Article
Cell Biology
Fang Li, Hua Liu, Kun Zhang, Dong-Jie Xiao, Chang Wang, Yun-Shan Wang
Summary: The study found that adipose-derived stromal cells (ADSCs) reduce lesion size and promote functional recovery in spinal cord neurons through activation of the TGF-beta 1/P-Samd3/PLOD2 pathway.
Article
Biochemistry & Molecular Biology
Katrin Radeloff, Dorothee Weiss, Rudolf Hagen, Norbert Kleinsasser, Andreas Radeloff
Summary: Adipose-derived stromal cells show chondrogenic differentiation capacity in vitro and have potential for cartilage replacement. Implantation of predifferentiated cell-seeded constructs into rabbit ear cartilage defects resulted in deposition of cartilage-like structures with evidence of endochondral ossification.
Article
Biochemistry & Molecular Biology
Yunxiao Liang, Xin Tang, Xue Zhang, Cuixiang Cao, Miao Yu, Miaojian Wan
Summary: Androgenic alopecia (AGA) is the most common type of hair loss caused by high levels of dihydrotestosterone (DHT). Adipose mesenchymal stromal cell-derived exosomes (ADSC-Exos) have been suggested as a potential treatment, but their functions and mechanisms in AGA are unclear. This study found that ADSC-Exos enhanced the proliferation, migration, and differentiation of dermal papilla cells (DPCs) and up-regulated the expression of cyclin, beta-catenin, versican, and BMP2. ADSC-Exos also mitigated the inhibitory effects of DHT on DPCs and down-regulated transforming growth factor-beta1 (TGF-beta 1) and its downstream genes. MiR-122-5p in ADSC-Exos played a crucial role through the inhibition of the TGF-beta/SMAD3 axis, promoting the regeneration of hair follicles in AGA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyrije Ademi, Katarzyna Michalak-Micka, Ueli Moehrlen, Thomas Biedermann, Agnes S. Klar
Summary: The secretome of adipose-derived stem cells (ASCs) has a positive effect on keratinocyte proliferation and wound healing. Specifically, the ASC secretome promotes keratinocyte proliferation by enhancing DNA synthesis and regulating cell cycle progression. Additionally, the ASC secretome can regulate keratinocyte differentiation and promote the expression of epidermal basal keratinocyte markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Andreina Bruno, Caterina Di Sano, Hans-Uwe Simon, Pascal Chanez, Angelo Maria Patti, Serena Di Vincenzo, Paola Dino, Vittoria D'Esposito, Pietro Formisano, Francesco Beguinot, Elisabetta Pace
Summary: The study found that leptin and TGF-beta directly regulate the expression of PREP1 in ASCs and mature adipocytes, with effects on immune receptors and cytokines limited to mature adipocytes. This suggests that modulating immune responses may depend on the differentiation state of adipose-derived stem cells. Further research is needed to understand the potential for new therapeutic approaches in obesity-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elle Koivunotko, Jasmi Snirvi, Arto Merivaara, Riina Harjumaki, Swarna Rautiainen, Minna Kelloniemi, Kirsi Kuismanen, Susanna Miettinen, Marjo Yliperttula, Raili Koivuniemi
Summary: Adipose-derived mesenchymal stromal cells (ASCs) hold great potential for cellular therapies and can differentiate into endothelial cells (ECs) and other angiogenic cell types. Nanofibrillated cellulose (NFC) hydrogel is a suitable matrix for 3D cell culture of ASCs and can stimulate angiogenesis. This study recommends the use of NFC hydrogel as an animal-free biomaterial scaffold for therapeutic angiogenesis and other cell therapy purposes.
Review
Biochemistry & Molecular Biology
Ivana Roberta Romano, Floriana D'Angeli, Nunzio Vicario, Cristina Russo, Carlo Genovese, Debora Lo Furno, Giuliana Mannino, Serena Tamburino, Rosalba Parenti, Rosario Giuffrida
Summary: This review discusses the osteogenic and chondrogenic differentiation ability of adipose-derived mesenchymal stromal cells (ASCs) and their potential therapeutic applications in bone and cartilage defects. ASCs can easily differentiate into chondrocyte-like and osteocyte-like elements and they can be used for tissue repair. Various strategies involving ASCs, such as transplantation of freshly harvested cells, in vitro expanded cells, or predifferentiated cells, are being developed globally. Combining ASCs with scaffolds can further enhance their positive effects and contribute to their osteogenic or chondrogenic differentiation.
Article
Agriculture, Dairy & Animal Science
Hannah J. Stage, Susanne Trappe, Katharina Soellig, Dagmar S. Trachsel, Katharina Kirsch, Cornelia Zieger, Roswitha Merle, Joerg R. Aschenbach, Heidrun Gehlen
Summary: This study investigated the proliferation and multilineage differentiation potential of equine adipose stem cells (ASCs) obtained from different tissue sources. The study found that ASCs had high proliferation and differentiation potential, but were unable to undergo cardiomyogenic differentiation. This study provides a basis for future research in equine medicine.
Article
Integrative & Complementary Medicine
Chunyan Liu, Mengzhen Xu, Luocheng Yan, Yulian Wang, Zhen Zhou, Shaocong Wang, Yajie Sun, Junfeng Zhang, Lei Dong
Summary: Honeysuckle-derived miR2911 exhibits anti-tumor effects in colon cancer by targeting TGF-beta 1 mRNA, promoting T lymphocytes infiltration, and ultimately impeding colon tumor development.
Article
Engineering, Biomedical
R. Tevlin, H. desJardins-Park, J. Huber, S. E. DiIorio, M. T. Longaker, D. C. Wan
Summary: Osteoarthritis is a global burden that affects joints and bones. Tissue engineering, specifically adipose-derived stromal cells, shows promise as a treatment option. Advancements in material science allow for improved engraftment of these cells and activation of biophysical signals through designed microstructures.
Article
Materials Science, Multidisciplinary
Jong Bo Park, Ji Yeon Ahn, Woo Sub Yang, Seong Chae Park, Young Jin Jung, Myungook Lee, Byung Hee Hong, Jeong Mook Lim
Summary: This study investigated the effect of nanoscale spacing by stacked graphene film on osteogenic differentiation of human adipose-derived mesenchymal stromal cells. The results showed that osteogenic differentiation was promoted as the stacking layer increased, with the most significant effects observed in the three layers. The study demonstrated that multilayer-stacked graphene created nanoscale spaces promote calcium deposit and cytoskeletal integrity in hADSC-related, in vitro-osteogenesis.
Article
Cell Biology
Wayne Carver, Ethan Fix, Charity Fix, Daping Fan, Mrinmay Chakrabarti, Mohamad Azhar
Summary: Studies have shown that emodin can attenuate TGF-beta 1-induced cardiac fibroblast activation and collagen accumulation, and it may function as an effective therapeutic agent for fibrosis through specific TGF-beta signaling pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Mariachiara Zuccarini, Catia Lambertucci, Marzia Carluccio, Patricia Giuliani, Maurizio Ronci, Andrea Spinaci, Rosaria Volpini, Renata Ciccarelli, Patrizia Di Iorio
Summary: The study found that A(1)R partial agonists or antagonists can limit the differentiation of adipose tissue cells into adipocytes, thereby preventing an increase in fat mass, which may help manage metabolic syndrome in obese individuals.
Review
Biochemistry & Molecular Biology
Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Monica Frinchi, Francesco Caciagli, Vanni Caruso, Renata Ciccarelli, Giuseppa Mudo, Patrizia Di Iorio
Summary: In the past decade, several compounds have been identified for treating obesity, but concerns about their efficacy and safety remain due to the complexity of the disease. Therefore, it is crucial to discover new factors involved in obesity induction and progression. Adipose stromal/stem cells release extracellular vesicles (EVs), which play an important role in regulating metabolic processes. However, there are advantages and disadvantages to using EVs as potential next-generation anti-obesity agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Angela Serena Maione, Ilaria Stadiotti, Chiara Assunta Pilato, Gianluca Lorenzo Perrucci, Valentina Saverio, Valentina Catto, Giulia Vettor, Michela Casella, Anna Guarino, Gianluca Polvani, Giulio Pompilio, Elena Sommariva
Summary: This study found that fibrotic markers are increased in cardiac biopsies of ACM patients compared to healthy controls, along with significantly higher levels of circulating TGF-beta1 in the ACM cohort. While this difference is not evident in isolated C-MSC, ACM C-MSC are more responsive to TGF-beta1 treatment, indicating their involvement in ACM fibrotic remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Aaron M. Newman, Chih Long Liu, Michael R. Green, Andrew J. Gentles, Weiguo Feng, Yue Xu, Chuong D. Hoang, Maximilian Diehn, Ash A. Alizadeh
Article
Oncology
Shizhao Cheng, Yue Xu, Zhenliang Shi, Yongbin Lin, Chuong D. Hoang, Xun Zhang
Article
Oncology
Yanyan Zheng, Cecile C. de la Cruz, Leanne C. Sayles, Chris Alleyne-Chin, Dedeepya Vaka, Tim D. Knaak, Marty Bigos, Yue Xu, Chuong D. Hoang, Joseph B. Shrager, Hans Joerg Fehling, Dorothy French, William Forrest, Zhaoshi Jiang, Richard A. D. Carano, Kai H. Barck, Erica L. Jackson, E. Alejandro Sweet-Cordero
Meeting Abstract
Oncology
Chuong D. Hoang, Andrew Gentles, Yue Xu, Sylvia K. Plevritis, Robert Merritt, Richard Whyte, Joseph Shrager, Robert A. Kratzke
Article
Oncology
Silvestre Vicent, Leanne C. Sayles, Dedeepya Vaka, Purvesh Khatri, Olivier Gevaert, Ron Chen, Yanyan Zheng, Anna K. Gillespie, Nicole Clarke, Yue Xu, Joseph Shrager, Chuong D. Hoang, Sylvia Plevritis, Atul J. Butte, E. Alejandro Sweet-Cordero
Article
Oncology
Ron Chen, Purvesh Khatri, Pawel K. Mazur, Melanie Polin, Yanyan Zheng, Dedeepya Vaka, Chuong D. Hoang, Joseph Shrager, Yue Xu, Silvestre Vicent, Atul J. Butte, E. Alejandro Sweet-Cordero
Letter
Critical Care Medicine
Yue Xu, Ming Zheng, Amanda Khuong, Robert E. Merritt, Joseph B. Shrager, Heather A. Wakelee, Robert A. Kratzke, Chuong D. Hoang
Article
Critical Care Medicine
Yue Xu, Ming Zheng, Robert E. Merritt, Joseph B. Shrager, Heather A. Wakelee, Robert A. Kratzke, Chuong D. Hoang
Article
Radiology, Nuclear Medicine & Medical Imaging
Olivier Gevaert, Jiajing Xu, Chuong D. Hoang, Ann N. Leung, Yue Xu, Andrew Quon, Daniel L. Rubin, Sandy Napel, Sylvia K. Plevritis
Article
Biochemical Research Methods
Manhong Wu, Yue Xu, William L. Fitch, Ming Zheng, Robert E. Merritt, Joseph B. Shrager, Weiruo Zhang, David L. Dill, Gary Peltz, Chuong D. Hoang
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2013)
Editorial Material
Medicine, General & Internal
Yan-Qiu Song, Yue Xu, Zhi-Gang Guo
CHINESE MEDICAL JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Tracey McLaughlin, Ingela Schnittger, Anna Nagy, Elizabeth Zanley, Yue Xu, Yanqiu Song, Koen Nieman, Jennifer A. Tremmel, Damini Dey, Jack Boyd, Harold Sacks
Summary: Inflammation in epicardial adipose tissue (EAT) is associated with coronary atherosclerosis. In individuals with myocardial bridge, EAT near atherosclerotic plaque exhibits higher levels of inflammation, especially in proportion to the severity of plaque burden. Higher inflammation and lower adipogenesis were observed in individuals with moderate to high plaque burden, indicating a potential cross talk between the coronary vasculature and EAT.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biotechnology & Applied Microbiology
Andrew J. Gentles, Angela Bik-Yu Hui, Weiguo Feng, Armon Azizi, Ramesh Nair, Gina Bouchard, David A. Knowles, Alice Yu, Youngtae Jeong, Alborz Bejnood, Erna Forgo, Sushama Varma, Yue Xu, Amanda Kuong, Viswam S. Nair, Rob West, Matt van de Rijn, Chuong D. Hoang, Maximilian Diehn, Sylvia K. Plevritis
Meeting Abstract
Oncology
Chuong Hoang, Yue Xu, Zhenliang Shi, Yongbin Lin, Robert E. Merritt, Joseph Shrager, Millie Das, Joel W. Neal, Heather A. Wakelee
JOURNAL OF THORACIC ONCOLOGY
(2013)
Meeting Abstract
Oncology
Chuong D. Hoang, Andrew Gentles, Yue Xu, Sylvia Plevritis, Robert E. Merritt, Richard I. Whyte, Joseph B. Shrager, Robert A. Kratzke
JOURNAL OF THORACIC ONCOLOGY
(2011)
