Article
Microbiology
Jan S. Stenkiewicz-Witeska, Iuliana V. Ene
Summary: Fungal infections are on the rise, causing over 1.5 billion cases and more than 1 million deaths annually. Candida infections, particularly in high-risk populations, are frequent due to the development of drug resistance and tolerance. The limited availability of antifungal drugs and the expansion of multidrug-resistant species have further contributed to the decline in their efficacy. Combining different categories of azole potentiators, including natural, repurposed, or novel compounds, can help prolong their utility.
Article
Microbiology
Amir Arastehfar, Melika Laal Kargar, Shahla Roudbar Mohammadi, Maryam Roudbary, Nayereh Ghods, Ladan Haghighi, Farnaz Daneshnia, Mahin Tavakoli, Jalal Jafarzadeh, Mohammad Taghi Hedayati, Huiwei Wang, Wenjie Fang, Agostinho Carvalho, Macit Ilkit, David S. Perlin, Cornelia Lass-Floerl
Summary: RVVC is a common fungal infection that may be caused by dysbiosis and other factors. FLZR and FLZT phenotypes were found to contribute to fluconazole therapeutic failure, with Iran having a heavy burden of RVVC. Research on RVVC remains limited.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Pao-Yu Chen, Yu-Chung Chuang, Un-In Wu, Hsin-Yun Sun, Jann-Tay Wang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang
Summary: The study found that azole resistance and trailing in Candida tropicalis differ phenotypically and genotypically, mainly due to mutations and up-regulation of ERG11 and MDR1 genes.
Review
Dermatology
Jack D. D. Sobel, Sreya Sebastian, Dina A. A. Boikov
Summary: This study evaluated the long-term antifungal susceptibility in patients with recurrent vulvovaginal candidiasis (RVVC) and found that resistance to fluconazole remained stable with rare reversal despite long-term use of the drug.
Article
Pharmacology & Pharmacy
Hongkang Wang, Zhe Ji, Yanru Feng, Tianhua Yan, Yongbing Cao, Hui Lu, Yuanying Jiang
Summary: Inhibiting sphingolipid biosynthesis to block membrane localization and inactivate Cdr1 was found to enhance the antifungal activity of azoles against azole-resistant C. albicans, suggesting its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Victoria McPherson, Haley Wolhart, Lindsay Engels, Kiah Sullivan, Angel Coria, Teresa Bicchieri, Brendon Torrey, P. Clint Spiegel, Sam Danforth, Gil Belofsky, Blaise Dondji
Summary: This study reports the isolation, characterization, and ex vivo bioassays of metabolites from Dalea pogonathera A. Gray, including a new chalcone pogonatheridin A (1) and three new prenylated flavanones (3, 6, and 12). Pogonatheridin A (1) exhibited significant activity against Ancylostoma ceylanicum hookworms, while the other compounds showed weak or no activity. Additionally, some of the compounds demonstrated toxicity towards healthy mammalian cells. The findings suggest the potential of Dalea spp. metabolites and provide valuable toxicity information.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Ewa Ksiezopolska, Miquel Angel Schikora-Tamarit, Reinhard Beyer, Juan Carlos Nunez-Rodriguez, Christoph Schuller, Toni Gabaldon
Summary: Fungal infections are becoming a growing concern in medicine, largely due to increased resistance to antifungal drugs. This study used experimental microevolution to examine the adaptation of the yeast pathogen Candida glabrata to two widely used antifungal drugs.
Article
Biochemistry & Molecular Biology
Mohammad Imran Khan, Hani Choudhry, Sadaf Jahan, Irfan A. A. Rather
Summary: With the increasing prevalence of multi-drug-resistant fungal infections, especially in developing countries, the development of new strategies and drugs to overcome drug resistance in fungal pathogens is crucial. This study investigated the potential of human neutrophil peptide (HNP) as a treatment for Candida infections. Results showed that HNP alone and in combination with fluconazole (FLC) exhibited antifungal activity against both susceptible and resistant C. albicans isolates. Furthermore, HNP inhibited biofilm formation and the activity of drug efflux pumps and their genes. These findings suggest that HNP could be used as a monotherapy or in combination with FLC to treat azole-resistant C. albicans.
Article
Mycology
Pablo Passero, Milagros Muthular, Sebastian Barcelo, Valeria Miozza, Cristina Perez
Summary: The flavonoid 8PP competitively inhibits oligomycin-sensitive ATPase activity associated with cdr transporters and reduces oxidoreductase-dependent cell viability in azole-resistant Candida albicans.
JOURNAL DE MYCOLOGIE MEDICALE
(2022)
Article
Infectious Diseases
Hongzhuo Shi, Yanli Zhang, Ming Zhang, Wenqiang Chang, Hongxiang Lou
Summary: This study identified multiple mechanisms contributing to azole resistance in clinical Candida albicans isolates, highlighting the importance of combination therapy in clinical practice.
MICROBIAL DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Piotr Krezel, Teresa Olejniczak, Aleksandra Toloczko, Joanna Gach, Marek Weselski, Robert Bronisz
Summary: The resistance of pathogenic yeasts like Candida albicans to azole antifungal drugs is a growing problem in clinical therapy. Combining natural compounds with azoles may offer a viable strategy to limit the use of these drugs. In vitro synergistic effects were observed between fluconazole and synthetic lactones, prompting the design of new fluconazole analogues with lower toxicity.
Article
Medical Laboratory Technology
Ning-ning Liu, Jia Zhou, Tong Jiang, Maureen Tarsio, Feifei Yu, Xuehan Zheng, Wanjun Qi, Lin Liu, Jing-cong Tan, Luqi Wei, Jun Ding, Jingquan LI, Lingbing Zeng, Biao Ren, Xiaotian Huang, Yibing Peng, Yong-bing Cao, Yanbin Zhao, Xin-yu Zhang, Patricia M. Kane, Changbin Chen, Hui Wang
Summary: Fungal infections pose a global threat to human health, with limited antifungal options and the rapid emergence of resistance. A specific epidermal growth factor receptor (EGFR) inhibitor has been found to enhance the efficacy of azole drugs against various fungal pathogens and overcome resistance. Mechanistic studies have revealed the mode of action of this inhibitor, providing a potential therapeutic strategy for treating life-threatening fungal infections and overcoming antifungal resistance.
TRANSLATIONAL RESEARCH
(2022)
Review
Microbiology
Rafael W. Bastos, Luana Rossato, Gustavo H. Goldman, Daniel A. Santos
Summary: Fungal infections are underestimated threats affecting over 1 billion people, with Candida spp., Cryptococcus spp., and Aspergillus spp. being the most fatal fungi. Antifungal drug use can lead to resistance, and resistant strains are not only found in patients undergoing long-term azole therapy but also in the environment. Environmental exposure to fungicides can have significant effects on the morphophysiology and virulence of fungal pathogens beyond just cross-resistance, impacting Candida and Cryptococcus as well.
Article
Infectious Diseases
A. D. Voropaev, D. A. Yekaterinchev, Y. N. Urban, V. V. Zverev, Yu Nesvizhsky, E. A. Voropaeva, E. Likhanskaya, M. S. Afanasiev, S. S. Afanasiev
Summary: Candida fungi are common opportunistic microorganisms that can cause various infections, especially in immunocompromised patients. This study conducted in the Moscow region of Russia aimed to assess the prevalence of drug resistance mechanisms in Candida isolates from HIV-infected patients. The results showed that the efflux transporters encoded by the CDR1 and CDR2 genes were the main drivers of acquired resistance.
INFEKTSIYA I IMMUNITET
(2022)
Article
Plant Sciences
Mariana Andrea Peralta, Maria Angel da Silva, Maria Gabriela Ortega, Jose Luis Cabrera, Maria Gabriela Paraje
Article
Plant Sciences
Mariana Andrea Peralta, Maria Angel da Silva, Maria Gabriela Ortega, Jose Luis Cabrera, Maria Gabriela Paraje
Article
Plant Sciences
Sebastian Barcelo, Mariana Peralta, Maximiliano Calise, Soledad Finck, Gabriela Ortega, Roberto A. Diez, Jose Luis Cabrerab, Cristina Perez
Article
Food Science & Technology
Mariana Andrea Peralta, Maria Gabriela Orteg, Jose Luis Cabrera, Maria Gabriela Paraje
FOOD AND CHEMICAL TOXICOLOGY
(2018)
Article
Plant Sciences
Mariana Andrea Peralta, Maria Gabriela Ortega, Alicia Marie Agnese, Jose Luis Cabrera
JOURNAL OF NATURAL PRODUCTS
(2011)
Article
Chemistry, Applied
Mariela Casado, Maria Gabriela Ortega, Mariana Peralta, Alicia Mariel Agnese, Jose Luis Cabrera
NATURAL PRODUCT RESEARCH
(2009)
Article
Plant Sciences
Mariana Andrea Peralta, Maria Daniela Santi, Alicia Mariel Agnese, Jose Luis Cabrera, Maria Gabriela Ortega
PHYTOCHEMISTRY LETTERS
(2014)
Article
Biochemistry & Molecular Biology
Maria D. Santi, Mariana A. Peralta, Marcelo Puiatti, Jose Luis Cabrera, Maria G. Ortega
BIOORGANIC & MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Maria D. Santi, Mariana A. Peralta, Caterine S. Mendoza, Jose Luis Cabrera, Maria G. Ortega
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)