Article
Chemistry, Organic
Rong Hu, Jia-Luo Huang, Fang-Yu Yuan, Xun Wei, Ming-Feng Zou, Gui-Hua Tang, Wei Li, Sheng Yin
Summary: Three unusual tigliane diterpenoids, named Crotonianoids A-C (1-3), were isolated from the seeds of Croton tiglium. Their structures were determined and compounds 1 and 2 showed significant inhibitory effects on prostate cancer cell growth, survival, and induced apoptosis. Mechanistic study revealed that compounds 1 and 2 could suppress androgen receptor signaling pathway by promoting the degradation of AR protein.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Claudio Roberto Novello, Elisangela Dusman, Rodolfo Bento Balbinot, Jessica Carreira de Paula, Celso Vataru Nakamura, Joao Carlos Palazzo de Mello, Maria Helena Sarragiotto
Summary: This study isolated two novel active compounds from the stem bark of Croton echioides, highlighting their potential as therapeutic agents for combating leishmaniasis.
NATURAL PRODUCT RESEARCH
(2022)
Article
Engineering, Chemical
Mariana M. B. Azevedo, Catia A. Almeida, Francisco C. M. Chaves, Eduardo Ricci-Junior, Andreza R. Garcia, Igor A. Rodrigues, Celuta S. Alviano, Daniela S. Alviano
Summary: This study successfully developed a stable nanoemulsion NECC with antifungal activity, which showed good inhibitory effects against Mucor ramosissimus and Candida albicans. The nanoemulsion also demonstrated potential to inhibit fungal extracellular proteases, while showing no hemolytic effect at the highest concentration tested.
Article
Microbiology
Rayara J. P. Carvalho, Pedro F. N. Souza, Ellen A. Malveira, Nilton A. S. Neto, Romerio R. S. Silva, Gabriel L. C. Melo, Ayrles F. B. Silva, Leandro B. Lima, Cynthia C. de Albuquerque, Rafael W. Bastos, Gustavo H. Goldman, Cleverson D. T. de Freitas
Summary: This study evaluated the antimicrobial potential and mechanisms of action of essential oil from C. pluriglandulosus on human pathogenic microorganisms. It found high inhibition rates against C. krusei and C. parapsilosis, and revealed the antimicrobial mechanism of CpEO through fluorescence and scanning electron microscopy. The results suggest that CpEO has the potential to be an effective alternative molecule of pharmaceutical interest.
Article
Plant Sciences
Govinda Rajan Sailaja, Venkatraman Sriramavaratharajan, Ramar Murugan, Gopal Rao Mallavarapu, David Raj Chellappan
Summary: The root essential oil nanoemulsion of P. vettiveroides exhibited significant vasorelaxant effect through multiple mechanisms, including nitric oxide-mediated pathway, G-protein coupled muscarinic (M3) receptor pathway, involvement of K+ channels (KATP, KIR, KCa), and blocking of the calcium influx by receptor-operated calcium channel.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Rosemarie Brandim Marques, Maria Das Dores Barreto Sousa, Wesley de Sousa Santos, Neirigelson Ferreira de Barros Leite, Esdras Morais Sobreiro Lima, Angelica Lima Soares, Charllyton Luis Sena da Costa, Francisco Artur e Silva Filho, Antonio Luiz Martins Maia Filho, Evandro Paulo Soare Martins, Ricardo Martins Ramos, Antonio de Macedo Filho
Summary: The development of new drugs through studies of candidate molecules using computational or in silico approaches is being utilized for predictions of pharmacokinetic properties and toxicological parameters. This study examined the in silico and in vivo pharmacokinetics and toxicology of the essential oil of Croton heliotropiifolius Kunth leaves. The findings showed high oral absorption, medium cellular permeability, and high blood brain permeability for the chemical constituents. In terms of toxicity, the constituents exhibited low to medium risk of cytotoxicity. In vivo evaluation showed no significant differences in mutagenicity compared to negative controls. Further investigations are needed to corroborate the findings.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Chemistry, Medicinal
Ileana Reyes-Hernandez, Paola E. Bravo-Perez, Fernando Novillo, Maria Teresa Ramirez-Apan, Maria Isabel Chavez, Ruben A. Toscano, Jose Luis Rodriguez-Chavez, Fabiola A. Lopez-Huerta, Carlos A. Mendez-Cuesta, Esteban M. Martinez, Clara H. Ramos, Guillermo Delgado
Summary: Three new ent-rosane diterpenes were isolated and characterized from the bioactive extract of Croton niveus Jacq., along with known compounds lupeol, cajucarinolide, and phytosterols. Two of the ent-rosane diterpenes exhibited activity against HCT-15 and PC-3 cancer cell lines, and docking calculations supported their proposed mode of action against PC-3 cells by interacting with NF-κB and STAT3 receptors.
Article
Plant Sciences
Katarine F. Silva, Diogo B. Peruchetti, Gabriela M. Sirtoli, Christina M. Takiya, Ana Acacia S. Pinheiro, Jose Henrique Leal-Cardoso, Celso Caruso-Neves
Summary: The study found that high doses of Croton zehntneri essential oil may induce tubule-interstitial injury in mouse kidneys, possibly mediated by protein overload in the proximal tubule.
Article
Plant Sciences
Phansuang Udomputtimekakul, Wilart Pompimon, Kittipong Chainok, Suwadee Jiajaroen, Puttinan Meepowpan, Saranchana Tata, Phatra Tasit, Puracheth Rithchumpon, Narong Nuntasaen
Summary: A new clerodane-type diterpenoid and a known compound were isolated from the leaves and twigs of C. krabas. The structures of these compounds were elucidated using spectroscopic methods and the relative stereochemistry was confirmed by X-ray diffraction analysis. In vitro antiviral activity of the extracts and compounds 1-2 was evaluated.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Infectious Diseases
Juana Liz Leslie Cucho-Medrano, Sammy Wesley Mendoza-Beingolea, Cesar Maximo Fuertes-Ruiton, Maria Elena Salazar-Salvatierra, Oscar Herrera-Calderon
Summary: The study aimed at determining the volatile phytochemical constituents in the essential oils of Croton species leaves and evaluating their antimicrobial activity. The oils showed in vitro antimicrobial activity against bacterial or fungal strains.
Article
Pharmacology & Pharmacy
Pablo Alvarez Auth, Gustavo Ratti da Silva, Eduarda Carolina Amaral, Victor Fajardo Bortoli, Mariana Inocencio Manzano, Lauro Mera de Souza, Evellyn Claudia Wietzikoski Lovato, Joao Tadeu Ribeiro-Paes, Arquimedes Gasparotto Junior, Francislaine Aparecida dos Reis Livero
Summary: Metabolic associated fatty liver disease (MAFLD) affects a large portion of the global population, and there are currently no drug therapies available. The study looked into the effects of Croton urucurana extract on a rat model of MAFLD and found promising hepatoprotective and lipid-lowering effects, indicating its potential as a future treatment option for MAFLD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Natielli Conceicao Santos, Jefferson Elias da Silva, Ane Caroline Celestino Santos, Jaciele de Oliveira Dantas, Swamy Rocha Siqueira Abreu Tavares, Valfran Silva Andrade, Sara Dayan da Silva Oliveira, Arie Fitzgerald Blank, Ana Paula Albano Araujo, Leandro Bacci
Summary: Natural biological control is crucial for regulating insect pest populations in agroecosystems, but its effectiveness has been compromised due to the indiscriminate use of pesticides. Therefore, finding environmentally safe pesticides for sustainable food production is essential. This study found that essential oils from Croton grewioides and its major compounds were toxic to the soybean pest Chrysodeixis includens and the predatory bug Podisus nigrispinus.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Microbiology
Ellen A. Malveira, Pedro F. N. Souza, Nilton A. S. Neto, Tawanny K. B. Aguiar, Natanael S. Rodrigues, Carlos W. B. Henrique, Ayrles F. B. Silva, Leandro B. Lima, Cynthia C. Albuquerque, Cleverson D. T. Freitas
Summary: This study evaluated the antimicrobial potential and mechanisms of action of Croton blanchetianus leaf essential oil (CbEO) on various fungi and bacteria. CbEO showed moderate inhibitory effects on certain bacteria and significant activity against Candida species. Furthermore, CbEO caused membrane damage, ROS overproduction, and apoptosis in Candida cells without inducing hemolysis in human red cells.
Article
Biochemistry & Molecular Biology
Angelo Antonio Barbosa de Moraes, Celeste de Jesus Pereira Franco, Oberdan Oliveira Ferreira, Everton Luiz Pompeu Varela, Lidiane Diniz do Nascimento, Marcia Moraes Cascaes, Dehon Ricardo Pereira da Silva, Sandro Percario, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade
Summary: This study reports the productivity, chemical composition, and antioxidant profile of the essential oil of Myrcia paivae, a species from the Myrtaceae family in the Amazon. The essential oil showed a production rate of 1.69% and predominantly consisted of hydrocarbon monoterpenes. It exhibited good antioxidant capacity, attributed to its high monoterpene content.
Article
Pharmacology & Pharmacy
Livia A. Tavares, Allan A. Rezende, Jymmys L. Santos, Charles S. Estevam, Ana M. O. Silva, Jaderson K. Schneider, John L. S. Cunha, Daniela Droppa-Almeida, Ivan J. Correia-Neto, Juliana C. Cardoso, Patricia Severino, Eliana B. Souto, Ricardo L. C. De Albuquerque-Junior
Summary: The study indicated that the essential oil of Cymbopogon winterianus can alleviate histological changes in pulmonary fibrosis by reducing oxidative stress, inflammation, and TGF-β-induced myofibroblast differentiation.
Article
Biochemistry & Molecular Biology
Romina J. Ronchi, Claire Beaufay, Joanne Bero, Juan B. Robirosa, Marcia Mazzuca, Jorge A. Palermo, Joelle Quetin-Leclercq, Marianela Sanchez
CHEMICAL BIOLOGY & DRUG DESIGN
(2019)
Article
Biochemical Research Methods
Claire Beaufay, Guillaume Henry, Camille Streel, Emilie Bony, Marie-France Herent, Joanne Hero, Joelle Quetin-Leclercq
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2019)
Article
Endocrinology & Metabolism
Rafael Teixeira Freire, Joanne Bero, Claire Beaufay, Denise Medeiros Selegato, Aline Coqueiro, Young Hae Choi, Joelle Quetin-Leclercq
Article
Food Science & Technology
Nguyen Le Anh Dao, Tran Minh Phu, Caroline Douny, Joelle Quetin-Leclercq, Bui Thi Buu Hue, Le Thi Bach, Truong Quynh Nhu, Bui Thi Bich Hang, Do Thi Thanh Huong, Nguyen Thanh Phuong, Patrick Kestemont, Marie-Louise Scippo
Summary: The study demonstrated that dip treatments in solutions of Phyllanthus amarus and Euphorbia hirta extracts significantly reduced total viable counts and lipid oxidation in striped catfish fillets, extending their shelf life.
JOURNAL OF AQUATIC FOOD PRODUCT TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Schioppa, Fanta Fall, Sergio Ortiz, Jacques H. Poupaert, Joelle Quetin-Leclercq
Summary: Pentacyclic triterpenes (PTs) are commonly found in medicinal plants with antiparasitic effects. This study aimed to determine the stability of triterpenic esters in different biological-like media and their main microsomal degradation products. The results showed that these esters exhibited good stability in aqueous and plasma solutions, but degradation was observed in acidic media. Moreover, hepatic microsomal metabolism varied depending on the concentration and position of the ester link, suggesting different metabolic pathways for these compounds.
Article
Biochemistry & Molecular Biology
Hafiz Abdul Khaliq, Sergio Ortiz, Mireille Alhouayek, Giulio G. Muccioli, Joelle Quetin-Leclercq
Summary: The anti-inflammatory potential of Convolvulus arvensis was evaluated and the results showed that the extracts and major constituents of the plant can significantly inhibit the expression of pro-inflammatory mediators, supporting its use in the treatment of inflammatory diseases.
Article
Infectious Diseases
Sandrine Verstraeten, Lucy Catteau, Laila Boukricha, Joelle Quetin-Leclercq, Marie-Paule Mingeot-Leclercq
Summary: The study showed the synergy between pentacyclic triterpenes and ampicillin towards Methicillin-Resistant S. aureus by binding to LTA, inducing membrane permeabilization and depolarization. This effect was not accompanied by significant changes in cellular concentration, suggesting a mediated effect through lipid membranes.
Review
Pharmacology & Pharmacy
Espoir K. Kambale, Joelle Quetin-Leclercq, Patrick B. Memvanga, Ana Beloqui
Summary: Diabetes is a chronic condition with high blood glucose levels that cannot be cured. Managing diabetes involves a healthy lifestyle, exercise, and medication. Nanoparticulate delivery systems have shown promise in enhancing the effectiveness of herbal treatments for diabetes, but further clinical trials are needed.
Article
Agriculture, Dairy & Animal Science
Esaie Tchetan, Pascal Abiodoun Olounlade, Erick Virgile Bertrand Azando, Hafiz Abdul Khaliq, Sergio Ortiz, Alban Houngbeme, Georcelin Goue Alowanou, Bossima Ivan Koura, Guenole Coovi Akouedegni, Marcel Romuald Benjamin Houinato, Sylvie Mawule Hounzangbe-Adote, Fernand Ahokanou Gbaguidi, Joelle Quetin-Leclercq
Summary: In this study, the anthelmintic activity, cytotoxicity, and chemical composition of plants used in Benin to treat digestive parasitosis in small ruminants were explored. The results are important for the rational use of these plants and for the identification of new anthelmintic molecules.
Article
Biochemistry & Molecular Biology
Caroline Waingeh Nain, Eric Mignolet, Marie-France Herent, Joelle Quetin-Leclercq, Cathy Debier, Melissa M. Page, Yvan Larondelle
Summary: This study compared the antioxidant activity of green tea extracts (GTEs) with different catechins profiles, and found that the EGC-rich GTE exhibited stronger antioxidant activity than the EGCG-rich GTE in DHA-rich oil.
Review
Food Science & Technology
Hafiz Abdul Khaliq, Mireille Alhouayek, Joelle Quetin-Leclercq, Giulio G. G. Muccioli
Summary: Inflammation is a defensive response of the organism to various injuries. Chronic inflammatory diseases are challenging to treat, and phytochemicals may provide an interesting alternative approach. AMP-activated protein kinase plays an important role in regulating inflammatory responses. This review summarizes studies on phytochemicals that activate AMPK to improve chronic inflammatory disease models, and highlights factors to consider when investigating AMPK in the context of phytochemicals.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Anais Pannequin, Joelle Quetin-Leclercq, Jean Costa, Aura Tintaru, Alain Muselli
Summary: Chromatographic and spectroscopic methods were used to investigate the volatile metabolites of the liverwort Plagiochila porelloides harvested in Corsica. Three new compounds were isolated and their structures were determined. The essential oil and extract of P. porelloides showed moderate antiprotozoal and anticancer activities.
Article
Biochemistry & Molecular Biology
Allison Ledoux, Carla Hamann, Olivier Bonnet, Kateline Jullien, Joelle Quetin-Leclercq, Alembert Tchinda, Jacqueline Smadja, Anne Gauvin-Bialecki, Erik Maquoi, Michel Frederich
Summary: Casearia coriacea Vent., a plant endemic to the Mascarene Islands, exhibited potent antiplasmodial activity through the presence of three identified compounds, caseamembrin T (1), corybulosin I (2), and isocaseamembrin E (3), with IC50 values ranging from 0.25 to 0.51 μg/mL. While these compounds also showed antileishmanial and antitrypanosomal properties, they exhibited selectivity towards the malaria parasite with selectivity indices ranging from 6 to 12 and 25 to 100, respectively. Additionally, compounds 1-3 demonstrated promising activity against pancreatic carcinoma cells (IC50 < 1 μg/mL). However, the main compound, caseamembrin T (1), displayed significant toxicity when evaluated on zebrafish embryos.
Article
Biochemistry & Molecular Biology
Esaie Tchetan, Sergio Ortiz, Pascal Abiodoun Olounlade, Kristelle Hughes, Patrick Laurent, Erick Virgile Bertrand Azando, Sylvie Mawule Hounzangbe-Adote, Fernand Ahokanou Gbaguidi, Joelle Quetin-Leclercq
Summary: By performing LC-MS/MS analysis and molecular networking, the main compounds in Terminalia leiocarpa were identified as ellagic acid and derivatives, gallic acid, astragalin, rutin, quinic acid, and fructose. Among them, ellagic acid and gallic acid showed good anthelmintic activity against C. elegans. Other unidentified compounds may also contribute to the observed activity.
Article
Biochemistry & Molecular Biology
Kristelle Hughes, Thanh Binh Le, Patrick Van Der Smissen, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq, Joelle Quetin-Leclercq
Summary: Leishmaniasis, a neglected tropical disease, still infects thousands of people per year worldwide. Resistance to major treatments has become a healthcare burden, especially in low-income countries. Eugenol, a phenylpropanoid, has shown antileishmanial activity against Leishmania mexicana mexicana (Lmm), but its mechanism of action is still unclear.
