Article
Cell Biology
Yahui Wang, Yong Xu, Guangdong Zhou, Yu Liu, Yilin Cao
Summary: In tissue engineering applications, an acellular dermal matrix (ADM) has been found to be more suitable for cartilage regeneration compared to an acellular cartilaginous matrix (ACM). ADM scaffolds exhibited better cell adhesion rate, more homogeneous chondrocyte distribution, and neocartilage formation. Subcutaneous implantation in a goat showed that ADM achieved more stable and matured cartilage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Otorhinolaryngology
Shivam Patel, Kasra Ziai, Jessyka G. Lighthall, Scott G. Walen
Summary: Acellular dermal matrices (ADMs) are composed of a basement membrane and acellular dermal layer of collagen, providing a platform for mucosal epithelization and neovascularization. They support adequate wound healing and soft tissue repairs, reducing the need for autologous tissue grafts and minimizing donor site morbidity. The literature on ADMs in head and neck reconstruction for cosmetic and reconstructive purposes is rapidly evolving.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Materials Science, Textiles
Xiaofei Gao, Guohua Jiang, Liming Ruan, Yanfang Sun, Khaydar E. Yunusov, Yanting Jing, Uladzislau E. Aharodnikau, Sergey O. Solomevich
Summary: Electrospun nanofibers with adjustable properties and drug delivery capabilities have been developed as a potential wound healing material. The electrospun polycaprolactone and porcine acellular dermal matrix composite scaffolds showed enhanced thermal stability and cell adhesion. In vivo experiments demonstrated their ability to promote wound healing through enhanced expression of vascular factor and reduced inflammation.
FIBERS AND POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Jiah Shin Chin, Leigh E. Madden, Anthony R. J. Phillips, Sing Yian Chew, David L. Becker
Summary: This study evaluated the effects of 3D fibrous scaffolds fabricated using wet electrospinning on wound healing. The results showed that the poly(epsilon-caprolactone) (PCL) scaffold promoted fibroblast migration and angiogenesis, facilitating re-epithelialization. On the other hand, the addition of rat tail type 1 collagen to the scaffold hindered re-epithelialization and induced an inflammatory response.
BIOENGINEERING-BASEL
(2022)
Article
Surgery
Laura M. Cabanas Weisz, Diego L. Guarin, William A. Townley
Summary: Facial palsy can cause disability, social and psychological impairment. Cheek slings provide static support to the midface. This study compared traditional sling material with a porcine-derived acellular dermal matrix alternative. The results suggest that Strattice is a safe sling material with satisfactory results and comparable medium-term maintenance of tensile strength to fascia lata.
ANNALS OF PLASTIC SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Yining Chen, Ying Zhang, Qi Wang, Nianhua Dan, Yuwen Li, Zhengjun Li, Weihua Dan, Yunbing Wang
Summary: Ideal tissue-engineered skin scaffolds with integrated therapeutic effects and multifunctionality, such as broad-spectrum antibacterial properties, adjustable mechanical properties, and bionic structure, have been developed for integrated infected wounds therapy. A balanceable crosslinking approach based on oxidized 2-hydroxypropyltrimethyl ammonium chloride chitosan (OHTCC) was used to convert acellular dermal matrix (ADM) into versatile skin scaffolds. The OHTCC-ADM scaffolds possess adjustable mechanical properties, broad-spectrum antibacterial performances, and desirable multifunctional properties, facilitating the healing process of infected wounds.
Review
Biochemistry & Molecular Biology
Marcin Gierek, Wojciech Labus, Diana Kitala, Andrzej Lorek, Gabriela Ochala-Gierek, Karolina Mikus Zagorska, Dariusz Waniczek, Karol Szyluk, Pawel Niemiec
Summary: Reconstructive surgery often deals with large tissue defects and requires materials that are both immunogenic but offer tissue filling. ADM, an acellular dermal matrix, is a commonly used biological collagen matrix without immunogenicity. This literature review examines the use of human ADM in reconstructive surgery across different fields, emphasizing the need for further research in this area.
Article
Biochemistry & Molecular Biology
Pietro Felice, Emira D'Amico, Tania Vanessa Pierfelice, Morena Petrini, Carlo Barausse, Maryia Karaban, Antonio Barone, Giovanna Iezzi
Summary: The features and biological activities of an acellular porcine dermis collagen matrix membrane applicable during dental surgery were investigated, and the effects of hydration with NaCl were evaluated. Results showed that the hydrated membrane promoted cell proliferation and attachment, and increased mineralization and gene expression related to osteoblasts in oral cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Miriam du Plessis, Patrick S. Cottler, Chris A. Campbell
Summary: The use of acellular dermal matrix in breast reconstruction has shown improvement in clinical safety outcomes and potential benefits such as decreased complications and accelerated wound healing. However, more long-term clinical data are needed to understand its performance and safety.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Yangyufan Wang, Bin Kong, Xiang Chen, Rui Liu, Yuanjin Zhao, Zhuxiao Gu, Qing Jiang
Summary: This study demonstrated the pro-osteogenic effects of exosomes derived from osteogenic differentiated BMSCs (OBMSCs) and introduced a novel exosome-functionalized decellularized fish scale (DE-FS) scaffold for promoting bone regeneration. The DE-FS scaffolds, obtained through decellularization and decalcification processes, exhibited high biocompatibility and low immunological rejection. The anisotropic structures of DE-FS enhanced the adhesion and proliferation ability of BMSCs, and the porous structure allowed for loading and release of exosomes, resulting in enhanced osteogenic differentiation. In vivo experiments showed that OBMSC exosome-modified DE-FS scaffolds effectively promoted bone regeneration in a mouse calvarial defect model.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Medicine, General & Internal
Kaja Skowronek, Wojciech Labus, Rafal Stojko, Diana Kitala, Marcin Sadlocha, Agnieszka Drosdzol-Cop
Summary: The study emphasizes on the benefits of using acellular dermal matrix (ADM) in urogynaecological and reconstructive surgery over traditional methods with higher durability and effectiveness without typical side effects of synthetic materials. Although ADM is not widely used in clinical practice, its potential is promising, prompting the need for more research to compare different surgical methods.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Yixin Wang, Fei Lu, Enling Hu, Kun Yu, Jiwei Li, Rong Bao, Fangyin Dai, Guangqian Lan, Ruiqi Xie
Summary: The study developed a transparent, porous, and elastic PADM by using a CaCl2-ethanol-H2O solution combined with an additional enzyme treatment. Changes in fiber organization and secondary structural changes in collagen were observed after treatment. The biocompatible PADM significantly expedited wound repair in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Chemical
Zhuang Ding, Nianhua Dan, Yining Chen
Summary: This study investigated the cross-linking of oxidized sodium hyaluronate (OSH) with porcine acellular dermal matrix (pADM) to enhance its hydrophilic and moisturizing properties. The results showed that OSH-pADM maintained the natural collagen structure and microporous structure of pADM, with increasing oxidation degree leading to increased hydrophilicity and moisture retention capacities. The degradation resistance of OSH-pADM also increased with increasing oxidation degree, and it exhibited acceptable cytotoxicity. In vivo experiments demonstrated that OSH-pADM had a significant ability to promote wound healing.
Review
Biochemistry & Molecular Biology
Sadia Perveen, Daniela Rossin, Emanuela Vitale, Rachele Rosso, Roberto Vanni, Caterina Cristallini, Raffaella Rastaldo, Claudia Giachino
Summary: Myocardial infarction is a leading cause of heart-related deaths worldwide, and the potential of acellular scaffolds in treating MI is significant, as they can improve cardiac regeneration, limit adverse LV remodelling, and enhance heart function recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Young-Joo Lee, Suhail K. Kanchwala, Hyesung Cho, Jason Christopher Jolly, Eric Jablonka, Michael Tanis, Randall D. Kamien, Shu Yang
Summary: To achieve successful and aesthetic breast reconstruction for breast cancer survivors, acellular dermal matrices (ADMs) are commonly used. However, traditional ADM sheets cannot fully cover breast implants without wrinkles. In this study, a kirigami strategy is proposed to cut ADM sheets with controlled stretchability, curvature, and elasticity. This approach allows for better conformity and support for reconstructed breasts, offering potential benefits in terms of outcomes and cost efficiency.
ADVANCED MATERIALS
(2023)
