Journal
PLANTA MEDICA
Volume 80, Issue 8-9, Pages 671-675Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1368592
Keywords
Schisandra chinensis; Schisandraceae; dibenzocyclooctadiene lignans; microglia; nitric oxide; structure-activity relationship
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Funding
- Natural Science Foundation of China [81202891]
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To explore the relationship of the dibenzocyclooctadiene lignans from Schisandra chinensis to their anti-inflammatory activities, series of dibenzocyclooctadiene lignans were isolated and assessed by testing their inhibitory effects on nitric oxide production in lipopolysaccharide-induced BV2 mouse microglia. It was found, for the first time, that dibenzocyclooctadiene lignans which have S-biphenyl and methylenedioxy groups strongly inhibited LPS-induced microglia activation. The methoxy group on the cyclooctadiene introduced more effectiveness, but the presence of an acetyl group on the cyclooctadiene or hydroxyl group on C-7 decreased the inhibitory activity.
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