Article
Chemistry, Multidisciplinary
Nan Li, Chenxing Huang, Jie Zhang, Junyue Zhang, Jia Huang, Shangshang Li, Xue Xia, Ziyu Wu, Chenglong Chen, Shuwan Tang, Xiangyu Xiao, Hui Gong, Yuxiang Dai, Chun Mao, Mimi Wan
Summary: This study proposes a method to protect recombinant granulocyte colony-stimulating factor (G-CSF) by constructing nitric oxide (NO)/hydrogen sulfide (H2S) nanomotors on its outside, which can efficiently deliver G-CSF to the ischemia-reperfusion injury (IRI) site. The synergistic effect of NO and H2S can regulate the IRI microenvironment, reduce oxidative stress, inflammation, and calcium overload, promoting G-CSF's cardioprotective role.
Article
Pharmacology & Pharmacy
Yaping Niu, Congkuo Du, Changting Cui, Haizeng Zhang, Yue Deng, Jun Cai, Zhenzhen Chen, Bin Geng
Summary: The study identified NW as a novel CSE agonist that enhances CSE generation of H2S, thereby alleviating kidney I/R injury and hypertension. NW shows potential therapeutic merit for cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Selda Emre Aydingoz, Ariyan Teimoori, Halit Guner Orhan, Oguzhan Ekin Efe, Seda Kibarog, S. Remzi Erdem
Summary: Through systematic literature review and meta-analysis, we evaluated the current evidence from animal studies for the protective effects of hydrogen sulfide (H2S) against kidney ischemia-reperfusion injury (IRI). The results showed that H2S treatment significantly decreased serum creatinine, blood urea nitrogen, tissue malondialdehyde, tunel positive cells, and tubular damage score. However, there was high heterogeneity across studies, and further preclinical studies focusing on GYY4137 are needed before clinical implication.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maurits Roorda, Jan Lj Miljkovic, Harry van Goor, Robert H. Henning, Hjalmar R. Bouma
Summary: Hydrogen sulfide (H2S), previously known as a putrid, toxic gas, is now recognized as the third gasotransmitter alongside nitric oxide (NO) and carbon monoxide (CO) in mammalian systems. H2S plays a critical role in regulating vascular and cellular function in the kidneys, impacting blood flow, glomerular filtration rate, and the renin-angiotensin axis. Furthermore, H2S offers protection against acute kidney injury (AKI) by enhancing ATP production and preventing damage due to free radicals during hypoxia or ischemia-reperfusion injury. Understanding the (sub)cellular signaling mechanisms of H2S can lead to novel therapeutic targets for preventing kidney injury.
Article
Immunology
Zhen Cao, Silong Mu, Maihuan Wang, Yun Zhang, Guijun Zou, Xinpu Yuan, Yun Huang, Siwang Yu, Jinming Zhang, Chaojun Zhang
Summary: Intestinal ischemia-reperfusion (I/R) injury disrupts the intestinal barrier composed of tight junction proteins, leading to the entry of bacteria and endotoxins into the bloodstream and causing distant organ damage. This study investigated the role of succinate, an intermediate product of the tricarboxylic acid cycle, in intestinal I/R injury, and found that pretreatment with succinate reduced tissue damage, necroptosis, and inflammation. The protective effect of succinate was associated with the upregulation of the inflammatory protein KLF4 and was diminished after inhibition of KLF4.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
L. Testai, R. Montanaro, L. Flori, E. Pagnotta, V. Vellecco, E. Gorica, L. Ugolini, L. Righetti, V. Brancaleone, M. Bucci, E. Piragine, A. Martelli, L. Di Cesare Mannelli, C. Ghelardini, V. Calderone
Summary: This study investigated the cardioprotective effects of ERU, an isothiocyanate derived from glucosinolate glucoerucin, and explored its mechanism of action, focusing on the role of mitochondrial Kv7.4 potassium channels. ERU was found to release H2S and protect H9c2 cells against oxidative damage. In an in vivo myocardial infarct model, ERU showed protective effects, reducing ischemic area, troponin I levels, and inflammatory outcomes, which were abolished by treatment with a Kv7.4 channel blocker. ERU also exhibited the characteristics of a mitochondrial potassium channel opener in isolated cardiac mitochondria and resulted in persulfidation of mitoKv7.4 channels.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Hematology
Jiayuan Zhong, Yili Sun, Yuan Han, Xiaoqiang Chen, Hairui Li, Yusheng Ma, Yanxian Lai, Guoquan Wei, Xiang He, Mengsha Li, Wangjun Liao, Yulin Liao, Shiping Cao, Jianping Bin
Summary: The study confirmed that hs-Mbs+US treatment can effectively dissolve both white and red thrombi and alleviate skeletal muscle IRI through US-triggered, organ-specific release of H2S. This integrated therapeutic strategy holds promise for treating thromboembolic diseases and subsequent IRI.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Anja V. Gruszczyk, Alva M. Casey, Andrew M. James, Hiran A. Prag, Nils Burger, Georgina R. Bates, Andrew R. Hall, Fay M. Allen, Thomas Krieg, Kourosh Saeb-Parsy, Michael P. Murphy
Summary: Cell models of cardiac ischemia-reperfusion injury are crucial for studying cardiac pathology, however, current monolayer cell models are inadequate in replicating in vivo injury. This study identified two reasons for the limitations: the presence of oxygen in cellular hypoxia models sustains mitochondrial oxidative phosphorylation, and the loss of lactate from cells during ischemia sustains glycolysis. By incubating isolated adult mouse cardiomyocytes anoxically and inhibiting lactate efflux, key markers of in vivo ischemia were recapitulated, allowing for the assessment of important aspects of cardiac IR injury in vitro.
Review
Cell Biology
Shuangyu Lv, Xiaotian Li, Shizhen Zhao, Huiyang Liu, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury refers to the changes in functional and structural changes during blood flow recovery after ischemia. Myocardial I/R injury, aggravated by sudden blood circulation disorder, is still not fully understood despite numerous studies. Hydrogen sulfide (H2S) has shown potential in improving myocardial I/R injury, but the underlying signal pathways remain unclear, warranting further research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stefanie Scheid, Max Goeller, Wolfgang Baar, Jakob Wollborn, Hartmut Buerkle, Gunther Schlunck, Wolf Lagreze, Ulrich Goebel, Felix Ulbrich
Summary: Experimental results confirm that inhaled H2S at appropriate concentrations can exert neuroprotective effects in rat retinal ischemia-reperfusion injury, reducing cell apoptosis and inflammation. H2S treatment modulates NF-kappa B activation and is expected to alleviate inflammation after retinal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Qiwei Hu, Changlei Zhu, Rynne A. Hankins, Allison R. Murmello, Glen S. Marrs, John C. Lukesh III
Summary: Hydrogen sulfide (H2S) is an important endogenous signaling molecule that plays a crucial role in neuroprotection, vasodilation, and hormonal regulation. This study explores the use of ortho-substituted, aryl boronate esters as donors for H2S release, identifying two different pathways: Lewis acid-facilitated hydrolysis and reactive oxygen species (ROS)-induced oxidation/cyclization. The study also demonstrates the development of an ROS-activated donor that synthesizes a benzoxazole-based fluorophore during H2S delivery, providing accurate monitoring of reaction progress and donor delivery of H2S in complex cellular environments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Liying Xu, Feng Ge, Yan Hu, Ying Yu, Kefang Guo, Changhong Miao
Summary: Sevoflurane postconditioning exerts hepatoprotective effects by inhibiting apoptosis, oxidative stress, and inflammatory response, improving survival rates in HIRI mice. Regulation of miR-142 and HMGB1 expression, as well as blocking the TLR4/NF-kappa B pathway activation, contribute to the protective effects of sevoflurane in hepatic I/R injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shuangyu Lv, Zhu Wang, Jie Wang, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury is a phenomenon characterized by restricting blood supply to organs followed by restoring blood flow and oxygenation, leading to various diseases. Autophagy, an important cellular pathway, plays a key role in maintaining cellular balance and participating in both physiological and pathological processes. Hydrogen sulfide (H2S) is a significant gas signal molecule that, along with carbon monoxide (CO) and nitric oxide (NO), regulates a range of physiological and pathological processes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhen Liu, Kai Hu, Yue-Sheng Chen, Ying-Jie Huang, Qian Hu, Wei Zeng, Yue Cao, Qin Xiao, Xue-Kang Zhang
Summary: This study reveals that JAK2/STAT3 signaling pathway suppresses autophagy during intestinal ischemia-reperfusion (I/R), and inhibiting JAK-STAT can protect against I/R injury by activating autophagy, providing new therapeutic targets for clinical treatment.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kun-Ling Tsai, Pei-Ling Hsieh, Wan-Ching Chou, Hui-Ching Cheng, Yu-Ting Huang, Shih-Hung Chan
Summary: The study suggests that DAPA may alleviate oxidative stress and cardiac apoptosis induced by ischemia/reperfusion injury through modulation of AMPK, improving cardiac function. Additionally, DAPA may protect cardiac cells by influencing mitochondrial function.
CELL AND BIOSCIENCE
(2021)
Review
Surgery
Peter W. Henderson, David Nash, Marta Laskowski, Robert T. Grant
AESTHETIC PLASTIC SURGERY
(2015)
Meeting Abstract
Surgery
Peter W. Henderson, Bhupesh W. Parasahar, David M. Otterburn, David I. Kutler, Marc A. Cohen, Jason A. Spector
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2015)
Article
Surgery
Philipp Franck, Peter W. Henderson, Kenneth O. Rothaus
CLINICS IN PLASTIC SURGERY
(2016)
Article
Surgery
Peter W. Henderson, John G. Fernandez, Yeliz Cemal, Babak J. Mehrara, Andrea L. Pusic, Colleen M. McCarthy, Evan Matros, Peter G. Cordeiro, Joseph J. Disa
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2016)
Article
Surgery
Peter W. Henderson, Wilmina Landford, Jason Gardenier, David M. Otterburn, Christine H. Rohde, Jason A. Spector
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2016)
Article
Oncology
Peter W. Henderson, David I. Kutler, Bhupesh Parashar, David M. Otterburn, Marc A. Cohen, Jason A. Spector
JOURNAL OF CONTEMPORARY BRACHYTHERAPY
(2016)
Article
Orthopedics
Benjamin F. Ricciardi, Peter W. Henderson, Alexander S. McLawhorn, Geoffrey H. Westrich, Mathias P. Bostrom, Lloyd B. Gayle
Article
Surgery
Alyssa J. Reiffel, Peter W. Henderson, John K. Karwowski, Jason A. Spector
ANNALS OF VASCULAR SURGERY
(2012)
Article
Surgery
Alyssa J. Reiffel, Allie M. Sohn, Peter W. Henderson, Natalia Fullerton, Jason A. Spector
JOURNAL OF CRANIOFACIAL SURGERY
(2012)
Review
Pediatrics
Deirdre C. Kelleher, Peter W. Henderson, Arnold Coran, Nitsana A. Spigland
PEDIATRIC SURGERY INTERNATIONAL
(2012)
Article
Surgery
Alyssa J. Reiffel, Peter W. Henderson, David D. Krijgh, Daniel A. Belkin, Ying Zheng, Lawrence J. Bonassar, Abraham D. Stroock, Jason A. Spector
PLASTIC AND RECONSTRUCTIVE SURGERY
(2012)
Article
Cell Biology
Peter W. Henderson, Sunil P. Singh, David D. Krijgh, Masaya Yamamoto, Daniel C. Rafii, Josephine J. Sung, Shahin Rafii, Sina Y. Rabbany, Jason A. Spector
WOUND REPAIR AND REGENERATION
(2011)
Article
Surgery
Brianne Sullivan, Isabel Ryan, Peter W. Henderson
Summary: The study compared FDA-approved breast implant products from four companies and highlighted the market trends. Technological innovation and the recognition of BIA-ALCL have led to changes in breast implant products, helping surgeons make decisions on breast implant procedures.
AESTHETIC PLASTIC SURGERY
(2021)
Letter
Surgery
Eric Bao, Annet Kuruvilla, Paul Shay, Taylor Ibelli, Peter Henderson
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Letter
Surgery
Jake M. Sharaf, Jordan Jacobs, Peter W. Henderson