Journal
PLANTA MEDICA
Volume 79, Issue 5, Pages 313-321Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1328211
Keywords
natural phenolic compounds; ischemic stroke; neuroprotection; hippocampus
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Funding
- Brain Research Center of the 21st Century Frontier Research Program [2010K000823]
- Republic of Korea
- Ministry of Education, Science and Technology [2010-0010580]
- National Research Foundation of Korea (NRF)
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We investigated effects of caffeic acid, syringic acid, and their synthesis on transient cerebral ischemic damage in the gerbil hippocampal CA1 region. In the 10 mg/kg caffeic acid-, syringic acid-, and 20 mg/kg syringic-treated ischemia groups, we did not find any significant neuroprotection in the ischemic hippocampal CA region. In the 20 mg/kg caffeic acid- and 10 mg/kg caffeic acid-syringic acid- treated ischemia groups, moderate neuroprotection was found in the hippocampal CA1 region. In the 20 mg/kg caffeic acid- syringic acid- treated ischemia group, a strong neuroprotective effect was found in the ischemic hippocampal CA1 region: about 89% of hippocampal CA1 region pyramidal neurons survived. We also observed changes in glial cells (astrocytes and microglia) in the ischemic hippocampal CA1 region in all the groups. Among them, the distribution pattern of the glial cells was only in the 20 mg/kg caffeic acid- syringic acid- treated ischemia group brief, 20 mg/kg caffeic acid-syringic acid showed a strong neuroprotective effect with an inhibition of glia activation in the hippocampal CA1 region induced by transient cerebral ischemia.
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