Article
Oncology
Jin Gu, Erlei Zhang, Binyong Liang, Zunyi Zhang, Xiaoping Chen, Min Xiong, Zhiyong Huang
Summary: In HCC patients with Child-Pugh grade A liver function, cirrhosis staging can be determined by measuring liver collagen contents using Collagen Proportional Area (CPA), which significantly affects the risk of Posthepatectomy Liver Failure (PHLF). The study also found a significant correlation between CPA and a non-invasive method called Cirrhotic Severity Scoring (CSS) proposed by the team, showing that higher CPA values and extent of hepatectomy are independent risk factors for PHLF, and there is a positive correlation between CPA and CSS.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jiang Li, Hai-su Tao, Jian Li, Wen-qiang Wang, Wei-wei Sheng, Zhi-yong Huang, Er-lei Zhang
Summary: This study compared the efficacy of liver resection (LR) and percutaneous microwave coagulation therapy (PMCT) for small hepatocellular carcinoma (HCC) with different degrees of liver cirrhosis. LR provided better surgical outcomes but PMCT had similar long-term results and lower surgical complications in HCC patients with severe cirrhosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Koya Yasukawa, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Kiyotaka Hosoda, Hikaru Hayashi, Yuji Soejima
Summary: This study aimed to investigate the impact of liver fibrosis on the prognosis of patients with hepatocellular carcinoma (HCC). The results showed that patients with more severe liver fibrosis had worse cancer-specific prognosis. Moreover, patients with liver fibrosis had a higher incidence of multiple recurrences.
Article
Nutrition & Dietetics
Xuan-vinh Kevin Nguyen, Jason Zhang, Ken Lee Chin, Stephen Bloom, Amanda J. Nicoll
Summary: This study compared the characteristics and survival rates of NAFLD-HCC patients to non-NAFLD-HCC patients, finding that NAFLD-HCC patients were more likely to be diagnosed based on symptoms and at an older age, with lower survival rates.
Article
Oncology
Michelle Junyi He, Wenjun Pu, Xi Wang, Xiaoni Zhong, Dong Zhao, Zhipeng Zeng, Wanxia Cai, Jiayi Liu, Jianrong Huang, Donge Tang, Yong Dai
Summary: This study utilized mass spectrometry mediated spatial metabolomics technique to investigate the metabolic changes in hepatocellular carcinoma (HCC). The results revealed that amino acid metabolism and glycerophospholipid metabolism exhibited the most significant alterations during HCC progression, and these altered metabolites and pathways were interconnected through the urea cycle.
CANCER CELL INTERNATIONAL
(2022)
Article
Genetics & Heredity
Zhaobin He, Cheng Peng, Tianen Li, Jie Li
Summary: This study used single cell differentiation trajectory analysis to investigate the relevance of liver cirrhosis and hepatocellular carcinoma (HCC). It was found that the cell differentiation trajectory of liver cirrhosis can predict the prognosis of HCC, providing new perspectives on the mechanisms of progression from liver cirrhosis to HCC.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Ji H. Nahm, Hye S. Lee, Haeryoung Kim, Sun Y. Yim, Ji-hyun Shin, Jeong E. Yoo, Sang H. Ahn, Jin S. Choi, Ju-Seog Lee, Young N. Park
Summary: This study developed a nomogram for predicting late recurrence of hepatocellular carcinoma (HCC) based on clinicopathological and molecular factors. The combination of pSTAT3, pERK1/2 and SYK immunoexpression with high lobular inflammatory activity and cirrhosis was found to predict late HCC recurrence.
LIVER INTERNATIONAL
(2021)
Article
Cell Biology
Naoto Fujiwara, Naoto Kubota, Emilie Crouchet, Bhuvaneswari Koneru, Cesia A. Marquez, Arun K. Jajoriya, Gayatri Panda, Tongqi Qian, Shijia Zhu, Nicolas Goossens, Xiaochen Wang, Shuang Liang, Zhenyu Zhong, Sara Lewis, Bachir Taouli, Myron E. Schwartz, Maria Isabel Fiel, Amit G. Singal, Jorge A. Marrero, Austin J. Fobar, Neehar D. Parikh, Indu Raman, Quan-Zhen Li, Masataka Taguri, Atsushi Ono, Hiroshi Aikata, Takashi Nakahara, Hayato Nakagawa, Yuki Matsushita, Ryosuke Tateishi, Kazuhiko Koike, Masahiro Kobayashi, Takaaki Higashi, Shigeki Nakagawa, Yo-ichi Yamashita, Toru Beppu, Hideo Baba, Hiromitsu Kumada, Kazuaki Chayama, Thomas F. Baumert, Yujin Hoshida
Summary: This study analyzed multiple cohorts of NAFLD patients globally to define and validate signatures predictive of long-term HCC risk in NAFLD patients. These signatures can accurately predict the risk of developing HCC in patients and provide assistance for clinical treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biology
Abdolamir Allameh, Nico Huettmann, Edouard Charlebois, Angeliki Katsarou, Wen Gu, Konstantinos Gkouvatsos, Elisa Pasini, Mamatha Bhat, Zoran Minic, Maxim Berezovski, Maria Guido, Carine Fillebeen, Kostas Pantopoulos
Summary: HJV has a hepatoprotective function and its deficiency in mice leads to mitochondrial dysfunction and hepatocarcinogenesis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Nutrition & Dietetics
Silvia Ferri, Bernardo Stefanini, Lorenzo Mulazzani, Margherita Alvisi, Francesco Tovoli, Simona Leoni, Luca Muratori, Tommaso Lotti, Alessandro Granito, Luigi Bolondi, Fabio Piscaglia
Summary: The role of moderate alcohol consumption in the evolution of NAFLD is still debated. This study evaluated the impact of current and lifelong alcohol consumption in NAFLD patients using a new estimation tool called LACU. The results showed that very low alcohol consumption was associated with lower rates of cirrhosis and hepatocellular carcinoma compared to abstainers and moderate consumers.
Article
Oncology
Ming-Wei Lai, Yu-De Chu, Chao-Wei Hsu, Yi-Cheng Chen, Kung-Hao Liang, Chau-Ting Yeh
Summary: Gut dysbiosis and impaired intestinal barrier are associated with different liver diseases, affecting the systemic immune environment through the gut-liver axis. This study identified common network features in patients with liver cirrhosis or hepatocellular carcinoma (HCC), as well as disease-specific signatures. Alterations in gut microbial/viral composition may contribute to pre-HCC disorders, metabolic reprogramming, or inflammatory microenvironments for hepatocarcinogenesis.
Article
Biochemical Research Methods
Gabor Toth, Domonkos Pal, Simon Sugar, Ilona Kovalszky, Katalin Dezso, Gitta Schlosser, Laszlo Drahos, Lilla Turiak
Summary: This study investigated the content and sulfation pattern of chondroitin sulfate (CS) and heparan sulfate (HS) in human hepatocellular carcinoma and cirrhotic liver tissues, considering the etiology of the diseases. Major differences were observed in the total abundance and sulfation pattern of CS and HS chains, providing important insights into the molecular mechanisms of chronic liver diseases.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Cell Biology
Venkateish Vp, Anbarasu Kannan, Madan Kumar Perumal
Summary: Extracellular vesicles, membrane-bound cargos of varying size, play a vital role in transmitting information between cells and organs. In obesity, dysfunctional adipocytes release extracellular vesicles with altered cargo contents, contributing to the progression of chronic liver diseases. This review extensively discusses the impact of adipocyte-derived extracellular vesicles on liver inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma, highlighting the need for newer approaches to utilize these vesicles as biomarkers for diagnosing initial liver inflammation before it becomes irreversible.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Oncology
Rosemary E. E. Faulkes, Zaira Rehman, Swetha Palanichamy, Nekisa Zakeri, Chris Coldham, Bobby V. M. Dasari, M. Thamara P. R. Perera, Neil Rajoriya, Shishir Shetty, Tahir Shah
Summary: Screening for liver cancer is recommended for high-risk patients, but the impact on survival is unclear. This study found that patients diagnosed through surveillance had smaller tumours and earlier stage cancer, but no difference in survival compared to patients not included in surveillance. Liver cirrhosis plays a significant role in tumour behaviour in HCC.
Article
Multidisciplinary Sciences
Hao-dan Mao, Shu-qin Zheng, Su-hua Yang, Ze-yu Huang, Yuan Xue, Min Zhou
Summary: This study aimed to evaluate the prediction values of non-invasive models for HCC development in HBV-related liver cirrhosis patients with long-term NA treatment. The results showed that the model (Age_DC_PLT_TBil) consisting of age, DC stage, PLT, and TBil had higher prediction accuracy and can be used as an alternative for predicting HCC development in HBV-related DC patients.