Journal
PLANTA MEDICA
Volume 77, Issue 1, Pages 46-51Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250093
Keywords
manzamine A; herpes simplex virus; corneal cells; acyclovir
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Funding
- NIH/NCRR [P20RR016456]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016456] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [R15EY020803] Funding Source: NIH RePORTER
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This study investigated the putative inhibitory effect of manzamine A on HSV-1 infection. Our results indicated that manzamine A effectively inhibited viral replication and infection in the cell line SIRC, a corneal cell line, at 1 mu M. The existing anti-HSV-1 drug acyclovir was analyzed and showed a comparable activity at 50 mu M. Plaque assays demonstrated that manzamine A reduced the release of infectious virus by 10(11)-fold. RTPCR assays indicated that HSV-1 virion host shutoff (vhs) activity and ICP0 transcription were decreased by manzamine A treatment. These results bode well for the development of manzamines as potential leads to reduce viral infection in corneal cells and to prevent HSV-1-induced eye infections such as keratitis.
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