Journal
PLANTA MEDICA
Volume 77, Issue 4, Pages 374-376Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250370
Keywords
Paeonia lactiflora; Paeoniaceae; BACE-1 inhibitors; resveratrol oligomer
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Funding
- Korea Research Council for Industrial Science & Technology (KOCI)
- Korea Forest Service [S120808L1101104]
- Korea Forest Service [S120808L1101104] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A new resveratrol oligomer (1) together with eight related components (2-9) were isolated from the seed extract of Paeonia lactiflora (Paeoniaceae) as active principles responsible for the inhibition of beta-site APP-cleaving enzyme 1 (BACE-1) in vitro. The chemical structure of 1 was established as (-)-7a, 8a-cis-e-viniferin with the aid of spectroscopic analyses including NOESY experiments. All isolated resveratrol oligomers (1-9) demonstrated significant inhibition on baculovirus-expressed BACE-1 in a dose-dependent manner, which was assessed by the FRET assay using Rh-EVNLDAEFK as a substrate in vitro.
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