Article
Medicine, General & Internal
Yaron Rudnicki, Ron Pery, Sherief Shawki, Susanne Warner, Sean Patrick Cleary, Kevin T. Behm
Summary: This case series describes the initial institutional experience of synchronous robotic colorectal and liver resections for metastatic colorectal cancer. Eight patients underwent the surgeries without any intra-operative complications or conversions. There were two post-operative complications, but overall short-term outcomes and oncologic resection quality were acceptable.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Alexandra Nassar, Stylianos Tzedakis, Alix Dhote, Marie Strigalev, Romain Coriat, Mehdi Karoui, Anthony Dohan, Martin Gaillard, Ugo Marchese, David Fuks
Summary: This literature review aimed to assess the feasibility of laparoscopic liver resection for multiple colorectal liver metastases. The minimally invasive approach for liver cancer has become a new standard of oncological care, and laparoscopic liver resection is a significant indication for multiple colorectal liver metastases. The purpose of this paper was to highlight the novelty and updates in the field of multiple minimally invasive liver resections and discuss the feasibility and outcomes of laparoscopic concomitant multiple liver resections for colorectal liver metastases.
Article
Oncology
Marco Solbiati, Tiziana Ierace, Riccardo Muglia, Vittorio Pedicini, Roberto Iezzi, Katia M. Passera, Alessandro C. Rotilio, S. Nahum Goldberg, Luigi A. Solbiati
Summary: This study reports the first clinical use of a new augmented reality guidance system called Endosight for percutaneous thermal ablations. The system showed high precision and reliability, with a targeting accuracy of 3.4 mm. The study demonstrates that augmented reality guidance can improve the accuracy and confidence of percutaneous thermal ablations.
Article
Oncology
Andrew A. Gumbs, Eric Lorenz, Tzu-Jung Tsai, Lee Starker, Joe Flanagan, Andrea Benedetti Cacciaguerra, Ng Jing Yu, Melinda Bajul, Elie Chouillard, Roland Croner, Mohammad Abu Hilal
Summary: This study examined the short-term outcomes of minimally invasive liver resection for patients with colorectal liver metastases. The results suggest that laparoscopic and robotic approaches may have advantages over open hepatectomy in terms of blood loss, hospital stay, and morbidity rates.
Article
Biochemistry & Molecular Biology
Juan Carlos Celis-Pinto, Adela Alonso Fernandez-Velasco, Maria Daniela Corte-Torres, Jorge Santos-Juanes, Noelia Blanco-Agudin, Kelvin Manuel Pina Batista, Jesus Merayo-Lloves, Luis M. Quiros, Ivan Fernandez-Vega
Summary: The study investigated the expression of PTEN-induced kinase-1 (PINK1) in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver. The results showed that positive PINK1 expression was observed in all tumoral tissues, and there were no differences between different CRCs. However, a significant under-expression of PINK1 was found in CRLMs derived from the rectum compared to other sites. Altered PINK1 expression in CRCs was associated with worse overall survival due to abnormal mitophagy function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Tobias S. Schiergens, Moritz Drefs, Maximilian Doersch, Florian Kuehn, Markus Albertsmeier, Hanno Niess, Markus B. Schoenberg, Matthias Assenmacher, Helmut Kuechenhoff, Wolfgang E. Thasler, Markus O. Guba, Martin K. Angele, Markus Rentsch, Jens Werner, Joachim Andrassy
Summary: The use of pedicle clamping during liver resection for colorectal cancer liver metastases showed favorable long-term outcomes and lower rates of increased transfusion demand without increasing postoperative morbidity. Further prospective evaluation is needed to fully understand the potential oncologic benefits of this technique for patients undergoing curative resection.
Article
Biochemistry & Molecular Biology
Eirini Martinou, Carla Moller-Levet, Dimitrios Karamanis, Izhar Bagwan, Angeliki M. Angelidi
Summary: HOXB9 plays an important role in colorectal cancer, promoting disease progression and affecting overall survival. In vitro experiments showed that HOXB9 overexpression increased cell proliferation and upregulated the expression of genes related to epithelial-mesenchymal transition. In patients with colorectal liver metastases, high expression of HOXB9 was associated with worse overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Fabio Procopio, Matteo Cimino, Flavio Milana, Eloisa Franchi, Bruno Branciforte, Guido Torzilli
Summary: This study demonstrates the feasibility of laparoscopic resection for colorectal liver metastases involving the hepatic vein at the caval confluence. It provides technical tricks for achieving parenchyma-sparing surgery in laparoscopy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Davit L. Aghayan, Gabriella d'Albenzio, Asmund A. Fretland, Egidijus Pelanis, Bard I. Rosok, Sheraz Yaqub, Rafael Palomar, Bjorn Edwin
Summary: This study aimed to evaluate the surgical and oncologic safety of laparoscopic parenchyma-sparing liver resection for large colorectal metastases. The results showed satisfactory short and long-term outcomes for patients with large colorectal liver metastases, with no impact of tumor size on survival.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Winifred M. M. Lo, Samer T. T. Tohme, David A. A. Geller
Summary: Minimally invasive surgery, including laparoscopic and robotic approaches, is a safe and effective option for treating liver metastases from colorectal cancer. Laparoscopic liver resection (LLR) is associated with shorter hospital stays and similar post-operative complications compared to open techniques. LLR allows for early initiation of chemotherapy and simultaneous resection of colorectal and liver tumors can be safe in selected patients. Robotic liver resection (RLR) has comparable safety and may improve resection rates. It is important to carefully select patients and ensure surgeon experience when considering minimally invasive liver surgery for colorectal liver metastases.
Article
Oncology
Andrew A. Gumbs, Roland Croner, Eric Lorenz, Andrea Benedetti Cacciaguerra, Tzu-Jung Tsai, Lee Starker, Joe Flanagan, Ng Jing Yu, Elie Chouillard, Mohammad Abu Hilal
Summary: This study evaluates the long-term outcomes of minimally invasive liver resection for colorectal liver metastases. The results show that laparoscopic and robotic approaches have similar survival rates and recurrence-free survival rates compared to open hepatectomy.
Article
Oncology
Lily V. Saadat, Thomas Boerner, Debra A. Goldman, Mithat Gonen, Timothy L. Frankel, Efsevia Vakiani, T. Peter Kingham, William R. Jarnagin, Alice C. Wei, Kevin C. Soares, David B. Solit, Michael I. D'Angelica
Summary: RAS mutations are prognostic for mCRC patients. KRAS exon 3/4 mutations are rare and may be associated with a more favorable prognosis, but the difference in oncologic outcomes based on the mutated exon appears to be smaller than previously reported.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Florian E. Buisman, Wills F. Filipe, Nancy E. Kemeny, Raja R. Narayan, Rami M. Srouji, Vinod P. Balachandran, Thomas Boerner, Jeffrey A. Drebin, William R. Jarnagin, T. Peter Kingham, Alice C. Wei, Dirk J. Grunhagen, Cornelis Verhoef, Bas Groot Koerkamp, Michael I. D'Angelica
Summary: This study investigated the effectiveness of adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after complete resection or ablation of recurrent colorectal liver metastases and found that adjuvant HAIP is associated with superior hepatic disease-free survival and overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
David Martinez-Cecilia, Dennis A. Wicherts, Federica Cipriani, Giammauro Berardi, Leonid Barkhatov, Panagiotis Lainas, Mathieu D'Hondt, Fernando Rotellar, Ibrahim Dagher, Luca Aldrighetti, Roberto I. Troisi, Bjorn Edwin, Mohammad Abu Hilal
Summary: This study found that a resection margin width less than 1 mm does not significantly impact OS after laparoscopic resection of CRLMs, but continues to affect RFS. Wider margins than 1 mm do not seem to improve oncological results in open or laparoscopic surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Geography, Physical
Guoyong Zhang, Jun Sun, Jianhua Gong, Dong Zhang, Shui Li, Weidong Hu, Yi Li
Summary: This study extended the rendering styles of color and size variables in AR geovisualization, and through user experiments, it was found that dynamic variables have higher guidance characteristics than static variables, with shape being one of the most guiding static variables. These results have implications for guiding visual variable selection in symbol design for AR geovisualization.
INTERNATIONAL JOURNAL OF DIGITAL EARTH
(2023)
Article
Surgery
Dimitrios Ntourakis, Michail Katsimpoulas, Anna Tanoglidi, Calypso Barbatis, Panayotis E. Karayannacos, Theodoros N. Sergentanis, Nikolaos Kostomitsopoulos, Anastasios Machairas
SURGICAL INNOVATION
(2016)
Article
Surgery
Julie Hallet, Antonio Sa Cunha, Daniel Cherqui, Brice Gayet, Diane Goere, Philippe Bachellier, Alexis Laurent, David Fuks, Francis Navarro, Patrick Pessaux
WORLD JOURNAL OF SURGERY
(2017)
Article
Surgery
Riccardo Memeo, Vito de Blasi, Rene Adam, Diane Goere, Tullio Piardi, Emilie Lermite, Olivier Turrini, Francis Navarro, Nicola de'Angelis, Antonio Sa Cunha, Patrick Pessaux, French Colorectal Liver
WORLD JOURNAL OF SURGERY
(2018)
Article
Gastroenterology & Hepatology
Vito De Blasi, Riccardo Memeo, Rene Adam, Diane Goere, Daniel Cherqui, Jean Marc Regimbeau, Michel Rivoire, Laura Ornella Perotto, Francis Navarro, Antonio Sa Cunha, Patrick Pessaux
Article
Surgery
Francesco Esposito, Chetana Lim, Antonio Sa Cunha, Patrick Pessaux, Francis Navarro, Daniel Azoulay
WORLD JOURNAL OF SURGERY
(2018)
Review
Anatomy & Morphology
Adamantios Michalinos, Dimitrios Schizas, Dimitrios Ntourakis, Dimitrios Filippou, Theodore Troupis
SURGICAL AND RADIOLOGIC ANATOMY
(2019)
Review
Endocrinology & Metabolism
Andreas Yiallouris, Constantinos Tsioutis, Eirini Agapidaki, Maria Zafeiri, Aris P. Agouridis, Dimitrios Ntourakis, Elizabeth O. Johnson
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Oncology
Alexandre Doussot, David Fuks, Jean-Marc Regimbeau, Olivier Farges, Antonio Sa-Cunha, Francois-Rene Pruvot, Rene Adam, Francis Navarro, Daniel Azoulay, Bruno Heyd, Patrick Pessaux, Cyril Cosse, Delphine Lignier, Julien Barbieux, Emilie Lermite, Antoine Hamy, Francois Mauvais, Christophe Laurent, Laurence Chiche, Irchid Al Naasan, Jacques Belghiti, Chady Salloum, Philippe Compagnon, Chetana Lim, Mohammed Sbai Idrissi, Frederic Martin, Jerome Atger, Emmanuel Boleslawski, Jacques Baulieux, Benjamin Darnis, Jean Yves Mabrut, Vahan Kepenekian, Julie Perinel, Mustapha Adham, Olivier Glehen, Michel Rivoire, Jean Hardwigsen, Anais Palen, Emilie Gregoire, Yves Patrice Le Treut, Jean Robert Delpero, Olivier Turrini, Astrid Herrero, Fabrizio Panaro, Ahmet Ayav, Laurent Bresler, Philippe Rauch, Francois Guillemin, Frederic Marchal, Jean Gugenheim, Antonio Iannelli, Stephane Benoist, Antoine Brouquet, Marc Pocard, Rea Lo Dico, Brice Gayet, Olivier Scatton, Olivier Soubrane, Jean-Christophe Vaillant, Tullio Piardi, Daniele Sommacale, Reza Kianmanesh, Michel Comy, Philippe Bachellier, Elie Oussoultzoglou, Pietro Addeo, Dimitrios Ntourakis, Didier Mutter, Jacques Marescaux, Loic Raoux, Bertrand Suc, Fabrice Muscari, Georges Elhomsy, Maximiliano Gelli, Denis Castaing, Gabriella Pittau, Oriana Ciacio, Eric Vibert, Daniel Cherqui, Dominique Elias, Diane Goere, Fabrizio Vittadello
Letter
Surgery
Dimitrios Ntourakis, Stylianos Kykalos, Adamantios Michalinos
ASIAN JOURNAL OF SURGERY
(2020)
Article
Surgery
Dimitrios Ntourakis, Adamantios Michalinos, Dimitrios Schizas
WORLD JOURNAL OF SURGERY
(2020)
Review
Gastroenterology & Hepatology
Adamantios Michalinos, Stavros A. Antoniou, Dimitrios Ntourakis, Dimitrios Schizas, Konstantinos Ekmektzoglou, Aris Angouridis, Elizabeth O. Johnson
DISEASES OF THE ESOPHAGUS
(2020)
Review
Biochemistry & Molecular Biology
Ilias P. Nikas, Tanja Proctor, Svenja Seide, Stylianos S. Chatziioannou, Jordan P. Reynolds, Dimitrios Ntourakis
Summary: The Papanicolaou Society of Cytopathology (PSC) reporting system provides guidance for management of pancreatobiliary samples. This systematic review evaluates the risk of malignancy (ROM) and sensitivity and specificity of pancreatic FNA cytology using the current PSC system. The proposed WHO international system changes could stratify pancreatic neoplasms more effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Dimitrios Schizas, Aikaterini Mastoraki, Eleni Papoutsi, Vassilis G. Giannakoulis, Prodromos Kanavidis, Diamantis Tsilimigras, Dimitrios Ntourakis, Orestis Lyros, Theodore Liakakos, Dimitrios Moris
WORLD JOURNAL OF CLINICAL CASES
(2020)
Review
Gastroenterology & Hepatology
Alexandros Hadjivasilis, Constantinos Tsioutis, Adamantios Michalinos, Dimitrios Ntourakis, Dimitrios K. Christodoulou, Aris P. Agouridis
ANNALS OF GASTROENTEROLOGY
(2019)