Article
Clinical Neurology
Lawrence R. Robinson
Summary: This article reviews the epidemiology, classification, localization, prognosis, and mechanisms of recovery of traumatic peripheral nerve injuries (PNIs). Electrodiagnostic assessments are critical in treating patients with PNIs, as they aid in localizing the injury and determining the extent of axon loss. Mechanisms of recovery may include recovery from conduction block, muscle fiber hypertrophy, distal axonal sprouting, and axon regrowth. Early surgical intervention is recommended for patients with complete or severe nerve injuries.
Article
Neurosciences
Cosmin I. Ciotu, Katrin Kistner, Ulrich Kaindl, Flavia Millesi, Tamara Weiss, Christine Radtke, Andreas Kremer, Katy Schmidt, Michael J. M. Fischer
Summary: Signal propagation is the key function of nerves. Lysophosphatidic acid 18:1 (LPA) selectively stimulates calcium signaling in Schwann cells but not neurons. Experimental observations in mice show clear changes in axonal function, with slowing and amplitude reduction in compound action potentials due to LPA exposure. Structural investigations reveal that LPA leads to evagination of axons in rat nerves, affecting myelination and conduction velocity. These structural and functional changes might explain sensory sensations such as itch and pain.
Article
Clinical Neurology
Anna Lena Fisse, Aristeidis H. Katsanos, Ralf Gold, Christos Krogias, Kalliopi Pitarokoili
Summary: The systematic review and meta-analysis of lower extremity nerves CSA reference values show differences in CSA among different regions and nerve sites, providing a basis for the development of an international standardized evaluation protocol.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Dermatology
Aishwarya Raja, Jamie Karch, Allen F. Shih, Henriette De La Garza, Antonio Jesus De Zepeda Diaz, Mayra B. C. Maymone, Tania J. Phillips, Eric Secemsky, Neelam Vashi
Summary: In this article, the epidemiology of peripheral vascular disease, its association with cutaneous symptoms, and the diagnosis and evaluation of cutaneous features of vascular disorders are reviewed. With the increasing prevalence of peripheral vascular disease globally, it is crucial for dermatologists to accurately recognize and diagnose cutaneous manifestations and direct individuals to receive appropriate care and treatment.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Engineering, Biomedical
Carrie A. Kubiak, Shelby R. Svientek, Amir Dehdashtian, Nathan G. Lawera, Vidhya Nadarajan, Jarred Bratley, Theodore A. Kung, Paul S. Cederna, Stephen W. P. Kemp
Summary: The muscle cuff regenerative peripheral nerve interface (MC-RPNI) can amplify efferent motor action potentials from intact nerves by several magnitudes without negatively impacting distal muscle function.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Aayush Kant, Victoria E. Johnson, John D. Arena, Jean-Pierre Dolle, Douglas H. Smith, Vivek B. Shenoy
Summary: This study investigated the mechanical stress transfer in axonal cytoskeleton after concussion, indicating the protective role of myelin sheath and actin/spectrin cortex in shielding microtubules from tissue stress. Softer axonal cortex leads to higher susceptibility of microtubules to failure. Both single and repetitive concussions were found to contribute to postinjury spectrin degradation, with more severe pathology observed following repetitive injuries.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Manufacturing
Andrea La Monaca, James W. Murray, Zhirong Liao, Alistair Speidel, Jose A. Robles-Linares, Dragos A. Axinte, Mark C. Hardy, Adam T. Clare
Summary: Material removal operations are crucial for manufacturing key components in engineering systems. Understanding the influence of machining-induced features on advanced materials' performance is essential at finer temporal and spatial scales. The interplay between metallurgical and micro-mechanical conditions induced by material removal processes and their in-service response will be thoroughly explored in this review.
INTERNATIONAL JOURNAL OF MACHINE TOOLS & MANUFACTURE
(2021)
Article
Biology
Nina Sarah Hoeger, Thomas Mittlmeier, Brigitte Vollmar, Ioannis Stratos, Geoffrey P. Dobson, Robert Rotter
Summary: Skeletal muscle injuries are common and often do not require surgery. ALM therapy, a novel solution, has shown promising results in improving muscle regeneration and reducing cell apoptosis. This study confirms the protective effects of ALM on traumatized skeletal muscle, suggesting that it could be a useful adjunct therapy option in clinical practice.
Article
Cell Biology
Daniel Hellenbrand, Clayton L. Haldeman, Jae-Sung Lee, Angela G. Gableman, Elena K. Dai, Stephen D. Ortmann, Jerrod C. Gotchy, Kierra K. Miller, Adrianna M. Doucas, Nicole C. Nowak, William L. Murphy, Amgad S. Hanna
Summary: The gold standard for treating peripheral nerve injuries with large nerve gaps is autologous nerve grafts. However, incorporating mineral coated microparticles (MCMs) to release growth factors like NGF and GDNF can significantly enhance axon growth and improve limb function in rats with nerve grafts.
NEURAL REGENERATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Jingqin Chen, Adam C. Sedgwick, Sajal Sen, Yaguang Ren, Qinchao Sun, Calvin Chau, Jonathan F. Arambula, Tridib Sarma, Liang Song, Jonathan L. Sessler, Chengbo Liu
Summary: The study evaluates two expanded porphyrins as contrast agents for photoacoustic imaging, which have good absorption in the NIR-II region and can respond to stimuli. The use of OctaNPs allows visualization of changes in the acidic environment of the stomach and differentiation between cancerous and healthy tissues.
Article
Engineering, Electrical & Electronic
Yoshiaki Adachi, Shigenori Kawabata, Jun Hashimoto, Yoshinori Okada, Yoshihisa Naijo, Taishi Watanabe, Yuki Miyano, Gen Uehara
Summary: The improved biomagnetometer system based on SQUID technology was developed for magnetoneurograms, with enhanced sensor array dimensions and modified cryostat design to facilitate examination of peripheral nerves at different body parts in various postures. Functional imaging of the brachial plexuses in symptom-provocative positions was successfully achieved with this improved system.
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2021)
Article
Pharmacology & Pharmacy
Aline Yen Ling Wang, Kuan-Hung Chen, Hsiu-Chao Lin, Charles Yuen Yung Loh, Yun-Ching Chang, Ana Elena Avina, Chin-Ming Lee, I-Ming Chu, Fu-Chan Wei
Summary: Vascularized composite allotransplantation is a strategy for reconstructing unique defects like amputated limbs. To ensure the function of transplanted limbs, the recovery of the anastomosed nerves is crucial. Tacrolimus has been shown to promote nerve recovery but has risks of systemic complications. A mixed thermosensitive hydrogel was developed for sustained release of tacrolimus, which improved functional recovery of injured nerves without adverse effects.
Review
Chemistry, Multidisciplinary
Abhishek Sirohiwal, Dimitrios A. Pantazis
Summary: In this paper, the authors highlight the importance of quantum-chemistry based excited-state computations and large-scale molecular dynamics simulations in understanding the primary events of oxygenic photosynthesis. The research reveals the mechanism of charge separation in the primary enzyme of oxygenic photosynthesis and provides insights into the factors that enable photosynthesis beyond the red limit.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Inorganic & Nuclear
Chisa Itoh, Haruka Yoshino, Taku Kitayama, Wataru Kosaka, Hitoshi Miyasaka
Summary: A new synthetic route for constructing functional paddlewheel diruthenium(II,II) complexes was developed, utilizing Schiff base condensation reactions. The attached Schiff base groups significantly affected the electronic states of the resulting complexes, as revealed by cyclic voltammetry and DFT calculations.
DALTON TRANSACTIONS
(2024)
Review
Thermodynamics
M. M. Mahmoud, T. G. Karayiannis
Summary: The study focuses on assessing the discrepancies in performance of enhanced surfaces for pool boiling heat transfer, providing insights into understanding the impact of fluid-surface combinations. Challenges in evaluating performance, effects of fluid type, and heat transfer enhancement mechanisms are discussed, with future recommendations for researchers. The paper aims to guide researchers in concluding on the best surface structure and manufacturing technique for specific fluids.
THERMAL SCIENCE AND ENGINEERING PROGRESS
(2021)
Review
Anatomy & Morphology
Jonathan I. Leckenby, Miranda A. Chacon, Kerstin Rolfe, Jeff W. Lichtman, Adriaan O. Grobbelaar
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2019)
Article
Surgery
Daniel P. Butler, Alethse De la Torre, Gregory H. Borschel, Tessa A. Hadlock, Carien Beurskens, Kathleen Bogart, Alexander Cardenas Mejia, Christopher Coombs, Jocelyne Copeland, Jacqueline Diels, Teresa Gonzalez-Otero, Louise Graham, Lisa Ishii, Raman Malhotra, Adelaida Martinez, Lisa McKinley, Mara W. Robinson, Sinikka Suominen, Akihiko Takushima, Evangelina Vazquez Curiel, Faye L. Wachs, Adriaan O. Grobbelaar
JAMA FACIAL PLASTIC SURGERY
(2019)
Article
Surgery
Jonathan Leckenby, Miranda A. Chacon, Adriaan O. Grobbelaar, Jeff W. Lichtman
JOURNAL OF SURGICAL RESEARCH
(2019)
Article
Orthopedics
Ioana Lese, Adriaan O. Grobbelaar, Dan Sabau, Alexandru Georgescu, Mihai A. Constantinescu, Radu Olariu
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2020)
Article
Surgery
Ioana Lese, Raphael Biedermann, Mihai Constantinescu, Adriaan O. Grobbelaar, Radu Olariu
Summary: This study aimed to identify individual risk factors leading to flap failure and vascular compromise in free tissue transfers and to create a predictability index. Patients with moderate and high-risk indices had significantly higher chances of vascular compromise. Additionally, the American Society of Anesthesiologists (ASA) classification was found to be a predictor of complications in free tissue transfer.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Surgery
A. C. S. Woollard, J. W. Lichtman, K. Rolfe, A. O. Grobbelaar
Summary: The study found that reinnervation occurs after nerve repair or graft, but the number and calibre of regenerating axons can vary, leading to smaller motor units. While all NMJ were reoccupied by regenerating axons, there were significant differences in the way small axons are remodelled between nerve repair and nerve graft groups.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Orthopedics
Stefanie Hirsiger, Heather Dawson, Adrian Ockert Grobbelaar, Esther Voegelin
Summary: This case presents a 31-year-old woman with a tumor on the ulnar side of her dominant right hand, which she had been experiencing for 12 months. The histopathological diagnosis revealed an atypical pleomorphous lipomatous tumor, a recently classified entity in the World Health Organization Classification of Soft Tissue and Bone Tumors.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2022)
Article
Cell & Tissue Engineering
David Milek, Scott R. Echternacht, Jonnby LaGuardia, Dalton LaBarge, Loel Turpin, Adriaan Grobbelaar, Jonathan Leckenby
Summary: A study aimed to evaluate the ability of Murphy Roths Large (MRL/MpJ) mice to heal with minimal or no scar formation in peripheral nerve regeneration. Although the MRL/MpJ strain demonstrated superior histological outcomes, there was no significant difference in functional outcomes compared to the C57BL/6J strain.
REGENERATIVE MEDICINE
(2023)
Article
Surgery
F. Ulrich, L. Elahi, L. Schiraldi, A. Grobbelaar, W. Raffoul
Summary: Radiofrequency (RF) is commonly used for aesthetic treatments, but it can lead to severe complications requiring reconstructive surgery.
Article
Medicine, General & Internal
Jeremy Bruhlmann, Ioana Lese, Adriaan O. Grobbelaar, Claudia Fischlin, Mihai Constantinescu, Radu Olariu
Summary: The study found that mentioning medical indications in the application letter increased the chances of insurance approval, while mentioning mental suffering decreased the likelihood of a positive response. High initial BMI and BMI reduction were associated with higher approval rates by insurance companies. Submitting an additional application letter to the insurance company and mentioning mechanical restrictions were also found to be associated with positive responses.
SWISS MEDICAL WEEKLY
(2022)
Article
Surgery
Helene Sophie Scheer, Yara Banz, Adriaan O. Grobbelaar, Esther Voegelin
Summary: The field of vascular anomalies has undergone changes in the past few decades, with pyogenic granuloma being the most commonly described anomaly. Hand surgeons have limited exposure to vascular anomalies, with arteriovenous fistula, venous aneurysms, and venous malformations being rare in hand surgery.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2021)
Review
Surgery
I. P. E. Bayard, A. O. Grobbelaar, M. A. Constantinescu
Summary: Necrotizing fasciitis (NF) is a rare and potentially fatal skin and soft tissue infection. Cases caused by mono-bacterial gram-negative organisms, particularly E. coli, are on the rise. Treatment involves radical debridement and antibiotic therapy, but short-term survival remains low.
Review
Surgery
Konstantinos Gasteratos, Saif Al Azzawi, Nikolaos Vlachopoulos, Ioana Lese, Georgia-Alexandra Spyropoulou, Adriaan O. Grobbelaar
Summary: This paper presents a systematic review of microsurgical free functional muscle transfer procedures in pediatric facial palsy, highlighting the long-term functional, aesthetic, and psychosocial outcomes achieved. The use of CFNG plus FFMT in a two-stage procedure may restore spontaneous emotional smiles in affected children, potentially due to greater brain plasticity in comparison to adults.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Surgery
Radu Olariu, Helen Laura Moser, Ioana Lese, Dan Sabau, Alexandru Valentin Georgescu, Adriaan Ockert Grobbelaar, Mihai Adrian Constantinescu
ARCHIVES OF PLASTIC SURGERY-APS
(2020)
Article
Surgery
Jonathan I. Leckenby, Rachel Deegan, Adriaan O. Grobbelaar
ANNALS OF PLASTIC SURGERY
(2018)