Article
Plant Sciences
Pornsuda Chawengrum, Jutatip Boonsombat, Chulabhorn Mahidol, Chatchakorn Eurtivong, Prasat Kittakoop, Sanit Thongnest, Somsak Ruchirawat
Summary: Investigation of bioactive compounds from Kaempferia elegans rhizomes led to the discovery of ten new diterpenoids, including five 12,13-seco-diterpenoids. The compound abieta-8,11,13-trien-11-ol was identified as the most potent aromatase inhibitor.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Romeo Arago Dougue Kentsop, Valeria Iobbi, Giuliana Donadio, Barbara Ruffoni, Nunziatina De Tommasi, Angela Bisio
Summary: Salvia corrugata hairy roots were obtained through transformation, serving as a potential source of abietane and abeo-abietane compounds with antibacterial, antitumor, and cytotoxic activities. The study demonstrated the presence of horminone, ferruginol, 7-O-acetylhorminone, and 7-O-methylhorminone in untransformed roots, while agastol and ferruginol were isolated and quantified from the hairy roots, indicating their potential as bioactive compound sources.
Article
Biochemistry & Molecular Biology
Wen-Chao Tu, Ying-Xin Zhao, Chang-Lin Yang, Xing-Jie Zhang, Xiao-Li Li, Kaunda-Joseph Sakah, Rui-Han Zhang, Wei-Lie Xiao, Mei-Feng Liu
Summary: Wulfenioidones A-K (1-11), abietane diterpenoids with highly oxidized 6/6/6 aromatic tricyclic skeleton, were isolated from the whole plant of Orthosiphon wulfenioides. Their planar structures and absolute configurations were determined through spectroscopic data interpretation, electronic circular dichroism calculation, and X-ray crystallography analysis. Bioactivity screening revealed the LDH inhibition effect of compounds 1-4, 6, and 8, with IC50 values ranging from 0.23 to 3.43 μM. Compound 1 selectively inhibited NLRP3 inflammasome and prevented macrophage cell pyroptosis.
BIOORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Abdukriem Kadir, Guijuan Zheng, Xiaofeng Zheng, Pengfei Jin, Maitinuer Maiwulanjiang, Biao Gao, Haji Akber Aisa, Guangmin Yao
Summary: Twenty-four diterpenoids were isolated from the roots of Salvia deserta, with 10 new compounds named salviadesertins A-J. The structures were determined using spectroscopic data interpretation, quantum-chemical calculations, and X-ray crystallography analysis. Cytotoxicity evaluation revealed 6-hydroxysalvinolone (Compound 14) showed potential against multiple cancer cell lines.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Applied
Ye Zhao, Hui-Hui Huang, Jiang-Chun Wei, Qing Wang, Guo-Qing Long, An-Hua Wang, Jing-Ming Jia
Summary: Two previously undescribed ent-abietane diterpenoids, Euphorfinoids M and N, along with seven known analogues, were isolated from the roots of wild Euphorbia fischeriana. Their structures were determined by spectroscopic analysis and comparison with structurally related known analogues. Compound 1 exhibited the highest activity with an IC50 value of 3.62 +/- 0.31 mu M against the proliferative effects of HeLa cell line.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Darius Vrubliauskas, Benjamin M. Gross, Christopher D. Vanderwal
Summary: In this article, the tolerance of Co-catalyzed MHAT-initiated radical bicyclizations towards oxidation at virtually every position in the substrate, oftentimes in unprotected form, is demonstrated. The functional groups in the substrate can also contribute to high levels of stereochemical control in these complexity-generating transformations. Furthermore, the utility of these reactions in the synthesis of three aromatic abietane diterpenoids is documented.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Plant Sciences
Kadidiatou O. Ndjoubi, Rajan Sharma, Jelili A. Badmus, Ayesha Jacobs, Audrey Jordaan, Jeanine Marnewick, Digby F. Warner, Ahmed A. Hussein
Summary: Plectranthus madagascariensis, a medicinal plant native to South Africa, has shown potential in the treatment of tuberculosis and psoriasis due to its bioactive compounds with antimicrobial and antioxidant properties. The phytochemical studies of this plant led to the isolation of five known royleanone abietanes, which showed promising results in inhibiting Mycobacterium tuberculosis and demonstrating comparable toxicity to tamoxifen against HaCaT cells. The plant is considered an important ethnomedicinal plant and a promising source of diterpenoids for potential therapeutic applications.
Article
Virology
Mihayl Varbanov, Stephanie Philippot, Miguel A. Gonzalez-Cardenete
Summary: In this study, a new ferruginol analogue was found to effectively reduce the virus titer and inhibit cytopathic effect of human coronavirus 229E (HCoV-229E) in vitro. In silico analysis was performed to predict the toxicity and estimate the bioavailability of the tested compounds. These findings demonstrate the antimicrobial and specifically antiviral activity of the tested compounds, indicating their potential as new antivirals.
Article
Biochemistry & Molecular Biology
Yue Sun, Hong-Ying Yang, Pei-Zhi Huang, Lan-Jun Zhang, Wei-Jiao Feng, Ya Li, Kun Gao
Summary: Nine undescribed abietane diterpenoids (1-9) and eleven known abietane analogs (10-20) were isolated from Callicarpa bodinieri and characterized by various methods. Compounds 3 and 8 exhibited potent anti-inflammatory activities with IC50 values of 36.35 ± 1.12 and 37.21 ± 0.92 μM. The mechanism studies showed that compound 3 inhibited the expression of nitric oxide synthase and p65 involved in the NF-κB pathway.
Article
Biochemistry & Molecular Biology
Qin-Feng Zhu, Guo-Bo Xu, Shang-Gao Liao, Xue-Long Yan
Summary: In this study, diterpenoids from the roots of Euphorbia fischeriana were investigated for their cytotoxic effects against cancer cells. Two new diterpenoids were isolated from this plant source and showed significant inhibitory effects against human prostate cancer cells.
Article
Environmental Sciences
Jian Li, Yueming Wu, Xiaotong Guo, Shan Jiang, Zhanrui Leng, Jiaojiao Xia, Chongyu Zhuo, Hui Jia, Daolin Du
Summary: Moderate iron supply improves the tolerance of Avicennia marina to cadmium stress by reducing cadmium uptake, enhancing photosynthesis, increasing phenolic and tannin concentrations, and upregulating antioxidant enzyme activity. This could be a potential way to mitigate mangrove degradation caused by cadmium contamination and restore contaminated mangrove ecosystems.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Ecology
Jerferson de Lima Freires, Frederico Lage-Pinto, Elaine Bernini
Summary: The record of severe defoliation caused by lepidopteran larvae in mangrove forests has increased in recent decades, causing concern for the already threatened ecosystem. This study used satellite data to assess the extent and health of the mangrove forest in response to severe defoliation caused by caterpillars of the invasive moth Hyblaea puera. The results showed that about 10% of the mangrove area was intensely affected by defoliation, with the A. schaueriana stand being more affected than the A. germinans stand. The health of both stands degraded in October 2020 but showed improvement in biomass production in June 2021. The study highlights the differences in resilience between the two mangrove species.
REGIONAL STUDIES IN MARINE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Huan Zhao, Yue Liu, Meng Zhang, Guo-dong Chen, Dan Hu, Liang-dong Guo, Zhong-xiang Zhao, Hui Zhi, Hao Gao
Summary: Two new diterpenoids were isolated from Biscogniauxia sp., with their structures elucidated through various analyses. Compound 1 exhibited short-term memory enhancement activity against Alzheimer's disease.
FRONTIERS IN CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jiadong Hu, Shi Qiu, Feiyan Wang, Qing Li, Chun-Lei Xiang, Peng Di, Ziding Wu, Rui Jiang, Jinxing Li, Zhen Zeng, Jing Wang, Xingxing Wang, Yuchen Zhang, Shiyuan Fang, Yuqi Qiao, Jie Ding, Yun Jiang, Zhichao Xu, Junfeng Chen, Wansheng Chen
Summary: This study reveals that the chemical diversity of abietane-type diterpenoids in Salvia species is induced by functional divergence of the CYP76AK subfamily, which leads to variations in oxidation at C-20.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Yang Liu, Qiang Wang, Dong-Kun Zheng, De Zhang, Zhen Xie, Jia-Wei Hu, Xin-Hua Xie, Jing Li, Shu-Ping Jiang
Summary: Two new abietane diterpenoids, named phlecarinatone A(1) and phlecarinatone B(2), as well as two known analogues (3 and 4), were isolated from Phlegmariurus carinatus in this study. Their structures were determined by comprehensive spectroscopic analyses. In addition, compound 2 exhibited moderate neuroprotective activity against H2O2-induced cell injury in vitro.
NATURAL PRODUCT RESEARCH
(2022)
