Journal
PLANTA MEDICA
Volume 75, Issue 4, Pages 375-377Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1112204
Keywords
Forsythia suspensa; Oleaceae; suspensine A; (-)-7 '-O-methylegenine; anti-inflammatory activity
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Two new alkaloids, named suspensine A (1) and (-)-7'-O-methylegenine (2), along with two known alkaloids, (-)-egenine (3) and (-)-bicuculline (4), were isolated from the ethanolic extract of the fruits of Forsythia suspensa. Their structures were established by means of chemical methods and spectroscopic analyses. In vitro, four alkaloids showed anti-inflammatory activities, with inhibition rates of release of beta-glucuronidase from polymorphonuclear leukocytes of rats being in the range 34.8% 39.6% at 10 mu M.
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