post-RFC surgery, along with a significant increase in intracranial volume (ICV) as a result of the procedure.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Medicine, General & Internal
Parinaz Rostamzad, Zehra F. Arslan, Irene M. J. Mathijssen, Maarten J. Koudstaal, Mieke M. Pleumeekers, Sarah L. Versnel, Sjoukje E. Loudon
Summary: This study aimed to describe the types and prevalence of ophthalmic abnormalities in patients with craniosynostosis. The results showed that strabismus and astigmatism were the most common anomalies in different types of craniosynostosis. Syndromic craniosynostosis also had a higher proportion of decreased visual acuity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Joel Ferri, Matthias Schlund, Sandrine Touzet-Roumazeille
Summary: Craniosynostosis leads to dental malocclusion requiring management through orthognathic surgery and orthodontic treatment. Case studies showed that most patients presented with class III malocclusion, and following treatment, the majority achieved stable optimal dental occlusion.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Review
Surgery
Fedra Fallahian, Anne Meyer, Kashyap Komarraju Tadisina, Alexander Y. Lin
Summary: This systematic review on isolated squamosal craniosynostosis (SQS) suggests a trend towards surgical management in cases with bilateral SQS as compared to unilateral SQS. It also highlights the need for careful monitoring of patients with isolated SQS, previously considered to be a nonsurgical finding, as there remains a risk of increased intracranial pressure.
ANNALS OF PLASTIC SURGERY
(2023)
Article
Clinical Neurology
V. Tcherbbis Testa, S. Jaimovich, R. Arganaraz, B. Mantese
Summary: Understanding the mechanisms of increased intracranial pressure and the role of cerebrospinal fluid is crucial in managing pediatric patients with syndromic craniosynostosis. Among 33 patients requiring craniofacial surgery, more than half developed ventriculomegaly and nearly 40% needed ventriculoperitoneal shunt placement.
ACTA NEUROCHIRURGICA
(2021)
Review
Clinical Neurology
Nathan A. Shlobin, Ronnie E. Baticulon, Carlos A. Ortega, Liping Du, Christopher M. Bonfield, Alison Wray, Christopher R. Forrest, Michael C. Dewan
Summary: Craniosynostosis is a common condition that affects the neurocognitive and craniofacial skeletal development of children worldwide. Initiatives to scale up capacity for craniosynostosis epidemiologic research and clinical care are warranted, particularly in low- and middle-income countries.
WORLD NEUROSURGERY
(2022)
Article
Anatomy & Morphology
Nay Myo Min Swe, Yukiho Kobayashi, Hiroyuki Kamimoto, Keiji Moriyama
Summary: The Wnt/β-catenin pathway was activated in the coronal sutures (CS) of Fgfr2(S252W/+) mice, with increased mRNA expression of Lrp5 and Lrp6 and upregulated signaling proteins. Inhibition of Lrp5 and Lrp6 reduced expression of key genes related to craniofacial development in cultured cells. These findings suggest the involvement of the Wnt/β-catenin pathway in the pathogenesis of CS synostosis in Fgfr2(S252W/+) mice.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Clinical Neurology
Omar Najjar, Naji AbouChebel, Carine Zeeni, Marwan W. Najjar
Summary: This study reviewed infants undergoing craniosynostosis surgery at a medical center in Lebanon from 2006 to 2018, demonstrating that open craniosynostosis surgery can be performed with minimal complications, low recurrence rates, and satisfactory cosmetic outcomes with appropriate perioperative precautions. Further population-level data are needed to better understand craniosynostosis patterns and outcomes in the Middle East.
PEDIATRIC NEUROSURGERY
(2021)
Article
Physiology
Angel Cabrera Pereira, Krishnakali Dasgupta, Thach-Vu Ho, Maria Pacheco-Vergara, Julie Kim, Niam Kataria, Yaowei Liang, Jeslyn Mei, Jinyeong Yu, Lukasz Witek, Yang Chai, Juhee Jeong
Summary: The calvaria is composed of bone and soft tissue joints called sutures, which are crucial to skull growth and morphogenesis. The gene Lmx1b plays a key role in the development of calvarial sutures, with regional specificity. This study found that Lmx1b is necessary for the development of certain sutures and has different effects on different parts of the skull.
FRONTIERS IN PHYSIOLOGY
(2023)
Editorial Material
Clinical Neurology
Jeffrey P. Blount
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Betsy Hopson, Madeline Eckenrode, Brandon G. Rocque, Jeffrey Blount, Emily Hooker, Virginia Rediker, Emma Cao, Nancy Tofil, Yung Lau, Carlie Stein Somerville
Summary: This article describes the development of the STEP program and the innovative use of Individualized Transition Plans (ITP) in the clinic setting. The STEP program improves the transition from pediatric to adult healthcare by conducting a provider needs' assessment, creating a transition policy, and establishing an interdisciplinary medical home. The ITP focuses on 5 individualized goals and has been implemented through interdisciplinary patient visits in collaboration with adult healthcare departments.
DISABILITY AND HEALTH JOURNAL
(2023)
Letter
Clinical Neurology
Adrian Caceres, Jeffrey Parker Blount
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Jeffrey P. Blount, Betsy D. Hopson, James M. Johnston, Brandon G. Rocque, Curtis J. Rozzelle, Jerry W. Oakes
Summary: Spina bifida (SB) is the most serious and common congenital anomaly of the human nervous system, which requires multi-disciplinary care. In utero myelomeningocele closure (IUMC) has revolutionized initial care for SB, but hydrocephalus remains a major concern. The development of a holistic and transitional care approach is crucial for the overall health and well-being of SB patients.
CHILDS NERVOUS SYSTEM
(2023)
Article
Oncology
Michael Dewan, Albert Isaacs, Michael J. Cools, Aaron Yengo-Kahn, Robert Naftel, Hailey Jensen, Ron W. Reeder, Richard Holubkov, Joseline Haizel-Cobbina, Jay Riva-Cambrin, Ryan J. Jafrani, Jonathan A. Pindrik, Eric Jackson, Brendan F. Judy, Elena Kurudza, Ian Pollack, Michael Mcdowell, Todd Hankinson, Susan Staulcup, Jason Hauptman, Koko Hall, Mandeep S. Tamber, Alex Cheong, Nebras Warsi, Brandon Rocque, Benjamin W. Saccomano, Rita Snyder, Abhaya Kulkarni, John R. W. Kestle, John Wellons III, Hydrocephalus Clinical Res Network
Summary: This study compared the treatment outcomes of VPS and ETV for persistent hydrocephalus following posterior fossa brain tumor resection. The overall success rates were similar between the two methods, but ETV had earlier failure time while VPS had persistent risk of failure beyond 5 years.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Editorial Material
Clinical Neurology
Jeffrey P. Blount, Brandon G. Rocque
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Clinical Neurology
Katherine Barnes, Kathrin Zimmerman, Ivan Herbey, Anastasia Arynchyna-Smith, Bobby May, Caroline Arata Wessinger, Laura E. Dreer, Lieu Thompson, Nataliya Ivankova, Curtis J. Rozzelle, James M. Johnston, Jeffrey P. Blount, Brandon G. Rocque
Summary: This study aims to understand and meet the needs of caregivers of children with hydrocephalus, identify gaps in resources and support, and determine opportunities for improvement in care. Findings from semi-structured interviews with parents of children with hydrocephalus reveal the importance of providing accurate information, psychosocial support, and access to recommended resources to help caregivers cope with complex emotions and uncertainty and provide optimal care for their children. Rating: 9 out of 10.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Clinical Neurology
Mark S. Dias, Ming Wang, Menglu Liang, Elias B. Rizk, Robin Bowman, Michael D. Partington, Jeffrey P. Blount, Brandon G. Rocque, Betsy Hopson, Amy Lee, William O. Walker
Summary: This study analyzed the National Spina Bifida Patient Registry to determine the ongoing risk for tethered cord release (TCR) among adults with myelomeningocele who had not undergone TCR during childhood. The study found that females were overrepresented among those who underwent first TCR as adults, while males had a decreased risk. Previous treatment for Chiari malformation was associated with a greater risk of TCR, while previous treatment for hydrocephalus was associated with a decreased risk.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Article
Clinical Neurology
Roxanna M. Garcia, Kemel A. Ghotme, Anastasia Arynchyna-Smith, Priyanka Mathur, Marinus Koning, Frederick Boop, Dan Peterson, Natalie Sheneman, Walter D. Johnson, Kee B. Park, Dylan Griswold, Camilla G. Aukrust, Ernest J. Barthelemy, Geoffrey Ibbotson, Jeffrey P. Blount, Gail L. Rosseau
Summary: This article reviews the significant progress and international efforts in global surgery/neurosurgery, focusing on policy advocacy and support for a new World Health Assembly resolution to prevent neural tube defects.
News Item
Clinical Neurology
Nathan A. Shlobin, Kemel Ghotme, Adrian Caceres, Eylem Ocal, Jogi V. Pattisapu, Gail Rosseau, Jeffrey P. Blount, Frederick A. Boop
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Pedram D. Maleknia, Andrew T. Hale, Cody Savage, Jeffrey P. Blount, Brandon G. Rocque, Curtis J. Rozzelle, James M. Johnston, Jesse G. A. Jones
Summary: This systematic review summarizes the published cases of pediatric dAVFs and reveals a lack of information in this field, with publication bias and difficulty in determining detailed complications.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Jonathan Roth, Lottem Bergman, Alexander G. Weil, Tristan Brunette-Clement, Howard L. Weiner, Jeffrey M. Treiber, Ben Shofty, Arthur Cukiert, Cristine Mella Cukiert, Manjari Tripathi, Poodipedi Sarat Chandra, Robert J. Bollo, Helio Rubens Machado, Marcelo Volpon Santos, William D. Gaillard, Chima O. Oluigbo, George M. Ibrahim, George I. Jallo, Nir Shimony, Brent R. O'Neill, Marcelo Budke, Maria Angeles Perez-Jimenez, Francesco T. Mangano, Masaki Iwasaki, Keiya Iijima, Jorge Gonzalez-Martinez, Kensuke Kawai, Yohei Ishishita, Samer K. Elbabaa, Luis Bello-Espinosa, Aria Fallah, Cassia A. B. Maniquis, Ido Ben-Zvi, Martin Tisdall, Manas Panigrahi, Sita Jayalakshmi, Jeffrey P. Blount, Georg Dorfmuller, Christine Bulteau, Scellig S. Stone, Jeffrey Bolton, Shimrit Uliel-Sibony
Summary: CC is vital in seizure control in children with LGS in whom VNS has failed. Surgical risks are low. A complete CC has a tendency toward better effectiveness than anterior CC for some seizure types.
Article
Clinical Neurology
Andrew T. Hale, Dagoberto Estevez-Ordonez, Jana Badrani, Wen Sha, Anastasia Arynchyna-Smith, Monisha Goyal, Ismail Mohamed, Pongkiat Kankirawatana, Curtis J. Rozzelle, Jeffrey P. Blount
Summary: The study aimed to validate the Hemispherectomy Outcome Prediction Scale (HOPS) through a 20-year retrospective study on 60 patients, but found that the HOPS score was not statistically significant in predicting seizure outcomes postoperatively. More rigorous testing is needed for seizure outcome prediction tools, with prospective, standardized, and longitudinal evaluations of patients undergoing hemispherectomy.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Clinical Neurology
Jonathan Roth, Howard L. Weiner, P. Sarat Chandra, Helio Rubens Machado, Jeffrey P. Blount, Georg Dorfmueller, Christian Dorfer, Manas Panigrahi, Shimrit Uliel-Sibony, Shlomi Constantini
Summary: There are significant disparities in access to epilepsy surgery technologies across countries and continents, highlighting the importance of collaboration between neurologists and neurosurgeons worldwide to enhance medical education, training, and increase technological availability.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Mark S. Dias, Ming Wang, Menglu Liang, Elias B. Rizk, Robin Bowman, Michael D. Partington, Jeffrey P. Blount, Brandon G. Rocque, Betsy Hopson, Amy Lee, William O. Walker
Summary: The authors analyzed the National Spina Bifida Patient Registry to determine the ongoing risk for tethered cord release among adults with myelomeningocele who had not previously undergone the surgery during childhood. They also identified the impact of lesion level, ambulation status, and prior treatments on the surgery rates.
JOURNAL OF NEUROSURGERY-SPINE
(2023)