Review
Biochemistry & Molecular Biology
Ines Ripa, Sabina Andreu, Jose Antonio Lopez-Guerrero, Raquel Bello-Morales
Summary: The article discusses the role of the HSV-1 viral protein ICP34.5 in controlling cellular antiviral responses and debates its controversial functions such as autophagy inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yuqi Liang, Chenchen Song, Mianxin Liu, Pulin Gong, Changsong Zhou, Thomas Knopfel
Summary: Cortical circuits generate patterned activities reflecting intrinsic brain dynamics, laying the foundation for various cognitive processes and behaviors. Investigating wave patterns in different frequency ranges reveals complex spatiotemporal organization properties and principles of population activities in the brain. The interaction of different wave patterns determines the dynamical evolution of spontaneous cortical activities, providing insights into the structural architecture across the cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Physical
Vijay Kumar Vishvakarma, Shweta Pal, Prashant Singh, Indra Bahadur
Summary: This study investigated the interaction of sex hormones (testosterone and progesterone) with the main protease (Mpro) of SARS-CoV-2 using molecular docking and molecular dynamics simulations. The results indicated that testosterone has better potential for inhibiting the main protease of SARS-CoV-2.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Nikolas Eggers, Peter B. Becker
Summary: Using a unique experimental system, this study explored the principles of DNA shape recognition and factor cooperativity in chromatin. By reconstituting chromatin on Drosophila genomes, the researchers identified the physiological binding profile of MSL2 through interaction with other factors and competition with non-functional sites. The results revealed novel aspects of target selection in a complex chromatin environment.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Materials Science, Multidisciplinary
Dan He, Haiyan Li
Summary: Cell-cell interactions are crucial in tissue and organ development, and the effects of biomaterials on these interactions have been gaining attention in tissue engineering research. This review provides comprehensive information on cell co-culture technologies and the effects of biomaterials on cell-cell interactions, aiming to promote further research in the field.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Rocio Sanchez-de-Armas, Nicolas Montenegro-Pohlhammer, Aysegul Develioglu, Enrique Burzuri, Carmen J. Calzado
Summary: This study investigates the integration of SCO molecules on active nanodevices through quantum chemistry calculations, focusing on the encapsulation of Fe(ii) spin-crossover complexes in single-walled carbon nanotubes. The research reveals that the applied external electric field affects the spin-transition, and the local conditions of the substrate impact the transport properties.
Article
Political Science
Sangyeon Kim, Howard Liu, Bruce Desmarais
Summary: This paper introduces a method for handling spatial dependence among moving actors. By utilizing the spatiotemporal histories of dyadic interactions, future interaction locations can be predicted and used to model the likelihood of future interactions. The study finds that using this method improves the predictive performance of the model and indicates a clear relationship between actors' past conflict locations and the likelihood of future conflicts.
POLITICAL SCIENCE RESEARCH AND METHODS
(2022)
Article
Food Science & Technology
Line Pedersen, Anne Sjorup Bertelsen, Derek V. Byrne, Ulla Kidmose
Summary: Fat and sugar-reduced foods and beverages are increasingly popular due to health concerns. However, reducing fat and sugar without compromising sensory properties is challenging. This study examines the sensory interactions between fat and sweetness in chocolate-flavored milk. Findings indicate that reducing fat decreases sweetness intensity, while reducing sucrose reduces cream flavor, fruity flavor, and lactic flavor. The perception of acesulfame-K is also affected by fat concentration. These results highlight the importance of considering the impact of reducing sugar and fat on non-sugar and fat-related attributes.
Article
Biochemistry & Molecular Biology
Xinyue Zhang, Dan Li, Kexin Wang, Jiao Xie, Yaojie Liu, Tianxin Wang, Suwen Liu, Qun Huang, Qingbin Guo, Hao Wang
Summary: Hyperoside, the main component of many anti-obesity plants, acts as a lipase inhibitor to reduce fat accumulation. It changes the secondary conformation of lipase, increases the alpha-helix content, and alters the microenvironment of lipase through static quenching. Hyperoside also protects against hepatic lipid accumulation and adipose tissue hypertrophy, reduces inflammatory factors expression, and inhibits lipase activity in serum, thus reducing lipid absorption.
Article
Multidisciplinary Sciences
Audrey R. Freischel, Mehdi Damaghi, Jessica J. Cunningham, Arig Ibrahim-Hashim, Robert J. Gillies, Robert A. Gatenby, Joel S. Brown
Summary: Tumors are dynamic ecosystems where cancer cell subpopulations compete for space and resources. In experiments with MCF-7 and MDA-MB-231 breast cancer cells, MCF-7 cells showed better growth rates and carrying capacities under certain conditions, but were not always able to outcompete MDA-MB-231 cells. The study suggests a reliance on frequency-dependent interactions in understanding competition dynamics among cancer cells.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Zixue Ma, Kevin D. Dorfman
Summary: Experimental data on DNA knots confined in nanochannels show that separated knots are more stable than intertwined knots, contrary to interactions observed in stretched polymers.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Mario Kekez, Vladimir Zanki, Ivan Anticevic, Jasmina Rokov-Plavec, Aleksandra Marsavelski
Summary: By studying the binding affinity of BEN1 variants towards NADP+, it was found that the truncated BEN1 showed higher affinity towards NADP+ compared to the full-length BEN1, but did not increase interactions with the nucleotide-binding site as expected. The truncation affected the intrinsic conformational dynamics, tuning the binding affinity by enhancing interaction occupancy and strength of key conserved interactions with NADP+.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Yossi Cohen, Zohar Pasternak, Susann Muller, Thomas Hubschmann, Florian Schattenberg, Kunjukrishnan Kamalakshi Sivakala, Alfred Abed-Rabbo, Antonis Chatzinotas, Edouard Jurkevitch
Summary: Research shows that bacterial predators in wastewater treatment plants can regulate prey populations in a density-dependent manner, leading to stable total population numbers. Predatory landscapes oscillate at different temporal scales, affecting both abundant and rarer prey populations, while the coexistence of numerous predators is explained through niche partitioning based on differential prey range. This study's approach using single-cell sorting and community sequencing could be applied to decipher community interactions in other systems.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Christian Kleiner, Patrick Haesner, Peter Birkholz
Summary: In this study, 23 subjects were examined for their production of cyclic transitions between rounded vowels and unrounded vowels at two specific speaking rates. The results showed that rounded vowels were typically produced with a lower larynx position than unrounded vowels, and this difference was further emphasized by producing unrounded vowels with a higher pitch. The study also found that larynx lowering was faster than larynx raising, and this difference was more pronounced in women than in men. Possible reasons for these findings were discussed, focusing on specific biomechanical properties.
Article
Biochemistry & Molecular Biology
Marina Minguez-Toral, Luis F. Pacios, Flora Sanchez, Fernando Ponz
Summary: The viability of viral-derived nanoparticles as functionalized by turnip mosaic virus coat protein has been studied through computational methodologies, revealing the importance of disorder in specific subdomains and their interaction with the CP core for a viable CP. Preserving these characteristics is crucial for obtaining viable CPs presenting peptides at their N-terminus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Surgery
Dries Opsomer, Tom Vyncke, Michelle Ryx, Koenraad Van Landuyt, Phillip Blondeel, Filip Stillaert
Summary: The lumbar artery perforator flap is a good alternative for breast reconstruction in selected patients, but donor site complications mainly include seromas, prolonged discomfort, and a noticeable scar. Patient-reported satisfaction is very high, with most patients willing to recommend the surgery to others.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2022)
Article
Surgery
Karel Claes, Henk Hoeksema, Cynthia Lafaire, Lieve De Cuyper, Katrien De Groote, Tom Vyncke, Ignace De Decker, Jozef Verbelen, Petra De Coninck, Bernard Depypere, Stan Monstrey
ACTA CHIRURGICA BELGICA
(2023)
Article
Clinical Neurology
Kevin Budding, Lill Eva Johansen, Inge Van de Walle, Kim Dijkxhoorn, Elisabeth de Zeeuw, Lauri M. Bloemenkamp, Jeroen W. Bos, Marc D. Jansen, Chantall A. D. Curial, Karen Silence, Hans de Haard, Christophe Blanchetot, Liesbeth Van de Ven, Jeanette H. W. Leusen, R. Jeroen Pasterkamp, Leonard H. van den Berg, C. Erik Hack, Peter Boross, W. Ludo van der Pol
Summary: This study investigated the role of complement in the pathology of multifocal motor neuropathy (MMN) and demonstrated that patient-derived antibodies can activate complement and affect neuronal function. By inhibiting complement activation, neurons can be protected from lysis.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Review
Surgery
Sjaak Pouwels, Salvatore Sanfilippo, Eloise Owen, Koen J. A. O. Ingels, Frank W. De Jongh, Phillip Blondeel, Stan J. Monstrey
Summary: The human face plays a crucial role in social interaction, conveying important cues such as health, trustworthiness, and emotions. Peripheral facial palsy (PFP) is a condition characterized by damage to the facial nerve and can have various causes, leading to long-term sequelae and severe dysfunction in a significant percentage of cases. Treating PFP is a challenge for facial plastic surgeons due to its debilitating effects on physical, psychosocial, and quality of life aspects. However, there is still a lack of consensus on how to measure the treatment outcomes, given the diversity in cosmetic appreciation, surgical goals, patient needs, and measuring tools.
EUROPEAN JOURNAL OF PLASTIC SURGERY
(2022)
Article
Critical Care Medicine
Ignace De Decker, Henk Hoeksema, Els Vanlerberghe, Anse Beeckman, Jozef Verbelen, Petra De Coninck, Marijn M. Speeckaert, Phillip Blondeel, Stan Monstrey, Karel E. Y. Claes
Summary: The study showed that moisturizers have better effects than liquid silicone gel in promoting scar healing. They provide proper hydration and achieve good occlusion. This suggests that moisturizers can be used as an alternative scar hydration therapy to replace silicone products, offering a more cost-effective and patient-friendly application.
Editorial Material
Surgery
Phillip Blondeel
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Immunology
Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Boehme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge van de Walle, Stephanie Sontag, Jolien Vandewalle, Bart Vandekerckhove, Georges Leclercq, Pieter Van Vlierberghe, Claude Libert, Filip Van Nieuwerburgh, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Gina Doody, Martin Zenke, Tom Taghon
Summary: The interaction between thymocytes and thymic stromal cells is crucial for T cell development. This study demonstrates that intrathymic development of dendritic cells (DCs) plays a role in supporting early stages of human T cell development. The transcription factor IRF8 and transmembrane TNF are involved in this process. Selective targeting of TNFR2 has the potential to enhance the generation of T cell precursors for clinical applications.
Article
Materials Science, Multidisciplinary
Aysu Arslan, Patrice Roose, Annemie Houben, Heidi Declercq, Sandra Van Vlierberghe, Peter Dubruel
Summary: In this research, the printability of inks formulated with AUP and Laponite was evaluated. The flow behavior of the AUP/Laponite hydrogel inks showed yielding and shear thinning behavior, dependent on the concentrations of AUP and Laponite. The flow behavior inside the printing needle was analyzed to gain insight into printability. The recovery mechanism of the inks was found to have a biexponential behavior, with fast and slow recovery steps.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Biomedical
Elanagai Rathinam, Sivaprakash Rajasekharan, Heidi Declercq, Christian Vanhove, Peter De Coster, Luc Martens
Summary: The gene expression profiles and histological outcomes of two different tricalcium silicate-based biomaterials in endodontic revitalisation therapy were compared in immature sheep teeth. Biodentine induced a larger area of neoformed tissue with cellularity and vascularity, showing potential for promoting dentin formation. Further studies with larger sample size are needed to confirm the effect of intracoronal sealing biomaterials on histological outcomes.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Editorial Material
Engineering, Biomedical
Mark Skylar-Scott, Heidi Declercq, Koichi Nakayama
ACTA BIOMATERIALIA
(2023)
Meeting Abstract
Cell & Tissue Engineering
Mendy Minne, Rebecca Wust, Lisanne Terrie, Lieven Thorrez, Heidi Declercq
TISSUE ENGINEERING PART A
(2023)
Meeting Abstract
Cell & Tissue Engineering
Jasper Smet, Lieven Thorrez, Heidi Declercq
TISSUE ENGINEERING PART A
(2023)
Meeting Abstract
Cell & Tissue Engineering
Rebecca Wust, Lisanne Terrie, Heidi Declercq, Lieven Thorrez
TISSUE ENGINEERING PART A
(2023)
Article
Clinical Neurology
Clare Campbell, Rhona McGonigal, Jennifer A. Barrie, Jolien Delaere, Laura Bracke, Madeleine E. Cunningham, Denggao Yao, Tim Delahaye, Inge Van de Walle, Hugh J. Willison
Summary: The involvement of complement pathway in the pathogenesis of Guillain-Barre syndrome has been demonstrated, and complement inhibition may provide protection from injury mediated by anti-ganglioside antibodies. However, the role of complement in the demyelinating variants has yet to be established. Complement inhibition shows potential as a therapeutic strategy for neuropathies associated with anti-GM1 antibodies.
BRAIN COMMUNICATIONS
(2022)
Meeting Abstract
Cell & Tissue Engineering
Mendy Minne, Lise De Moor, Lisanne Terrie, Laurens Parmentier, Sandra Van Vlierberghe, Lieven Thorrez, Heidi Declercq
TISSUE ENGINEERING PART A
(2022)