Article
Plant Sciences
Yue Zhang, Yi-Ming Zhao, Xiao-Jing Shao, Xue-Hui Wang, Tian -Tian Bei, Yi-Ran Jiang, Hyun-Sun Lee, Meng-Xue Xiu, Jian Song, Long Cui
Summary: Three new sesquilignans (Eleutherocosus A (1), Eleutherocosus B (2) and Eleutherocosus C (3)) and seven known lignans (4-10) were isolated from the EtOAc-soluble extract of Eleutherococcus senticosus. The structures were determined through spectroscopic and physicochemical analyses. The inhibitory activity of all isolates against DGAT1 and DGAT2 was evaluated. Compounds 1-3 exhibited the most potent inhibitory activity against DGAT1 with IC50 values of 71.4 +/- 1.3, 79.1 +/- 1.1, and 65.2 +/- 1.2 μM, respectively.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Medicine, Research & Experimental
Babiker Saad Almugadam, Peng Yang, Li Tang
Summary: The study revealed a significant decrease in richness and diversity of jejunum microbiota in T2DM, while Ceftriaxone sodium-induced gut dysbiosis reduced food-water intake and affected microbiota diversity, along with diabetic parameters.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Mahtab Ghanbari Rad, Mohammadreza Sharifi, Rokhsareh Meamar, Nepton Soltani
Summary: This study investigated the effects of thiamine disulfide (TD) on hyperglycemia and insulin sensitivity in diabetic rats. The results showed that TD treatment significantly reduced blood glucose levels, improved insulin levels, and enhanced pancreatic function.
NUTRITION & DIABETES
(2022)
Article
Multidisciplinary Sciences
Isaac Kyei-Barffour, Roselind Kyei Baah Kwarkoh, Ophelia Duke Arthur, Samuel Addo Akwetey, Desmond Omane Acheampong, Benjamin Aboagye, Augustine Suurinobah Brah, Isaac Kingsley Amponsah, Christian Kweku Adokoh
Summary: The alkaloidal extract derived from Zanthoxylum zanthoxyloides showed antidiabetic and insulin secretory effects in normoglycemic and experimental diabetic rats, with potential for diabetes management. The extract improved glucose kinetics, restored islet population, and insulin levels, and stimulated insulin secretion, indicating its potential as a treatment for diabetes.
Article
Biochemistry & Molecular Biology
Yu Yin, Ruyi Xu, Lei Ning, Zhimin Yu
Summary: Diabetic retinopathy is a leading cause of blindness and visual impairment in diabetes patients. This study found that Bergenin has significant therapeutic effects on diabetic retinopathy rats.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Debora de Oliveira Fernandes, Fernanda Gracia Cesar, Bruno Pereira Melo, Jessica da Silva Faria Brandao, Kelvin Jaques dos Santos, Marcelo Teixeira de Andrade, Marisa Cristina da Fonseca Casteluber, Moises Vieira de Carvalho, Luiz Alexandre Medrado de Barcellos, Danusa Dias Soares, Juliana Bohnen Guimaraes
Summary: This study found that chronic supplementation of Noni juice can improve exercise performance and glycemic control in diabetic rats, but it can also cause kidney toxicity.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Biology
Md Fahim Ahmad, Nida Naseem, Inamur Rahman, Nazia Imam, Hina Younus, Swaroop Kumar Pandey, Waseem A. Siddiqui
Summary: This study investigated the potential use of naringin, a flavanone, in treating streptozotocin-induced diabetic neuropathy (DN) in rat models. The results showed that naringin treatment improved DN symptoms and helped restore the normal structure of the brain and pancreas tissues. The neuroprotective properties of naringin may be attributed to its ability to suppress the overactivation of inflammatory molecules and mediators of oxidative stress.
Article
Agriculture, Multidisciplinary
Chenyang Wang, Donghui Luo, Lin Zheng, Mouming Zhao
Summary: Casein hydrolysates have shown potential as anti-diabetic food, with the newly identified peptide Val-Pro-Leu-Gly demonstrating effectiveness in reducing blood glucose levels when orally administered to mice. P-FCH activates the non-insulin-mediated AMPK pathway to exert its hypoglycemic effect in diabetic rats and HepG2 cells.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Nutrition & Dietetics
Jakub Michal Kurek, Ewelina Krol, Zbigniew Krejpcio
Summary: The study found that dietary supplementation with steviol glycosides can normalize lipid metabolism, alleviate internal organ damage in diabetic rats, and have no significant effect on blood glucose, insulin, and insulin resistance indices.
Article
Immunology
Anand Kumar, Priyanka Prajapati, Vinit Raj, Seong-Cheol Kim, Vikas Mishra, Chaitany Jayprakash Raorane, Ritu Raj, Dinesh Kumar, Sapana Kushwaha
Summary: This study found that salbutamol can alleviate muscle atrophy and has antioxidant and anti-inflammatory effects in streptozotocin-induced diabetic rats.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Alba Rodriguez-Nogales, Francesca Algieri, Julio Galvez, Pilar Aranda, Maria Montes-Bayon, Juan Llopis
Summary: The study found that diabetic rats had higher inflammatory status and lower hematological parameters, but these improved after treatment with V, with higher serum iron levels. V reduced the gene expression of hepcidin in diabetic rats, improving the anemic state caused by diabetes.
Article
Medicine, Research & Experimental
Mingzhi Ren, Jianfei Pan, Xueying Yu, Kaile Chang, Xiaopeng Yuan, Chunbo Zhang
Summary: The study shows that CTRP1 improves glucose homeostasis, prevents obesity and fatty liver by increasing energy expenditure and reducing food intake. It also exerts anti-inflammatory effects by regulating gene expression and signaling pathways in adipose tissue.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Subhash Dwivedi, Anuhya Gottipati, Raghu Ganugula, Meenakshi Arora, Richard Friend, Robert Osburne, Aline Rodrigues-Hoffman, Rita Basu, Hui-Lin Pan, M. N. V. Ravi Kumar
Summary: The study suggests that double-headed nanosystems containing curcumin (nCUR) can alleviate diabetic peripheral neuropathy (DPN) and show better outcomes when combined with long-acting subcutaneous insulin (INS). nCUR can protect nerve axons and fibers, reduce inflammation and cell death. Therefore, nCUR may be a potential treatment for DPN.
MOLECULAR PHARMACEUTICS
(2022)
Article
Food Science & Technology
Reshmi Somanathan Karthiga, Shinde Vijay Sukhdeo, Sudha Madhugiri Lakshminarayan, Shashirekha Mysuru Nanjarajurs
Summary: The study investigated the efficacy of Citrus maxima fruit segments fortified paranthas in diabetic rats. The group treated with paranthas fortified with pomelo fruit segment showed significant improvements in weight gain, plasma glucose levels, serum protein, and insulin levels compared to the diabetic control group. The antidiabetic activity was found to be more pronounced in the order of pomelo juice > fortified paranthas > naringin.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Endocrinology & Metabolism
Xudong Yang, Lifeng Wang, Liangzhi Zhang, Xia Zhai, Xiusheng Sheng, Hengjun Lin, Helong Quan
Summary: This study examined the potential of exercise in mitigating skeletal muscle atrophy induced by SGLT2i treatment and found that resistance training is more effective in increasing skeletal muscle mass and muscle fiber cross-sectional area in rats with T2DM compared to aerobic exercise.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
