Journal
PLANTA MEDICA
Volume 78, Issue 18, Pages 1971-1975Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1327875
Keywords
Lygodium japonicum (Thunb.) Sw.; Lygodiaceae; 9,19:24,32-dicyclotetracyclic triterpenoid; liver X receptor alpha
Categories
Funding
- National Natural Science Foundation of China [81102339]
- Natural Science Foundation of Guangdong Province [S2011040002429]
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Lygodipenoids A (1) and B (2), two novel C33 tetracyclic triterpenoids with a new 9,19:24,32-dicyclopropane skeleton, were isolated from the whole grass of Lygodium japonicum. Their structures were elucidated by spectroscopic and chemical means. Compounds 1 and 2 were tested in transfected cultured human embryonic kidney 293 HEK293 cells for an agonist assay, and compound 1 was identified as a partial agonist for liver X receptor alpha.
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