Journal
PLANTA MEDICA
Volume 79, Issue 9, Pages 782-787Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1328550
Keywords
Nauclea officinalis; Rubiaceae; indole alkaloid; anti-inflammatory effect
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Funding
- National Natural Science Foundation of China [81102781]
- Taishan Scholar Project
- Undergraduate Scientific and Technological Innovation Project of Yantai University [121408]
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3-(Hydroxymethyl)-6,7-dihydroindolo[2,3-a]quinolizin-(12H)-one is a bioactive indole alkaloid isolated from Nauclea officinalis, a plant species which is used as a traditional Chinese medicine. We investigated the anti-inflammatory properties of 3-(hydroxymethyl)-6,7-dihydroindolo [2,3-a] quinolizin-(12H)-one in RAW 264.7 murine macrophages. The results indicated that it inhibited the overproduction of NO and the release of TNF-alpha. Furthermore, this compound inhibited the expression of iNOS and COX-2 proteins, the enzymatic activity of iNOS, and the translocation of NF-kappa B to the nucleus induced by LPS. Therefore, we suggested that the effect of 3-(hydroxymethyl)-6,7-dihydroindolo[2,3-a] quinolizin-(12H)-one-mediated inhibition of the expression of LPS-induced iNOS and COX-2 genes is due to the suppression of NF-kappa B activation in the transcriptional level.
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