Article
Biochemistry & Molecular Biology
Neil B. Metcalfe, Mats Olsson
Summary: This review highlights the dynamic processes of ROS production, telomeric DNA damage, and DNA repair, emphasizing the trade-off between energetic efficiency and telomere protection. Mitochondrial features and ATP production efficiency play crucial roles in maintaining DNA integrity and telomere dynamics, with implications for individual variation and adaptation to changing environmental contexts.
Article
Cell Biology
Ryan L. Brown, Elissa E. Epel, Jue Lin, Dena B. Dubal, Aric A. Prather
Summary: Aging biomarkers may be interconnected through direct co-regulation or common processes associated with aging or stress. Klotho, an aging regulator, is involved in regulating insulin signaling, phosphate homeostasis, oxidative stress, and age-related inflammation. This study investigated the association between klotho levels and telomere length in immune cells among mothers caregiving for children with or without autism spectrum disorder (ASD), to understand the potential impact of high caregiving stress on these aging biomarkers. Our results showed a positive association between klotho levels and telomere length in certain immune cells among high-stress mothers of children with ASD, but not among low-stress mothers of neurotypical children. There were no significant associations between klotho and telomerase activity in either group.
Article
Biochemistry & Molecular Biology
Emily Ho, Carmen P. Wong, Janet C. King
Summary: Dr. Bruce Ames pioneered the understanding of oxidative stress, DNA damage, and the connection between micronutrient deficiencies and DNA damage. Zinc is essential for human health, playing a critical role in cellular antioxidant defense, DNA integrity, and immune function. Studies have shown that zinc deficiency is associated with oxidative stress, susceptibility to DNA damage, and chronic inflammation, emphasizing the importance of adequate nutrition for healthy aging.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Cell Biology
Mariarosaria De Rosa, Samuel A. Johnson, Patricia L. Opresko
Summary: Telomeres are protective nucleoprotein structures that cap linear chromosome ends, vital for genome stability. Shortening and dysfunction of telomeres may lead to cellular senescence, aging, or tumorigenesis. The enzyme telomerase is expressed in human reproductive cells, some stem cells, and most cancer cells to maintain telomere length by restoring telomeric DNA. Oxidative stress from excess reactive oxygen species is associated with accelerated telomere shortening and damage, which may contribute to degenerative diseases and cancer. The highly conserved guanine oxidation system involves specialized enzymes to mitigate the effects of mutagenic base lesions at telomeres.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Samantha L. Sanford, Griffin A. Welfer, Bret D. Freudenthal, Patricia L. Opresko
Summary: Telomeres at the ends of linear chromosomes are essential for genome maintenance and cellular proliferation, but shorten with each cell division. Telomerase compensates for this by lengthening the telomeric 3' single strand overhang, and has the unique ability to synthesize multiple GGTTAG repeats in a process called repeat addition processivity. Understanding telomerase's unique properties and catalytic mechanism may help in selectively manipulating telomerase activity for therapeutic purposes, particularly in cancer treatment.
Article
Cell Biology
Tenghui Yu, Jesse Slone, Wensheng Liu, Ryan Barnes, Patricia L. Opresko, Landon Wark, Sabine Mai, Steve Horvath, Taosheng Huang
Summary: Mitochondrial dysfunction plays a crucial role in the aging process, and the accumulation of mutations in the mitochondrial genome is believed to contribute to this dysfunction. By studying a mouse model with error-prone mitochondrial DNA polymerase, researchers found that high levels of mitochondrial DNA mutations can lead to oxidative damage, compromised DNA integrity, and accelerated aging. These findings suggest that mitochondria play a central role in aging and may guide future research on potential therapeutics to mitigate the aging process.
Article
Cell Biology
Ling Wang, Zeyuan Lu, Juan Zhao, Madison Schank, Dechao Cao, Xindi Dang, Lam Nhat Nguyen, Lam Ngoc Thao Nguyen, Sushant Khanal, Jinyu Zhang, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao
Summary: Oxidative stress leads to dual injury in T cells through crosstalk between telomeres and mitochondria, resulting in cell death. Blocking ROS production can reverse this damage.
Article
Genetics & Heredity
Angelica Dominguez-de-Barros, Ines Sifaoui, Zuzanna Borecka, Roberto Dorta-Guerra, Jacob Lorenzo-Morales, Rafael Castro-Fuentes, Elizabeth Cordoba-Lanus
Summary: This study found that telomeres shorten with age in Psittacidae species and that short-lived birds accumulate more oxidative stress products but have lower antioxidant capacity compared to long-lived birds. Breeding is also related to telomere shortening, with short-lived birds experiencing increased oxidative damage during breeding while long-lived birds are able to counteract this damage with increased antioxidant capacity.
FRONTIERS IN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Antonio Torres-Montaner
Summary: Direct cancer originating from normal stem cells is rare, and telomere damage appears to be a necessary step in the transformation process. The transformation of stem cells is directly linked to the disruption of telomere maintenance mechanisms, and the inherent resistance of stem cells to transformation may be related to specific mechanisms that maintain telomere integrity.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ziyi Shen, Yuanhui Wang, Guanzhen Wang, Wei Gu, Shengchao Zhao, Xiaomeng Hu, Wei Liu, Yi Cai, Zhihong Ma, Rupesh K. Gautam, Jia Jia, Chunpeng (Craig) Wan, Tingdong Yan
Summary: Telomeres are unique structures at the ends of chromosomes that stabilize chromosomal structures. Telomerase, a reverse transcriptase ribonucleoprotein complex, synthesizes telomeres. Telomerase activity is generally absent in human somatic cells, except in stem cells and germ cells. However, most human cancer cells have increased telomerase activity, allowing them to divide continuously. Developing drugs targeting telomerase has been a focus of research for inhibiting cancer growth and delaying aging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Sinem Yilmaz, Erdal Bedir, Petek Ballar Kirmizibayrak
Summary: The small molecule telomerase activator Cycloastragenol (CA) has been found to have a positive impact on age-related pathophysiologies by increasing NRF2 activity, regulating telomerase activity, and enhancing proteasome activity. These findings suggest that CA plays a role in multiple cellular pathways associated with aging.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Cristina Polidori, Patrizia Mecocci
Summary: This review explores the role of oxidative stress in aging and frailty, highlighting the need for effective management strategies to prevent and address frailty.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Environmental Sciences
C. Chaney, K. S. Wiley
Summary: This study analyzed the association between serum PFAS levels and measures of biological aging, and found a negative correlation between PFAS exposure and certain aging indicators, regardless of gender and reproductive stage.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cell Biology
Jue Lin, Elissa Epel
Summary: Short telomeres may increase the risk of degenerative diseases, with stress-induced telomere damage being an important pathway. The initial setting point of telomere length at birth appears to be influential, possibly affected by stress. Intergenerational stress effects on telomeres include prenatal stress and direct inheritance of short telomeres.
AGEING RESEARCH REVIEWS
(2022)
Article
Cell Biology
M. Donatella Semeraro, Gunter Almer, Wilfried Renner, Hans-Juergen Gruber, Markus Herrmann
Summary: This study questions the utility of RTL in PBMCs as a biomarker for individual aging assessment.
Article
Biochemistry & Molecular Biology
Nicoletta Plotegher, Dany Perocheau, Ruggero Ferrazza, Giulia Massaro, Gauri Bhosale, Federico Zambon, Ahad A. Rahim, Graziano Guella, Simon N. Waddington, Gyorgy Szabadkai, Michael R. Duchen
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Biochemistry & Molecular Biology
Nurfairuz Abdul Malik, Mahaneem Mohamed, Mohd Zulkifli Mustafa, Azalina Zainuddin
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Giulia Massaro, Michael P. Hughes, Sammie M. Whaler, Kerri-Lee Wallom, David A. Priestman, Frances M. Platt, Simon N. Waddington, Ahad A. Rahim
HUMAN MOLECULAR GENETICS
(2020)
Correction
Biochemistry & Molecular Biology
Nicoletta Plotegher, Dany Perocheau, Ruggero Ferrazza, Giulia Massaro, Gauri Bhosale, Federico Zambon, Ahad A. Rahim, Graziano Guella, Simon N. Waddington, Gyorgy Szabadkai, Michael R. Duchen
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Integrative & Complementary Medicine
Nur Fatin Nabilah Mohd Sahardi, Faizul Jaafar, Mariam Firdhaus Mad Nordin, Suzana Makpol
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Chemistry, Applied
Samia Mokh, Khaled El Hawari, Haifa Abdul Rahim, Mohamad Al Iskandarani, Farouk Jaber
FOOD ADDITIVES & CONTAMINANTS PART B-SURVEILLANCE
(2020)
Article
Pharmacology & Pharmacy
Nayab Tahir, Asadullah Madni, Wei Li, Alexandra Correia, Muhammad Muzamil Khan, Muhammad Abdur Rahim, Helder A. Santos
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Review
Neurosciences
Laura Poupon-Bejuit, Eridan Rocha-Ferreira, Claire Thornton, Henrik Hagberg, Ahad A. Rahim
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Editorial Material
Clinical Neurology
Ahad A. Rahim, Paul Gissen
Article
Integrative & Complementary Medicine
Suzana Makpol, Nur Fathiah Abdul Sani, Nur Haleeda Hakimi, Nazirah Ab Rani, Siti Nor Asyikin Zakaria, Ahmad Fais Abd Rasid, Geetha Gunasekaran, Nur Fatin Nabilah Mohd Sahardi, Jen Kit Tan, Norzana Abd Ghafar, Mariam Firdhaus Mad Nordin
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Berna Seker Yilmaz, Julien Baruteau, Ahad A. Rahim, Paul Gissen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Cell Biology
Nuraqila Mohd Murshid, Faridah Aminullah Lubis, Suzana Makpol
Summary: Epigenetic mechanisms involving histone methylation and acetylation play a crucial role in gene expression and protein function regulation in neuronal cells. Manipulations of these mechanisms have been shown to affect the susceptibility of neurons to degeneration and apoptosis in neurodegenerative disorders.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Nasrullah Jan, Asadullah Madni, Muhammad Abdur Rahim, Naveed Ullah Khan, Talha Jamshaid, Arshad Khan, Abdul Jabar, Safiullah Khan, Hassan Shah
Summary: The study aimed to develop and evaluate PCL nanoparticles loaded with cytarabine for sustained release behavior and anti-leukemic influence. The developed nanoparticles showed efficient toxicity against leukemic and breast cancer cell lines, with sustained release pattern enhancing the anti-cancer effects.
Article
Neurosciences
Florence Hui Ping Tan, Ghows Azzam, Nazalan Najimudin, Shaharum Shamsuddin, Azalina Zainuddin
Summary: Alzheimer's disease is a common neurological ailment characterized by the aggregation of amyloid-beta (Aβ) in the brain. Aβ42, the most neurotoxic isomer, plays a significant role in the disease pathology. Animal models, such as the fruit fly Drosophila melanogaster, have been used to study neurodegenerative diseases. In this study, Aβ42-expressing Drosophila exhibited degenerated eye structures, shortened lifespan, and declined mobility function compared to the wildtype control. RNA sequencing revealed differentially expressed genes associated with carbon metabolism, oxidative phosphorylation, antimicrobial peptides, and longevity-regulating pathways. The findings provide insights into the molecular connections of AD and offer potential for the development of new anti-AD medications.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Business
Hafinas Halid, Daisy Mui Hung Kee, Noor Fareen Abdul Rahim
GLOBAL BUSINESS REVIEW
(2020)