Article
Medicine, Research & Experimental
Xiaoyan Yu, Qing Su, Jianan Geng, Hui Liu, Yumeng Liu, Jinm Eng Liu, Yan Shi, Yinggang Zou
Summary: The present study demonstrates that GBE prevents ECM accumulation in DN by suppressing tTG expression, primarily mediated by TGF-beta.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biophysics
Batoul Maatouk, Miran A. Jaffa, Mia Karam, Duaa Fahs, Wared Nour-Eldine, Anwarul Hasan, Ayad A. Jaffa, Rami Mhanna
Summary: DFUs lack CTGF and IGF-I, leading to poor tissue repair. AlgSulf/PCL NPs with high affinity and sustained release of CTGF and IGF-I could promote diabetic wound healing, with no cytotoxic effects observed in HaCaT cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Rheumatology
Jiaqi Ren, Lin Sun, Xing Sun, Zhenzhen Ma, Xinyu Wang, Zhuo An, Jinxia Zhao
Summary: The prevalence of serum CTGF was significantly higher in RA patients compared to other rheumatic diseases and healthy controls, indicating its potential value as a diagnostic biomarker for RA. CTGF-positive patients had higher levels of anti-CCP antibody, RF, IgG, and IgM, while the presence of ILD in RA patients was associated with a higher positivity rate of serum CTGF. Further studies are needed to fully understand the diagnostic performance of CTGF in RA.
CLINICAL RHEUMATOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Rong Liu, Min Zhu, Jiaojiao Chen, Junwei Gai, Jing Huang, Yingqun Zhou, Yakun Wan, Chuantao Tu
Summary: In this study, a novel nanobody (Nb) against human connective tissue growth factor (CTGF) was identified, which showed antifibrotic effects in vitro by regulating the biological functions of human stellate cells. This study is of great importance for the development of antifibrotic therapies for liver fibrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Cell Biology
You -Tien Tsai, Hsiang -Yuan Yeh, Chia -Ter Chao, Jenq-Wen Huang, Chih-Kang Chiang
Summary: This study found that the transforming growth factor-beta (TGF-beta) plays a crucial role in vascular calcification (VC). The mechanism of TGF-beta's involvement in VC was investigated using experimental models and clinical specimens. The results revealed that TGF-beta 1 can regulate the occurrence and progression of VC by modulating the miR-378a-3p/CTGF signaling pathway at specific time points.
Article
Agriculture, Dairy & Animal Science
Jianguo Zhu, Xingyi Teng, Liuxiong Wang, Mingde Zheng, Yu Meng, Tingwu Liu, Ying Liu, Haixia Huan, Daoqing Gong, Peng Xie
Summary: The study aimed to investigate the role of prolactin in regulating the proliferation of pigeon crop epithelium through the Hippo signaling pathway. The results showed that prolactin can promote cell proliferation by increasing CTGF levels and reducing YAP phosphorylation.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yilan Shen, Wei Chen, Lei Han, Qi Bian, Jiajun Fan, Zhonglian Cao, Xin Jin, Tao Ding, Zongshu Xian, Zhiyong Guo, Wei Zhang, Dianwen Ju, Xiaobin Mei
Summary: The combination of VEGF-B and IL-22 may help reduce the progression of DN by regulating glycolipid metabolism to decrease inflammation and ROS accumulation.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biochemistry & Molecular Biology
Jeong Hee Lee, Jongsu Kim, Hong Sook Kim, Young Jin Kang
Summary: This study highlights the clinical significance of connective tissue growth factor (CTGF) as a prognostic marker in triple-negative breast cancer (TNBC) and explores the potential therapeutic effects of kahweol, a coffee diterpene molecule, in TNBC treatment. The findings demonstrate that CTGF is involved in migratory pathways relevant to TNBC treatment, and kahweol can regulate CTGF expression to suppress cell motility in TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Toyoshi Yanagihara, Kazuya Tsubouchi, Mahsa Gholiof, Sy Giin Chong, Kenneth E. Lipson, Quan Zhou, Ciaran Scallan, Chandak Upagupta, Jussi Tikkanen, Shaf Keshavjee, Kjetil Ask, Martin R. J. Kolb
Summary: Idiopathic pulmonary fibrosis is a fatal lung disease characterized by the accumulation of myofibroblasts. The study found that connective-tissue growth factor (CTGF) plays a key role in pulmonary fibrosis. Increased levels of CTGF exacerbate lung fibrosis and CTGF expression is upregulated in patients with idiopathic pulmonary fibrosis. Different cells contribute to the maintenance of the fibrotic phenotype during fibrogenesis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Panxia Wang, Minghui Wang, Yuehuai Hu, Jianxing Chen, Yanjun Cao, Cui Liu, Zhongkai Wu, Juan Shen, Jing Lu, Peiqing Liu
Summary: YAP1 plays a significant role in Dox-induced cardiomyopathy, while Isorhapontigenin (Isor) could be a potential new compound for combating Dox-induced cardiotoxicity by increasing YAP1 expression.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Xiaoqi Nie, Qianqian Yu, Long Li, Minxiao Yi, Bili Wu, Yongbiao Huang, Yonghui Zhang, Hu Han, Xianglin Yuan
Summary: Kinsenoside alleviates radiation-induced liver fibrosis by regulating the TGF-beta 1/Smad/CTGF pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zuping Wu, Sirui Chen, Yuying He, Demao Zhang, Shujuan Zou, Jing Xie, Chenchen Zhou
Summary: This study revealed that CTGF promotes cell-cell communication in hPDLSCs through the MAPK and PI3K pathways. Additionally, CTGF enhances cell migration by up-regulating Cx43 and Panx1, providing insights into the mechanisms of cell-cell interaction.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Immunology
Gan Wu, Can Liu, Ben Cao, Zelin Cao, Haige Zhai, Bin Liu, Shengwei Jin, Xinyu Yang, Chen Lv, Jianguang Wang
Summary: This study successfully synthesized high-affinity single-stranded DNA aptamers targeting CTGF and demonstrated their potential in diagnosing and treating RA by inhibiting proliferation and angiogenesis, as well as showing therapeutic effects on joint injury and inflammatory response. The aptamers exhibited high affinity, sensitivity, and specificity towards CTGF, and their binding to CTGF was mediated by the TSP1 domain of CTGF.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Yuxiang Yang, Wei Piao, Kun Huang, Hongyun Fang, Lahong Ju, Liyun Zhao, Dongmei Yu, Yanan Ma
Summary: This study aimed to examine the relationship between dietary patterns and hyperuricemia among Chinese elderly over 60 years old. The results showed that typical Chinese, modern Chinese, and tuber and fermented vegetables dietary patterns were associated with a lower risk of hyperuricemia, while animal products and alcohol dietary pattern was positively associated with hyperuricemia.
Article
Obstetrics & Gynecology
Yanqin Zhang, Xiangyu Chang, Di Wu, Mengqi Deng, Jinwei Miao, Zhaoyu Jin
Summary: Exosomal miR-214-3p can inhibit fibrosis in endometriosis by targeting CCN2, providing a potential therapeutic approach for EMs.
REPRODUCTIVE SCIENCES
(2021)