Review
Biochemistry & Molecular Biology
Anna Och, Marek Och, Renata Nowak, Dominika Podgorska, Rafal Podgorski
Summary: Berberine, a plant alkaloid, has various health benefits including preventing atherosclerosis, type 2 diabetes, obesity, and cancer. It improves blood glucose and insulin resistance, stimulates insulin secretion, and inhibits glucose and fat synthesis in the liver. It also has anti-inflammatory, neuroprotective, and anticancer effects.
Article
Biochemistry & Molecular Biology
Miguel Z. Martin-Gonzalez, Hector Palacios-Jordan, Anna Mas-Capdevila, Miguel A. Rodriguez, Francisca Bravo, Begona Muguerza, Gerard Aragones
Summary: The study found that long-term administration of MIX can improve cardiometabolic risk factors associated with MetS in rats fed a cafeteria diet, including improvements in lipid and glucose homeostasis, as well as significant antihypertensive properties.
Review
Endocrinology & Metabolism
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: Metabolic syndrome is a complex metabolic disorder characterized by obesity, hyperglycemia, hypertension, and hyperlipidemia. Insulin resistance, adipose tissue dysfunction, and chronic inflammation are believed to play a role in the development of metabolic syndrome, but effective clinical prevention and treatment measures are still lacking. Studies have shown that myostatin (MSTN) may be a potential therapeutic target for metabolic syndrome as it is involved in the development of obesity, hyperlipidemia, diabetes, and hypertension. This article discusses the transcriptional regulation and receptor binding pathway of MSTN, its role in regulating mitochondrial function and autophagy, and reviews the progress of MSTN research in metabolic syndrome. Additionally, MSTN inhibitors under clinical trial are summarized and proposed as potential targets for the treatment of metabolic syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Medicine, Legal
Roger W. Byard, Ian Musgrave
Summary: The recent cases of sudden deaths of previously healthy dogs in Victoria, Australia, associated with the ingestion of raw meat contaminated by indospicine from native Australian plants, highlight the potential risks of herbal toxicity in domestic animals. The use of herbal remedies in domestic animals, while increasing, lacks sufficient evidence of efficacy and poses risks of adverse effects.
FORENSIC SCIENCE MEDICINE AND PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohanambal Moorthy, Chong Chun Wie, Eliana Marino, Uma D. Palanisamy
Summary: In this study, it was found that Geraniin and its enriched extract, GEE, can improve high-fat diet-induced metabolic syndrome. Although the composition of gut microbiota was not significantly altered by geraniin and GEE, the relative abundance of butyrate-producing bacteria increased, suggesting a potential prebiotic role.
Review
Biotechnology & Applied Microbiology
Yan-Xia Liu, Yan-He Zhou, Chang-Hong Jiang, Junyan Liu, Ding-Qiang Chen
Summary: The COVID-19 pandemic is ongoing and countries such as China have been widely using herbal medicine for prevention and treatment with positive outcomes. However, the clinical and economic value of herbal medicine in COVID-19 treatment has not been fully evaluated.
Article
Agriculture, Dairy & Animal Science
Karrar I. A. Al-Shammari, Justyna Batkowska, Magdalena Gryzinska, Lukasz Wlazlo, Mateusz Ossowski, Bozena Nowakowicz-Debek
Summary: The aim of this study was to evaluate the effects of disinfection with aqueous solutions of ginger, garlic, oregano, and cinnamon extracts on microbial traits, hatchability, and chick quality. The results showed that these plant extracts had good antimicrobial properties and did not affect hatchability and chick growth.
Article
Spectroscopy
Qian Chang, Lili Lan, Wanzhen Xiao, Yong Guo, Guoxiang Sun
Summary: This study established an integrated quality control method based on fingerprint and four-dimensional antioxidant activity profile. The method combined comprehensive ratio quantitative fingerprint method, multi-markers assay, and online-HPLC-DPPH-FIA method to achieve consistency control and antioxidant capacity prediction of herbal preparations. The results showed that mid-level data fusion of the four types of data produced better classification results.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Claire Mayer, Martine Come, Lionel Ulmann, Isabelle Martin, Graziella Chini Zittelli, Cecilia Faraloni, Khadija Ouguerram, Benoit Chenais, Virginie Mimouni
Summary: The study found that the microalgae Diacronema lutheri, which is rich in n-3 LC-PUFAs, has beneficial effects on metabolic disorders associated with obesity, preventing weight gain and improving lipid and glucose homeostasis.
Article
Medicine, General & Internal
Khin Thandar Htun, Krit Jaikumkao, Jie Pan, Aye Thidar Moe Moe, Nuttawadee Intachai, Sasivimon Promsan, Anusorn Lungkaphin, Monruedee Tapanya, Duanghathai Pasanta, Montree Tungjai, Siriprapa Kaewjaeng, Hong Joo Kim, Jakrapong Kaewkhao, Christopher Lai, Suchart Kothan
Summary: This study investigated the relationship between ectopic fat distribution and metabolite profiles induced by high-fat diets in rats. Visceral fat was found to have the strongest correlation with blood cholesterol levels, while liver fat content showed high correlation with specific metabolites like (-CH2)(n) VLDL/LDL and lactate. Five potential metabolic biomarkers were identified to differentiate between high-fat diet and normal diet groups.
Review
Physiology
Runyu Miao, Xinyi Fang, Jiahua Wei, Haoran Wu, Xinmiao Wang, Jiaxing Tian
Summary: The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a key regulator of glucose and lipid metabolism and plays a vital role in maintaining the steady state of metabolism and cellular responses. It can be considered as a potential drug target for the treatment of metabolic syndrome.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ancuta Cristina Raclariu-Manolica, Quentin Mauvisseau, Hugo J. de Boer
Summary: Although herbal medicines and preparations are widely used in healthcare systems globally, there are concerns about their quality and safety. The introduction of new herbal products under varying regulatory frameworks, with no global consensus on their definition or characterization, creates concerns about contamination and profit-driven adulteration. Collaboration between industry, academia, and regulatory bodies is necessary to develop innovative strategies for identification and authentication of botanicals and their preparations to ensure quality control.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Veterinary Sciences
Asmaa M. El-kady, Iman A. M. Abdel-Rahman, Eman Sayed, Majed H. Wakid, Hussah M. Alobaid, Khalil Mohamed, Eman Abdullah Alshehri, Hayam Elshazly, Wafa Abdullah I. Al-Megrin, Furhan Iqbal, Hatem A. Elshabrawy, Ashraf G. Timsah
Summary: This study evaluated the efficacy of Artemisia annua extract in treating experimentally induced trichinellosis. The results showed that A. annua treatment reduced the number of adult worms in the intestine, restored normal intestinal architecture, and alleviated inflammation, highlighting its therapeutic potential for intestinal trichinellosis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Qi Yao, Xue Zhu, Maozhen Han, Chaoyun Chen, Wei Li, Hong Bai, Kang Ning
Summary: With the development of high-throughput sequencing technology, the multi-barcode sequencing approach has been successfully used to identify biological ingredients in Traditional Chinese Medicine (TCM) preparations. In this study, the approach was applied to four representative TCM preparations, and the results showed good universality, sensitivity, and reliability in decoding the herbal materials in these preparations.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Physical
Ya-Li Zhang, Ya-Lei Wang, Ke Yan, Qi-Qi Deng, Fang-Zhou Li, Xing-Jie Liang, Qian Hua
Summary: Through the study of nanomaterials in Chinese herbal medicines (CHMs), the material basis of CHMs can be understood, and their applications in specific disease treatment can be explored. These CHM-derived nanostructures include extracted CHMs, polymer nanoparticles, liposomes, micelles, and nanofibers. The therapeutic efficacy of CHMs can be effectively studied using these nanostructures, but there are still challenges and opportunities in their development.
NANOSCALE HORIZONS
(2023)
